3MIPA

I-msoi re-designed for altered dna cleavage specificity (-8gcg)
Total Genus 50
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
50
sequence length
161
structure length
161
Chain Sequence
TLQPTEAAYIAGFLDGDGSIYARLEPRPDYKDIKYQVRLAISFIQRKDKFPYLQDIYDQLGKRGILRKDRGDGIADYRIYGSTHLSIILPDLVPYLRIKKKQANRILHIINLYPQAQKNPSKFLDLVKIVDDVQNLNKRADELKSTNYDRLLEEFLKAGKI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs.
pubmed doi rcsb
molecule tags De novo protein/dna
source organism Synthetic construct
molecule keywords Mso-8G
total genus 50
structure length 161
sequence length 161
chains with identical sequence B
ec nomenclature
pdb deposition date 2010-04-11
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.10.28.10 Alpha Beta Roll Endonuclease I-creI Homing endonucleases 3mipA00
4UN7G 3MIPA 1DQ3A 1G9ZA 2CW7A 2VBLB 1BP7A 3UVFA 2XE0B 1M5XA 1T9IA 4Z20A 2VBJB 2VBLA 4YITA 4D6OA 4AADA 1JVAA 2VS8A 3C0XA 3E54A 4LOXA 4UN9A 3MXBA 4AAEA 4AAFA 4UT0A 1EF0A 5A0MA 1G9YA 4AQXA 2AB5A 4D6NA 3OOLA 2QOJZ 4UN8G 5E5OA 4UN9G 2VS7A 1P8KZ 3MXAA 4Z1ZA 3KO2A 5AK9A 5E63A 3MXBB 1MOWA 4UN8A 2I3QA 5A74A 5A0MB 5A78A 4UNAA 4YHXA 1U0CA 4EFJA 2VBNB 3EH8A 2VBNA 3MX9A 4YISA 2DCHX 5AKNA 1B24A 3FD2A 1R7MA 3QQYA 3R7PA 2EX5A 2VBOB 5E5SA 4AAGA 2I3PA 1LWSA 1DFAA 1N3EA 1U0DA 2CW8A 5AKFA 2VBOA 1VDEA 5A72A 4AQUA 2FLDA 2XE0A 3C0WA 4UNCA 5A77A 2VBJA 4UN7A 2O7MA 5E67A 4UNBA 5AKMA 1N3FA 1UM2A 3HYJA 4LQ0A 4AABA 1AF5A 3OORA 1LWTA 5A0WA 3HYIA 3MISA 1T9JA 4Z1XA
chains in the Genus database with same CATH superfamily
4UN7G 3MIPA 1DQ3A 1G9ZA 2CW7A 2VBLB 1BP7A 3UVFA 2XE0B 1M5XA 1T9IA 4Z20A 2VBJB 2VBLA 4YITA 4D6OA 4AADA 1JVAA 2VS8A 3C0XA 3E54A 4LOXA 4UN9A 3MXBA 4AAEA 4AAFA 4UT0A 1EF0A 5A0MA 1G9YA 4AQXA 2AB5A 4D6NA 3OOLA 2QOJZ 4UN8G 5E5OA 4UN9G 2VS7A 1P8KZ 3MXAA 4Z1ZA 3KO2A 5AK9A 2F4LA 5E63A 3MXBB 1MOWA 4UN8A 2I3QA 5A74A 5A0MB 5A78A 4UNAA 4YHXA 1U0CA 4EFJA 2VBNB 3EH8A 2VBNA 3MX9A 4YISA 2DCHX 5AKNA 1B24A 3FD2A 1R7MA 3QQYA 3R7PA 2EX5A 2VBOB 5E5SA 4AAGA 2I3PA 1LWSA 1DFAA 1N3EA 1U0DA 2CW8A 5AKFA 2VBOA 4KZSA 1VDEA 5A72A 4AQUA 2FLDA 2XE0A 3C0WA 4UNCA 5A77A 2VBJA 4UN7A 2O7MA 5E67A 4UNBA 5AKMA 1N3FA 1UM2A 3HYJA 4LQ0A 4AABA 1AF5A 3OORA 1LWTA 5A0WA 3HYIA 3MISA 1T9JA 4Z1XA
chains in the Genus database with same CATH topology
4UN7G 3MIPA 1DQ3A 1G9ZA 2CW7A 2VBLB 1BP7A 3UVFA 2XE0B 1M5XA 1T9IA 4Z20A 2VBJB 2VBLA 4YITA 4D6OA 4AADA 1JVAA 2VS8A 3C0XA 3E54A 4LOXA 4UN9A 3MXBA 4AAEA 4AAFA 4UT0A 1EF0A 5A0MA 1G9YA 4AQXA 2AB5A 4D6NA 3OOLA 2QOJZ 4UN8G 5E5OA 4UN9G 2VS7A 1P8KZ 3MXAA 4Z1ZA 3KO2A 5AK9A 5E63A 3MXBB 1MOWA 4UN8A 2I3QA 5A74A 5A0MB 5A78A 4UNAA 4YHXA 1U0CA 4EFJA 2VBNB 3EH8A 2VBNA 3MX9A 4YISA 2DCHX 5AKNA 1B24A 3FD2A 1R7MA 3QQYA 3R7PA 2EX5A 2VBOB 5E5SA 4AAGA 2I3PA 1LWSA 1DFAA 1N3EA 1U0DA 2CW8A 5AKFA 2VBOA 1VDEA 5A72A 4AQUA 2FLDA 2XE0A 3C0WA 4UNCA 5A77A 2VBJA 4UN7A 2O7MA 5E67A 4UNBA 5AKMA 1N3FA 1UM2A 3HYJA 4LQ0A 4AABA 1AF5A 3OORA 1LWTA 5A0WA 3HYIA 3MISA 1T9JA 4Z1XA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4UN7 G;  3MIP A;  1DQ3 A;  1G9Z A;  2CW7 A;  2VBL B;  1BP7 A;  3UVF A;  2XE0 B;  1M5X A;  1T9I A;  4Z20 A;  2VBJ B;  2VBL A;  4YIT A;  4D6O A;  4AAD A;  1JVA A;  2VS8 A;  3C0X A;  3E54 A;  4LOX A;  4UN9 A;  3MXB A;  4AAE A;  4AAF A;  4UT0 A;  1EF0 A;  5A0M A;  1G9Y A;  4AQX A;  2AB5 A;  4D6N A;  3OOL A;  2QOJ Z;  4UN8 G;  5E5O A;  4UN9 G;  2VS7 A;  1P8K Z;  3MXA A;  4Z1Z A;  3KO2 A;  5AK9 A;  5E63 A;  3MXB B;  1MOW A;  4UN8 A;  2I3Q A;  5A74 A;  5A0M B;  5A78 A;  4UNA A;  4YHX A;  1U0C A;  4EFJ A;  2VBN B;  3EH8 A;  2VBN A;  3MX9 A;  4YIS A;  2DCH X;  5AKN A;  1B24 A;  3FD2 A;  1R7M A;  3QQY A;  3R7P A;  2EX5 A;  2VBO B;  5E5S A;  4AAG A;  2I3P A;  1LWS A;  1DFA A;  1N3E A;  1U0D A;  2CW8 A;  5AKF A;  2VBO A;  1VDE A;  5A72 A;  4AQU A;  2FLD A;  2XE0 A;  3C0W A;  4UNC A;  5A77 A;  2VBJ A;  4UN7 A;  2O7M A;  5E67 A;  4UNB A;  5AKM A;  1N3F A;  1UM2 A;  3HYJ A;  4LQ0 A;  4AAB A;  1AF5 A;  3OOR A;  1LWT A;  5A0W A;  3HYI A;  3MIS A;  1T9J A;  4Z1X A; 
#chains in the Genus database with same CATH topology
 4UN7 G;  3MIP A;  1DQ3 A;  1G9Z A;  2CW7 A;  2VBL B;  1BP7 A;  3UVF A;  2XE0 B;  1M5X A;  1T9I A;  4Z20 A;  2VBJ B;  2VBL A;  4YIT A;  4D6O A;  4AAD A;  1JVA A;  2VS8 A;  3C0X A;  3E54 A;  4LOX A;  4UN9 A;  3MXB A;  4AAE A;  4AAF A;  4UT0 A;  1EF0 A;  5A0M A;  1G9Y A;  4AQX A;  2AB5 A;  4D6N A;  3OOL A;  2QOJ Z;  4UN8 G;  5E5O A;  4UN9 G;  2VS7 A;  1P8K Z;  3MXA A;  4Z1Z A;  3KO2 A;  5AK9 A;  2F4L A;  5E63 A;  3MXB B;  1MOW A;  4UN8 A;  2I3Q A;  5A74 A;  5A0M B;  5A78 A;  4UNA A;  4YHX A;  1U0C A;  4EFJ A;  2VBN B;  3EH8 A;  2VBN A;  3MX9 A;  4YIS A;  2DCH X;  5AKN A;  1B24 A;  3FD2 A;  1R7M A;  3QQY A;  3R7P A;  2EX5 A;  2VBO B;  5E5S A;  4AAG A;  2I3P A;  1LWS A;  1DFA A;  1N3E A;  1U0D A;  2CW8 A;  5AKF A;  2VBO A;  4KZS A;  1VDE A;  5A72 A;  4AQU A;  2FLD A;  2XE0 A;  3C0W A;  4UNC A;  5A77 A;  2VBJ A;  4UN7 A;  2O7M A;  5E67 A;  4UNB A;  5AKM A;  1N3F A;  1UM2 A;  3HYJ A;  4LQ0 A;  4AAB A;  1AF5 A;  3OOR A;  1LWT A;  5A0W A;  3HYI A;  3MIS A;  1T9J A;  4Z1X A; 
#chains in the Genus database with same CATH homology
 4UN7 G;  3MIP A;  1DQ3 A;  1G9Z A;  2CW7 A;  2VBL B;  1BP7 A;  3UVF A;  2XE0 B;  1M5X A;  1T9I A;  4Z20 A;  2VBJ B;  2VBL A;  4YIT A;  4D6O A;  4AAD A;  1JVA A;  2VS8 A;  3C0X A;  3E54 A;  4LOX A;  4UN9 A;  3MXB A;  4AAE A;  4AAF A;  4UT0 A;  1EF0 A;  5A0M A;  1G9Y A;  4AQX A;  2AB5 A;  4D6N A;  3OOL A;  2QOJ Z;  4UN8 G;  5E5O A;  4UN9 G;  2VS7 A;  1P8K Z;  3MXA A;  4Z1Z A;  3KO2 A;  5AK9 A;  5E63 A;  3MXB B;  1MOW A;  4UN8 A;  2I3Q A;  5A74 A;  5A0M B;  5A78 A;  4UNA A;  4YHX A;  1U0C A;  4EFJ A;  2VBN B;  3EH8 A;  2VBN A;  3MX9 A;  4YIS A;  2DCH X;  5AKN A;  1B24 A;  3FD2 A;  1R7M A;  3QQY A;  3R7P A;  2EX5 A;  2VBO B;  5E5S A;  4AAG A;  2I3P A;  1LWS A;  1DFA A;  1N3E A;  1U0D A;  2CW8 A;  5AKF A;  2VBO A;  1VDE A;  5A72 A;  4AQU A;  2FLD A;  2XE0 A;  3C0W A;  4UNC A;  5A77 A;  2VBJ A;  4UN7 A;  2O7M A;  5E67 A;  4UNB A;  5AKM A;  1N3F A;  1UM2 A;  3HYJ A;  4LQ0 A;  4AAB A;  1AF5 A;  3OOR A;  1LWT A;  5A0W A;  3HYI A;  3MIS A;  1T9J A;  4Z1X A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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