2XE0A

Molecular basis of engineered meganuclease targeting of the endogenous human rag1 locus
Total Genus 48
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
48
sequence length
152
structure length
152
Chain Sequence
NTKYNKEFLLYLAGFVDGDGSIIAQINPNASSKFKHRLRLTFYVTQKTQRRWFLDKLVDEIGVGYVRDSGSVSQYVLSEIAPLHNFLTQLQPFLKLKQKQANLVLKIIEQLPSAKASPAAFLEVCTWVDQIAALNDSATRKTTSETVAAVLD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Dna binding protein/dna
source organism Chlamydomonas reinhardtii
publication title Molecular Basis of Engineered Meganuclease Targeting of the Endogenous Human Rag1 Locus
pubmed doi rcsb
molecule keywords I-CREI V2V3 VARIANT
total genus 48
structure length 152
sequence length 152
ec nomenclature
pdb deposition date 2010-05-10
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.10.28.10 Alpha Beta Roll Endonuclease I-creI Homing endonucleases 2xe0A00
1BP7A 5A0MB 4UN7G 4YISA 1B24A 3MXBA 4LOXA 2XE0B 3MXBB 1T9IA 1DQ3A 4UT0A 4UN9G 4YHXA 2VBJB 2QOJZ 4AAEA 5A78A 1N3FA 5E5OA 4LQ0A 2VBLA 5AKMA 5AKFA 1U0DA 4UN7A 2VBNA 4UN8G 1R7MA 5AKNA 4UNCA 2EX5A 2CW7A 1VDEA 3R7PA 2VBOA 2AB5A 1G9YA 4EFJA 4D6OA 4UN9A 5E5SA 3UVFA 5A77A 4AABA 2VS7A 4AQUA 2DCHX 3OOLA 1LWTA 1N3EA 1LWSA 2VBLB 5A74A 4UN8A 2FLDA 5E67A 3E54A 2VBNB 4AADA 4D6NA 1T9JA 2CW8A 3KO2A 2I3PA 1UM2A 3C0XA 3FD2A 1U0CA 2VBOB 4Z20A 1AF5A 5E63A 4YITA 4Z1ZA 3MX9A 5A0MA 4UNAA 4AAFA 5A72A 2I3QA 2VS8A 3EH8A 3QQYA 3OORA 2XE0A 3C0WA 5AK9A 3MISA 5A0WA 4UNBA 3HYIA 1JVAA 4AQXA 3HYJA 1DFAA 2VBJA 2O7MA 1P8KZ 1EF0A 1G9ZA 3MIPA 4AAGA 1M5XA 4Z1XA 1MOWA 3MXAA
chains in the Genus database with same CATH superfamily
1BP7A 5A0MB 4UN7G 4YISA 1B24A 3MXBA 4LOXA 2XE0B 3MXBB 1T9IA 1DQ3A 4UT0A 4UN9G 4YHXA 2VBJB 2QOJZ 4AAEA 5A78A 1N3FA 5E5OA 4LQ0A 2VBLA 5AKMA 5AKFA 1U0DA 4UN7A 2VBNA 4UN8G 1R7MA 5AKNA 4UNCA 2EX5A 2CW7A 1VDEA 3R7PA 2VBOA 2AB5A 1G9YA 4EFJA 4D6OA 4UN9A 5E5SA 3UVFA 5A77A 4AABA 2VS7A 4AQUA 2DCHX 3OOLA 1LWTA 1N3EA 1LWSA 2VBLB 5A74A 4UN8A 2FLDA 5E67A 3E54A 2VBNB 4AADA 4D6NA 1T9JA 2CW8A 3KO2A 2I3PA 1UM2A 3C0XA 3FD2A 1U0CA 2VBOB 4Z20A 1AF5A 5E63A 4YITA 4Z1ZA 3MX9A 5A0MA 4UNAA 4AAFA 5A72A 2I3QA 2VS8A 3EH8A 3QQYA 4KZSA 3OORA 2XE0A 3C0WA 5AK9A 3MISA 2F4LA 5A0WA 4UNBA 3HYIA 1JVAA 4AQXA 3HYJA 1DFAA 2VBJA 2O7MA 1P8KZ 1EF0A 1G9ZA 3MIPA 4AAGA 1M5XA 4Z1XA 1MOWA 3MXAA
chains in the Genus database with same CATH topology
1BP7A 5A0MB 4UN7G 4YISA 1B24A 3MXBA 4LOXA 2XE0B 3MXBB 1T9IA 1DQ3A 4UT0A 4UN9G 4YHXA 2VBJB 2QOJZ 4AAEA 5A78A 1N3FA 5E5OA 4LQ0A 2VBLA 5AKMA 5AKFA 1U0DA 4UN7A 2VBNA 4UN8G 1R7MA 5AKNA 4UNCA 2EX5A 2CW7A 1VDEA 3R7PA 2VBOA 2AB5A 1G9YA 4EFJA 4D6OA 4UN9A 5E5SA 3UVFA 5A77A 4AABA 2VS7A 4AQUA 2DCHX 3OOLA 1LWTA 1N3EA 1LWSA 2VBLB 5A74A 4UN8A 2FLDA 5E67A 3E54A 2VBNB 4AADA 4D6NA 1T9JA 2CW8A 3KO2A 2I3PA 1UM2A 3C0XA 3FD2A 1U0CA 2VBOB 4Z20A 1AF5A 5E63A 4YITA 4Z1ZA 3MX9A 5A0MA 4UNAA 4AAFA 5A72A 2I3QA 2VS8A 3EH8A 3QQYA 3OORA 2XE0A 3C0WA 5AK9A 3MISA 5A0WA 4UNBA 3HYIA 1JVAA 4AQXA 3HYJA 1DFAA 2VBJA 2O7MA 1P8KZ 1EF0A 1G9ZA 3MIPA 4AAGA 1M5XA 4Z1XA 1MOWA 3MXAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1BP7 A;  5A0M B;  4UN7 G;  4YIS A;  1B24 A;  3MXB A;  4LOX A;  2XE0 B;  3MXB B;  1T9I A;  1DQ3 A;  4UT0 A;  4UN9 G;  4YHX A;  2VBJ B;  2QOJ Z;  4AAE A;  5A78 A;  1N3F A;  5E5O A;  4LQ0 A;  2VBL A;  5AKM A;  5AKF A;  1U0D A;  4UN7 A;  2VBN A;  4UN8 G;  1R7M A;  5AKN A;  4UNC A;  2EX5 A;  2CW7 A;  1VDE A;  3R7P A;  2VBO A;  2AB5 A;  1G9Y A;  4EFJ A;  4D6O A;  4UN9 A;  5E5S A;  3UVF A;  5A77 A;  4AAB A;  2VS7 A;  4AQU A;  2DCH X;  3OOL A;  1LWT A;  1N3E A;  1LWS A;  2VBL B;  5A74 A;  4UN8 A;  2FLD A;  5E67 A;  3E54 A;  2VBN B;  4AAD A;  4D6N A;  1T9J A;  2CW8 A;  3KO2 A;  2I3P A;  1UM2 A;  3C0X A;  3FD2 A;  1U0C A;  2VBO B;  4Z20 A;  1AF5 A;  5E63 A;  4YIT A;  4Z1Z A;  3MX9 A;  5A0M A;  4UNA A;  4AAF A;  5A72 A;  2I3Q A;  2VS8 A;  3EH8 A;  3QQY A;  3OOR A;  2XE0 A;  3C0W A;  5AK9 A;  3MIS A;  5A0W A;  4UNB A;  3HYI A;  1JVA A;  4AQX A;  3HYJ A;  1DFA A;  2VBJ A;  2O7M A;  1P8K Z;  1EF0 A;  1G9Z A;  3MIP A;  4AAG A;  1M5X A;  4Z1X A;  1MOW A;  3MXA A; 
#chains in the Genus database with same CATH topology
 1BP7 A;  5A0M B;  4UN7 G;  4YIS A;  1B24 A;  3MXB A;  4LOX A;  2XE0 B;  3MXB B;  1T9I A;  1DQ3 A;  4UT0 A;  4UN9 G;  4YHX A;  2VBJ B;  2QOJ Z;  4AAE A;  5A78 A;  1N3F A;  5E5O A;  4LQ0 A;  2VBL A;  5AKM A;  5AKF A;  1U0D A;  4UN7 A;  2VBN A;  4UN8 G;  1R7M A;  5AKN A;  4UNC A;  2EX5 A;  2CW7 A;  1VDE A;  3R7P A;  2VBO A;  2AB5 A;  1G9Y A;  4EFJ A;  4D6O A;  4UN9 A;  5E5S A;  3UVF A;  5A77 A;  4AAB A;  2VS7 A;  4AQU A;  2DCH X;  3OOL A;  1LWT A;  1N3E A;  1LWS A;  2VBL B;  5A74 A;  4UN8 A;  2FLD A;  5E67 A;  3E54 A;  2VBN B;  4AAD A;  4D6N A;  1T9J A;  2CW8 A;  3KO2 A;  2I3P A;  1UM2 A;  3C0X A;  3FD2 A;  1U0C A;  2VBO B;  4Z20 A;  1AF5 A;  5E63 A;  4YIT A;  4Z1Z A;  3MX9 A;  5A0M A;  4UNA A;  4AAF A;  5A72 A;  2I3Q A;  2VS8 A;  3EH8 A;  3QQY A;  4KZS A;  3OOR A;  2XE0 A;  3C0W A;  5AK9 A;  3MIS A;  2F4L A;  5A0W A;  4UNB A;  3HYI A;  1JVA A;  4AQX A;  3HYJ A;  1DFA A;  2VBJ A;  2O7M A;  1P8K Z;  1EF0 A;  1G9Z A;  3MIP A;  4AAG A;  1M5X A;  4Z1X A;  1MOW A;  3MXA A; 
#chains in the Genus database with same CATH homology
 1BP7 A;  5A0M B;  4UN7 G;  4YIS A;  1B24 A;  3MXB A;  4LOX A;  2XE0 B;  3MXB B;  1T9I A;  1DQ3 A;  4UT0 A;  4UN9 G;  4YHX A;  2VBJ B;  2QOJ Z;  4AAE A;  5A78 A;  1N3F A;  5E5O A;  4LQ0 A;  2VBL A;  5AKM A;  5AKF A;  1U0D A;  4UN7 A;  2VBN A;  4UN8 G;  1R7M A;  5AKN A;  4UNC A;  2EX5 A;  2CW7 A;  1VDE A;  3R7P A;  2VBO A;  2AB5 A;  1G9Y A;  4EFJ A;  4D6O A;  4UN9 A;  5E5S A;  3UVF A;  5A77 A;  4AAB A;  2VS7 A;  4AQU A;  2DCH X;  3OOL A;  1LWT A;  1N3E A;  1LWS A;  2VBL B;  5A74 A;  4UN8 A;  2FLD A;  5E67 A;  3E54 A;  2VBN B;  4AAD A;  4D6N A;  1T9J A;  2CW8 A;  3KO2 A;  2I3P A;  1UM2 A;  3C0X A;  3FD2 A;  1U0C A;  2VBO B;  4Z20 A;  1AF5 A;  5E63 A;  4YIT A;  4Z1Z A;  3MX9 A;  5A0M A;  4UNA A;  4AAF A;  5A72 A;  2I3Q A;  2VS8 A;  3EH8 A;  3QQY A;  3OOR A;  2XE0 A;  3C0W A;  5AK9 A;  3MIS A;  5A0W A;  4UNB A;  3HYI A;  1JVA A;  4AQX A;  3HYJ A;  1DFA A;  2VBJ A;  2O7M A;  1P8K Z;  1EF0 A;  1G9Z A;  3MIP A;  4AAG A;  1M5X A;  4Z1X A;  1MOW A;  3MXA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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