3MIPA

I-msoi re-designed for altered dna cleavage specificity (-8gcg)
Total Genus 50
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
50
sequence length
161
structure length
161
Chain Sequence
TLQPTEAAYIAGFLDGDGSIYARLEPRPDYKDIKYQVRLAISFIQRKDKFPYLQDIYDQLGKRGILRKDRGDGIADYRIYGSTHLSIILPDLVPYLRIKKKQANRILHIINLYPQAQKNPSKFLDLVKIVDDVQNLNKRADELKSTNYDRLLEEFLKAGKI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs.
pubmed doi rcsb
molecule tags De novo protein/dna
source organism Synthetic construct
molecule keywords Mso-8G
total genus 50
structure length 161
sequence length 161
chains with identical sequence B
ec nomenclature
pdb deposition date 2010-04-11
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.10.28.10 Alpha Beta Roll Endonuclease I-creI Homing endonucleases 3mipA00
1DQ3A 2O7MA 3OORA 4UT0A 1AF5A 2VBJA 2QOJZ 2VS8A 2VS7A 1T9IA 3R7PA 1N3EA 1LWTA 4AAEA 1M5XA 1VDEA 2CW8A 1U0CA 1G9ZA 2EX5A 4AQXA 2VBOB 1DFAA 5AKFA 1R7MA 5E5SA 2VBLB 5AKMA 3HYJA 2DCHX 4UN8G 5A77A 1U0DA 5A0MA 1UM2A 2FLDA 2VBNA 2AB5A 2XE0A 3MISA 2I3PA 3C0XA 4UN9G 3C0WA 1N3FA 1BP7A 3UVFA 3MXBB 2VBLA 4UNCA 2CW7A 1MOWA 4D6NA 4UNBA 5E67A 3E54A 5E63A 4Z1XA 3MIPA 1EF0A 3OOLA 4AAGA 4UN7G 5AK9A 1G9YA 1B24A 3EH8A 2VBJB 4AABA 2VBOA 1JVAA 3MX9A 1LWSA 3FD2A 5E5OA 4EFJA 4UN8A 4UN7A 3HYIA 4UNAA 5A74A 4Z20A 4D6OA 5A72A 4UN9A 4LQ0A 3MXAA 4YISA 5A0WA 3QQYA 3MXBA 4Z1ZA 1P8KZ 5A0MB 5A78A 4YHXA 1T9JA 2VBNB 2I3QA 5AKNA 4AQUA 4AADA 4YITA 4LOXA 3KO2A 2XE0B 4AAFA
chains in the Genus database with same CATH superfamily
1DQ3A 2O7MA 3OORA 4UT0A 1AF5A 2VBJA 2QOJZ 2VS8A 2VS7A 1T9IA 3R7PA 1N3EA 1LWTA 4AAEA 1M5XA 1VDEA 2CW8A 1U0CA 1G9ZA 2EX5A 4AQXA 2VBOB 1DFAA 5AKFA 1R7MA 5E5SA 2VBLB 5AKMA 3HYJA 2DCHX 4UN8G 5A77A 1U0DA 5A0MA 1UM2A 2FLDA 2VBNA 2AB5A 2XE0A 3MISA 2I3PA 3C0XA 4UN9G 3C0WA 1N3FA 1BP7A 3UVFA 4KZSA 3MXBB 2VBLA 4UNCA 2CW7A 1MOWA 4D6NA 4UNBA 5E67A 3E54A 5E63A 4Z1XA 3MIPA 1EF0A 3OOLA 4AAGA 4UN7G 5AK9A 1G9YA 1B24A 3EH8A 2VBJB 4AABA 2VBOA 1JVAA 3MX9A 1LWSA 3FD2A 5E5OA 4EFJA 4UN8A 4UN7A 3HYIA 4UNAA 5A74A 4Z20A 4D6OA 5A72A 4UN9A 4LQ0A 3MXAA 4YISA 5A0WA 3QQYA 3MXBA 4Z1ZA 1P8KZ 2F4LA 5A0MB 5A78A 4YHXA 1T9JA 2VBNB 2I3QA 5AKNA 4AQUA 4AADA 4YITA 4LOXA 3KO2A 2XE0B 4AAFA
chains in the Genus database with same CATH topology
1DQ3A 2O7MA 3OORA 4UT0A 1AF5A 2VBJA 2QOJZ 2VS8A 2VS7A 1T9IA 3R7PA 1N3EA 1LWTA 4AAEA 1M5XA 1VDEA 2CW8A 1U0CA 1G9ZA 2EX5A 4AQXA 2VBOB 1DFAA 5AKFA 1R7MA 5E5SA 2VBLB 5AKMA 3HYJA 2DCHX 4UN8G 5A77A 1U0DA 5A0MA 1UM2A 2FLDA 2VBNA 2AB5A 2XE0A 3MISA 2I3PA 3C0XA 4UN9G 3C0WA 1N3FA 1BP7A 3UVFA 3MXBB 2VBLA 4UNCA 2CW7A 1MOWA 4D6NA 4UNBA 5E67A 3E54A 5E63A 4Z1XA 3MIPA 1EF0A 3OOLA 4AAGA 4UN7G 5AK9A 1G9YA 1B24A 3EH8A 2VBJB 4AABA 2VBOA 1JVAA 3MX9A 1LWSA 3FD2A 5E5OA 4EFJA 4UN8A 4UN7A 3HYIA 4UNAA 5A74A 4Z20A 4D6OA 5A72A 4UN9A 4LQ0A 3MXAA 4YISA 5A0WA 3QQYA 3MXBA 4Z1ZA 1P8KZ 5A0MB 5A78A 4YHXA 1T9JA 2VBNB 2I3QA 5AKNA 4AQUA 4AADA 4YITA 4LOXA 3KO2A 2XE0B 4AAFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1DQ3 A;  2O7M A;  3OOR A;  4UT0 A;  1AF5 A;  2VBJ A;  2QOJ Z;  2VS8 A;  2VS7 A;  1T9I A;  3R7P A;  1N3E A;  1LWT A;  4AAE A;  1M5X A;  1VDE A;  2CW8 A;  1U0C A;  1G9Z A;  2EX5 A;  4AQX A;  2VBO B;  1DFA A;  5AKF A;  1R7M A;  5E5S A;  2VBL B;  5AKM A;  3HYJ A;  2DCH X;  4UN8 G;  5A77 A;  1U0D A;  5A0M A;  1UM2 A;  2FLD A;  2VBN A;  2AB5 A;  2XE0 A;  3MIS A;  2I3P A;  3C0X A;  4UN9 G;  3C0W A;  1N3F A;  1BP7 A;  3UVF A;  3MXB B;  2VBL A;  4UNC A;  2CW7 A;  1MOW A;  4D6N A;  4UNB A;  5E67 A;  3E54 A;  5E63 A;  4Z1X A;  3MIP A;  1EF0 A;  3OOL A;  4AAG A;  4UN7 G;  5AK9 A;  1G9Y A;  1B24 A;  3EH8 A;  2VBJ B;  4AAB A;  2VBO A;  1JVA A;  3MX9 A;  1LWS A;  3FD2 A;  5E5O A;  4EFJ A;  4UN8 A;  4UN7 A;  3HYI A;  4UNA A;  5A74 A;  4Z20 A;  4D6O A;  5A72 A;  4UN9 A;  4LQ0 A;  3MXA A;  4YIS A;  5A0W A;  3QQY A;  3MXB A;  4Z1Z A;  1P8K Z;  5A0M B;  5A78 A;  4YHX A;  1T9J A;  2VBN B;  2I3Q A;  5AKN A;  4AQU A;  4AAD A;  4YIT A;  4LOX A;  3KO2 A;  2XE0 B;  4AAF A; 
#chains in the Genus database with same CATH topology
 1DQ3 A;  2O7M A;  3OOR A;  4UT0 A;  1AF5 A;  2VBJ A;  2QOJ Z;  2VS8 A;  2VS7 A;  1T9I A;  3R7P A;  1N3E A;  1LWT A;  4AAE A;  1M5X A;  1VDE A;  2CW8 A;  1U0C A;  1G9Z A;  2EX5 A;  4AQX A;  2VBO B;  1DFA A;  5AKF A;  1R7M A;  5E5S A;  2VBL B;  5AKM A;  3HYJ A;  2DCH X;  4UN8 G;  5A77 A;  1U0D A;  5A0M A;  1UM2 A;  2FLD A;  2VBN A;  2AB5 A;  2XE0 A;  3MIS A;  2I3P A;  3C0X A;  4UN9 G;  3C0W A;  1N3F A;  1BP7 A;  3UVF A;  4KZS A;  3MXB B;  2VBL A;  4UNC A;  2CW7 A;  1MOW A;  4D6N A;  4UNB A;  5E67 A;  3E54 A;  5E63 A;  4Z1X A;  3MIP A;  1EF0 A;  3OOL A;  4AAG A;  4UN7 G;  5AK9 A;  1G9Y A;  1B24 A;  3EH8 A;  2VBJ B;  4AAB A;  2VBO A;  1JVA A;  3MX9 A;  1LWS A;  3FD2 A;  5E5O A;  4EFJ A;  4UN8 A;  4UN7 A;  3HYI A;  4UNA A;  5A74 A;  4Z20 A;  4D6O A;  5A72 A;  4UN9 A;  4LQ0 A;  3MXA A;  4YIS A;  5A0W A;  3QQY A;  3MXB A;  4Z1Z A;  1P8K Z;  2F4L A;  5A0M B;  5A78 A;  4YHX A;  1T9J A;  2VBN B;  2I3Q A;  5AKN A;  4AQU A;  4AAD A;  4YIT A;  4LOX A;  3KO2 A;  2XE0 B;  4AAF A; 
#chains in the Genus database with same CATH homology
 1DQ3 A;  2O7M A;  3OOR A;  4UT0 A;  1AF5 A;  2VBJ A;  2QOJ Z;  2VS8 A;  2VS7 A;  1T9I A;  3R7P A;  1N3E A;  1LWT A;  4AAE A;  1M5X A;  1VDE A;  2CW8 A;  1U0C A;  1G9Z A;  2EX5 A;  4AQX A;  2VBO B;  1DFA A;  5AKF A;  1R7M A;  5E5S A;  2VBL B;  5AKM A;  3HYJ A;  2DCH X;  4UN8 G;  5A77 A;  1U0D A;  5A0M A;  1UM2 A;  2FLD A;  2VBN A;  2AB5 A;  2XE0 A;  3MIS A;  2I3P A;  3C0X A;  4UN9 G;  3C0W A;  1N3F A;  1BP7 A;  3UVF A;  3MXB B;  2VBL A;  4UNC A;  2CW7 A;  1MOW A;  4D6N A;  4UNB A;  5E67 A;  3E54 A;  5E63 A;  4Z1X A;  3MIP A;  1EF0 A;  3OOL A;  4AAG A;  4UN7 G;  5AK9 A;  1G9Y A;  1B24 A;  3EH8 A;  2VBJ B;  4AAB A;  2VBO A;  1JVA A;  3MX9 A;  1LWS A;  3FD2 A;  5E5O A;  4EFJ A;  4UN8 A;  4UN7 A;  3HYI A;  4UNA A;  5A74 A;  4Z20 A;  4D6O A;  5A72 A;  4UN9 A;  4LQ0 A;  3MXA A;  4YIS A;  5A0W A;  3QQY A;  3MXB A;  4Z1Z A;  1P8K Z;  5A0M B;  5A78 A;  4YHX A;  1T9J A;  2VBN B;  2I3Q A;  5AKN A;  4AQU A;  4AAD A;  4YIT A;  4LOX A;  3KO2 A;  2XE0 B;  4AAF A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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