4HLF | Genus

Total Genus 48

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	48
sequence length	161
structure length	161
Chain Sequence	GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSA

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

molecule tags	Transferase
source organism	Homo sapiens
publication title	Screening and structural analysis of flavones inhibiting tankyrases. pubmed doi rcsb
molecule keywords	Tankyrase-2
total genus	48
structure length	161
sequence length	161
chains with identical sequence	B
ec nomenclature	ec 2.4.2.30: NAD(+) ADP-ribosyltransferase.
pdb deposition date	2012-10-17

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.90.228.10	Alpha Beta	Alpha-Beta Complex	Phosphoenolpyruvate Carboxykinase; domain 3	Phosphoenolpyruvate Carboxykinase; domain 3	4hlfA00

3KCZA 3GEYA 5ETYA 4K4EA 4L0TA 3CE0A 4L32A 4AVUA 4BFPA 4LI7A 4HL5A 4TVJA 4LI8A 4UVLA 4KZQA 5FPFA 3UA9A 4W5IA 4HMHA 4PNTA 4UX4A 1EFYA 4R5WA 4ZZXA 4PAXA 3KJDA 4L33A 5AL3A 4OQAC 4PNNA 4L7NA 3C4HA 4UI5A 4GV0A 4IUEA 3P0PA 4L6ZA 4KZUA 4BU3A 4BUIA 4F1LA 3HKVA 3C49A 4GV7A 4XHUA 4HLMA 5AEHA 4HKNA 4PNRA 4UVSA 4BUEA 5ADTA 4TJYA 4X52A 3BLJA 4LI6A 4UVTA 5C5QA 4M7BA 1UK1A 3GN7A 3PAXA 1A26A 4L0SA 4BUVA 4UVOA 4F0EA 4ZZZA 4L09A 1PAXA 4BU7A 4F1QA 4PJVA 3W51A 5ADRA 4UI4A 4W5SA 4UI3A 4TORA 4TK5A 3P0QA 4TKGA 4L2KA 4ZZYA 4L6SA 4BUXA 4UI7A 4HLGA 4HLKA 4TK0A 4UVVA 3U9YA 4L7OA 4KRSA 4MSKA 4UVWA 4UI8A 3GJWA 4UW1A 4TOSA 4UNDA 4UVNA 4W6EA 3L3LA 3SMJA 4J3LA 4BUUA 4L0BA 4L0VA 3UH2A 4J21A 4UFYA 4HKIA 3KR8A 4HLFA 2PAWA 4PNLA 4BUSA 5DCZA 5ADQA 4UFUA 4R6EA 4BJ9A 4BU6A 4BUTA 3UH4A 5C5RA 2RF5A 3FHBA 4HYFA 4BU8A 5LYHA 4TJWA 3L3MA 3MHKA 2RD6A 4L7PA 4UVPA 4N4VA 4U6AA 4PNQA 4J1ZA 4L2FA 4OA7A 4L7LA 4J22A 5AKUA 1WOKA 5AL4A 4UXBA 4OPXC 4HHYA 4TKIA 3U9HA 4UVZA 3SMIA 3P0NA 5LX6A 4L7UA 4UVYA 4HLHA 4UHGA 4DVIA 4AVWA 4I9IA 4GV2A 4PNSA 4OQBC 4KZLA 4L34A 3UDDA 4PY4A 4N4TA 3MHJA 2PQFA 4TKFA 4BU5A 4BUDA 4UUHA 4L2GA 5AL1A 4L70A 2RCWA 5ECEA 4BS4A 4BUAA 4UVXA 1GS0A 4MT9A 5C5PA 4DQYC 5EBTA 4BU9A 4K4FA 4BUWA 4BUYA 4HHZA 5ADSA 4PJTA 2X5YA 4UVUA 4L10A 4HKKA 5AL5A 5AKWA 4BJCA 4L0IA 4MSGA 4BUFA 4N3RA 4PMLA 5LXPA 3SE2A 4RV6A 4TJUA 3GOYA 5A00A 1UK0A 4PNMA 4L31A 4L7RA 4UI6A 5FPGA 3KR7A 2PAXA 4J3MA 5AL2A 4GV4A 4BJBA
chains in the Genus database with same CATH superfamily

3MOHA 3KCZA 3GEYA 4WIEA 4K4EA 4L0TA 3CE0A 4L32A 5ETYA 4AVUA 1J3BA 2FAHA 2GMVA 3DTBA 4LI7A 4HL5A 4TVJA 4BFPA 1KHGA 4LI8A 4UVLA 4KZQA 5FPFA 5FH5A 2OLQA 4GMWA 3UA9A 4W5IA 1OENA 4HMHA 4PNTA 4UX4A 1EFYA 4R5WA 4ZZXA 4PAXA 2FAFA 3KJDA 4L33A 5AL3A 4OQAC 3MOEA 4GNOA 4PNNA 4L7NA 3C4HA 4UI5A 4GV0A 1NHXA 4IUEA 3P0PA 4L6ZA 4KZUA 4BU3A 4BUIA 4F1LA 3HKVA 3C49A 1YTMA 2QEYA 4GV7A 4HLMA 4WPTA 4XHUA 4GNMA 5AEHA 4HKNA 4PNRA 4UVSA 4BUEA 2RKEA 5ADTA 4TJYA 4X52A 3BLJA 4YW9A 4LI6A 4UVTA 5C5QA 4M7BA 1UK1A 3GN7A 3PAXA 1A26A 4L0SA 4BUVA 4UVOA 4F0EA 4ZZZA 5FH3A 4L09A 4WPVA 1PAXA 4BU7A 4F1QA 4WIUA 4YWBA 4PJVA 3W51A 5ADRA 4UI4A 4W5SA 4UI3A 2PY7X 4TORA 4TK5A 3P0QA 4TKGA 4L2KA 4ZZYA 4L6SA 4BUXA 4UI7A 5FH2A 4HLGA 4HLKA 4TK0A 1AQ2A 4UVVA 5I67A 3U9YA 4L7OA 4GNQA 4KRSA 4MSKA 2QF1A 4UI8A 3GJWA 1YVYA 4TOSA 4UVWA 4OX2A 4UNDA 4UW1A 4UVNA 4W6EA 1KHFA 3L3LA 4J3LA 3SMJA 4BUUA 4L0BA 1XKVA 2RKDA 4L0VA 4J21A 3UH2A 2QZYA 4UFYA 4HKIA 3DT2A 3KR8A 2PAWA 4HLFA 4PNLA 4BUSA 5DCZA 5ADQA 2QEWA 4R6EA 4UFUA 4BJ9A 5FH1A 4BU6A 4BUTA 1M51A 3UH4A 1II2A 2PC9A 5C5RA 2RF5A 3FHBA 4HYFA 4BU8A 4YW8A 4TJWA 5LYHA 3L3MA 3MHKA 2RD6A 4L7PA 3DT7A 4UVPA 4GNLA 4N4VA 4WOUA 4U6AA 4PNQA 4J1ZA 4L2FA 4OA7A 4L7LA 4J22A 1YLHA 5AKUA 1KHBA 1WOKA 4R43A 4UXBA 5AL4A 4OPXC 4HHYA 2ZCIA 4GNPA 4TKIA 3U9HA 4UVZA 3SMIA 4RCGA 3P0NA 5LX6A 4L7UA 4UVYA 4HLHA 4UHGA 2RK8A 4YWDA 4AVWA 4DVIA 4I9IA 4GV2A 4PNSA 4OQBC 4KZLA 1K3CA 1K3DA 4L34A 4PY4A 5FH4A 4N4TA 4WL8A 3UDDA 3MHJA 2PQFA 4TKFA 4BU5A 4BUDA 4UUHA 4L2GA 5AL1A 4L70A 2RCWA 2RK7A 5ECEA 5FH0A 4BS4A 4UVXA 4BUAA 1GS0A 2RKAA 2OLRA 2PXZX 4MT9A 4GMUA 5C5PA 5EBTA 4WPUA 4DQYC 4BU9A 4K4FA 4BUWA 4BUYA 4HHZA 5ADSA 3MOFA 2X5YA 4PJTA 4UVUA 4L10A 4HKKA 5AL5A 2QF2A 5AKWA 4L0IA 4MSGA 4BJCA 4BUFA 4N3RA 4PMLA 5LXPA 3SE2A 4GMZA 4RV6A 1OS1A 4TJUA 3DT4A 3GOYA 5A00A 1UK0A 4PNMA 1YGGA 4L31A 4L7RA 4UI6A 5FPGA 3KR7A 2PAXA 4J3MA 5AL2A 4GV4A 4BJBA 1KHEA 1AYLA 4GMMA
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 3KCZ A;  3GEY A;  5ETY A;  4K4E A;  4L0T A;  3CE0 A;  4L32 A;  4AVU A;  4BFP A;  4LI7 A;  4HL5 A;  4TVJ A;  4LI8 A;  4UVL A;  4KZQ A;  5FPF A;  3UA9 A;  4W5I A;  4HMH A;  4PNT A;  4UX4 A;  1EFY A;  4R5W A;  4ZZX A;  4PAX A;  3KJD A;  4L33 A;  5AL3 A;  4OQA C;  4PNN A;  4L7N A;  3C4H A;  4UI5 A;  4GV0 A;  4IUE A;  3P0P A;  4L6Z A;  4KZU A;  4BU3 A;  4BUI A;  4F1L A;  3HKV A;  3C49 A;  4GV7 A;  4XHU A;  4HLM A;  5AEH A;  4HKN A;  4PNR A;  4UVS A;  4BUE A;  5ADT A;  4TJY A;  4X52 A;  3BLJ A;  4LI6 A;  4UVT A;  5C5Q A;  4M7B A;  1UK1 A;  3GN7 A;  3PAX A;  1A26 A;  4L0S A;  4BUV A;  4UVO A;  4F0E A;  4ZZZ A;  4L09 A;  1PAX A;  4BU7 A;  4F1Q A;  4PJV A;  3W51 A;  5ADR A;  4UI4 A;  4W5S A;  4UI3 A;  4TOR A;  4TK5 A;  3P0Q A;  4TKG A;  4L2K A;  4ZZY A;  4L6S A;  4BUX A;  4UI7 A;  4HLG A;  4HLK A;  4TK0 A;  4UVV A;  3U9Y A;  4L7O A;  4KRS A;  4MSK A;  4UVW A;  4UI8 A;  3GJW A;  4UW1 A;  4TOS A;  4UND A;  4UVN A;  4W6E A;  3L3L A;  3SMJ A;  4J3L A;  4BUU A;  4L0B A;  4L0V A;  3UH2 A;  4J21 A;  4UFY A;  4HKI A;  3KR8 A;  4HLF A;  2PAW A;  4PNL A;  4BUS A;  5DCZ A;  5ADQ A;  4UFU A;  4R6E A;  4BJ9 A;  4BU6 A;  4BUT A;  3UH4 A;  5C5R A;  2RF5 A;  3FHB A;  4HYF A;  4BU8 A;  5LYH A;  4TJW A;  3L3M A;  3MHK A;  2RD6 A;  4L7P A;  4UVP A;  4N4V A;  4U6A A;  4PNQ A;  4J1Z A;  4L2F A;  4OA7 A;  4L7L A;  4J22 A;  5AKU A;  1WOK A;  5AL4 A;  4UXB A;  4OPX C;  4HHY A;  4TKI A;  3U9H A;  4UVZ A;  3SMI A;  3P0N A;  5LX6 A;  4L7U A;  4UVY A;  4HLH A;  4UHG A;  4DVI A;  4AVW A;  4I9I A;  4GV2 A;  4PNS A;  4OQB C;  4KZL A;  4L34 A;  3UDD A;  4PY4 A;  4N4T A;  3MHJ A;  2PQF A;  4TKF A;  4BU5 A;  4BUD A;  4UUH A;  4L2G A;  5AL1 A;  4L70 A;  2RCW A;  5ECE A;  4BS4 A;  4BUA A;  4UVX A;  1GS0 A;  4MT9 A;  5C5P A;  4DQY C;  5EBT A;  4BU9 A;  4K4F A;  4BUW A;  4BUY A;  4HHZ A;  5ADS A;  4PJT A;  2X5Y A;  4UVU A;  4L10 A;  4HKK A;  5AL5 A;  5AKW A;  4BJC A;  4L0I A;  4MSG A;  4BUF A;  4N3R A;  4PML A;  5LXP A;  3SE2 A;  4RV6 A;  4TJU A;  3GOY A;  5A00 A;  1UK0 A;  4PNM A;  4L31 A;  4L7R A;  4UI6 A;  5FPG A;  3KR7 A;  2PAX A;  4J3M A;  5AL2 A;  4GV4 A;  4BJB A; 
#chains in the Genus database with same CATH topology
 3MOH A;  3KCZ A;  3GEY A;  4WIE A;  4K4E A;  4L0T A;  3CE0 A;  4L32 A;  5ETY A;  4AVU A;  1J3B A;  2FAH A;  2GMV A;  3DTB A;  4LI7 A;  4HL5 A;  4TVJ A;  4BFP A;  1KHG A;  4LI8 A;  4UVL A;  4KZQ A;  5FPF A;  5FH5 A;  2OLQ A;  4GMW A;  3UA9 A;  4W5I A;  1OEN A;  4HMH A;  4PNT A;  4UX4 A;  1EFY A;  4R5W A;  4ZZX A;  4PAX A;  2FAF A;  3KJD A;  4L33 A;  5AL3 A;  4OQA C;  3MOE A;  4GNO A;  4PNN A;  4L7N A;  3C4H A;  4UI5 A;  4GV0 A;  1NHX A;  4IUE A;  3P0P A;  4L6Z A;  4KZU A;  4BU3 A;  4BUI A;  4F1L A;  3HKV A;  3C49 A;  1YTM A;  2QEY A;  4GV7 A;  4HLM A;  4WPT A;  4XHU A;  4GNM A;  5AEH A;  4HKN A;  4PNR A;  4UVS A;  4BUE A;  2RKE A;  5ADT A;  4TJY A;  4X52 A;  3BLJ A;  4YW9 A;  4LI6 A;  4UVT A;  5C5Q A;  4M7B A;  1UK1 A;  3GN7 A;  3PAX A;  1A26 A;  4L0S A;  4BUV A;  4UVO A;  4F0E A;  4ZZZ A;  5FH3 A;  4L09 A;  4WPV A;  1PAX A;  4BU7 A;  4F1Q A;  4WIU A;  4YWB A;  4PJV A;  3W51 A;  5ADR A;  4UI4 A;  4W5S A;  4UI3 A;  2PY7 X;  4TOR A;  4TK5 A;  3P0Q A;  4TKG A;  4L2K A;  4ZZY A;  4L6S A;  4BUX A;  4UI7 A;  5FH2 A;  4HLG A;  4HLK A;  4TK0 A;  1AQ2 A;  4UVV A;  5I67 A;  3U9Y A;  4L7O A;  4GNQ A;  4KRS A;  4MSK A;  2QF1 A;  4UI8 A;  3GJW A;  1YVY A;  4TOS A;  4UVW A;  4OX2 A;  4UND A;  4UW1 A;  4UVN A;  4W6E A;  1KHF A;  3L3L A;  4J3L A;  3SMJ A;  4BUU A;  4L0B A;  1XKV A;  2RKD A;  4L0V A;  4J21 A;  3UH2 A;  2QZY A;  4UFY A;  4HKI A;  3DT2 A;  3KR8 A;  2PAW A;  4HLF A;  4PNL A;  4BUS A;  5DCZ A;  5ADQ A;  2QEW A;  4R6E A;  4UFU A;  4BJ9 A;  5FH1 A;  4BU6 A;  4BUT A;  1M51 A;  3UH4 A;  1II2 A;  2PC9 A;  5C5R A;  2RF5 A;  3FHB A;  4HYF A;  4BU8 A;  4YW8 A;  4TJW A;  5LYH A;  3L3M A;  3MHK A;  2RD6 A;  4L7P A;  3DT7 A;  4UVP A;  4GNL A;  4N4V A;  4WOU A;  4U6A A;  4PNQ A;  4J1Z A;  4L2F A;  4OA7 A;  4L7L A;  4J22 A;  1YLH A;  5AKU A;  1KHB A;  1WOK A;  4R43 A;  4UXB A;  5AL4 A;  4OPX C;  4HHY A;  2ZCI A;  4GNP A;  4TKI A;  3U9H A;  4UVZ A;  3SMI A;  4RCG A;  3P0N A;  5LX6 A;  4L7U A;  4UVY A;  4HLH A;  4UHG A;  2RK8 A;  4YWD A;  4AVW A;  4DVI A;  4I9I A;  4GV2 A;  4PNS A;  4OQB C;  4KZL A;  1K3C A;  1K3D A;  4L34 A;  4PY4 A;  5FH4 A;  4N4T A;  4WL8 A;  3UDD A;  3MHJ A;  2PQF A;  4TKF A;  4BU5 A;  4BUD A;  4UUH A;  4L2G A;  5AL1 A;  4L70 A;  2RCW A;  2RK7 A;  5ECE A;  5FH0 A;  4BS4 A;  4UVX A;  4BUA A;  1GS0 A;  2RKA A;  2OLR A;  2PXZ X;  4MT9 A;  4GMU A;  5C5P A;  5EBT A;  4WPU A;  4DQY C;  4BU9 A;  4K4F A;  4BUW A;  4BUY A;  4HHZ A;  5ADS A;  3MOF A;  2X5Y A;  4PJT A;  4UVU A;  4L10 A;  4HKK A;  5AL5 A;  2QF2 A;  5AKW A;  4L0I A;  4MSG A;  4BJC A;  4BUF A;  4N3R A;  4PML A;  5LXP A;  3SE2 A;  4GMZ A;  4RV6 A;  1OS1 A;  4TJU A;  3DT4 A;  3GOY A;  5A00 A;  1UK0 A;  4PNM A;  1YGG A;  4L31 A;  4L7R A;  4UI6 A;  5FPG A;  3KR7 A;  2PAX A;  4J3M A;  5AL2 A;  4GV4 A;  4BJB A;  1KHE A;  1AYL A;  4GMM A; 
#chains in the Genus database with same CATH homology
 3MOH A;  3KCZ A;  3GEY A;  4WIE A;  4K4E A;  4L0T A;  3CE0 A;  4L32 A;  5ETY A;  4AVU A;  1J3B A;  2FAH A;  2GMV A;  3DTB A;  4LI7 A;  4HL5 A;  4TVJ A;  4BFP A;  1KHG A;  4LI8 A;  4UVL A;  4KZQ A;  5FPF A;  5FH5 A;  2OLQ A;  4GMW A;  3UA9 A;  4W5I A;  1OEN A;  4HMH A;  4PNT A;  4UX4 A;  1EFY A;  4R5W A;  4ZZX A;  4PAX A;  2FAF A;  3KJD A;  4L33 A;  5AL3 A;  4OQA C;  3MOE A;  4GNO A;  4PNN A;  4L7N A;  3C4H A;  4UI5 A;  4GV0 A;  1NHX A;  4IUE A;  3P0P A;  4L6Z A;  4KZU A;  4BU3 A;  4BUI A;  4F1L A;  3HKV A;  3C49 A;  1YTM A;  2QEY A;  4GV7 A;  4HLM A;  4WPT A;  4XHU A;  4GNM A;  5AEH A;  4HKN A;  4PNR A;  4UVS A;  4BUE A;  2RKE A;  5ADT A;  4TJY A;  4X52 A;  3BLJ A;  4YW9 A;  4LI6 A;  4UVT A;  5C5Q A;  4M7B A;  1UK1 A;  3GN7 A;  3PAX A;  1A26 A;  4L0S A;  4BUV A;  4UVO A;  4F0E A;  4ZZZ A;  5FH3 A;  4L09 A;  4WPV A;  1PAX A;  4BU7 A;  4F1Q A;  4WIU A;  4YWB A;  4PJV A;  3W51 A;  5ADR A;  4UI4 A;  4W5S A;  4UI3 A;  2PY7 X;  4TOR A;  4TK5 A;  3P0Q A;  4TKG A;  4L2K A;  4ZZY A;  4L6S A;  4BUX A;  4UI7 A;  5FH2 A;  4HLG A;  4HLK A;  4TK0 A;  1AQ2 A;  4UVV A;  5I67 A;  3U9Y A;  4L7O A;  4GNQ A;  4KRS A;  4MSK A;  2QF1 A;  4UI8 A;  3GJW A;  1YVY A;  4TOS A;  4UVW A;  4OX2 A;  4UND A;  4UW1 A;  4UVN A;  4W6E A;  1KHF A;  3L3L A;  4J3L A;  3SMJ A;  4BUU A;  4L0B A;  1XKV A;  2RKD A;  4L0V A;  4J21 A;  3UH2 A;  2QZY A;  4UFY A;  4HKI A;  3DT2 A;  3KR8 A;  2PAW A;  4HLF A;  4PNL A;  4BUS A;  5DCZ A;  5ADQ A;  2QEW A;  4R6E A;  4UFU A;  4BJ9 A;  5FH1 A;  4BU6 A;  4BUT A;  1M51 A;  3UH4 A;  1II2 A;  2PC9 A;  5C5R A;  2RF5 A;  3FHB A;  4HYF A;  4BU8 A;  4YW8 A;  4TJW A;  5LYH A;  3L3M A;  3MHK A;  2RD6 A;  4L7P A;  3DT7 A;  4UVP A;  4GNL A;  4N4V A;  4WOU A;  4U6A A;  4PNQ A;  4J1Z A;  4L2F A;  4OA7 A;  4L7L A;  4J22 A;  1YLH A;  5AKU A;  1KHB A;  1WOK A;  4R43 A;  4UXB A;  5AL4 A;  4OPX C;  4HHY A;  2ZCI A;  4GNP A;  4TKI A;  3U9H A;  4UVZ A;  3SMI A;  4RCG A;  3P0N A;  5LX6 A;  4L7U A;  4UVY A;  4HLH A;  4UHG A;  2RK8 A;  4YWD A;  4AVW A;  4DVI A;  4I9I A;  4GV2 A;  4PNS A;  4OQB C;  4KZL A;  1K3C A;  1K3D A;  4L34 A;  4PY4 A;  5FH4 A;  4N4T A;  4WL8 A;  3UDD A;  3MHJ A;  2PQF A;  4TKF A;  4BU5 A;  4BUD A;  4UUH A;  4L2G A;  5AL1 A;  4L70 A;  2RCW A;  2RK7 A;  5ECE A;  5FH0 A;  4BS4 A;  4UVX A;  4BUA A;  1GS0 A;  2RKA A;  2OLR A;  2PXZ X;  4MT9 A;  4GMU A;  5C5P A;  5EBT A;  4WPU A;  4DQY C;  4BU9 A;  4K4F A;  4BUW A;  4BUY A;  4HHZ A;  5ADS A;  3MOF A;  2X5Y A;  4PJT A;  4UVU A;  4L10 A;  4HKK A;  5AL5 A;  2QF2 A;  5AKW A;  4L0I A;  4MSG A;  4BJC A;  4BUF A;  4N3R A;  4PML A;  5LXP A;  3SE2 A;  4GMZ A;  4RV6 A;  1OS1 A;  4TJU A;  3DT4 A;  3GOY A;  5A00 A;  1UK0 A;  4PNM A;  1YGG A;  4L31 A;  4L7R A;  4UI6 A;  5FPG A;  3KR7 A;  2PAX A;  4J3M A;  5AL2 A;  4GV4 A;  4BJB A;  1KHE A;  1AYL A;  4GMM A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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4HLFA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization