2VBJB

Molecular basis of human xpc gene recognition and cleavage by engineered homing endonuclease heterodimers
Total Genus 48
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
48
sequence length
152
structure length
152
Chain Sequence
NTKYNKEFLLYLAGFVDADGSIIAQIEPNQSSKFKHRLKLTFQVTQKTQRRWFLDKLVDEIGVGYVRDSGSVSNYILSEIKPLHNFLTQLQPFLKLKQKQANLVLKIIEQLPSAKESPDKFLEVCTWVDQIAALNDSKTRKTTSETVRAVLD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Molecular Basis of Xeroderma Pigmentosum Group C DNA Recognition by Engineered Meganucleases
pubmed doi rcsb
molecule keywords DNA ENDONUCLEASE I-CREI
molecule tags Hydrolase/dna
source organism Chlamydomonas reinhardtii
total genus 48
structure length 152
sequence length 152
ec nomenclature ec 3.1.-.-:
pdb deposition date 2007-09-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00961 LAGLIDADG_1 LAGLIDADG endonuclease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.10.28.10 Alpha Beta Roll Endonuclease I-creI Homing endonucleases 2vbjB00
5A0MA 3FD2A 1BP7A 1LWTA 4UN9G 1U0CA 4UNAA 4Z20A 4UN7G 3UVFA 3OOLA 3QQYA 3MXAA 4UN7A 4AQXA 1R7MA 4EFJA 3C0WA 4Z1ZA 3E54A 3R7PA 3MISA 2VBNA 1G9YA 3OORA 4D6NA 2QOJZ 1AF5A 3EH8A 4AADA 2FLDA 3MXBA 1M5XA 4UN9A 5AKNA 2VS7A 4AABA 1N3FA 4AQUA 5A74A 2VBLB 2CW8A 4AAEA 3HYJA 4UN8G 4AAFA 1T9IA 4D6OA 2XE0B 2O7MA 5A77A 1JVAA 2VBOB 1MOWA 1P8KZ 1EF0A 5E63A 4UN8A 2I3PA 1N3EA 1G9ZA 4LQ0A 4YITA 4UT0A 5AKMA 2VBLA 2CW7A 5AKFA 1LWSA 5A0MB 2VBJB 1DFAA 4UNCA 4LOXA 4AAGA 1T9JA 1U0DA 3C0XA 1UM2A 2I3QA 3KO2A 2VBJA 5E5SA 5AK9A 1B24A 2VS8A 3MIPA 3MX9A 5E5OA 4YISA 2AB5A 2VBNB 5A78A 5E67A 4YHXA 2XE0A 5A72A 2VBOA 5A0WA 1DQ3A 1VDEA 4UNBA 4Z1XA 2EX5A 3MXBB 3HYIA 2DCHX
chains in the Genus database with same CATH superfamily
5A0MA 3FD2A 1BP7A 1LWTA 4UN9G 1U0CA 4UNAA 4Z20A 4UN7G 3UVFA 3OOLA 3QQYA 3MXAA 4UN7A 4KZSA 4AQXA 1R7MA 4EFJA 3C0WA 4Z1ZA 3E54A 3R7PA 3MISA 2VBNA 1G9YA 2F4LA 3OORA 4D6NA 2QOJZ 1AF5A 3EH8A 4AADA 2FLDA 3MXBA 1M5XA 4UN9A 5AKNA 2VS7A 4AABA 1N3FA 4AQUA 5A74A 2VBLB 2CW8A 4AAEA 3HYJA 4UN8G 4AAFA 1T9IA 4D6OA 2XE0B 2O7MA 5A77A 1JVAA 2VBOB 1MOWA 1P8KZ 1EF0A 5E63A 4UN8A 2I3PA 1N3EA 1G9ZA 4LQ0A 4YITA 4UT0A 5AKMA 2VBLA 2CW7A 5AKFA 1LWSA 5A0MB 2VBJB 1DFAA 4UNCA 4LOXA 4AAGA 1T9JA 1U0DA 3C0XA 1UM2A 2I3QA 3KO2A 2VBJA 5E5SA 5AK9A 1B24A 2VS8A 3MIPA 3MX9A 5E5OA 4YISA 2AB5A 2VBNB 5A78A 5E67A 4YHXA 2XE0A 5A72A 2VBOA 5A0WA 1DQ3A 1VDEA 4UNBA 4Z1XA 2EX5A 3MXBB 3HYIA 2DCHX
chains in the Genus database with same CATH topology
5A0MA 3FD2A 1BP7A 1LWTA 4UN9G 1U0CA 4UNAA 4Z20A 4UN7G 3UVFA 3OOLA 3QQYA 3MXAA 4UN7A 4AQXA 1R7MA 4EFJA 3C0WA 4Z1ZA 3E54A 3R7PA 3MISA 2VBNA 1G9YA 3OORA 4D6NA 2QOJZ 1AF5A 3EH8A 4AADA 2FLDA 3MXBA 1M5XA 4UN9A 5AKNA 2VS7A 4AABA 1N3FA 4AQUA 5A74A 2VBLB 2CW8A 4AAEA 3HYJA 4UN8G 4AAFA 1T9IA 4D6OA 2XE0B 2O7MA 5A77A 1JVAA 2VBOB 1MOWA 1P8KZ 1EF0A 5E63A 4UN8A 2I3PA 1N3EA 1G9ZA 4LQ0A 4YITA 4UT0A 5AKMA 2VBLA 2CW7A 5AKFA 1LWSA 5A0MB 2VBJB 1DFAA 4UNCA 4LOXA 4AAGA 1T9JA 1U0DA 3C0XA 1UM2A 2I3QA 3KO2A 2VBJA 5E5SA 5AK9A 1B24A 2VS8A 3MIPA 3MX9A 5E5OA 4YISA 2AB5A 2VBNB 5A78A 5E67A 4YHXA 2XE0A 5A72A 2VBOA 5A0WA 1DQ3A 1VDEA 4UNBA 4Z1XA 2EX5A 3MXBB 3HYIA 2DCHX
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 5A0M A;  3FD2 A;  1BP7 A;  1LWT A;  4UN9 G;  1U0C A;  4UNA A;  4Z20 A;  4UN7 G;  3UVF A;  3OOL A;  3QQY A;  3MXA A;  4UN7 A;  4AQX A;  1R7M A;  4EFJ A;  3C0W A;  4Z1Z A;  3E54 A;  3R7P A;  3MIS A;  2VBN A;  1G9Y A;  3OOR A;  4D6N A;  2QOJ Z;  1AF5 A;  3EH8 A;  4AAD A;  2FLD A;  3MXB A;  1M5X A;  4UN9 A;  5AKN A;  2VS7 A;  4AAB A;  1N3F A;  4AQU A;  5A74 A;  2VBL B;  2CW8 A;  4AAE A;  3HYJ A;  4UN8 G;  4AAF A;  1T9I A;  4D6O A;  2XE0 B;  2O7M A;  5A77 A;  1JVA A;  2VBO B;  1MOW A;  1P8K Z;  1EF0 A;  5E63 A;  4UN8 A;  2I3P A;  1N3E A;  1G9Z A;  4LQ0 A;  4YIT A;  4UT0 A;  5AKM A;  2VBL A;  2CW7 A;  5AKF A;  1LWS A;  5A0M B;  2VBJ B;  1DFA A;  4UNC A;  4LOX A;  4AAG A;  1T9J A;  1U0D A;  3C0X A;  1UM2 A;  2I3Q A;  3KO2 A;  2VBJ A;  5E5S A;  5AK9 A;  1B24 A;  2VS8 A;  3MIP A;  3MX9 A;  5E5O A;  4YIS A;  2AB5 A;  2VBN B;  5A78 A;  5E67 A;  4YHX A;  2XE0 A;  5A72 A;  2VBO A;  5A0W A;  1DQ3 A;  1VDE A;  4UNB A;  4Z1X A;  2EX5 A;  3MXB B;  3HYI A;  2DCH X; 
#chains in the Genus database with same CATH topology
 5A0M A;  3FD2 A;  1BP7 A;  1LWT A;  4UN9 G;  1U0C A;  4UNA A;  4Z20 A;  4UN7 G;  3UVF A;  3OOL A;  3QQY A;  3MXA A;  4UN7 A;  4KZS A;  4AQX A;  1R7M A;  4EFJ A;  3C0W A;  4Z1Z A;  3E54 A;  3R7P A;  3MIS A;  2VBN A;  1G9Y A;  2F4L A;  3OOR A;  4D6N A;  2QOJ Z;  1AF5 A;  3EH8 A;  4AAD A;  2FLD A;  3MXB A;  1M5X A;  4UN9 A;  5AKN A;  2VS7 A;  4AAB A;  1N3F A;  4AQU A;  5A74 A;  2VBL B;  2CW8 A;  4AAE A;  3HYJ A;  4UN8 G;  4AAF A;  1T9I A;  4D6O A;  2XE0 B;  2O7M A;  5A77 A;  1JVA A;  2VBO B;  1MOW A;  1P8K Z;  1EF0 A;  5E63 A;  4UN8 A;  2I3P A;  1N3E A;  1G9Z A;  4LQ0 A;  4YIT A;  4UT0 A;  5AKM A;  2VBL A;  2CW7 A;  5AKF A;  1LWS A;  5A0M B;  2VBJ B;  1DFA A;  4UNC A;  4LOX A;  4AAG A;  1T9J A;  1U0D A;  3C0X A;  1UM2 A;  2I3Q A;  3KO2 A;  2VBJ A;  5E5S A;  5AK9 A;  1B24 A;  2VS8 A;  3MIP A;  3MX9 A;  5E5O A;  4YIS A;  2AB5 A;  2VBN B;  5A78 A;  5E67 A;  4YHX A;  2XE0 A;  5A72 A;  2VBO A;  5A0W A;  1DQ3 A;  1VDE A;  4UNB A;  4Z1X A;  2EX5 A;  3MXB B;  3HYI A;  2DCH X; 
#chains in the Genus database with same CATH homology
 5A0M A;  3FD2 A;  1BP7 A;  1LWT A;  4UN9 G;  1U0C A;  4UNA A;  4Z20 A;  4UN7 G;  3UVF A;  3OOL A;  3QQY A;  3MXA A;  4UN7 A;  4AQX A;  1R7M A;  4EFJ A;  3C0W A;  4Z1Z A;  3E54 A;  3R7P A;  3MIS A;  2VBN A;  1G9Y A;  3OOR A;  4D6N A;  2QOJ Z;  1AF5 A;  3EH8 A;  4AAD A;  2FLD A;  3MXB A;  1M5X A;  4UN9 A;  5AKN A;  2VS7 A;  4AAB A;  1N3F A;  4AQU A;  5A74 A;  2VBL B;  2CW8 A;  4AAE A;  3HYJ A;  4UN8 G;  4AAF A;  1T9I A;  4D6O A;  2XE0 B;  2O7M A;  5A77 A;  1JVA A;  2VBO B;  1MOW A;  1P8K Z;  1EF0 A;  5E63 A;  4UN8 A;  2I3P A;  1N3E A;  1G9Z A;  4LQ0 A;  4YIT A;  4UT0 A;  5AKM A;  2VBL A;  2CW7 A;  5AKF A;  1LWS A;  5A0M B;  2VBJ B;  1DFA A;  4UNC A;  4LOX A;  4AAG A;  1T9J A;  1U0D A;  3C0X A;  1UM2 A;  2I3Q A;  3KO2 A;  2VBJ A;  5E5S A;  5AK9 A;  1B24 A;  2VS8 A;  3MIP A;  3MX9 A;  5E5O A;  4YIS A;  2AB5 A;  2VBN B;  5A78 A;  5E67 A;  4YHX A;  2XE0 A;  5A72 A;  2VBO A;  5A0W A;  1DQ3 A;  1VDE A;  4UNB A;  4Z1X A;  2EX5 A;  3MXB B;  3HYI A;  2DCH X;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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