3MIPA

I-msoi re-designed for altered dna cleavage specificity (-8gcg)
Total Genus 50
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
50
sequence length
161
structure length
161
Chain Sequence
TLQPTEAAYIAGFLDGDGSIYARLEPRPDYKDIKYQVRLAISFIQRKDKFPYLQDIYDQLGKRGILRKDRGDGIADYRIYGSTHLSIILPDLVPYLRIKKKQANRILHIINLYPQAQKNPSKFLDLVKIVDDVQNLNKRADELKSTNYDRLLEEFLKAGKI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags De novo protein/dna
source organism Synthetic construct
publication title Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs.
pubmed doi rcsb
molecule keywords Mso-8G
total genus 50
structure length 161
sequence length 161
chains with identical sequence B
ec nomenclature
pdb deposition date 2010-04-11
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.10.28.10 Alpha Beta Roll Endonuclease I-creI Homing endonucleases 3mipA00
4UN7A 5AKNA 4YISA 2VBNB 4UT0A 3R7PA 5A0MA 3EH8A 5A72A 2VBOA 4UN7G 1LWTA 5AKMA 2I3PA 1B24A 5AKFA 4AABA 4D6NA 5E63A 3MXAA 2XE0A 4AAGA 2VBOB 1LWSA 2XE0B 2VBLA 5A74A 4AQXA 4LQ0A 3MIPA 4UNBA 3MXBB 2VBJA 5E5OA 1VDEA 1AF5A 5E67A 1G9ZA 3OOLA 1T9IA 3MX9A 5A0MB 3C0XA 1G9YA 2FLDA 4UN9A 1BP7A 2VS8A 1P8KZ 4UNCA 1T9JA 1UM2A 2VBLB 4UN8A 4UN9G 5E5SA 3KO2A 4LOXA 4AADA 1EF0A 2AB5A 2QOJZ 2VBJB 3E54A 4UN8G 4D6OA 2EX5A 1DQ3A 3MISA 2O7MA 2VS7A 1DFAA 4AQUA 4YITA 3OORA 5A78A 3HYIA 1JVAA 1R7MA 1U0DA 4Z1XA 4EFJA 4AAFA 5A77A 1M5XA 1U0CA 5A0WA 3QQYA 1N3EA 3UVFA 4YHXA 3C0WA 4UNAA 3HYJA 2CW7A 2DCHX 3MXBA 2CW8A 3FD2A 4Z1ZA 1MOWA 1N3FA 4AAEA 2VBNA 4Z20A 5AK9A 2I3QA
chains in the Genus database with same CATH superfamily
4UN7A 5AKNA 4YISA 2VBNB 4UT0A 3R7PA 5A0MA 3EH8A 5A72A 2VBOA 4UN7G 1LWTA 5AKMA 2I3PA 1B24A 5AKFA 4AABA 4D6NA 5E63A 3MXAA 2XE0A 4AAGA 2VBOB 1LWSA 2XE0B 2VBLA 5A74A 4AQXA 4LQ0A 3MIPA 4UNBA 3MXBB 2VBJA 5E5OA 1VDEA 1AF5A 5E67A 1G9ZA 3OOLA 1T9IA 3MX9A 5A0MB 3C0XA 1G9YA 2FLDA 4UN9A 1BP7A 2VS8A 1P8KZ 4UNCA 1T9JA 1UM2A 2VBLB 4UN8A 4UN9G 5E5SA 3KO2A 4LOXA 4AADA 1EF0A 2AB5A 2QOJZ 2VBJB 2F4LA 3E54A 4UN8G 4D6OA 2EX5A 1DQ3A 3MISA 2O7MA 2VS7A 1DFAA 4AQUA 4YITA 3OORA 5A78A 3HYIA 1JVAA 1R7MA 1U0DA 4Z1XA 4EFJA 4KZSA 4AAFA 5A77A 1M5XA 1U0CA 5A0WA 3QQYA 1N3EA 3UVFA 4YHXA 3C0WA 4UNAA 3HYJA 2CW7A 2DCHX 3MXBA 2CW8A 3FD2A 4Z1ZA 1MOWA 1N3FA 4AAEA 2VBNA 4Z20A 5AK9A 2I3QA
chains in the Genus database with same CATH topology
4UN7A 5AKNA 4YISA 2VBNB 4UT0A 3R7PA 5A0MA 3EH8A 5A72A 2VBOA 4UN7G 1LWTA 5AKMA 2I3PA 1B24A 5AKFA 4AABA 4D6NA 5E63A 3MXAA 2XE0A 4AAGA 2VBOB 1LWSA 2XE0B 2VBLA 5A74A 4AQXA 4LQ0A 3MIPA 4UNBA 3MXBB 2VBJA 5E5OA 1VDEA 1AF5A 5E67A 1G9ZA 3OOLA 1T9IA 3MX9A 5A0MB 3C0XA 1G9YA 2FLDA 4UN9A 1BP7A 2VS8A 1P8KZ 4UNCA 1T9JA 1UM2A 2VBLB 4UN8A 4UN9G 5E5SA 3KO2A 4LOXA 4AADA 1EF0A 2AB5A 2QOJZ 2VBJB 3E54A 4UN8G 4D6OA 2EX5A 1DQ3A 3MISA 2O7MA 2VS7A 1DFAA 4AQUA 4YITA 3OORA 5A78A 3HYIA 1JVAA 1R7MA 1U0DA 4Z1XA 4EFJA 4AAFA 5A77A 1M5XA 1U0CA 5A0WA 3QQYA 1N3EA 3UVFA 4YHXA 3C0WA 4UNAA 3HYJA 2CW7A 2DCHX 3MXBA 2CW8A 3FD2A 4Z1ZA 1MOWA 1N3FA 4AAEA 2VBNA 4Z20A 5AK9A 2I3QA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4UN7 A;  5AKN A;  4YIS A;  2VBN B;  4UT0 A;  3R7P A;  5A0M A;  3EH8 A;  5A72 A;  2VBO A;  4UN7 G;  1LWT A;  5AKM A;  2I3P A;  1B24 A;  5AKF A;  4AAB A;  4D6N A;  5E63 A;  3MXA A;  2XE0 A;  4AAG A;  2VBO B;  1LWS A;  2XE0 B;  2VBL A;  5A74 A;  4AQX A;  4LQ0 A;  3MIP A;  4UNB A;  3MXB B;  2VBJ A;  5E5O A;  1VDE A;  1AF5 A;  5E67 A;  1G9Z A;  3OOL A;  1T9I A;  3MX9 A;  5A0M B;  3C0X A;  1G9Y A;  2FLD A;  4UN9 A;  1BP7 A;  2VS8 A;  1P8K Z;  4UNC A;  1T9J A;  1UM2 A;  2VBL B;  4UN8 A;  4UN9 G;  5E5S A;  3KO2 A;  4LOX A;  4AAD A;  1EF0 A;  2AB5 A;  2QOJ Z;  2VBJ B;  3E54 A;  4UN8 G;  4D6O A;  2EX5 A;  1DQ3 A;  3MIS A;  2O7M A;  2VS7 A;  1DFA A;  4AQU A;  4YIT A;  3OOR A;  5A78 A;  3HYI A;  1JVA A;  1R7M A;  1U0D A;  4Z1X A;  4EFJ A;  4AAF A;  5A77 A;  1M5X A;  1U0C A;  5A0W A;  3QQY A;  1N3E A;  3UVF A;  4YHX A;  3C0W A;  4UNA A;  3HYJ A;  2CW7 A;  2DCH X;  3MXB A;  2CW8 A;  3FD2 A;  4Z1Z A;  1MOW A;  1N3F A;  4AAE A;  2VBN A;  4Z20 A;  5AK9 A;  2I3Q A; 
#chains in the Genus database with same CATH topology
 4UN7 A;  5AKN A;  4YIS A;  2VBN B;  4UT0 A;  3R7P A;  5A0M A;  3EH8 A;  5A72 A;  2VBO A;  4UN7 G;  1LWT A;  5AKM A;  2I3P A;  1B24 A;  5AKF A;  4AAB A;  4D6N A;  5E63 A;  3MXA A;  2XE0 A;  4AAG A;  2VBO B;  1LWS A;  2XE0 B;  2VBL A;  5A74 A;  4AQX A;  4LQ0 A;  3MIP A;  4UNB A;  3MXB B;  2VBJ A;  5E5O A;  1VDE A;  1AF5 A;  5E67 A;  1G9Z A;  3OOL A;  1T9I A;  3MX9 A;  5A0M B;  3C0X A;  1G9Y A;  2FLD A;  4UN9 A;  1BP7 A;  2VS8 A;  1P8K Z;  4UNC A;  1T9J A;  1UM2 A;  2VBL B;  4UN8 A;  4UN9 G;  5E5S A;  3KO2 A;  4LOX A;  4AAD A;  1EF0 A;  2AB5 A;  2QOJ Z;  2VBJ B;  2F4L A;  3E54 A;  4UN8 G;  4D6O A;  2EX5 A;  1DQ3 A;  3MIS A;  2O7M A;  2VS7 A;  1DFA A;  4AQU A;  4YIT A;  3OOR A;  5A78 A;  3HYI A;  1JVA A;  1R7M A;  1U0D A;  4Z1X A;  4EFJ A;  4KZS A;  4AAF A;  5A77 A;  1M5X A;  1U0C A;  5A0W A;  3QQY A;  1N3E A;  3UVF A;  4YHX A;  3C0W A;  4UNA A;  3HYJ A;  2CW7 A;  2DCH X;  3MXB A;  2CW8 A;  3FD2 A;  4Z1Z A;  1MOW A;  1N3F A;  4AAE A;  2VBN A;  4Z20 A;  5AK9 A;  2I3Q A; 
#chains in the Genus database with same CATH homology
 4UN7 A;  5AKN A;  4YIS A;  2VBN B;  4UT0 A;  3R7P A;  5A0M A;  3EH8 A;  5A72 A;  2VBO A;  4UN7 G;  1LWT A;  5AKM A;  2I3P A;  1B24 A;  5AKF A;  4AAB A;  4D6N A;  5E63 A;  3MXA A;  2XE0 A;  4AAG A;  2VBO B;  1LWS A;  2XE0 B;  2VBL A;  5A74 A;  4AQX A;  4LQ0 A;  3MIP A;  4UNB A;  3MXB B;  2VBJ A;  5E5O A;  1VDE A;  1AF5 A;  5E67 A;  1G9Z A;  3OOL A;  1T9I A;  3MX9 A;  5A0M B;  3C0X A;  1G9Y A;  2FLD A;  4UN9 A;  1BP7 A;  2VS8 A;  1P8K Z;  4UNC A;  1T9J A;  1UM2 A;  2VBL B;  4UN8 A;  4UN9 G;  5E5S A;  3KO2 A;  4LOX A;  4AAD A;  1EF0 A;  2AB5 A;  2QOJ Z;  2VBJ B;  3E54 A;  4UN8 G;  4D6O A;  2EX5 A;  1DQ3 A;  3MIS A;  2O7M A;  2VS7 A;  1DFA A;  4AQU A;  4YIT A;  3OOR A;  5A78 A;  3HYI A;  1JVA A;  1R7M A;  1U0D A;  4Z1X A;  4EFJ A;  4AAF A;  5A77 A;  1M5X A;  1U0C A;  5A0W A;  3QQY A;  1N3E A;  3UVF A;  4YHX A;  3C0W A;  4UNA A;  3HYJ A;  2CW7 A;  2DCH X;  3MXB A;  2CW8 A;  3FD2 A;  4Z1Z A;  1MOW A;  1N3F A;  4AAE A;  2VBN A;  4Z20 A;  5AK9 A;  2I3Q A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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