2XE0B

Molecular basis of engineered meganuclease targeting of the endogenous human rag1 locus
Total Genus 48
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
48
sequence length
152
structure length
152
Chain Sequence
NTKYNKEFLLYLAGFVDGDGSIIAQIKPRASNKFAHQLSLTFAVTQKTQRRWFLDKLVDEIGVGYVYDSGSVSDYRLSEIKPLHNFLTQLQPFLKLKQKQANLVLAIIEQLPSAKASPDAFLEVCTWVDQIAALNDSKTRATTSATVRAALD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Molecular Basis of Engineered Meganuclease Targeting of the Endogenous Human Rag1 Locus
pubmed doi rcsb
molecule tags Dna binding protein/dna
source organism Chlamydomonas reinhardtii
molecule keywords I-CREI V2V3 VARIANT
total genus 48
structure length 152
sequence length 152
ec nomenclature
pdb deposition date 2010-05-10
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.10.28.10 Alpha Beta Roll Endonuclease I-creI Homing endonucleases 2xe0B00
2XE0A 4AABA 1DFAA 2VS8A 3MISA 2VBJA 2CW7A 3MIPA 3FD2A 1BP7A 1JVAA 5A0MA 2O7MA 4UN7A 1U0CA 5E67A 2I3QA 5AKMA 3MXAA 1G9YA 1UM2A 4YITA 4UNAA 4UN9G 2VS7A 3EH8A 5AKFA 4AAFA 3QQYA 2VBNA 3MXBA 5AK9A 3R7PA 1MOWA 4UN8A 5AKNA 1U0DA 4YISA 5A78A 4AQUA 5A72A 5A77A 1G9ZA 5E5SA 1LWTA 1R7MA 1VDEA 2FLDA 4YHXA 2VBLA 1AF5A 1T9JA 5E5OA 3C0WA 3HYJA 1P8KZ 1LWSA 2XE0B 4UT0A 2CW8A 5A0WA 2VBOA 4Z1XA 4EFJA 1B24A 4UN9A 2VBJB 1DQ3A 5A74A 3C0XA 1N3FA 3MX9A 3UVFA 5A0MB 4UNBA 1N3EA 4LOXA 3OORA 4AAEA 2QOJZ 1EF0A 4Z20A 4AADA 4D6OA 3KO2A 3OOLA 2VBNB 3MXBB 2VBOB 2I3PA 4UN7G 1T9IA 4LQ0A 2EX5A 1M5XA 3E54A 4AAGA 2AB5A 4Z1ZA 5E63A 3HYIA 2VBLB 4UNCA 2DCHX 4UN8G 4D6NA 4AQXA
chains in the Genus database with same CATH superfamily
2XE0A 4AABA 1DFAA 2VS8A 3MISA 2VBJA 2CW7A 3MIPA 3FD2A 1BP7A 1JVAA 5A0MA 2O7MA 4UN7A 1U0CA 5E67A 2I3QA 5AKMA 3MXAA 1G9YA 1UM2A 4YITA 4UNAA 4UN9G 2VS7A 3EH8A 5AKFA 4AAFA 3QQYA 2VBNA 3MXBA 5AK9A 3R7PA 1MOWA 4UN8A 5AKNA 1U0DA 4YISA 5A78A 4AQUA 5A72A 5A77A 1G9ZA 5E5SA 1LWTA 1R7MA 1VDEA 2FLDA 4KZSA 4YHXA 2VBLA 1AF5A 1T9JA 5E5OA 3C0WA 3HYJA 1P8KZ 1LWSA 2XE0B 4UT0A 2CW8A 5A0WA 2F4LA 2VBOA 4Z1XA 4EFJA 1B24A 4UN9A 2VBJB 1DQ3A 5A74A 3C0XA 1N3FA 3MX9A 3UVFA 5A0MB 4UNBA 1N3EA 4LOXA 3OORA 4AAEA 2QOJZ 1EF0A 4Z20A 4AADA 4D6OA 3KO2A 3OOLA 2VBNB 3MXBB 2VBOB 2I3PA 4UN7G 1T9IA 4LQ0A 2EX5A 1M5XA 3E54A 4AAGA 2AB5A 4Z1ZA 5E63A 3HYIA 2VBLB 4UNCA 2DCHX 4UN8G 4D6NA 4AQXA
chains in the Genus database with same CATH topology
2XE0A 4AABA 1DFAA 2VS8A 3MISA 2VBJA 2CW7A 3MIPA 3FD2A 1BP7A 1JVAA 5A0MA 2O7MA 4UN7A 1U0CA 5E67A 2I3QA 5AKMA 3MXAA 1G9YA 1UM2A 4YITA 4UNAA 4UN9G 2VS7A 3EH8A 5AKFA 4AAFA 3QQYA 2VBNA 3MXBA 5AK9A 3R7PA 1MOWA 4UN8A 5AKNA 1U0DA 4YISA 5A78A 4AQUA 5A72A 5A77A 1G9ZA 5E5SA 1LWTA 1R7MA 1VDEA 2FLDA 4YHXA 2VBLA 1AF5A 1T9JA 5E5OA 3C0WA 3HYJA 1P8KZ 1LWSA 2XE0B 4UT0A 2CW8A 5A0WA 2VBOA 4Z1XA 4EFJA 1B24A 4UN9A 2VBJB 1DQ3A 5A74A 3C0XA 1N3FA 3MX9A 3UVFA 5A0MB 4UNBA 1N3EA 4LOXA 3OORA 4AAEA 2QOJZ 1EF0A 4Z20A 4AADA 4D6OA 3KO2A 3OOLA 2VBNB 3MXBB 2VBOB 2I3PA 4UN7G 1T9IA 4LQ0A 2EX5A 1M5XA 3E54A 4AAGA 2AB5A 4Z1ZA 5E63A 3HYIA 2VBLB 4UNCA 2DCHX 4UN8G 4D6NA 4AQXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2XE0 A;  4AAB A;  1DFA A;  2VS8 A;  3MIS A;  2VBJ A;  2CW7 A;  3MIP A;  3FD2 A;  1BP7 A;  1JVA A;  5A0M A;  2O7M A;  4UN7 A;  1U0C A;  5E67 A;  2I3Q A;  5AKM A;  3MXA A;  1G9Y A;  1UM2 A;  4YIT A;  4UNA A;  4UN9 G;  2VS7 A;  3EH8 A;  5AKF A;  4AAF A;  3QQY A;  2VBN A;  3MXB A;  5AK9 A;  3R7P A;  1MOW A;  4UN8 A;  5AKN A;  1U0D A;  4YIS A;  5A78 A;  4AQU A;  5A72 A;  5A77 A;  1G9Z A;  5E5S A;  1LWT A;  1R7M A;  1VDE A;  2FLD A;  4YHX A;  2VBL A;  1AF5 A;  1T9J A;  5E5O A;  3C0W A;  3HYJ A;  1P8K Z;  1LWS A;  2XE0 B;  4UT0 A;  2CW8 A;  5A0W A;  2VBO A;  4Z1X A;  4EFJ A;  1B24 A;  4UN9 A;  2VBJ B;  1DQ3 A;  5A74 A;  3C0X A;  1N3F A;  3MX9 A;  3UVF A;  5A0M B;  4UNB A;  1N3E A;  4LOX A;  3OOR A;  4AAE A;  2QOJ Z;  1EF0 A;  4Z20 A;  4AAD A;  4D6O A;  3KO2 A;  3OOL A;  2VBN B;  3MXB B;  2VBO B;  2I3P A;  4UN7 G;  1T9I A;  4LQ0 A;  2EX5 A;  1M5X A;  3E54 A;  4AAG A;  2AB5 A;  4Z1Z A;  5E63 A;  3HYI A;  2VBL B;  4UNC A;  2DCH X;  4UN8 G;  4D6N A;  4AQX A; 
#chains in the Genus database with same CATH topology
 2XE0 A;  4AAB A;  1DFA A;  2VS8 A;  3MIS A;  2VBJ A;  2CW7 A;  3MIP A;  3FD2 A;  1BP7 A;  1JVA A;  5A0M A;  2O7M A;  4UN7 A;  1U0C A;  5E67 A;  2I3Q A;  5AKM A;  3MXA A;  1G9Y A;  1UM2 A;  4YIT A;  4UNA A;  4UN9 G;  2VS7 A;  3EH8 A;  5AKF A;  4AAF A;  3QQY A;  2VBN A;  3MXB A;  5AK9 A;  3R7P A;  1MOW A;  4UN8 A;  5AKN A;  1U0D A;  4YIS A;  5A78 A;  4AQU A;  5A72 A;  5A77 A;  1G9Z A;  5E5S A;  1LWT A;  1R7M A;  1VDE A;  2FLD A;  4KZS A;  4YHX A;  2VBL A;  1AF5 A;  1T9J A;  5E5O A;  3C0W A;  3HYJ A;  1P8K Z;  1LWS A;  2XE0 B;  4UT0 A;  2CW8 A;  5A0W A;  2F4L A;  2VBO A;  4Z1X A;  4EFJ A;  1B24 A;  4UN9 A;  2VBJ B;  1DQ3 A;  5A74 A;  3C0X A;  1N3F A;  3MX9 A;  3UVF A;  5A0M B;  4UNB A;  1N3E A;  4LOX A;  3OOR A;  4AAE A;  2QOJ Z;  1EF0 A;  4Z20 A;  4AAD A;  4D6O A;  3KO2 A;  3OOL A;  2VBN B;  3MXB B;  2VBO B;  2I3P A;  4UN7 G;  1T9I A;  4LQ0 A;  2EX5 A;  1M5X A;  3E54 A;  4AAG A;  2AB5 A;  4Z1Z A;  5E63 A;  3HYI A;  2VBL B;  4UNC A;  2DCH X;  4UN8 G;  4D6N A;  4AQX A; 
#chains in the Genus database with same CATH homology
 2XE0 A;  4AAB A;  1DFA A;  2VS8 A;  3MIS A;  2VBJ A;  2CW7 A;  3MIP A;  3FD2 A;  1BP7 A;  1JVA A;  5A0M A;  2O7M A;  4UN7 A;  1U0C A;  5E67 A;  2I3Q A;  5AKM A;  3MXA A;  1G9Y A;  1UM2 A;  4YIT A;  4UNA A;  4UN9 G;  2VS7 A;  3EH8 A;  5AKF A;  4AAF A;  3QQY A;  2VBN A;  3MXB A;  5AK9 A;  3R7P A;  1MOW A;  4UN8 A;  5AKN A;  1U0D A;  4YIS A;  5A78 A;  4AQU A;  5A72 A;  5A77 A;  1G9Z A;  5E5S A;  1LWT A;  1R7M A;  1VDE A;  2FLD A;  4YHX A;  2VBL A;  1AF5 A;  1T9J A;  5E5O A;  3C0W A;  3HYJ A;  1P8K Z;  1LWS A;  2XE0 B;  4UT0 A;  2CW8 A;  5A0W A;  2VBO A;  4Z1X A;  4EFJ A;  1B24 A;  4UN9 A;  2VBJ B;  1DQ3 A;  5A74 A;  3C0X A;  1N3F A;  3MX9 A;  3UVF A;  5A0M B;  4UNB A;  1N3E A;  4LOX A;  3OOR A;  4AAE A;  2QOJ Z;  1EF0 A;  4Z20 A;  4AAD A;  4D6O A;  3KO2 A;  3OOL A;  2VBN B;  3MXB B;  2VBO B;  2I3P A;  4UN7 G;  1T9I A;  4LQ0 A;  2EX5 A;  1M5X A;  3E54 A;  4AAG A;  2AB5 A;  4Z1Z A;  5E63 A;  3HYI A;  2VBL B;  4UNC A;  2DCH X;  4UN8 G;  4D6N A;  4AQX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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