3MXBB

Molecular basis of engineered meganuclease targeting of the endogenous human rag1 locus
Total Genus 53
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
53
sequence length
153
structure length
153
Chain Sequence
NTKYNEEFLLYLAGFVDSDGSIIAQIKPRQSNKFKHQLSLTFAVTQKTQRRWFLDKLVDEIGVGYVYDSGSVSDYRLSEIKPLHNFLTQLQPFLKLKQKQANLVLKIIEQLPSAKESPDKFLEVCTWVDQIAALNDSKTRKTTSETVRAVLDS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Molecular basis of engineered meganuclease targeting of the endogenous human RAG1 locus.
pubmed doi rcsb
molecule tags Hydrolase/dna
source organism Chlamydomonas reinhardtii
molecule keywords V3(E8K)
total genus 53
structure length 153
sequence length 153
chains with identical sequence S
ec nomenclature
pdb deposition date 2010-05-07
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.10.28.10 Alpha Beta Roll Endonuclease I-creI Homing endonucleases 3mxbB00
4UNCA 2XE0A 1R7MA 5AK9A 4UNAA 3HYJA 3MXBA 1UM2A 3OOLA 4D6NA 4Z1XA 1AF5A 2VBNB 5A0WA 1DFAA 5A0MB 4AQXA 2VBJB 4UN8A 4AAFA 1VDEA 4D6OA 3C0XA 3UVFA 3C0WA 3HYIA 1BP7A 2AB5A 4Z20A 2EX5A 5E5OA 5AKNA 1EF0A 2O7MA 2VBOA 4LQ0A 1DQ3A 4UN9A 2I3PA 5A72A 4UN7G 5AKMA 1M5XA 3MISA 4AABA 1G9ZA 2VBLB 2VS8A 2VS7A 3OORA 4AAGA 2DCHX 3R7PA 3E54A 4Z1ZA 3MXAA 5AKFA 4AAEA 1N3EA 1T9IA 3KO2A 5A74A 3MX9A 1U0CA 4YHXA 1B24A 1P8KZ 2XE0B 2VBNA 2FLDA 3FD2A 1G9YA 4UT0A 5A0MA 3MXBB 4UNBA 1LWTA 2VBJA 2CW7A 1JVAA 4UN8G 4EFJA 5E67A 3QQYA 1LWSA 5E5SA 5A77A 4YISA 4LOXA 1U0DA 1T9JA 4YITA 5A78A 2CW8A 4UN9G 2VBOB 2VBLA 4UN7A 5E63A 2QOJZ 1N3FA 4AADA 4AQUA 2I3QA 3EH8A 3MIPA 1MOWA
chains in the Genus database with same CATH superfamily
4UNCA 2XE0A 1R7MA 5AK9A 4UNAA 3HYJA 3MXBA 1UM2A 3OOLA 4D6NA 4Z1XA 1AF5A 2VBNB 5A0WA 1DFAA 5A0MB 4AQXA 2VBJB 4UN8A 4AAFA 1VDEA 4D6OA 3C0XA 3UVFA 3C0WA 3HYIA 1BP7A 2AB5A 4Z20A 2EX5A 5E5OA 5AKNA 1EF0A 2O7MA 2VBOA 4LQ0A 1DQ3A 4UN9A 2I3PA 5A72A 4UN7G 5AKMA 1M5XA 3MISA 4AABA 1G9ZA 2VBLB 2VS8A 2VS7A 3OORA 4AAGA 2DCHX 3R7PA 3E54A 4Z1ZA 3MXAA 2F4LA 5AKFA 4AAEA 1N3EA 1T9IA 3KO2A 5A74A 3MX9A 1U0CA 4YHXA 1B24A 1P8KZ 2XE0B 2VBNA 2FLDA 3FD2A 1G9YA 4UT0A 5A0MA 3MXBB 4UNBA 1LWTA 2VBJA 2CW7A 1JVAA 4UN8G 4EFJA 5E67A 3QQYA 1LWSA 5E5SA 5A77A 4YISA 4LOXA 1U0DA 4KZSA 1T9JA 4YITA 5A78A 2CW8A 4UN9G 2VBOB 2VBLA 4UN7A 5E63A 2QOJZ 1N3FA 4AADA 4AQUA 2I3QA 3EH8A 3MIPA 1MOWA
chains in the Genus database with same CATH topology
4UNCA 2XE0A 1R7MA 5AK9A 4UNAA 3HYJA 3MXBA 1UM2A 3OOLA 4D6NA 4Z1XA 1AF5A 2VBNB 5A0WA 1DFAA 5A0MB 4AQXA 2VBJB 4UN8A 4AAFA 1VDEA 4D6OA 3C0XA 3UVFA 3C0WA 3HYIA 1BP7A 2AB5A 4Z20A 2EX5A 5E5OA 5AKNA 1EF0A 2O7MA 2VBOA 4LQ0A 1DQ3A 4UN9A 2I3PA 5A72A 4UN7G 5AKMA 1M5XA 3MISA 4AABA 1G9ZA 2VBLB 2VS8A 2VS7A 3OORA 4AAGA 2DCHX 3R7PA 3E54A 4Z1ZA 3MXAA 5AKFA 4AAEA 1N3EA 1T9IA 3KO2A 5A74A 3MX9A 1U0CA 4YHXA 1B24A 1P8KZ 2XE0B 2VBNA 2FLDA 3FD2A 1G9YA 4UT0A 5A0MA 3MXBB 4UNBA 1LWTA 2VBJA 2CW7A 1JVAA 4UN8G 4EFJA 5E67A 3QQYA 1LWSA 5E5SA 5A77A 4YISA 4LOXA 1U0DA 1T9JA 4YITA 5A78A 2CW8A 4UN9G 2VBOB 2VBLA 4UN7A 5E63A 2QOJZ 1N3FA 4AADA 4AQUA 2I3QA 3EH8A 3MIPA 1MOWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4UNC A;  2XE0 A;  1R7M A;  5AK9 A;  4UNA A;  3HYJ A;  3MXB A;  1UM2 A;  3OOL A;  4D6N A;  4Z1X A;  1AF5 A;  2VBN B;  5A0W A;  1DFA A;  5A0M B;  4AQX A;  2VBJ B;  4UN8 A;  4AAF A;  1VDE A;  4D6O A;  3C0X A;  3UVF A;  3C0W A;  3HYI A;  1BP7 A;  2AB5 A;  4Z20 A;  2EX5 A;  5E5O A;  5AKN A;  1EF0 A;  2O7M A;  2VBO A;  4LQ0 A;  1DQ3 A;  4UN9 A;  2I3P A;  5A72 A;  4UN7 G;  5AKM A;  1M5X A;  3MIS A;  4AAB A;  1G9Z A;  2VBL B;  2VS8 A;  2VS7 A;  3OOR A;  4AAG A;  2DCH X;  3R7P A;  3E54 A;  4Z1Z A;  3MXA A;  5AKF A;  4AAE A;  1N3E A;  1T9I A;  3KO2 A;  5A74 A;  3MX9 A;  1U0C A;  4YHX A;  1B24 A;  1P8K Z;  2XE0 B;  2VBN A;  2FLD A;  3FD2 A;  1G9Y A;  4UT0 A;  5A0M A;  3MXB B;  4UNB A;  1LWT A;  2VBJ A;  2CW7 A;  1JVA A;  4UN8 G;  4EFJ A;  5E67 A;  3QQY A;  1LWS A;  5E5S A;  5A77 A;  4YIS A;  4LOX A;  1U0D A;  1T9J A;  4YIT A;  5A78 A;  2CW8 A;  4UN9 G;  2VBO B;  2VBL A;  4UN7 A;  5E63 A;  2QOJ Z;  1N3F A;  4AAD A;  4AQU A;  2I3Q A;  3EH8 A;  3MIP A;  1MOW A; 
#chains in the Genus database with same CATH topology
 4UNC A;  2XE0 A;  1R7M A;  5AK9 A;  4UNA A;  3HYJ A;  3MXB A;  1UM2 A;  3OOL A;  4D6N A;  4Z1X A;  1AF5 A;  2VBN B;  5A0W A;  1DFA A;  5A0M B;  4AQX A;  2VBJ B;  4UN8 A;  4AAF A;  1VDE A;  4D6O A;  3C0X A;  3UVF A;  3C0W A;  3HYI A;  1BP7 A;  2AB5 A;  4Z20 A;  2EX5 A;  5E5O A;  5AKN A;  1EF0 A;  2O7M A;  2VBO A;  4LQ0 A;  1DQ3 A;  4UN9 A;  2I3P A;  5A72 A;  4UN7 G;  5AKM A;  1M5X A;  3MIS A;  4AAB A;  1G9Z A;  2VBL B;  2VS8 A;  2VS7 A;  3OOR A;  4AAG A;  2DCH X;  3R7P A;  3E54 A;  4Z1Z A;  3MXA A;  2F4L A;  5AKF A;  4AAE A;  1N3E A;  1T9I A;  3KO2 A;  5A74 A;  3MX9 A;  1U0C A;  4YHX A;  1B24 A;  1P8K Z;  2XE0 B;  2VBN A;  2FLD A;  3FD2 A;  1G9Y A;  4UT0 A;  5A0M A;  3MXB B;  4UNB A;  1LWT A;  2VBJ A;  2CW7 A;  1JVA A;  4UN8 G;  4EFJ A;  5E67 A;  3QQY A;  1LWS A;  5E5S A;  5A77 A;  4YIS A;  4LOX A;  1U0D A;  4KZS A;  1T9J A;  4YIT A;  5A78 A;  2CW8 A;  4UN9 G;  2VBO B;  2VBL A;  4UN7 A;  5E63 A;  2QOJ Z;  1N3F A;  4AAD A;  4AQU A;  2I3Q A;  3EH8 A;  3MIP A;  1MOW A; 
#chains in the Genus database with same CATH homology
 4UNC A;  2XE0 A;  1R7M A;  5AK9 A;  4UNA A;  3HYJ A;  3MXB A;  1UM2 A;  3OOL A;  4D6N A;  4Z1X A;  1AF5 A;  2VBN B;  5A0W A;  1DFA A;  5A0M B;  4AQX A;  2VBJ B;  4UN8 A;  4AAF A;  1VDE A;  4D6O A;  3C0X A;  3UVF A;  3C0W A;  3HYI A;  1BP7 A;  2AB5 A;  4Z20 A;  2EX5 A;  5E5O A;  5AKN A;  1EF0 A;  2O7M A;  2VBO A;  4LQ0 A;  1DQ3 A;  4UN9 A;  2I3P A;  5A72 A;  4UN7 G;  5AKM A;  1M5X A;  3MIS A;  4AAB A;  1G9Z A;  2VBL B;  2VS8 A;  2VS7 A;  3OOR A;  4AAG A;  2DCH X;  3R7P A;  3E54 A;  4Z1Z A;  3MXA A;  5AKF A;  4AAE A;  1N3E A;  1T9I A;  3KO2 A;  5A74 A;  3MX9 A;  1U0C A;  4YHX A;  1B24 A;  1P8K Z;  2XE0 B;  2VBN A;  2FLD A;  3FD2 A;  1G9Y A;  4UT0 A;  5A0M A;  3MXB B;  4UNB A;  1LWT A;  2VBJ A;  2CW7 A;  1JVA A;  4UN8 G;  4EFJ A;  5E67 A;  3QQY A;  1LWS A;  5E5S A;  5A77 A;  4YIS A;  4LOX A;  1U0D A;  1T9J A;  4YIT A;  5A78 A;  2CW8 A;  4UN9 G;  2VBO B;  2VBL A;  4UN7 A;  5E63 A;  2QOJ Z;  1N3F A;  4AAD A;  4AQU A;  2I3Q A;  3EH8 A;  3MIP A;  1MOW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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