3OORA

I-scei mutant (k86r/g100t)complexed with c/g+4 dna substrate
Total Genus 64
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
64
sequence length
223
structure length
223
Chain Sequence
NIKKNQVMNLGPNSKLLKEYKSQLIELNIEQFEAGIGLILGDAYIRSRDEGKTYCMQFEWKNKAYMDHVCLLYDQWVLSPPHKRERVNHLGNLVITWTAQTFKHQAFNKLANLFIVNNKKTIPNNLVENYLTPMSLAYWFMDDGGKWDYNKNSTNKSIVLNTQSFTFEEVEYLVKGLRNKFQLNCYVKINKNKPIIYIDSMSYLIFYNLIKPYLIPQMMYKLP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Evolution of I-SceI Homing Endonucleases with Increased DNA Recognition Site Specificity.
pubmed doi rcsb
molecule tags Hydrolase/dna
source organism Saccharomyces cerevisiae
molecule keywords Intron encoded endonuclease I-SceI
total genus 64
structure length 223
sequence length 223
ec nomenclature ec 3.1.-.-:
pdb deposition date 2010-08-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03161 LAGLIDADG_2 LAGLIDADG DNA endonuclease family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.10.28.10 Alpha Beta Roll Endonuclease I-creI Homing endonucleases 3oorA01
3.10.28.10 Alpha Beta Roll Endonuclease I-creI Homing endonucleases 3oorA02
2XE0B 2I3PA 4LOXA 4Z1XA 3R7PA 2EX5A 5AKNA 1AF5A 3UVFA 3KO2A 4AADA 2VBOB 3MX9A 4LQ0A 4AQXA 3MXBB 1U0CA 5AKMA 4Z20A 1VDEA 2CW8A 2VBJB 5AKFA 2VS7A 4UNCA 4UT0A 5E67A 1B24A 1EF0A 4D6NA 1UM2A 5E63A 5A0MA 4AAFA 5E5SA 4AAEA 4UN8A 3HYIA 1BP7A 4UN9G 4YISA 4D6OA 4Z1ZA 5A78A 2VBNB 4EFJA 2FLDA 1M5XA 1DFAA 3EH8A 1G9ZA 1T9JA 1U0DA 2VBLA 3QQYA 2DCHX 2O7MA 1P8KZ 3FD2A 1JVAA 2XE0A 1N3FA 3E54A 4UNBA 4AAGA 5A0WA 3C0WA 4UN7A 2VS8A 3MIPA 3C0XA 3MISA 2QOJZ 1R7MA 2VBOA 2I3QA 1MOWA 3OORA 1T9IA 3MXBA 1G9YA 2CW7A 5E5OA 3HYJA 5A74A 4YITA 2VBJA 3MXAA 4UN8G 1N3EA 5A0MB 1DQ3A 4AQUA 4AABA 2AB5A 4UNAA 5AK9A 1LWTA 1LWSA 2VBNA 4UN9A 4YHXA 2VBLB 3OOLA 5A77A 5A72A 4UN7G
chains in the Genus database with same CATH superfamily
2XE0B 2I3PA 4LOXA 4Z1XA 3R7PA 2EX5A 5AKNA 1AF5A 4KZSA 3UVFA 3KO2A 4AADA 2VBOB 3MX9A 4LQ0A 4AQXA 3MXBB 1U0CA 5AKMA 4Z20A 1VDEA 2CW8A 2VBJB 5AKFA 2VS7A 4UNCA 4UT0A 5E67A 1B24A 1EF0A 4D6NA 1UM2A 5E63A 5A0MA 4AAFA 5E5SA 4AAEA 4UN8A 3HYIA 1BP7A 4UN9G 4YISA 4D6OA 4Z1ZA 5A78A 2VBNB 4EFJA 2FLDA 1M5XA 1DFAA 3EH8A 1G9ZA 1T9JA 1U0DA 2VBLA 3QQYA 2DCHX 2O7MA 1P8KZ 3FD2A 1JVAA 2XE0A 1N3FA 3E54A 4UNBA 4AAGA 5A0WA 3C0WA 4UN7A 2VS8A 3MIPA 3C0XA 3MISA 2QOJZ 2F4LA 1R7MA 2VBOA 2I3QA 1MOWA 3OORA 1T9IA 3MXBA 1G9YA 2CW7A 5E5OA 3HYJA 5A74A 4YITA 2VBJA 3MXAA 4UN8G 1N3EA 5A0MB 1DQ3A 4AQUA 4AABA 2AB5A 4UNAA 5AK9A 1LWTA 1LWSA 2VBNA 4UN9A 4YHXA 2VBLB 3OOLA 5A77A 5A72A 4UN7G
chains in the Genus database with same CATH topology
2XE0B 2I3PA 4LOXA 4Z1XA 3R7PA 2EX5A 5AKNA 1AF5A 3UVFA 3KO2A 4AADA 2VBOB 3MX9A 4LQ0A 4AQXA 3MXBB 1U0CA 5AKMA 4Z20A 1VDEA 2CW8A 2VBJB 5AKFA 2VS7A 4UNCA 4UT0A 5E67A 1B24A 1EF0A 4D6NA 1UM2A 5E63A 5A0MA 4AAFA 5E5SA 4AAEA 4UN8A 3HYIA 1BP7A 4UN9G 4YISA 4D6OA 4Z1ZA 5A78A 2VBNB 4EFJA 2FLDA 1M5XA 1DFAA 3EH8A 1G9ZA 1T9JA 1U0DA 2VBLA 3QQYA 2DCHX 2O7MA 1P8KZ 3FD2A 1JVAA 2XE0A 1N3FA 3E54A 4UNBA 4AAGA 5A0WA 3C0WA 4UN7A 2VS8A 3MIPA 3C0XA 3MISA 2QOJZ 1R7MA 2VBOA 2I3QA 1MOWA 3OORA 1T9IA 3MXBA 1G9YA 2CW7A 5E5OA 3HYJA 5A74A 4YITA 2VBJA 3MXAA 4UN8G 1N3EA 5A0MB 1DQ3A 4AQUA 4AABA 2AB5A 4UNAA 5AK9A 1LWTA 1LWSA 2VBNA 4UN9A 4YHXA 2VBLB 3OOLA 5A77A 5A72A 4UN7G
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2XE0 B;  2I3P A;  4LOX A;  4Z1X A;  3R7P A;  2EX5 A;  5AKN A;  1AF5 A;  3UVF A;  3KO2 A;  4AAD A;  2VBO B;  3MX9 A;  4LQ0 A;  4AQX A;  3MXB B;  1U0C A;  5AKM A;  4Z20 A;  1VDE A;  2CW8 A;  2VBJ B;  5AKF A;  2VS7 A;  4UNC A;  4UT0 A;  5E67 A;  1B24 A;  1EF0 A;  4D6N A;  1UM2 A;  5E63 A;  5A0M A;  4AAF A;  5E5S A;  4AAE A;  4UN8 A;  3HYI A;  1BP7 A;  4UN9 G;  4YIS A;  4D6O A;  4Z1Z A;  5A78 A;  2VBN B;  4EFJ A;  2FLD A;  1M5X A;  1DFA A;  3EH8 A;  1G9Z A;  1T9J A;  1U0D A;  2VBL A;  3QQY A;  2DCH X;  2O7M A;  1P8K Z;  3FD2 A;  1JVA A;  2XE0 A;  1N3F A;  3E54 A;  4UNB A;  4AAG A;  5A0W A;  3C0W A;  4UN7 A;  2VS8 A;  3MIP A;  3C0X A;  3MIS A;  2QOJ Z;  1R7M A;  2VBO A;  2I3Q A;  1MOW A;  3OOR A;  1T9I A;  3MXB A;  1G9Y A;  2CW7 A;  5E5O A;  3HYJ A;  5A74 A;  4YIT A;  2VBJ A;  3MXA A;  4UN8 G;  1N3E A;  5A0M B;  1DQ3 A;  4AQU A;  4AAB A;  2AB5 A;  4UNA A;  5AK9 A;  1LWT A;  1LWS A;  2VBN A;  4UN9 A;  4YHX A;  2VBL B;  3OOL A;  5A77 A;  5A72 A;  4UN7 G; 
#chains in the Genus database with same CATH topology
 2XE0 B;  2I3P A;  4LOX A;  4Z1X A;  3R7P A;  2EX5 A;  5AKN A;  1AF5 A;  4KZS A;  3UVF A;  3KO2 A;  4AAD A;  2VBO B;  3MX9 A;  4LQ0 A;  4AQX A;  3MXB B;  1U0C A;  5AKM A;  4Z20 A;  1VDE A;  2CW8 A;  2VBJ B;  5AKF A;  2VS7 A;  4UNC A;  4UT0 A;  5E67 A;  1B24 A;  1EF0 A;  4D6N A;  1UM2 A;  5E63 A;  5A0M A;  4AAF A;  5E5S A;  4AAE A;  4UN8 A;  3HYI A;  1BP7 A;  4UN9 G;  4YIS A;  4D6O A;  4Z1Z A;  5A78 A;  2VBN B;  4EFJ A;  2FLD A;  1M5X A;  1DFA A;  3EH8 A;  1G9Z A;  1T9J A;  1U0D A;  2VBL A;  3QQY A;  2DCH X;  2O7M A;  1P8K Z;  3FD2 A;  1JVA A;  2XE0 A;  1N3F A;  3E54 A;  4UNB A;  4AAG A;  5A0W A;  3C0W A;  4UN7 A;  2VS8 A;  3MIP A;  3C0X A;  3MIS A;  2QOJ Z;  2F4L A;  1R7M A;  2VBO A;  2I3Q A;  1MOW A;  3OOR A;  1T9I A;  3MXB A;  1G9Y A;  2CW7 A;  5E5O A;  3HYJ A;  5A74 A;  4YIT A;  2VBJ A;  3MXA A;  4UN8 G;  1N3E A;  5A0M B;  1DQ3 A;  4AQU A;  4AAB A;  2AB5 A;  4UNA A;  5AK9 A;  1LWT A;  1LWS A;  2VBN A;  4UN9 A;  4YHX A;  2VBL B;  3OOL A;  5A77 A;  5A72 A;  4UN7 G; 
#chains in the Genus database with same CATH homology
 2XE0 B;  2I3P A;  4LOX A;  4Z1X A;  3R7P A;  2EX5 A;  5AKN A;  1AF5 A;  3UVF A;  3KO2 A;  4AAD A;  2VBO B;  3MX9 A;  4LQ0 A;  4AQX A;  3MXB B;  1U0C A;  5AKM A;  4Z20 A;  1VDE A;  2CW8 A;  2VBJ B;  5AKF A;  2VS7 A;  4UNC A;  4UT0 A;  5E67 A;  1B24 A;  1EF0 A;  4D6N A;  1UM2 A;  5E63 A;  5A0M A;  4AAF A;  5E5S A;  4AAE A;  4UN8 A;  3HYI A;  1BP7 A;  4UN9 G;  4YIS A;  4D6O A;  4Z1Z A;  5A78 A;  2VBN B;  4EFJ A;  2FLD A;  1M5X A;  1DFA A;  3EH8 A;  1G9Z A;  1T9J A;  1U0D A;  2VBL A;  3QQY A;  2DCH X;  2O7M A;  1P8K Z;  3FD2 A;  1JVA A;  2XE0 A;  1N3F A;  3E54 A;  4UNB A;  4AAG A;  5A0W A;  3C0W A;  4UN7 A;  2VS8 A;  3MIP A;  3C0X A;  3MIS A;  2QOJ Z;  1R7M A;  2VBO A;  2I3Q A;  1MOW A;  3OOR A;  1T9I A;  3MXB A;  1G9Y A;  2CW7 A;  5E5O A;  3HYJ A;  5A74 A;  4YIT A;  2VBJ A;  3MXA A;  4UN8 G;  1N3E A;  5A0M B;  1DQ3 A;  4AQU A;  4AAB A;  2AB5 A;  4UNA A;  5AK9 A;  1LWT A;  1LWS A;  2VBN A;  4UN9 A;  4YHX A;  2VBL B;  3OOL A;  5A77 A;  5A72 A;  4UN7 G; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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