2XE0A

Molecular basis of engineered meganuclease targeting of the endogenous human rag1 locus
Total Genus 48
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
48
sequence length
152
structure length
152
Chain Sequence
NTKYNKEFLLYLAGFVDGDGSIIAQINPNASSKFKHRLRLTFYVTQKTQRRWFLDKLVDEIGVGYVRDSGSVSQYVLSEIAPLHNFLTQLQPFLKLKQKQANLVLKIIEQLPSAKASPAAFLEVCTWVDQIAALNDSATRKTTSETVAAVLD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Molecular Basis of Engineered Meganuclease Targeting of the Endogenous Human Rag1 Locus
pubmed doi rcsb
molecule tags Dna binding protein/dna
source organism Chlamydomonas reinhardtii
molecule keywords I-CREI V2V3 VARIANT
total genus 48
structure length 152
sequence length 152
ec nomenclature
pdb deposition date 2010-05-10
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.10.28.10 Alpha Beta Roll Endonuclease I-creI Homing endonucleases 2xe0A00
1UM2A 3MISA 1N3EA 4UN9G 1M5XA 1BP7A 4UNBA 3HYIA 1JVAA 1LWSA 2VBNB 4UNAA 2CW8A 4UN8G 2VBJB 3OOLA 5E5SA 4EFJA 2VBJA 3MIPA 2CW7A 3HYJA 5AKMA 2VBOB 2EX5A 3QQYA 4UNCA 2DCHX 1B24A 3OORA 4D6OA 2I3QA 3MXBB 1DQ3A 2VBOA 1EF0A 2I3PA 5A78A 5A77A 4UT0A 2AB5A 4YISA 4UN7A 4AADA 1G9ZA 4AABA 5E63A 3C0XA 1LWTA 5E5OA 2O7MA 1U0CA 4YITA 2VS8A 5AKNA 1T9JA 3MX9A 4AAEA 2XE0B 4YHXA 5A72A 4UN9A 5E67A 4AAGA 4AAFA 1T9IA 2FLDA 5A0MB 2XE0A 1VDEA 3EH8A 5A0WA 4D6NA 1MOWA 5A0MA 4UN8A 2VBLB 5A74A 5AKFA 2VBLA 1G9YA 3E54A 4AQUA 3R7PA 1N3FA 3KO2A 3C0WA 3FD2A 4Z1ZA 5AK9A 4Z1XA 4LQ0A 1U0DA 4UN7G 1R7MA 2VBNA 4Z20A 4LOXA 4AQXA 2QOJZ 2VS7A 3UVFA 1AF5A 3MXAA 1DFAA 3MXBA 1P8KZ
chains in the Genus database with same CATH superfamily
1UM2A 3MISA 1N3EA 4UN9G 1M5XA 1BP7A 4UNBA 3HYIA 1JVAA 1LWSA 2VBNB 4UNAA 2CW8A 4UN8G 2VBJB 3OOLA 5E5SA 4KZSA 4EFJA 2VBJA 3MIPA 2CW7A 3HYJA 5AKMA 2VBOB 2EX5A 3QQYA 4UNCA 2DCHX 1B24A 3OORA 4D6OA 2I3QA 3MXBB 1DQ3A 2VBOA 1EF0A 2I3PA 5A78A 5A77A 4UT0A 2AB5A 4YISA 4UN7A 4AADA 1G9ZA 4AABA 5E63A 3C0XA 1LWTA 5E5OA 2O7MA 1U0CA 4YITA 2VS8A 5AKNA 1T9JA 3MX9A 4AAEA 2XE0B 4YHXA 5A72A 4UN9A 5E67A 4AAGA 4AAFA 1T9IA 2F4LA 2FLDA 5A0MB 2XE0A 1VDEA 3EH8A 5A0WA 4D6NA 1MOWA 5A0MA 4UN8A 2VBLB 5A74A 5AKFA 2VBLA 1G9YA 3E54A 4AQUA 3R7PA 1N3FA 3KO2A 3C0WA 3FD2A 4Z1ZA 5AK9A 4Z1XA 4LQ0A 1U0DA 4UN7G 1R7MA 2VBNA 4Z20A 4LOXA 4AQXA 2QOJZ 2VS7A 3UVFA 1AF5A 3MXAA 1DFAA 3MXBA 1P8KZ
chains in the Genus database with same CATH topology
1UM2A 3MISA 1N3EA 4UN9G 1M5XA 1BP7A 4UNBA 3HYIA 1JVAA 1LWSA 2VBNB 4UNAA 2CW8A 4UN8G 2VBJB 3OOLA 5E5SA 4EFJA 2VBJA 3MIPA 2CW7A 3HYJA 5AKMA 2VBOB 2EX5A 3QQYA 4UNCA 2DCHX 1B24A 3OORA 4D6OA 2I3QA 3MXBB 1DQ3A 2VBOA 1EF0A 2I3PA 5A78A 5A77A 4UT0A 2AB5A 4YISA 4UN7A 4AADA 1G9ZA 4AABA 5E63A 3C0XA 1LWTA 5E5OA 2O7MA 1U0CA 4YITA 2VS8A 5AKNA 1T9JA 3MX9A 4AAEA 2XE0B 4YHXA 5A72A 4UN9A 5E67A 4AAGA 4AAFA 1T9IA 2FLDA 5A0MB 2XE0A 1VDEA 3EH8A 5A0WA 4D6NA 1MOWA 5A0MA 4UN8A 2VBLB 5A74A 5AKFA 2VBLA 1G9YA 3E54A 4AQUA 3R7PA 1N3FA 3KO2A 3C0WA 3FD2A 4Z1ZA 5AK9A 4Z1XA 4LQ0A 1U0DA 4UN7G 1R7MA 2VBNA 4Z20A 4LOXA 4AQXA 2QOJZ 2VS7A 3UVFA 1AF5A 3MXAA 1DFAA 3MXBA 1P8KZ
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1UM2 A;  3MIS A;  1N3E A;  4UN9 G;  1M5X A;  1BP7 A;  4UNB A;  3HYI A;  1JVA A;  1LWS A;  2VBN B;  4UNA A;  2CW8 A;  4UN8 G;  2VBJ B;  3OOL A;  5E5S A;  4EFJ A;  2VBJ A;  3MIP A;  2CW7 A;  3HYJ A;  5AKM A;  2VBO B;  2EX5 A;  3QQY A;  4UNC A;  2DCH X;  1B24 A;  3OOR A;  4D6O A;  2I3Q A;  3MXB B;  1DQ3 A;  2VBO A;  1EF0 A;  2I3P A;  5A78 A;  5A77 A;  4UT0 A;  2AB5 A;  4YIS A;  4UN7 A;  4AAD A;  1G9Z A;  4AAB A;  5E63 A;  3C0X A;  1LWT A;  5E5O A;  2O7M A;  1U0C A;  4YIT A;  2VS8 A;  5AKN A;  1T9J A;  3MX9 A;  4AAE A;  2XE0 B;  4YHX A;  5A72 A;  4UN9 A;  5E67 A;  4AAG A;  4AAF A;  1T9I A;  2FLD A;  5A0M B;  2XE0 A;  1VDE A;  3EH8 A;  5A0W A;  4D6N A;  1MOW A;  5A0M A;  4UN8 A;  2VBL B;  5A74 A;  5AKF A;  2VBL A;  1G9Y A;  3E54 A;  4AQU A;  3R7P A;  1N3F A;  3KO2 A;  3C0W A;  3FD2 A;  4Z1Z A;  5AK9 A;  4Z1X A;  4LQ0 A;  1U0D A;  4UN7 G;  1R7M A;  2VBN A;  4Z20 A;  4LOX A;  4AQX A;  2QOJ Z;  2VS7 A;  3UVF A;  1AF5 A;  3MXA A;  1DFA A;  3MXB A;  1P8K Z; 
#chains in the Genus database with same CATH topology
 1UM2 A;  3MIS A;  1N3E A;  4UN9 G;  1M5X A;  1BP7 A;  4UNB A;  3HYI A;  1JVA A;  1LWS A;  2VBN B;  4UNA A;  2CW8 A;  4UN8 G;  2VBJ B;  3OOL A;  5E5S A;  4KZS A;  4EFJ A;  2VBJ A;  3MIP A;  2CW7 A;  3HYJ A;  5AKM A;  2VBO B;  2EX5 A;  3QQY A;  4UNC A;  2DCH X;  1B24 A;  3OOR A;  4D6O A;  2I3Q A;  3MXB B;  1DQ3 A;  2VBO A;  1EF0 A;  2I3P A;  5A78 A;  5A77 A;  4UT0 A;  2AB5 A;  4YIS A;  4UN7 A;  4AAD A;  1G9Z A;  4AAB A;  5E63 A;  3C0X A;  1LWT A;  5E5O A;  2O7M A;  1U0C A;  4YIT A;  2VS8 A;  5AKN A;  1T9J A;  3MX9 A;  4AAE A;  2XE0 B;  4YHX A;  5A72 A;  4UN9 A;  5E67 A;  4AAG A;  4AAF A;  1T9I A;  2F4L A;  2FLD A;  5A0M B;  2XE0 A;  1VDE A;  3EH8 A;  5A0W A;  4D6N A;  1MOW A;  5A0M A;  4UN8 A;  2VBL B;  5A74 A;  5AKF A;  2VBL A;  1G9Y A;  3E54 A;  4AQU A;  3R7P A;  1N3F A;  3KO2 A;  3C0W A;  3FD2 A;  4Z1Z A;  5AK9 A;  4Z1X A;  4LQ0 A;  1U0D A;  4UN7 G;  1R7M A;  2VBN A;  4Z20 A;  4LOX A;  4AQX A;  2QOJ Z;  2VS7 A;  3UVF A;  1AF5 A;  3MXA A;  1DFA A;  3MXB A;  1P8K Z; 
#chains in the Genus database with same CATH homology
 1UM2 A;  3MIS A;  1N3E A;  4UN9 G;  1M5X A;  1BP7 A;  4UNB A;  3HYI A;  1JVA A;  1LWS A;  2VBN B;  4UNA A;  2CW8 A;  4UN8 G;  2VBJ B;  3OOL A;  5E5S A;  4EFJ A;  2VBJ A;  3MIP A;  2CW7 A;  3HYJ A;  5AKM A;  2VBO B;  2EX5 A;  3QQY A;  4UNC A;  2DCH X;  1B24 A;  3OOR A;  4D6O A;  2I3Q A;  3MXB B;  1DQ3 A;  2VBO A;  1EF0 A;  2I3P A;  5A78 A;  5A77 A;  4UT0 A;  2AB5 A;  4YIS A;  4UN7 A;  4AAD A;  1G9Z A;  4AAB A;  5E63 A;  3C0X A;  1LWT A;  5E5O A;  2O7M A;  1U0C A;  4YIT A;  2VS8 A;  5AKN A;  1T9J A;  3MX9 A;  4AAE A;  2XE0 B;  4YHX A;  5A72 A;  4UN9 A;  5E67 A;  4AAG A;  4AAF A;  1T9I A;  2FLD A;  5A0M B;  2XE0 A;  1VDE A;  3EH8 A;  5A0W A;  4D6N A;  1MOW A;  5A0M A;  4UN8 A;  2VBL B;  5A74 A;  5AKF A;  2VBL A;  1G9Y A;  3E54 A;  4AQU A;  3R7P A;  1N3F A;  3KO2 A;  3C0W A;  3FD2 A;  4Z1Z A;  5AK9 A;  4Z1X A;  4LQ0 A;  1U0D A;  4UN7 G;  1R7M A;  2VBN A;  4Z20 A;  4LOX A;  4AQX A;  2QOJ Z;  2VS7 A;  3UVF A;  1AF5 A;  3MXA A;  1DFA A;  3MXB A;  1P8K Z; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...