4KZL | Genus

Total Genus 47

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	47
sequence length	161
structure length	161
Chain Sequence	GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSA

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

molecule tags	Transferase/transferase inhibitor
source organism	Homo sapiens
publication title	Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. pubmed doi rcsb
molecule keywords	Tankyrase-2
total genus	47
structure length	161
sequence length	161
chains with identical sequence	B
ec nomenclature	ec 2.4.2.30: NAD(+) ADP-ribosyltransferase.
pdb deposition date	2013-05-30

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.90.228.10	Alpha Beta	Alpha-Beta Complex	Phosphoenolpyruvate Carboxykinase; domain 3	Phosphoenolpyruvate Carboxykinase; domain 3	4kzlA00

4BUFA 4BUVA 3FHBA 4KZUA 4PNRA 5C5RA 4R6EA 1UK0A 4IUEA 3KCZA 4BU6A 4L09A 2RD6A 4L7OA 4AVUA 3KJDA 4J22A 4UVVA 5ADQA 4X52A 4J1ZA 5AL4A 4ZZXA 5AL1A 4L7RA 4L2FA 4M7BA 4BJ9A 4TORA 3UA9A 3BLJA 4MSKA 4OQBC 4TJWA 4LI7A 4UVOA 4L34A 4UVNA 4TJUA 4U6AA 5FPGA 4UVSA 4L7NA 4BUUA 3P0PA 3HKVA 4L2GA 4GV7A 4K4EA 4L10A 5ADRA 5ETYA 4UVWA 5C5PA 1UK1A 1A26A 3UH4A 4BJBA 3W51A 4HKNA 3GOYA 4AVWA 4L7LA 3L3MA 4BU5A 4L7UA 3MHJA 4UI8A 4BJCA 3SE2A 4ZZYA 5AKWA 3UH2A 4TOSA 4BU3A 4L70A 3U9HA 4HKKA 4UVXA 2X5YA 4N3RA 4L6ZA 4UW1A 4J21A 4BUAA 4HKIA 4PNNA 3SMJA 4J3LA 4MT9A 4KZLA 4UVYA 5EBTA 3GN7A 4PAXA 4TK5A 5FPFA 4RV6A 4BUEA 4TKIA 5DCZA 5AL5A 5LYHA 4BUXA 3KR8A 4L0VA 4HMHA 4UFYA 4UX4A 3C4HA 4DVIA 4HLKA 4ZZZA 4UI6A 4BS4A 4HYFA 5LX6A 4PJVA 4HLHA 2PAWA 4L7PA 4BUDA 4HLMA 4PNQA 4PNLA 5AKUA 3SMIA 4BUWA 4F0EA 4DQYC 5LXPA 4LI6A 4W6EA 4HL5A 4PMLA 4TK0A 4OA7A 4PNMA 3GJWA 4L0TA 2RCWA 4UI4A 4UVTA 4PJTA 4PNSA 4BUIA 4UVPA 4L32A 5AEHA 4BU8A 4BUTA 5ECEA 4HLFA 5A00A 4UI7A 4L0BA 4UVLA 3C49A 4J3MA 4OQAC 4L31A 4UUHA 4L0SA 4BU7A 1PAXA 1EFYA 3GEYA 4GV0A 4GV2A 4KRSA 4N4VA 4UFUA 5AL3A 4TVJA 5C5QA 5ADTA 3P0NA 4UVZA 4LI8A 5AL2A 4BUYA 3UDDA 4MSGA 4BUSA 4L2KA 4UNDA 4PNTA 4L0IA 4HHZA 4TKGA 4XHUA 2RF5A 4N4TA 4BFPA 1WOKA 4F1QA 3MHKA 2PAXA 4UHGA 4KZQA 4PY4A 4TJYA 4F1LA 4L33A 4BU9A 3P0QA 3PAXA 4HLGA 4I9IA 4UI5A 4UVUA 4UI3A 4W5SA 4K4FA 2PQFA 3KR7A 4OPXC 4TKFA 4GV4A 4W5IA 4L6SA 3CE0A 4HHYA 1GS0A 3U9YA 4R5WA 3L3LA 5ADSA 4UXBA
chains in the Genus database with same CATH superfamily

1YGGA 4YWDA 4BUFA 2QF1A 2QEWA 3FHBA 4KZUA 4PNRA 5C5RA 4R6EA 1UK0A 4BUVA 4IUEA 3KCZA 4GNOA 4L09A 2RD6A 4BU6A 4L7OA 4AVUA 3KJDA 4J22A 2OLQA 4UVVA 5ADQA 4X52A 4J1ZA 5AL4A 4ZZXA 5AL1A 4L7RA 4L2FA 4M7BA 4BJ9A 4TORA 3UA9A 3BLJA 4MSKA 4OQBC 4TJWA 4LI7A 4GNMA 4L34A 4UVOA 4WL8A 4UVNA 4TJUA 4U6AA 5FPGA 4UVSA 4L7NA 4BUUA 2RK8A 3P0PA 1YTMA 3HKVA 4L2GA 5FH2A 4GV7A 4K4EA 4WIUA 4L10A 4GNQA 5ADRA 1OENA 3DT2A 5ETYA 4UVWA 2RKEA 2PXZX 5C5PA 1UK1A 1A26A 3UH4A 4GMMA 4BJBA 2FAFA 3W51A 4HKNA 3GOYA 4AVWA 4L7LA 4WPVA 2FAHA 3L3MA 4YW8A 2RKAA 4BU5A 4L7UA 3MHJA 3MOEA 4UI8A 4BJCA 5I67A 3SE2A 4ZZYA 5AKWA 3UH2A 4GMUA 4TOSA 4BU3A 2RKDA 4L70A 3U9HA 4HKKA 1K3DA 2X5YA 4N3RA 4GNLA 4L6ZA 4J21A 4GMZA 1XKVA 4HKIA 4PNNA 4J3LA 4UW1A 3SMJA 4MT9A 2RK7A 4KZLA 1KHGA 4UVYA 5EBTA 3GN7A 4PAXA 4TK5A 2PY7X 5FPFA 4RV6A 4BUEA 4TKIA 5DCZA 5AL5A 4R43A 5LYHA 4BUXA 3KR8A 4L0VA 4HMHA 4UFYA 5FH4A 4UX4A 5FH0A 4GNPA 3C4HA 4DVIA 4HLKA 4ZZZA 1AYLA 4UI6A 1KHFA 4WIEA 1AQ2A 1OS1A 1NHXA 4HYFA 4BS4A 5LX6A 4PJVA 4HLHA 2PAWA 4L7PA 4BUDA 4HLMA 4PNQA 4PNLA 5AKUA 3DT7A 4OX2A 3SMIA 4BUWA 4F0EA 4DQYC 1II2A 3MOHA 5LXPA 4LI6A 4UVXA 4W6EA 4WPUA 4HL5A 4PMLA 4TK0A 5ADTA 4OA7A 4PNMA 3GJWA 4L0TA 2RCWA 4UI4A 4UVTA 4PJTA 4PNSA 4BUIA 4RCGA 5FH5A 4UVPA 2QZYA 4L32A 5AEHA 4BU8A 4BUTA 5ECEA 4HLFA 5A00A 4UI7A 4WOUA 4L0BA 4GMWA 4UVLA 2QF2A 3C49A 4J3MA 4OQAC 2OLRA 4L31A 4UUHA 4L0SA 4BU7A 5FH1A 1EFYA 1PAXA 2PC9A 3GEYA 4GV0A 4GV2A 4KRSA 4N4VA 4UFUA 4TVJA 5AL3A 5C5QA 3P0NA 3DTBA 4UVZA 4LI8A 5AL2A 4BUYA 5FH3A 4WPTA 2QEYA 3UDDA 4MSGA 2GMVA 4BUSA 1YVYA 4L2KA 4UNDA 4PNTA 3MOFA 4HHZA 4L0IA 1K3CA 4TKGA 4XHUA 1M51A 4YW9A 2RF5A 4N4TA 4BFPA 1WOKA 4F1QA 3MHKA 2PAXA 4UHGA 4KZQA 1YLHA 1J3BA 3DT4A 4L33A 4PY4A 3P0QA 1KHBA 3PAXA 4HLGA 4TJYA 4BU9A 4BUAA 4I9IA 4UI5A 4YWBA 4F1LA 4UVUA 4UI3A 4W5SA 4K4FA 2PQFA 3KR7A 4OPXC 2ZCIA 4TKFA 4GV4A 4W5IA 4L6SA 3CE0A 4HHYA 1GS0A 3U9YA 1KHEA 4R5WA 3L3LA 5ADSA 4UXBA
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 4BUF A;  4BUV A;  3FHB A;  4KZU A;  4PNR A;  5C5R A;  4R6E A;  1UK0 A;  4IUE A;  3KCZ A;  4BU6 A;  4L09 A;  2RD6 A;  4L7O A;  4AVU A;  3KJD A;  4J22 A;  4UVV A;  5ADQ A;  4X52 A;  4J1Z A;  5AL4 A;  4ZZX A;  5AL1 A;  4L7R A;  4L2F A;  4M7B A;  4BJ9 A;  4TOR A;  3UA9 A;  3BLJ A;  4MSK A;  4OQB C;  4TJW A;  4LI7 A;  4UVO A;  4L34 A;  4UVN A;  4TJU A;  4U6A A;  5FPG A;  4UVS A;  4L7N A;  4BUU A;  3P0P A;  3HKV A;  4L2G A;  4GV7 A;  4K4E A;  4L10 A;  5ADR A;  5ETY A;  4UVW A;  5C5P A;  1UK1 A;  1A26 A;  3UH4 A;  4BJB A;  3W51 A;  4HKN A;  3GOY A;  4AVW A;  4L7L A;  3L3M A;  4BU5 A;  4L7U A;  3MHJ A;  4UI8 A;  4BJC A;  3SE2 A;  4ZZY A;  5AKW A;  3UH2 A;  4TOS A;  4BU3 A;  4L70 A;  3U9H A;  4HKK A;  4UVX A;  2X5Y A;  4N3R A;  4L6Z A;  4UW1 A;  4J21 A;  4BUA A;  4HKI A;  4PNN A;  3SMJ A;  4J3L A;  4MT9 A;  4KZL A;  4UVY A;  5EBT A;  3GN7 A;  4PAX A;  4TK5 A;  5FPF A;  4RV6 A;  4BUE A;  4TKI A;  5DCZ A;  5AL5 A;  5LYH A;  4BUX A;  3KR8 A;  4L0V A;  4HMH A;  4UFY A;  4UX4 A;  3C4H A;  4DVI A;  4HLK A;  4ZZZ A;  4UI6 A;  4BS4 A;  4HYF A;  5LX6 A;  4PJV A;  4HLH A;  2PAW A;  4L7P A;  4BUD A;  4HLM A;  4PNQ A;  4PNL A;  5AKU A;  3SMI A;  4BUW A;  4F0E A;  4DQY C;  5LXP A;  4LI6 A;  4W6E A;  4HL5 A;  4PML A;  4TK0 A;  4OA7 A;  4PNM A;  3GJW A;  4L0T A;  2RCW A;  4UI4 A;  4UVT A;  4PJT A;  4PNS A;  4BUI A;  4UVP A;  4L32 A;  5AEH A;  4BU8 A;  4BUT A;  5ECE A;  4HLF A;  5A00 A;  4UI7 A;  4L0B A;  4UVL A;  3C49 A;  4J3M A;  4OQA C;  4L31 A;  4UUH A;  4L0S A;  4BU7 A;  1PAX A;  1EFY A;  3GEY A;  4GV0 A;  4GV2 A;  4KRS A;  4N4V A;  4UFU A;  5AL3 A;  4TVJ A;  5C5Q A;  5ADT A;  3P0N A;  4UVZ A;  4LI8 A;  5AL2 A;  4BUY A;  3UDD A;  4MSG A;  4BUS A;  4L2K A;  4UND A;  4PNT A;  4L0I A;  4HHZ A;  4TKG A;  4XHU A;  2RF5 A;  4N4T A;  4BFP A;  1WOK A;  4F1Q A;  3MHK A;  2PAX A;  4UHG A;  4KZQ A;  4PY4 A;  4TJY A;  4F1L A;  4L33 A;  4BU9 A;  3P0Q A;  3PAX A;  4HLG A;  4I9I A;  4UI5 A;  4UVU A;  4UI3 A;  4W5S A;  4K4F A;  2PQF A;  3KR7 A;  4OPX C;  4TKF A;  4GV4 A;  4W5I A;  4L6S A;  3CE0 A;  4HHY A;  1GS0 A;  3U9Y A;  4R5W A;  3L3L A;  5ADS A;  4UXB A; 
#chains in the Genus database with same CATH topology
 1YGG A;  4YWD A;  4BUF A;  2QF1 A;  2QEW A;  3FHB A;  4KZU A;  4PNR A;  5C5R A;  4R6E A;  1UK0 A;  4BUV A;  4IUE A;  3KCZ A;  4GNO A;  4L09 A;  2RD6 A;  4BU6 A;  4L7O A;  4AVU A;  3KJD A;  4J22 A;  2OLQ A;  4UVV A;  5ADQ A;  4X52 A;  4J1Z A;  5AL4 A;  4ZZX A;  5AL1 A;  4L7R A;  4L2F A;  4M7B A;  4BJ9 A;  4TOR A;  3UA9 A;  3BLJ A;  4MSK A;  4OQB C;  4TJW A;  4LI7 A;  4GNM A;  4L34 A;  4UVO A;  4WL8 A;  4UVN A;  4TJU A;  4U6A A;  5FPG A;  4UVS A;  4L7N A;  4BUU A;  2RK8 A;  3P0P A;  1YTM A;  3HKV A;  4L2G A;  5FH2 A;  4GV7 A;  4K4E A;  4WIU A;  4L10 A;  4GNQ A;  5ADR A;  1OEN A;  3DT2 A;  5ETY A;  4UVW A;  2RKE A;  2PXZ X;  5C5P A;  1UK1 A;  1A26 A;  3UH4 A;  4GMM A;  4BJB A;  2FAF A;  3W51 A;  4HKN A;  3GOY A;  4AVW A;  4L7L A;  4WPV A;  2FAH A;  3L3M A;  4YW8 A;  2RKA A;  4BU5 A;  4L7U A;  3MHJ A;  3MOE A;  4UI8 A;  4BJC A;  5I67 A;  3SE2 A;  4ZZY A;  5AKW A;  3UH2 A;  4GMU A;  4TOS A;  4BU3 A;  2RKD A;  4L70 A;  3U9H A;  4HKK A;  1K3D A;  2X5Y A;  4N3R A;  4GNL A;  4L6Z A;  4J21 A;  4GMZ A;  1XKV A;  4HKI A;  4PNN A;  4J3L A;  4UW1 A;  3SMJ A;  4MT9 A;  2RK7 A;  4KZL A;  1KHG A;  4UVY A;  5EBT A;  3GN7 A;  4PAX A;  4TK5 A;  2PY7 X;  5FPF A;  4RV6 A;  4BUE A;  4TKI A;  5DCZ A;  5AL5 A;  4R43 A;  5LYH A;  4BUX A;  3KR8 A;  4L0V A;  4HMH A;  4UFY A;  5FH4 A;  4UX4 A;  5FH0 A;  4GNP A;  3C4H A;  4DVI A;  4HLK A;  4ZZZ A;  1AYL A;  4UI6 A;  1KHF A;  4WIE A;  1AQ2 A;  1OS1 A;  1NHX A;  4HYF A;  4BS4 A;  5LX6 A;  4PJV A;  4HLH A;  2PAW A;  4L7P A;  4BUD A;  4HLM A;  4PNQ A;  4PNL A;  5AKU A;  3DT7 A;  4OX2 A;  3SMI A;  4BUW A;  4F0E A;  4DQY C;  1II2 A;  3MOH A;  5LXP A;  4LI6 A;  4UVX A;  4W6E A;  4WPU A;  4HL5 A;  4PML A;  4TK0 A;  5ADT A;  4OA7 A;  4PNM A;  3GJW A;  4L0T A;  2RCW A;  4UI4 A;  4UVT A;  4PJT A;  4PNS A;  4BUI A;  4RCG A;  5FH5 A;  4UVP A;  2QZY A;  4L32 A;  5AEH A;  4BU8 A;  4BUT A;  5ECE A;  4HLF A;  5A00 A;  4UI7 A;  4WOU A;  4L0B A;  4GMW A;  4UVL A;  2QF2 A;  3C49 A;  4J3M A;  4OQA C;  2OLR A;  4L31 A;  4UUH A;  4L0S A;  4BU7 A;  5FH1 A;  1EFY A;  1PAX A;  2PC9 A;  3GEY A;  4GV0 A;  4GV2 A;  4KRS A;  4N4V A;  4UFU A;  4TVJ A;  5AL3 A;  5C5Q A;  3P0N A;  3DTB A;  4UVZ A;  4LI8 A;  5AL2 A;  4BUY A;  5FH3 A;  4WPT A;  2QEY A;  3UDD A;  4MSG A;  2GMV A;  4BUS A;  1YVY A;  4L2K A;  4UND A;  4PNT A;  3MOF A;  4HHZ A;  4L0I A;  1K3C A;  4TKG A;  4XHU A;  1M51 A;  4YW9 A;  2RF5 A;  4N4T A;  4BFP A;  1WOK A;  4F1Q A;  3MHK A;  2PAX A;  4UHG A;  4KZQ A;  1YLH A;  1J3B A;  3DT4 A;  4L33 A;  4PY4 A;  3P0Q A;  1KHB A;  3PAX A;  4HLG A;  4TJY A;  4BU9 A;  4BUA A;  4I9I A;  4UI5 A;  4YWB A;  4F1L A;  4UVU A;  4UI3 A;  4W5S A;  4K4F A;  2PQF A;  3KR7 A;  4OPX C;  2ZCI A;  4TKF A;  4GV4 A;  4W5I A;  4L6S A;  3CE0 A;  4HHY A;  1GS0 A;  3U9Y A;  1KHE A;  4R5W A;  3L3L A;  5ADS A;  4UXB A; 
#chains in the Genus database with same CATH homology
 1YGG A;  4YWD A;  4BUF A;  2QF1 A;  2QEW A;  3FHB A;  4KZU A;  4PNR A;  5C5R A;  4R6E A;  1UK0 A;  4BUV A;  4IUE A;  3KCZ A;  4GNO A;  4L09 A;  2RD6 A;  4BU6 A;  4L7O A;  4AVU A;  3KJD A;  4J22 A;  2OLQ A;  4UVV A;  5ADQ A;  4X52 A;  4J1Z A;  5AL4 A;  4ZZX A;  5AL1 A;  4L7R A;  4L2F A;  4M7B A;  4BJ9 A;  4TOR A;  3UA9 A;  3BLJ A;  4MSK A;  4OQB C;  4TJW A;  4LI7 A;  4GNM A;  4L34 A;  4UVO A;  4WL8 A;  4UVN A;  4TJU A;  4U6A A;  5FPG A;  4UVS A;  4L7N A;  4BUU A;  2RK8 A;  3P0P A;  1YTM A;  3HKV A;  4L2G A;  5FH2 A;  4GV7 A;  4K4E A;  4WIU A;  4L10 A;  4GNQ A;  5ADR A;  1OEN A;  3DT2 A;  5ETY A;  4UVW A;  2RKE A;  2PXZ X;  5C5P A;  1UK1 A;  1A26 A;  3UH4 A;  4GMM A;  4BJB A;  2FAF A;  3W51 A;  4HKN A;  3GOY A;  4AVW A;  4L7L A;  4WPV A;  2FAH A;  3L3M A;  4YW8 A;  2RKA A;  4BU5 A;  4L7U A;  3MHJ A;  3MOE A;  4UI8 A;  4BJC A;  5I67 A;  3SE2 A;  4ZZY A;  5AKW A;  3UH2 A;  4GMU A;  4TOS A;  4BU3 A;  2RKD A;  4L70 A;  3U9H A;  4HKK A;  1K3D A;  2X5Y A;  4N3R A;  4GNL A;  4L6Z A;  4J21 A;  4GMZ A;  1XKV A;  4HKI A;  4PNN A;  4J3L A;  4UW1 A;  3SMJ A;  4MT9 A;  2RK7 A;  4KZL A;  1KHG A;  4UVY A;  5EBT A;  3GN7 A;  4PAX A;  4TK5 A;  2PY7 X;  5FPF A;  4RV6 A;  4BUE A;  4TKI A;  5DCZ A;  5AL5 A;  4R43 A;  5LYH A;  4BUX A;  3KR8 A;  4L0V A;  4HMH A;  4UFY A;  5FH4 A;  4UX4 A;  5FH0 A;  4GNP A;  3C4H A;  4DVI A;  4HLK A;  4ZZZ A;  1AYL A;  4UI6 A;  1KHF A;  4WIE A;  1AQ2 A;  1OS1 A;  1NHX A;  4HYF A;  4BS4 A;  5LX6 A;  4PJV A;  4HLH A;  2PAW A;  4L7P A;  4BUD A;  4HLM A;  4PNQ A;  4PNL A;  5AKU A;  3DT7 A;  4OX2 A;  3SMI A;  4BUW A;  4F0E A;  4DQY C;  1II2 A;  3MOH A;  5LXP A;  4LI6 A;  4UVX A;  4W6E A;  4WPU A;  4HL5 A;  4PML A;  4TK0 A;  5ADT A;  4OA7 A;  4PNM A;  3GJW A;  4L0T A;  2RCW A;  4UI4 A;  4UVT A;  4PJT A;  4PNS A;  4BUI A;  4RCG A;  5FH5 A;  4UVP A;  2QZY A;  4L32 A;  5AEH A;  4BU8 A;  4BUT A;  5ECE A;  4HLF A;  5A00 A;  4UI7 A;  4WOU A;  4L0B A;  4GMW A;  4UVL A;  2QF2 A;  3C49 A;  4J3M A;  4OQA C;  2OLR A;  4L31 A;  4UUH A;  4L0S A;  4BU7 A;  5FH1 A;  1EFY A;  1PAX A;  2PC9 A;  3GEY A;  4GV0 A;  4GV2 A;  4KRS A;  4N4V A;  4UFU A;  4TVJ A;  5AL3 A;  5C5Q A;  3P0N A;  3DTB A;  4UVZ A;  4LI8 A;  5AL2 A;  4BUY A;  5FH3 A;  4WPT A;  2QEY A;  3UDD A;  4MSG A;  2GMV A;  4BUS A;  1YVY A;  4L2K A;  4UND A;  4PNT A;  3MOF A;  4HHZ A;  4L0I A;  1K3C A;  4TKG A;  4XHU A;  1M51 A;  4YW9 A;  2RF5 A;  4N4T A;  4BFP A;  1WOK A;  4F1Q A;  3MHK A;  2PAX A;  4UHG A;  4KZQ A;  1YLH A;  1J3B A;  3DT4 A;  4L33 A;  4PY4 A;  3P0Q A;  1KHB A;  3PAX A;  4HLG A;  4TJY A;  4BU9 A;  4BUA A;  4I9I A;  4UI5 A;  4YWB A;  4F1L A;  4UVU A;  4UI3 A;  4W5S A;  4K4F A;  2PQF A;  3KR7 A;  4OPX C;  2ZCI A;  4TKF A;  4GV4 A;  4W5I A;  4L6S A;  3CE0 A;  4HHY A;  1GS0 A;  3U9Y A;  1KHE A;  4R5W A;  3L3L A;  5ADS A;  4UXB A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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4KZLA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization