2VBOB

Molecular basis of human xpc gene recognition and cleavage by engineered homing endonuclease heterodimers
Total Genus 49
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
49
sequence length
152
structure length
152
Chain Sequence
NTKYNKEFLLYLAGFVDGDGSIIAQIEPNQSYKFKHRLKLTFKVTQKTQRRWFLDKLVDEIGVGYVSDSGSVSNYILSEIKPLHNFLTQLQPFLKLKQKQANLVLKIIEQLPSAKESPDKFLEVCTWVDQIAALNDSKTRKTTSETVRAVLD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Molecular Basis of Xeroderma Pigmentosum Group C DNA Recognition by Engineered Meganucleases
pubmed doi rcsb
molecule tags Hydrolase
source organism Chlamydomonas reinhardtii
molecule keywords DNA ENDONUCLEASE I-CREI
total genus 49
structure length 152
sequence length 152
ec nomenclature ec 3.1.-.-:
pdb deposition date 2007-09-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00961 LAGLIDADG_1 LAGLIDADG endonuclease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.10.28.10 Alpha Beta Roll Endonuclease I-creI Homing endonucleases 2vboB00
1T9JA 3EH8A 4UN7A 1R7MA 3MIPA 4Z1ZA 4UN8A 4YISA 2XE0A 3C0WA 2VBOB 2VBJB 3E54A 4AQXA 5AK9A 2VBNB 2VS7A 5A77A 2I3QA 5A0MA 4AABA 4Z20A 5AKNA 4LQ0A 5A72A 1B24A 5AKFA 4AQUA 4UNBA 2DCHX 3C0XA 1BP7A 5E67A 5A78A 2XE0B 3UVFA 4YHXA 3MISA 1EF0A 2EX5A 3MXBA 2VBLA 1AF5A 1JVAA 4UN9A 5A0MB 4UNCA 2VS8A 2QOJZ 2VBOA 4UN9G 5E63A 1U0DA 3OORA 1LWSA 1G9YA 4Z1XA 2AB5A 5AKMA 1UM2A 2FLDA 2CW8A 1T9IA 3OOLA 3MX9A 4AAFA 3QQYA 3HYJA 2CW7A 3MXAA 4UNAA 1VDEA 1N3FA 2O7MA 3KO2A 2VBLB 1M5XA 1G9ZA 1MOWA 5A74A 1N3EA 1DQ3A 1LWTA 4D6OA 5E5OA 2VBJA 4UN7G 4AAGA 4AADA 4UT0A 4UN8G 4AAEA 3FD2A 4LOXA 5E5SA 2VBNA 3HYIA 4D6NA 3R7PA 4EFJA 1U0CA 1P8KZ 4YITA 3MXBB 2I3PA 1DFAA 5A0WA
chains in the Genus database with same CATH superfamily
1T9JA 3EH8A 4UN7A 1R7MA 3MIPA 4Z1ZA 4UN8A 4YISA 2XE0A 3C0WA 2VBOB 2F4LA 2VBJB 3E54A 4AQXA 5AK9A 2VBNB 2VS7A 5A77A 2I3QA 5A0MA 4AABA 4Z20A 5AKNA 4LQ0A 5A72A 1B24A 5AKFA 4AQUA 4UNBA 2DCHX 3C0XA 1BP7A 5E67A 5A78A 2XE0B 3UVFA 4YHXA 3MISA 1EF0A 2EX5A 3MXBA 2VBLA 1AF5A 1JVAA 4UN9A 5A0MB 4UNCA 2VS8A 2QOJZ 2VBOA 4UN9G 5E63A 1U0DA 3OORA 1LWSA 1G9YA 4Z1XA 2AB5A 5AKMA 1UM2A 2FLDA 2CW8A 4KZSA 1T9IA 3OOLA 3MX9A 4AAFA 3QQYA 3HYJA 2CW7A 3MXAA 4UNAA 1VDEA 1N3FA 2O7MA 3KO2A 2VBLB 1M5XA 1G9ZA 1MOWA 5A74A 1N3EA 1DQ3A 1LWTA 4D6OA 5E5OA 2VBJA 4UN7G 4AAGA 4AADA 4UT0A 4UN8G 4AAEA 3FD2A 4LOXA 5E5SA 2VBNA 3HYIA 4D6NA 3R7PA 4EFJA 1U0CA 1P8KZ 4YITA 3MXBB 2I3PA 1DFAA 5A0WA
chains in the Genus database with same CATH topology
1T9JA 3EH8A 4UN7A 1R7MA 3MIPA 4Z1ZA 4UN8A 4YISA 2XE0A 3C0WA 2VBOB 2VBJB 3E54A 4AQXA 5AK9A 2VBNB 2VS7A 5A77A 2I3QA 5A0MA 4AABA 4Z20A 5AKNA 4LQ0A 5A72A 1B24A 5AKFA 4AQUA 4UNBA 2DCHX 3C0XA 1BP7A 5E67A 5A78A 2XE0B 3UVFA 4YHXA 3MISA 1EF0A 2EX5A 3MXBA 2VBLA 1AF5A 1JVAA 4UN9A 5A0MB 4UNCA 2VS8A 2QOJZ 2VBOA 4UN9G 5E63A 1U0DA 3OORA 1LWSA 1G9YA 4Z1XA 2AB5A 5AKMA 1UM2A 2FLDA 2CW8A 1T9IA 3OOLA 3MX9A 4AAFA 3QQYA 3HYJA 2CW7A 3MXAA 4UNAA 1VDEA 1N3FA 2O7MA 3KO2A 2VBLB 1M5XA 1G9ZA 1MOWA 5A74A 1N3EA 1DQ3A 1LWTA 4D6OA 5E5OA 2VBJA 4UN7G 4AAGA 4AADA 4UT0A 4UN8G 4AAEA 3FD2A 4LOXA 5E5SA 2VBNA 3HYIA 4D6NA 3R7PA 4EFJA 1U0CA 1P8KZ 4YITA 3MXBB 2I3PA 1DFAA 5A0WA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 1T9J A;  3EH8 A;  4UN7 A;  1R7M A;  3MIP A;  4Z1Z A;  4UN8 A;  4YIS A;  2XE0 A;  3C0W A;  2VBO B;  2VBJ B;  3E54 A;  4AQX A;  5AK9 A;  2VBN B;  2VS7 A;  5A77 A;  2I3Q A;  5A0M A;  4AAB A;  4Z20 A;  5AKN A;  4LQ0 A;  5A72 A;  1B24 A;  5AKF A;  4AQU A;  4UNB A;  2DCH X;  3C0X A;  1BP7 A;  5E67 A;  5A78 A;  2XE0 B;  3UVF A;  4YHX A;  3MIS A;  1EF0 A;  2EX5 A;  3MXB A;  2VBL A;  1AF5 A;  1JVA A;  4UN9 A;  5A0M B;  4UNC A;  2VS8 A;  2QOJ Z;  2VBO A;  4UN9 G;  5E63 A;  1U0D A;  3OOR A;  1LWS A;  1G9Y A;  4Z1X A;  2AB5 A;  5AKM A;  1UM2 A;  2FLD A;  2CW8 A;  1T9I A;  3OOL A;  3MX9 A;  4AAF A;  3QQY A;  3HYJ A;  2CW7 A;  3MXA A;  4UNA A;  1VDE A;  1N3F A;  2O7M A;  3KO2 A;  2VBL B;  1M5X A;  1G9Z A;  1MOW A;  5A74 A;  1N3E A;  1DQ3 A;  1LWT A;  4D6O A;  5E5O A;  2VBJ A;  4UN7 G;  4AAG A;  4AAD A;  4UT0 A;  4UN8 G;  4AAE A;  3FD2 A;  4LOX A;  5E5S A;  2VBN A;  3HYI A;  4D6N A;  3R7P A;  4EFJ A;  1U0C A;  1P8K Z;  4YIT A;  3MXB B;  2I3P A;  1DFA A;  5A0W A; 
#chains in the Genus database with same CATH topology
 1T9J A;  3EH8 A;  4UN7 A;  1R7M A;  3MIP A;  4Z1Z A;  4UN8 A;  4YIS A;  2XE0 A;  3C0W A;  2VBO B;  2F4L A;  2VBJ B;  3E54 A;  4AQX A;  5AK9 A;  2VBN B;  2VS7 A;  5A77 A;  2I3Q A;  5A0M A;  4AAB A;  4Z20 A;  5AKN A;  4LQ0 A;  5A72 A;  1B24 A;  5AKF A;  4AQU A;  4UNB A;  2DCH X;  3C0X A;  1BP7 A;  5E67 A;  5A78 A;  2XE0 B;  3UVF A;  4YHX A;  3MIS A;  1EF0 A;  2EX5 A;  3MXB A;  2VBL A;  1AF5 A;  1JVA A;  4UN9 A;  5A0M B;  4UNC A;  2VS8 A;  2QOJ Z;  2VBO A;  4UN9 G;  5E63 A;  1U0D A;  3OOR A;  1LWS A;  1G9Y A;  4Z1X A;  2AB5 A;  5AKM A;  1UM2 A;  2FLD A;  2CW8 A;  4KZS A;  1T9I A;  3OOL A;  3MX9 A;  4AAF A;  3QQY A;  3HYJ A;  2CW7 A;  3MXA A;  4UNA A;  1VDE A;  1N3F A;  2O7M A;  3KO2 A;  2VBL B;  1M5X A;  1G9Z A;  1MOW A;  5A74 A;  1N3E A;  1DQ3 A;  1LWT A;  4D6O A;  5E5O A;  2VBJ A;  4UN7 G;  4AAG A;  4AAD A;  4UT0 A;  4UN8 G;  4AAE A;  3FD2 A;  4LOX A;  5E5S A;  2VBN A;  3HYI A;  4D6N A;  3R7P A;  4EFJ A;  1U0C A;  1P8K Z;  4YIT A;  3MXB B;  2I3P A;  1DFA A;  5A0W A; 
#chains in the Genus database with same CATH homology
 1T9J A;  3EH8 A;  4UN7 A;  1R7M A;  3MIP A;  4Z1Z A;  4UN8 A;  4YIS A;  2XE0 A;  3C0W A;  2VBO B;  2VBJ B;  3E54 A;  4AQX A;  5AK9 A;  2VBN B;  2VS7 A;  5A77 A;  2I3Q A;  5A0M A;  4AAB A;  4Z20 A;  5AKN A;  4LQ0 A;  5A72 A;  1B24 A;  5AKF A;  4AQU A;  4UNB A;  2DCH X;  3C0X A;  1BP7 A;  5E67 A;  5A78 A;  2XE0 B;  3UVF A;  4YHX A;  3MIS A;  1EF0 A;  2EX5 A;  3MXB A;  2VBL A;  1AF5 A;  1JVA A;  4UN9 A;  5A0M B;  4UNC A;  2VS8 A;  2QOJ Z;  2VBO A;  4UN9 G;  5E63 A;  1U0D A;  3OOR A;  1LWS A;  1G9Y A;  4Z1X A;  2AB5 A;  5AKM A;  1UM2 A;  2FLD A;  2CW8 A;  1T9I A;  3OOL A;  3MX9 A;  4AAF A;  3QQY A;  3HYJ A;  2CW7 A;  3MXA A;  4UNA A;  1VDE A;  1N3F A;  2O7M A;  3KO2 A;  2VBL B;  1M5X A;  1G9Z A;  1MOW A;  5A74 A;  1N3E A;  1DQ3 A;  1LWT A;  4D6O A;  5E5O A;  2VBJ A;  4UN7 G;  4AAG A;  4AAD A;  4UT0 A;  4UN8 G;  4AAE A;  3FD2 A;  4LOX A;  5E5S A;  2VBN A;  3HYI A;  4D6N A;  3R7P A;  4EFJ A;  1U0C A;  1P8K Z;  4YIT A;  3MXB B;  2I3P A;  1DFA A;  5A0W A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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