3C0WA

I-scei in complex with a bottom nicked dna substrate
Total Genus 69
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
69
sequence length
223
structure length
223
Chain Sequence
NIKKNQVMNLGPNSKLLKEYKSQLIELNIEQFEAGIGLILGDAYIRSRDEGKTYCMQFEWKNKAYMDHVCLLYDQWVLSPPHKKERVNHLGNLVITWGAQTFKHQAFNKLANLFIVNNKKTIPNNLVENYLTPMSLAYWFMDDGGKWDYNKNSTNKSIVLNTQSFTFEEVEYLVKGLRNKFQLNCYVKINKNKPIIYIDSMSYLIFYNLIKPYLIPQMMYKLP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structures of I-SceI complexed to nicked DNA substrates: snapshots of intermediates along the DNA cleavage reaction pathway.
pubmed doi rcsb
molecule tags Hydrolase/dna
source organism Saccharomyces cerevisiae
molecule keywords DNA (5'-D(*DAP*DCP*DGP*DCP*DTP*DAP*DGP*DGP*DGP*DAP*DTP*DAP*D
total genus 69
structure length 223
sequence length 223
ec nomenclature ec 3.1.-.-:
pdb deposition date 2008-01-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03161 LAGLIDADG_2 LAGLIDADG DNA endonuclease family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.10.28.10 Alpha Beta Roll Endonuclease I-creI Homing endonucleases 3c0wA01
3.10.28.10 Alpha Beta Roll Endonuclease I-creI Homing endonucleases 3c0wA02
1LWTA 1BP7A 3MX9A 4UN7A 1AF5A 5E67A 4UNBA 1N3EA 4AAEA 3E54A 1MOWA 3MIPA 3OORA 3HYIA 4UN9A 3UVFA 5A0MB 1JVAA 2VS8A 4AAGA 2CW7A 3QQYA 4D6OA 1P8KZ 2VBLB 5E5SA 5A74A 3C0WA 3MXAA 1G9ZA 5A0WA 2DCHX 5A78A 2O7MA 4EFJA 4UNCA 5A0MA 2CW8A 1DQ3A 4AAFA 4YITA 3MISA 2VBLA 4AQXA 4UNAA 1EF0A 1T9JA 4D6NA 4YISA 1DFAA 4AADA 2FLDA 1UM2A 1T9IA 4AABA 2I3PA 5AKFA 5A77A 4YHXA 5AKMA 4Z20A 3EH8A 2QOJZ 2AB5A 1R7MA 5AK9A 1U0CA 5E63A 2XE0B 1G9YA 3R7PA 3MXBA 3FD2A 4AQUA 3MXBB 1U0DA 1LWSA 2VBOA 3OOLA 4Z1XA 2VS7A 1N3FA 4UN8G 4LQ0A 2VBOB 2I3QA 1M5XA 2VBNA 2VBNB 4LOXA 1B24A 2EX5A 4UN7G 3HYJA 5AKNA 2XE0A 1VDEA 2VBJA 4UT0A 5A72A 4UN8A 4UN9G 3KO2A 2VBJB 5E5OA 4Z1ZA 3C0XA
chains in the Genus database with same CATH superfamily
1LWTA 1BP7A 3MX9A 4UN7A 1AF5A 5E67A 4UNBA 1N3EA 4AAEA 3E54A 1MOWA 3MIPA 3OORA 3HYIA 4UN9A 5A0MB 1JVAA 2VS8A 3UVFA 4AAGA 2CW7A 3QQYA 4D6OA 1P8KZ 2VBLB 5E5SA 5A74A 3C0WA 3MXAA 1G9ZA 5A0WA 2DCHX 5A78A 2O7MA 4EFJA 4UNCA 5A0MA 2CW8A 1DQ3A 4AAFA 4YITA 3MISA 2VBLA 4AQXA 4UNAA 1EF0A 1T9JA 4D6NA 4YISA 1DFAA 4AADA 2FLDA 1UM2A 1T9IA 4AABA 2I3PA 5AKFA 4KZSA 2F4LA 5A77A 4YHXA 5AKMA 4Z20A 3EH8A 2QOJZ 2AB5A 1R7MA 5AK9A 1U0CA 5E63A 2XE0B 1G9YA 3R7PA 3MXBA 3FD2A 4AQUA 3MXBB 1U0DA 1LWSA 2VBOA 3OOLA 4Z1XA 2VS7A 1N3FA 4UN8G 4LQ0A 2VBOB 2I3QA 1M5XA 2VBNA 2VBNB 4LOXA 1B24A 2EX5A 4UN7G 3HYJA 5AKNA 2XE0A 1VDEA 2VBJA 4UT0A 5A72A 4UN8A 4UN9G 3KO2A 2VBJB 5E5OA 4Z1ZA 3C0XA
chains in the Genus database with same CATH topology
1LWTA 1BP7A 3MX9A 4UN7A 1AF5A 5E67A 4UNBA 1N3EA 4AAEA 3E54A 1MOWA 3MIPA 3OORA 3HYIA 4UN9A 3UVFA 5A0MB 1JVAA 2VS8A 4AAGA 2CW7A 3QQYA 4D6OA 1P8KZ 2VBLB 5E5SA 5A74A 3C0WA 3MXAA 1G9ZA 5A0WA 2DCHX 5A78A 2O7MA 4EFJA 4UNCA 5A0MA 2CW8A 1DQ3A 4AAFA 4YITA 3MISA 2VBLA 4AQXA 4UNAA 1EF0A 1T9JA 4D6NA 4YISA 1DFAA 4AADA 2FLDA 1UM2A 1T9IA 4AABA 2I3PA 5AKFA 5A77A 4YHXA 5AKMA 4Z20A 3EH8A 2QOJZ 2AB5A 1R7MA 5AK9A 1U0CA 5E63A 2XE0B 1G9YA 3R7PA 3MXBA 3FD2A 4AQUA 3MXBB 1U0DA 1LWSA 2VBOA 3OOLA 4Z1XA 2VS7A 1N3FA 4UN8G 4LQ0A 2VBOB 2I3QA 1M5XA 2VBNA 2VBNB 4LOXA 1B24A 2EX5A 4UN7G 3HYJA 5AKNA 2XE0A 1VDEA 2VBJA 4UT0A 5A72A 4UN8A 4UN9G 3KO2A 2VBJB 5E5OA 4Z1ZA 3C0XA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1LWT A;  1BP7 A;  3MX9 A;  4UN7 A;  1AF5 A;  5E67 A;  4UNB A;  1N3E A;  4AAE A;  3E54 A;  1MOW A;  3MIP A;  3OOR A;  3HYI A;  4UN9 A;  3UVF A;  5A0M B;  1JVA A;  2VS8 A;  4AAG A;  2CW7 A;  3QQY A;  4D6O A;  1P8K Z;  2VBL B;  5E5S A;  5A74 A;  3C0W A;  3MXA A;  1G9Z A;  5A0W A;  2DCH X;  5A78 A;  2O7M A;  4EFJ A;  4UNC A;  5A0M A;  2CW8 A;  1DQ3 A;  4AAF A;  4YIT A;  3MIS A;  2VBL A;  4AQX A;  4UNA A;  1EF0 A;  1T9J A;  4D6N A;  4YIS A;  1DFA A;  4AAD A;  2FLD A;  1UM2 A;  1T9I A;  4AAB A;  2I3P A;  5AKF A;  5A77 A;  4YHX A;  5AKM A;  4Z20 A;  3EH8 A;  2QOJ Z;  2AB5 A;  1R7M A;  5AK9 A;  1U0C A;  5E63 A;  2XE0 B;  1G9Y A;  3R7P A;  3MXB A;  3FD2 A;  4AQU A;  3MXB B;  1U0D A;  1LWS A;  2VBO A;  3OOL A;  4Z1X A;  2VS7 A;  1N3F A;  4UN8 G;  4LQ0 A;  2VBO B;  2I3Q A;  1M5X A;  2VBN A;  2VBN B;  4LOX A;  1B24 A;  2EX5 A;  4UN7 G;  3HYJ A;  5AKN A;  2XE0 A;  1VDE A;  2VBJ A;  4UT0 A;  5A72 A;  4UN8 A;  4UN9 G;  3KO2 A;  2VBJ B;  5E5O A;  4Z1Z A;  3C0X A; 
#chains in the Genus database with same CATH topology
 1LWT A;  1BP7 A;  3MX9 A;  4UN7 A;  1AF5 A;  5E67 A;  4UNB A;  1N3E A;  4AAE A;  3E54 A;  1MOW A;  3MIP A;  3OOR A;  3HYI A;  4UN9 A;  5A0M B;  1JVA A;  2VS8 A;  3UVF A;  4AAG A;  2CW7 A;  3QQY A;  4D6O A;  1P8K Z;  2VBL B;  5E5S A;  5A74 A;  3C0W A;  3MXA A;  1G9Z A;  5A0W A;  2DCH X;  5A78 A;  2O7M A;  4EFJ A;  4UNC A;  5A0M A;  2CW8 A;  1DQ3 A;  4AAF A;  4YIT A;  3MIS A;  2VBL A;  4AQX A;  4UNA A;  1EF0 A;  1T9J A;  4D6N A;  4YIS A;  1DFA A;  4AAD A;  2FLD A;  1UM2 A;  1T9I A;  4AAB A;  2I3P A;  5AKF A;  4KZS A;  2F4L A;  5A77 A;  4YHX A;  5AKM A;  4Z20 A;  3EH8 A;  2QOJ Z;  2AB5 A;  1R7M A;  5AK9 A;  1U0C A;  5E63 A;  2XE0 B;  1G9Y A;  3R7P A;  3MXB A;  3FD2 A;  4AQU A;  3MXB B;  1U0D A;  1LWS A;  2VBO A;  3OOL A;  4Z1X A;  2VS7 A;  1N3F A;  4UN8 G;  4LQ0 A;  2VBO B;  2I3Q A;  1M5X A;  2VBN A;  2VBN B;  4LOX A;  1B24 A;  2EX5 A;  4UN7 G;  3HYJ A;  5AKN A;  2XE0 A;  1VDE A;  2VBJ A;  4UT0 A;  5A72 A;  4UN8 A;  4UN9 G;  3KO2 A;  2VBJ B;  5E5O A;  4Z1Z A;  3C0X A; 
#chains in the Genus database with same CATH homology
 1LWT A;  1BP7 A;  3MX9 A;  4UN7 A;  1AF5 A;  5E67 A;  4UNB A;  1N3E A;  4AAE A;  3E54 A;  1MOW A;  3MIP A;  3OOR A;  3HYI A;  4UN9 A;  3UVF A;  5A0M B;  1JVA A;  2VS8 A;  4AAG A;  2CW7 A;  3QQY A;  4D6O A;  1P8K Z;  2VBL B;  5E5S A;  5A74 A;  3C0W A;  3MXA A;  1G9Z A;  5A0W A;  2DCH X;  5A78 A;  2O7M A;  4EFJ A;  4UNC A;  5A0M A;  2CW8 A;  1DQ3 A;  4AAF A;  4YIT A;  3MIS A;  2VBL A;  4AQX A;  4UNA A;  1EF0 A;  1T9J A;  4D6N A;  4YIS A;  1DFA A;  4AAD A;  2FLD A;  1UM2 A;  1T9I A;  4AAB A;  2I3P A;  5AKF A;  5A77 A;  4YHX A;  5AKM A;  4Z20 A;  3EH8 A;  2QOJ Z;  2AB5 A;  1R7M A;  5AK9 A;  1U0C A;  5E63 A;  2XE0 B;  1G9Y A;  3R7P A;  3MXB A;  3FD2 A;  4AQU A;  3MXB B;  1U0D A;  1LWS A;  2VBO A;  3OOL A;  4Z1X A;  2VS7 A;  1N3F A;  4UN8 G;  4LQ0 A;  2VBO B;  2I3Q A;  1M5X A;  2VBN A;  2VBN B;  4LOX A;  1B24 A;  2EX5 A;  4UN7 G;  3HYJ A;  5AKN A;  2XE0 A;  1VDE A;  2VBJ A;  4UT0 A;  5A72 A;  4UN8 A;  4UN9 G;  3KO2 A;  2VBJ B;  5E5O A;  4Z1Z A;  3C0X A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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