4YISA

Crystal structure of laglidadg meganuclease i-cpami bound to uncleaved dna
Total Genus 87
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
87
sequence length
295
structure length
295
Chain Sequence
SFNPWFLTGFSDAECSFSILIQANSKYSTGWRIKPVFAIGLHKKDNELLKRIQSYLGVGKIHIHGKDSIQFRIDSPKELEVIINHFENYPLVTAKQADYTLFKKALDVIKNKEHLSQKGLLKLVGIKASLNLGLNGSLKEAFPNWEELQIDRPSYVNKGIPDPNWISGFASGDSSFNVKISNSPTSLLNKRVQLRFGIGLNIREKALIQYLVAYFDLSDNLKNIYFDLNSARFEVVKFSDITDKIIPFFDKYSIQGKKSQDYQNFKEVADIIKSKNHLTSEGFQEILDIKASMNK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity.
pubmed doi rcsb
molecule keywords Meganuclease I-CpaMI
molecule tags Hydrolase/dna
source organism Cryphonectria parasitica
total genus 87
structure length 295
sequence length 295
chains with identical sequence B
ec nomenclature
pdb deposition date 2015-03-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00961 LAGLIDADG_1 LAGLIDADG endonuclease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.10.28.10 Alpha Beta Roll Endonuclease I-creI Homing endonucleases 4yisA01
3.10.28.10 Alpha Beta Roll Endonuclease I-creI Homing endonucleases 4yisA02
5A0MB 2CW8A 4YISA 5A0WA 4D6OA 1R7MA 1B24A 1BP7A 1G9ZA 4Z1XA 4D6NA 4EFJA 3HYJA 2XE0B 1N3FA 2VS7A 2I3PA 1T9IA 2DCHX 3MISA 4UN9G 1U0CA 1EF0A 4AADA 4LQ0A 4Z20A 3QQYA 3MXBB 3KO2A 5AK9A 1DFAA 5E5OA 5AKNA 4UN8A 4LOXA 5AKMA 3FD2A 2O7MA 1VDEA 3R7PA 4UNBA 2VS8A 5A72A 4UN7A 5E5SA 2I3QA 4AAGA 3MXAA 2VBOB 3OORA 4AQXA 4AAFA 1UM2A 3OOLA 2VBLA 5E63A 1JVAA 4AQUA 2VBJA 2VBOA 2FLDA 4AAEA 4Z1ZA 1M5XA 3HYIA 2VBNB 3E54A 1AF5A 4UN9A 2VBLB 4YITA 3UVFA 1MOWA 4UT0A 4UN7G 4UNAA 3C0WA 2CW7A 2VBJB 2VBNA 4AABA 1LWTA 1U0DA 1T9JA 4YHXA 1P8KZ 1LWSA 1DQ3A 3MX9A 4UN8G 5A77A 1G9YA 5A74A 1N3EA 5A0MA 2QOJZ 5E67A 3EH8A 2XE0A 3C0XA 5A78A 5AKFA 4UNCA 2AB5A 3MIPA 3MXBA 2EX5A
chains in the Genus database with same CATH superfamily
5A0MB 2CW8A 4YISA 5A0WA 4D6OA 1R7MA 1B24A 1BP7A 1G9ZA 4Z1XA 4D6NA 4EFJA 3HYJA 2XE0B 1N3FA 2VS7A 2I3PA 1T9IA 2DCHX 3MISA 4UN9G 1U0CA 1EF0A 4AADA 4LQ0A 4Z20A 3QQYA 3MXBB 3KO2A 5AK9A 1DFAA 5E5OA 5AKNA 4UN8A 4LOXA 5AKMA 3FD2A 2O7MA 1VDEA 3R7PA 4UNBA 2VS8A 5A72A 4UN7A 5E5SA 2I3QA 4AAGA 3MXAA 2VBOB 3OORA 4AQXA 4AAFA 1UM2A 3OOLA 2VBLA 5E63A 1JVAA 4AQUA 2VBJA 2VBOA 2FLDA 4AAEA 4Z1ZA 1M5XA 3HYIA 2VBNB 3E54A 1AF5A 4UN9A 2VBLB 4YITA 3UVFA 1MOWA 4UT0A 4UN7G 4UNAA 3C0WA 2CW7A 2VBJB 2VBNA 4AABA 1LWTA 1U0DA 1T9JA 4KZSA 4YHXA 1P8KZ 1LWSA 1DQ3A 3MX9A 4UN8G 5A77A 1G9YA 2F4LA 5A74A 1N3EA 5A0MA 2QOJZ 5E67A 3EH8A 2XE0A 3C0XA 5A78A 5AKFA 4UNCA 2AB5A 3MIPA 3MXBA 2EX5A
chains in the Genus database with same CATH topology
5A0MB 2CW8A 4YISA 5A0WA 4D6OA 1R7MA 1B24A 1BP7A 1G9ZA 4Z1XA 4D6NA 4EFJA 3HYJA 2XE0B 1N3FA 2VS7A 2I3PA 1T9IA 2DCHX 3MISA 4UN9G 1U0CA 1EF0A 4AADA 4LQ0A 4Z20A 3QQYA 3MXBB 3KO2A 5AK9A 1DFAA 5E5OA 5AKNA 4UN8A 4LOXA 5AKMA 3FD2A 2O7MA 1VDEA 3R7PA 4UNBA 2VS8A 5A72A 4UN7A 5E5SA 2I3QA 4AAGA 3MXAA 2VBOB 3OORA 4AQXA 4AAFA 1UM2A 3OOLA 2VBLA 5E63A 1JVAA 4AQUA 2VBJA 2VBOA 2FLDA 4AAEA 4Z1ZA 1M5XA 3HYIA 2VBNB 3E54A 1AF5A 4UN9A 2VBLB 4YITA 3UVFA 1MOWA 4UT0A 4UN7G 4UNAA 3C0WA 2CW7A 2VBJB 2VBNA 4AABA 1LWTA 1U0DA 1T9JA 4YHXA 1P8KZ 1LWSA 1DQ3A 3MX9A 4UN8G 5A77A 1G9YA 5A74A 1N3EA 5A0MA 2QOJZ 5E67A 3EH8A 2XE0A 3C0XA 5A78A 5AKFA 4UNCA 2AB5A 3MIPA 3MXBA 2EX5A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 5A0M B;  2CW8 A;  4YIS A;  5A0W A;  4D6O A;  1R7M A;  1B24 A;  1BP7 A;  1G9Z A;  4Z1X A;  4D6N A;  4EFJ A;  3HYJ A;  2XE0 B;  1N3F A;  2VS7 A;  2I3P A;  1T9I A;  2DCH X;  3MIS A;  4UN9 G;  1U0C A;  1EF0 A;  4AAD A;  4LQ0 A;  4Z20 A;  3QQY A;  3MXB B;  3KO2 A;  5AK9 A;  1DFA A;  5E5O A;  5AKN A;  4UN8 A;  4LOX A;  5AKM A;  3FD2 A;  2O7M A;  1VDE A;  3R7P A;  4UNB A;  2VS8 A;  5A72 A;  4UN7 A;  5E5S A;  2I3Q A;  4AAG A;  3MXA A;  2VBO B;  3OOR A;  4AQX A;  4AAF A;  1UM2 A;  3OOL A;  2VBL A;  5E63 A;  1JVA A;  4AQU A;  2VBJ A;  2VBO A;  2FLD A;  4AAE A;  4Z1Z A;  1M5X A;  3HYI A;  2VBN B;  3E54 A;  1AF5 A;  4UN9 A;  2VBL B;  4YIT A;  3UVF A;  1MOW A;  4UT0 A;  4UN7 G;  4UNA A;  3C0W A;  2CW7 A;  2VBJ B;  2VBN A;  4AAB A;  1LWT A;  1U0D A;  1T9J A;  4YHX A;  1P8K Z;  1LWS A;  1DQ3 A;  3MX9 A;  4UN8 G;  5A77 A;  1G9Y A;  5A74 A;  1N3E A;  5A0M A;  2QOJ Z;  5E67 A;  3EH8 A;  2XE0 A;  3C0X A;  5A78 A;  5AKF A;  4UNC A;  2AB5 A;  3MIP A;  3MXB A;  2EX5 A; 
#chains in the Genus database with same CATH topology
 5A0M B;  2CW8 A;  4YIS A;  5A0W A;  4D6O A;  1R7M A;  1B24 A;  1BP7 A;  1G9Z A;  4Z1X A;  4D6N A;  4EFJ A;  3HYJ A;  2XE0 B;  1N3F A;  2VS7 A;  2I3P A;  1T9I A;  2DCH X;  3MIS A;  4UN9 G;  1U0C A;  1EF0 A;  4AAD A;  4LQ0 A;  4Z20 A;  3QQY A;  3MXB B;  3KO2 A;  5AK9 A;  1DFA A;  5E5O A;  5AKN A;  4UN8 A;  4LOX A;  5AKM A;  3FD2 A;  2O7M A;  1VDE A;  3R7P A;  4UNB A;  2VS8 A;  5A72 A;  4UN7 A;  5E5S A;  2I3Q A;  4AAG A;  3MXA A;  2VBO B;  3OOR A;  4AQX A;  4AAF A;  1UM2 A;  3OOL A;  2VBL A;  5E63 A;  1JVA A;  4AQU A;  2VBJ A;  2VBO A;  2FLD A;  4AAE A;  4Z1Z A;  1M5X A;  3HYI A;  2VBN B;  3E54 A;  1AF5 A;  4UN9 A;  2VBL B;  4YIT A;  3UVF A;  1MOW A;  4UT0 A;  4UN7 G;  4UNA A;  3C0W A;  2CW7 A;  2VBJ B;  2VBN A;  4AAB A;  1LWT A;  1U0D A;  1T9J A;  4KZS A;  4YHX A;  1P8K Z;  1LWS A;  1DQ3 A;  3MX9 A;  4UN8 G;  5A77 A;  1G9Y A;  2F4L A;  5A74 A;  1N3E A;  5A0M A;  2QOJ Z;  5E67 A;  3EH8 A;  2XE0 A;  3C0X A;  5A78 A;  5AKF A;  4UNC A;  2AB5 A;  3MIP A;  3MXB A;  2EX5 A; 
#chains in the Genus database with same CATH homology
 5A0M B;  2CW8 A;  4YIS A;  5A0W A;  4D6O A;  1R7M A;  1B24 A;  1BP7 A;  1G9Z A;  4Z1X A;  4D6N A;  4EFJ A;  3HYJ A;  2XE0 B;  1N3F A;  2VS7 A;  2I3P A;  1T9I A;  2DCH X;  3MIS A;  4UN9 G;  1U0C A;  1EF0 A;  4AAD A;  4LQ0 A;  4Z20 A;  3QQY A;  3MXB B;  3KO2 A;  5AK9 A;  1DFA A;  5E5O A;  5AKN A;  4UN8 A;  4LOX A;  5AKM A;  3FD2 A;  2O7M A;  1VDE A;  3R7P A;  4UNB A;  2VS8 A;  5A72 A;  4UN7 A;  5E5S A;  2I3Q A;  4AAG A;  3MXA A;  2VBO B;  3OOR A;  4AQX A;  4AAF A;  1UM2 A;  3OOL A;  2VBL A;  5E63 A;  1JVA A;  4AQU A;  2VBJ A;  2VBO A;  2FLD A;  4AAE A;  4Z1Z A;  1M5X A;  3HYI A;  2VBN B;  3E54 A;  1AF5 A;  4UN9 A;  2VBL B;  4YIT A;  3UVF A;  1MOW A;  4UT0 A;  4UN7 G;  4UNA A;  3C0W A;  2CW7 A;  2VBJ B;  2VBN A;  4AAB A;  1LWT A;  1U0D A;  1T9J A;  4YHX A;  1P8K Z;  1LWS A;  1DQ3 A;  3MX9 A;  4UN8 G;  5A77 A;  1G9Y A;  5A74 A;  1N3E A;  5A0M A;  2QOJ Z;  5E67 A;  3EH8 A;  2XE0 A;  3C0X A;  5A78 A;  5AKF A;  4UNC A;  2AB5 A;  3MIP A;  3MXB A;  2EX5 A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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