2VBJB

Molecular basis of human xpc gene recognition and cleavage by engineered homing endonuclease heterodimers
Total Genus 48
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
48
sequence length
152
structure length
152
Chain Sequence
NTKYNKEFLLYLAGFVDADGSIIAQIEPNQSSKFKHRLKLTFQVTQKTQRRWFLDKLVDEIGVGYVRDSGSVSNYILSEIKPLHNFLTQLQPFLKLKQKQANLVLKIIEQLPSAKESPDKFLEVCTWVDQIAALNDSKTRKTTSETVRAVLD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Molecular Basis of Xeroderma Pigmentosum Group C DNA Recognition by Engineered Meganucleases
pubmed doi rcsb
molecule keywords DNA ENDONUCLEASE I-CREI
molecule tags Hydrolase/dna
source organism Chlamydomonas reinhardtii
total genus 48
structure length 152
sequence length 152
ec nomenclature ec 3.1.-.-:
pdb deposition date 2007-09-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00961 LAGLIDADG_1 LAGLIDADG endonuclease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.10.28.10 Alpha Beta Roll Endonuclease I-creI Homing endonucleases 2vbjB00
4AAFA 4UN8G 2VS8A 4AQUA 1EF0A 4Z1ZA 5AKNA 1LWTA 3FD2A 3HYIA 2FLDA 4YITA 5A77A 4UNBA 1G9YA 4YHXA 4UN9A 3HYJA 1DFAA 4UN9G 2VBLB 4Z20A 3C0WA 3KO2A 1BP7A 2VS7A 5A74A 2VBLA 3QQYA 4AAEA 1R7MA 2DCHX 1B24A 5A72A 2QOJZ 1U0CA 5E67A 2AB5A 1T9JA 1T9IA 3OORA 4EFJA 1JVAA 2VBJB 4LQ0A 5A0WA 2VBJA 1M5XA 2XE0B 5E63A 3EH8A 5E5SA 1N3FA 2XE0A 4UT0A 5AKFA 1UM2A 1MOWA 3C0XA 3MISA 1U0DA 4UN7A 1G9ZA 1VDEA 3E54A 4AADA 2EX5A 2CW7A 1LWSA 3MX9A 1DQ3A 1AF5A 4AQXA 1P8KZ 3MXBB 3R7PA 2O7MA 4Z1XA 4UNAA 5A0MB 4D6OA 3MXBA 2I3PA 2I3QA 5AK9A 4D6NA 4UN7G 2VBOB 5E5OA 5A78A 3MIPA 5A0MA 2CW8A 4AABA 2VBOA 4UNCA 4LOXA 2VBNB 3OOLA 1N3EA 2VBNA 3MXAA 4YISA 3UVFA 4UN8A 4AAGA 5AKMA
chains in the Genus database with same CATH superfamily
4AAFA 4UN8G 2VS8A 4AQUA 1EF0A 4Z1ZA 5AKNA 1LWTA 3FD2A 3HYIA 2FLDA 4YITA 5A77A 4UNBA 1G9YA 4YHXA 4UN9A 3HYJA 1DFAA 4UN9G 2VBLB 4Z20A 3C0WA 3KO2A 1BP7A 2VS7A 5A74A 2VBLA 3QQYA 4AAEA 1R7MA 2DCHX 1B24A 5A72A 2QOJZ 1U0CA 5E67A 2AB5A 1T9JA 1T9IA 3OORA 4EFJA 2VBJB 4LQ0A 5A0WA 2VBJA 1M5XA 2XE0B 5E63A 3EH8A 5E5SA 1N3FA 2XE0A 4UT0A 5AKFA 1UM2A 1MOWA 3C0XA 3MISA 1U0DA 4UN7A 1G9ZA 1VDEA 3E54A 4AADA 2EX5A 2CW7A 3UVFA 1LWSA 3MX9A 1DQ3A 1AF5A 4AQXA 1P8KZ 3MXBB 3R7PA 2O7MA 4Z1XA 4UNAA 5A0MB 4D6OA 3MXBA 2I3PA 2I3QA 5AK9A 4D6NA 2F4LA 4UN7G 2VBOB 5E5OA 5A78A 4KZSA 5A0MA 3MIPA 2CW8A 4AABA 2VBOA 4UNCA 4LOXA 2VBNB 3OOLA 1N3EA 2VBNA 3MXAA 4YISA 1JVAA 4UN8A 4AAGA 5AKMA
chains in the Genus database with same CATH topology
4AAFA 4UN8G 2VS8A 4AQUA 1EF0A 4Z1ZA 5AKNA 1LWTA 3FD2A 3HYIA 2FLDA 4YITA 5A77A 4UNBA 1G9YA 4YHXA 4UN9A 3HYJA 1DFAA 4UN9G 2VBLB 4Z20A 3C0WA 3KO2A 1BP7A 2VS7A 5A74A 2VBLA 3QQYA 4AAEA 1R7MA 2DCHX 1B24A 5A72A 2QOJZ 1U0CA 5E67A 2AB5A 1T9JA 1T9IA 3OORA 4EFJA 1JVAA 2VBJB 4LQ0A 5A0WA 2VBJA 1M5XA 2XE0B 5E63A 3EH8A 5E5SA 1N3FA 2XE0A 4UT0A 5AKFA 1UM2A 1MOWA 3C0XA 3MISA 1U0DA 4UN7A 1G9ZA 1VDEA 3E54A 4AADA 2EX5A 2CW7A 1LWSA 3MX9A 1DQ3A 1AF5A 4AQXA 1P8KZ 3MXBB 3R7PA 2O7MA 4Z1XA 4UNAA 5A0MB 4D6OA 3MXBA 2I3PA 2I3QA 5AK9A 4D6NA 4UN7G 2VBOB 5E5OA 5A78A 3MIPA 5A0MA 2CW8A 4AABA 2VBOA 4UNCA 4LOXA 2VBNB 3OOLA 1N3EA 2VBNA 3MXAA 4YISA 3UVFA 4UN8A 4AAGA 5AKMA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4AAF A;  4UN8 G;  2VS8 A;  4AQU A;  1EF0 A;  4Z1Z A;  5AKN A;  1LWT A;  3FD2 A;  3HYI A;  2FLD A;  4YIT A;  5A77 A;  4UNB A;  1G9Y A;  4YHX A;  4UN9 A;  3HYJ A;  1DFA A;  4UN9 G;  2VBL B;  4Z20 A;  3C0W A;  3KO2 A;  1BP7 A;  2VS7 A;  5A74 A;  2VBL A;  3QQY A;  4AAE A;  1R7M A;  2DCH X;  1B24 A;  5A72 A;  2QOJ Z;  1U0C A;  5E67 A;  2AB5 A;  1T9J A;  1T9I A;  3OOR A;  4EFJ A;  1JVA A;  2VBJ B;  4LQ0 A;  5A0W A;  2VBJ A;  1M5X A;  2XE0 B;  5E63 A;  3EH8 A;  5E5S A;  1N3F A;  2XE0 A;  4UT0 A;  5AKF A;  1UM2 A;  1MOW A;  3C0X A;  3MIS A;  1U0D A;  4UN7 A;  1G9Z A;  1VDE A;  3E54 A;  4AAD A;  2EX5 A;  2CW7 A;  1LWS A;  3MX9 A;  1DQ3 A;  1AF5 A;  4AQX A;  1P8K Z;  3MXB B;  3R7P A;  2O7M A;  4Z1X A;  4UNA A;  5A0M B;  4D6O A;  3MXB A;  2I3P A;  2I3Q A;  5AK9 A;  4D6N A;  4UN7 G;  2VBO B;  5E5O A;  5A78 A;  3MIP A;  5A0M A;  2CW8 A;  4AAB A;  2VBO A;  4UNC A;  4LOX A;  2VBN B;  3OOL A;  1N3E A;  2VBN A;  3MXA A;  4YIS A;  3UVF A;  4UN8 A;  4AAG A;  5AKM A; 
#chains in the Genus database with same CATH topology
 4AAF A;  4UN8 G;  2VS8 A;  4AQU A;  1EF0 A;  4Z1Z A;  5AKN A;  1LWT A;  3FD2 A;  3HYI A;  2FLD A;  4YIT A;  5A77 A;  4UNB A;  1G9Y A;  4YHX A;  4UN9 A;  3HYJ A;  1DFA A;  4UN9 G;  2VBL B;  4Z20 A;  3C0W A;  3KO2 A;  1BP7 A;  2VS7 A;  5A74 A;  2VBL A;  3QQY A;  4AAE A;  1R7M A;  2DCH X;  1B24 A;  5A72 A;  2QOJ Z;  1U0C A;  5E67 A;  2AB5 A;  1T9J A;  1T9I A;  3OOR A;  4EFJ A;  2VBJ B;  4LQ0 A;  5A0W A;  2VBJ A;  1M5X A;  2XE0 B;  5E63 A;  3EH8 A;  5E5S A;  1N3F A;  2XE0 A;  4UT0 A;  5AKF A;  1UM2 A;  1MOW A;  3C0X A;  3MIS A;  1U0D A;  4UN7 A;  1G9Z A;  1VDE A;  3E54 A;  4AAD A;  2EX5 A;  2CW7 A;  3UVF A;  1LWS A;  3MX9 A;  1DQ3 A;  1AF5 A;  4AQX A;  1P8K Z;  3MXB B;  3R7P A;  2O7M A;  4Z1X A;  4UNA A;  5A0M B;  4D6O A;  3MXB A;  2I3P A;  2I3Q A;  5AK9 A;  4D6N A;  2F4L A;  4UN7 G;  2VBO B;  5E5O A;  5A78 A;  4KZS A;  5A0M A;  3MIP A;  2CW8 A;  4AAB A;  2VBO A;  4UNC A;  4LOX A;  2VBN B;  3OOL A;  1N3E A;  2VBN A;  3MXA A;  4YIS A;  1JVA A;  4UN8 A;  4AAG A;  5AKM A; 
#chains in the Genus database with same CATH homology
 4AAF A;  4UN8 G;  2VS8 A;  4AQU A;  1EF0 A;  4Z1Z A;  5AKN A;  1LWT A;  3FD2 A;  3HYI A;  2FLD A;  4YIT A;  5A77 A;  4UNB A;  1G9Y A;  4YHX A;  4UN9 A;  3HYJ A;  1DFA A;  4UN9 G;  2VBL B;  4Z20 A;  3C0W A;  3KO2 A;  1BP7 A;  2VS7 A;  5A74 A;  2VBL A;  3QQY A;  4AAE A;  1R7M A;  2DCH X;  1B24 A;  5A72 A;  2QOJ Z;  1U0C A;  5E67 A;  2AB5 A;  1T9J A;  1T9I A;  3OOR A;  4EFJ A;  1JVA A;  2VBJ B;  4LQ0 A;  5A0W A;  2VBJ A;  1M5X A;  2XE0 B;  5E63 A;  3EH8 A;  5E5S A;  1N3F A;  2XE0 A;  4UT0 A;  5AKF A;  1UM2 A;  1MOW A;  3C0X A;  3MIS A;  1U0D A;  4UN7 A;  1G9Z A;  1VDE A;  3E54 A;  4AAD A;  2EX5 A;  2CW7 A;  1LWS A;  3MX9 A;  1DQ3 A;  1AF5 A;  4AQX A;  1P8K Z;  3MXB B;  3R7P A;  2O7M A;  4Z1X A;  4UNA A;  5A0M B;  4D6O A;  3MXB A;  2I3P A;  2I3Q A;  5AK9 A;  4D6N A;  4UN7 G;  2VBO B;  5E5O A;  5A78 A;  3MIP A;  5A0M A;  2CW8 A;  4AAB A;  2VBO A;  4UNC A;  4LOX A;  2VBN B;  3OOL A;  1N3E A;  2VBN A;  3MXA A;  4YIS A;  3UVF A;  4UN8 A;  4AAG A;  5AKM A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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