4HYFA

Structural basis and sar for od 270, a lead stage 1,2,4-triazole based specific tankyrase1/2 inhibitor
Total Genus 59
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
59
sequence length
227
structure length
227
Chain Sequence
GTENLYFQSMLNTSGSGTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPEG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Basis and SAR for G007-LK, a Lead Stage 1,2,4-Triazole Based Specific Tankyrase 1/2 Inhibitor.
pubmed doi rcsb
molecule tags Transferase/transferase inhibitor
source organism Homo sapiens
molecule keywords Tankyrase-2
total genus 59
structure length 227
sequence length 227
chains with identical sequence B, C
ec nomenclature ec 2.4.2.30: NAD(+) ADP-ribosyltransferase.
pdb deposition date 2012-11-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00644 PARP Poly(ADP-ribose) polymerase catalytic domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.228.10 Alpha Beta Alpha-Beta Complex Phosphoenolpyruvate Carboxykinase; domain 3 Phosphoenolpyruvate Carboxykinase; domain 3 4hyfA00
5ADTA 4LI8A 4PNLA 4UI7A 4PAXA 4PJTA 4ZZXA 4TORA 4L7PA 4L7RA 4LI6A 3GN7A 3UA9A 2RCWA 4HKNA 4TVJA 3SE2A 4K4EA 4BUAA 4X52A 5C5RA 4L2GA 3MHKA 3SMJA 4L7LA 1A26A 4UI8A 5AKWA 3KR7A 4L70A 4HL5A 4GV4A 4BU6A 4F0EA 4UI6A 2RF5A 4TJWA 5DCZA 5AL5A 4UW1A 4M7BA 4TJYA 4U6AA 4HLKA 4MSKA 4UVOA 4DQYC 4HLFA 4UI5A 4BUSA 5FPGA 5A00A 3U9YA 5LXPA 4K4FA 4N3RA 4BFPA 3P0PA 4OPXC 4KZUA 4PNTA 4UI4A 4UVSA 2RD6A 5C5QA 4IUEA 3CE0A 4F1QA 4UVTA 4AVUA 4L7OA 4F1LA 4GV7A 5AL1A 5AEHA 2PQFA 4PNSA 3KR8A 4L2FA 3BLJA 4L0BA 5LYHA 4ZZZA 4OQBC 4L10A 4KZLA 4OA7A 1PAXA 4BJBA 3GJWA 3P0QA 4BU7A 4L2KA 5AKUA 4UVPA 5ADSA 4AVWA 4TKGA 4BJ9A 4BU5A 3C4HA 4TKFA 4W5IA 3UH2A 2X5YA 4BUDA 1UK0A 3GOYA 4LI7A 4N4VA 4BUXA 4J1ZA 4J3LA 4MSGA 4UXBA 4BUFA 5ECEA 4HKKA 4UFUA 4TOSA 4BUVA 4UVVA 4L31A 4PNNA 4PNRA 4UI3A 5FPFA 4L33A 4ZZYA 4L0IA 4HLMA 3L3LA 5ADQA 4UVUA 4MT9A 4BUIA 1GS0A 2PAWA 4L6ZA 3UDDA 4HHZA 4L0SA 5ETYA 4BUEA 3L3MA 4L0TA 4GV0A 3MHJA 3U9HA 4OQAC 4UHGA 4UVXA 3UH4A 4J21A 4BS4A 3FHBA 4L7UA 4N4TA 4TJUA 3HKVA 4UFYA 4PNQA 4L7NA 5AL2A 1EFYA 5AL4A 3PAXA 4HLHA 4BUWA 4PJVA 5C5PA 3KJDA 4PNMA 4DVIA 3KCZA 4I9IA 5LX6A 4UVWA 4BU9A 3C49A 4J3MA 4L09A 4R6EA 4L6SA 4BJCA 4TK0A 4BU3A 4XHUA 5AL3A 4HKIA 2PAXA 1UK1A 4HLGA 3W51A 4W5SA 4UVLA 4PMLA 4RV6A 4L32A 4UVZA 4L34A 4BUYA 3GEYA 4HMHA 4GV2A 4KRSA 4TKIA 4TK5A 4UNDA 3P0NA 4BUUA 5ADRA 4W6EA 4HHYA 4PY4A 4UUHA 4UX4A 4BUTA 4BU8A 4J22A 4R5WA 4KZQA 4UVNA 5EBTA 1WOKA 3SMIA 4UVYA 4L0VA 4HYFA
chains in the Genus database with same CATH superfamily
1KHBA 2QEYA 5ADTA 4LI8A 4PNLA 1YTMA 2QF1A 4PAXA 4PJTA 4UI7A 4TORA 4ZZXA 4L7PA 5FH3A 4L7RA 4LI6A 3GN7A 3UA9A 2RCWA 4HKNA 4TVJA 5FH1A 4YWDA 5FH2A 3SE2A 4GNPA 4K4EA 4BUAA 4X52A 5C5RA 4L2GA 3MHKA 3SMJA 4BUTA 4L7LA 2RK7A 1A26A 4UI8A 5AKWA 2QZYA 3KR7A 4L70A 4HL5A 5FH0A 1YLHA 4GV4A 4BU6A 4UI6A 2RF5A 4TJWA 4F0EA 3MOHA 3MOEA 5DCZA 5AL5A 4UW1A 4M7BA 3DT2A 4GMWA 1XKVA 4TJYA 4U6AA 4HLKA 2RKAA 4MSKA 4UVOA 4DQYC 4HLFA 4UI5A 4BUSA 5FPGA 5A00A 3U9YA 5LXPA 4K4FA 4N3RA 4BFPA 4OX2A 3P0PA 4OPXC 4KZUA 4PNTA 3DTBA 4UI4A 2RD6A 2ZCIA 4IUEA 4UVSA 3CE0A 5C5QA 5FH5A 4GNQA 4F1QA 4UVTA 4AVUA 4L7OA 4F1LA 4WOUA 4GV7A 5AL1A 2QF2A 5AEHA 2PQFA 4PNSA 2FAHA 3KR8A 4L2FA 3BLJA 4L0BA 5ADRA 4YW9A 4ZZZA 5LYHA 4OQBC 4L10A 4KZLA 4OA7A 1PAXA 2OLQA 4BJBA 3GJWA 3P0QA 4BU7A 1J3BA 4L2KA 5AKUA 4UVPA 5ADSA 4AVWA 5I67A 4TKGA 4BJ9A 4BU5A 4RCGA 3C4HA 1AYLA 4TKFA 4W5IA 4GMUA 4WIEA 3UH2A 2FAFA 2X5YA 1NHXA 4WPTA 4BUDA 1UK0A 3GOYA 4LI7A 4N4VA 4BUXA 4J3LA 4J1ZA 2PC9A 4MSGA 4UXBA 4YWBA 2QEWA 4BUFA 1KHGA 5ECEA 4HKKA 3DT4A 2PXZX 4UFUA 4TOSA 4BUVA 4UVVA 4L31A 4GNLA 4PNRA 4PNNA 4UI3A 5FPFA 1OENA 4L33A 4YW8A 4ZZYA 4L0IA 4HLMA 2GMVA 3L3LA 5ADQA 4UVUA 4MT9A 4BUIA 1GS0A 2PAWA 4L6ZA 4R43A 3UDDA 4GNOA 4HHZA 4L0SA 5ETYA 4BUEA 3L3MA 1M51A 4L0TA 4GNMA 4GV0A 3MHJA 3U9HA 4OQAC 4UHGA 4UVXA 2PY7X 3UH4A 4J21A 4BS4A 4WPUA 2RK8A 3FHBA 4WIUA 2OLRA 4L7UA 4N4TA 4GMMA 4TJUA 3DT7A 3HKVA 4UFYA 4PNQA 4L7NA 5AL2A 1EFYA 5AL4A 3PAXA 4HLHA 4BUWA 3MOFA 4PJVA 1K3CA 5C5PA 3KJDA 4PNMA 4DVIA 3KCZA 4I9IA 5LX6A 4UVWA 1KHFA 4BU9A 3C49A 4J3MA 4L09A 4R6EA 4L6SA 4BJCA 4TK0A 1YVYA 4WPVA 4XHUA 1II2A 4BU3A 5AL3A 4HKIA 1UK1A 2PAXA 4HLGA 3W51A 1AQ2A 4W5SA 4UVLA 4PMLA 4RV6A 4L32A 4UVZA 4L34A 4WL8A 4BUYA 3GEYA 4HMHA 1OS1A 4GMZA 4GV2A 4KRSA 4TKIA 3P0NA 4TK5A 4UNDA 4BUUA 4W6EA 4HHYA 4PY4A 4UUHA 1KHEA 4UX4A 1K3DA 2RKDA 4BU8A 4J22A 4R5WA 5FH4A 1YGGA 4KZQA 4UVNA 5EBTA 2RKEA 1WOKA 3SMIA 4UVYA 4L0VA 4HYFA
chains in the Genus database with same CATH topology
1KHBA 2QEYA 5ADTA 4LI8A 4PNLA 1YTMA 2QF1A 4PAXA 4PJTA 4UI7A 4TORA 4ZZXA 4L7PA 5FH3A 4L7RA 4LI6A 3GN7A 3UA9A 2RCWA 4HKNA 4TVJA 5FH1A 4YWDA 5FH2A 3SE2A 4GNPA 4K4EA 4BUAA 4X52A 5C5RA 4L2GA 3MHKA 3SMJA 4BUTA 4L7LA 2RK7A 1A26A 4UI8A 5AKWA 2QZYA 3KR7A 4L70A 4HL5A 5FH0A 1YLHA 4GV4A 4BU6A 4UI6A 2RF5A 4TJWA 4F0EA 3MOHA 3MOEA 5DCZA 5AL5A 4UW1A 4M7BA 3DT2A 4GMWA 1XKVA 4TJYA 4U6AA 4HLKA 2RKAA 4MSKA 4UVOA 4DQYC 4HLFA 4UI5A 4BUSA 5FPGA 5A00A 3U9YA 5LXPA 4K4FA 4N3RA 4BFPA 4OX2A 3P0PA 4OPXC 4KZUA 4PNTA 3DTBA 4UI4A 2RD6A 2ZCIA 4IUEA 4UVSA 3CE0A 5C5QA 5FH5A 4GNQA 4F1QA 4UVTA 4AVUA 4L7OA 4F1LA 4WOUA 4GV7A 5AL1A 2QF2A 5AEHA 2PQFA 4PNSA 2FAHA 3KR8A 4L2FA 3BLJA 4L0BA 5ADRA 4YW9A 4ZZZA 5LYHA 4OQBC 4L10A 4KZLA 4OA7A 1PAXA 2OLQA 4BJBA 3GJWA 3P0QA 4BU7A 1J3BA 4L2KA 5AKUA 4UVPA 5ADSA 4AVWA 5I67A 4TKGA 4BJ9A 4BU5A 4RCGA 3C4HA 1AYLA 4TKFA 4W5IA 4GMUA 4WIEA 3UH2A 2FAFA 2X5YA 1NHXA 4WPTA 4BUDA 1UK0A 3GOYA 4LI7A 4N4VA 4BUXA 4J3LA 4J1ZA 2PC9A 4MSGA 4UXBA 4YWBA 2QEWA 4BUFA 1KHGA 5ECEA 4HKKA 3DT4A 2PXZX 4UFUA 4TOSA 4BUVA 4UVVA 4L31A 4GNLA 4PNRA 4PNNA 4UI3A 5FPFA 1OENA 4L33A 4YW8A 4ZZYA 4L0IA 4HLMA 2GMVA 3L3LA 5ADQA 4UVUA 4MT9A 4BUIA 1GS0A 2PAWA 4L6ZA 4R43A 3UDDA 4GNOA 4HHZA 4L0SA 5ETYA 4BUEA 3L3MA 1M51A 4L0TA 4GNMA 4GV0A 3MHJA 3U9HA 4OQAC 4UHGA 4UVXA 2PY7X 3UH4A 4J21A 4BS4A 4WPUA 2RK8A 3FHBA 4WIUA 2OLRA 4L7UA 4N4TA 4GMMA 4TJUA 3DT7A 3HKVA 4UFYA 4PNQA 4L7NA 5AL2A 1EFYA 5AL4A 3PAXA 4HLHA 4BUWA 3MOFA 4PJVA 1K3CA 5C5PA 3KJDA 4PNMA 4DVIA 3KCZA 4I9IA 5LX6A 4UVWA 1KHFA 4BU9A 3C49A 4J3MA 4L09A 4R6EA 4L6SA 4BJCA 4TK0A 1YVYA 4WPVA 4XHUA 1II2A 4BU3A 5AL3A 4HKIA 1UK1A 2PAXA 4HLGA 3W51A 1AQ2A 4W5SA 4UVLA 4PMLA 4RV6A 4L32A 4UVZA 4L34A 4WL8A 4BUYA 3GEYA 4HMHA 1OS1A 4GMZA 4GV2A 4KRSA 4TKIA 3P0NA 4TK5A 4UNDA 4BUUA 4W6EA 4HHYA 4PY4A 4UUHA 1KHEA 4UX4A 1K3DA 2RKDA 4BU8A 4J22A 4R5WA 5FH4A 1YGGA 4KZQA 4UVNA 5EBTA 2RKEA 1WOKA 3SMIA 4UVYA 4L0VA 4HYFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5ADT A;  4LI8 A;  4PNL A;  4UI7 A;  4PAX A;  4PJT A;  4ZZX A;  4TOR A;  4L7P A;  4L7R A;  4LI6 A;  3GN7 A;  3UA9 A;  2RCW A;  4HKN A;  4TVJ A;  3SE2 A;  4K4E A;  4BUA A;  4X52 A;  5C5R A;  4L2G A;  3MHK A;  3SMJ A;  4L7L A;  1A26 A;  4UI8 A;  5AKW A;  3KR7 A;  4L70 A;  4HL5 A;  4GV4 A;  4BU6 A;  4F0E A;  4UI6 A;  2RF5 A;  4TJW A;  5DCZ A;  5AL5 A;  4UW1 A;  4M7B A;  4TJY A;  4U6A A;  4HLK A;  4MSK A;  4UVO A;  4DQY C;  4HLF A;  4UI5 A;  4BUS A;  5FPG A;  5A00 A;  3U9Y A;  5LXP A;  4K4F A;  4N3R A;  4BFP A;  3P0P A;  4OPX C;  4KZU A;  4PNT A;  4UI4 A;  4UVS A;  2RD6 A;  5C5Q A;  4IUE A;  3CE0 A;  4F1Q A;  4UVT A;  4AVU A;  4L7O A;  4F1L A;  4GV7 A;  5AL1 A;  5AEH A;  2PQF A;  4PNS A;  3KR8 A;  4L2F A;  3BLJ A;  4L0B A;  5LYH A;  4ZZZ A;  4OQB C;  4L10 A;  4KZL A;  4OA7 A;  1PAX A;  4BJB A;  3GJW A;  3P0Q A;  4BU7 A;  4L2K A;  5AKU A;  4UVP A;  5ADS A;  4AVW A;  4TKG A;  4BJ9 A;  4BU5 A;  3C4H A;  4TKF A;  4W5I A;  3UH2 A;  2X5Y A;  4BUD A;  1UK0 A;  3GOY A;  4LI7 A;  4N4V A;  4BUX A;  4J1Z A;  4J3L A;  4MSG A;  4UXB A;  4BUF A;  5ECE A;  4HKK A;  4UFU A;  4TOS A;  4BUV A;  4UVV A;  4L31 A;  4PNN A;  4PNR A;  4UI3 A;  5FPF A;  4L33 A;  4ZZY A;  4L0I A;  4HLM A;  3L3L A;  5ADQ A;  4UVU A;  4MT9 A;  4BUI A;  1GS0 A;  2PAW A;  4L6Z A;  3UDD A;  4HHZ A;  4L0S A;  5ETY A;  4BUE A;  3L3M A;  4L0T A;  4GV0 A;  3MHJ A;  3U9H A;  4OQA C;  4UHG A;  4UVX A;  3UH4 A;  4J21 A;  4BS4 A;  3FHB A;  4L7U A;  4N4T A;  4TJU A;  3HKV A;  4UFY A;  4PNQ A;  4L7N A;  5AL2 A;  1EFY A;  5AL4 A;  3PAX A;  4HLH A;  4BUW A;  4PJV A;  5C5P A;  3KJD A;  4PNM A;  4DVI A;  3KCZ A;  4I9I A;  5LX6 A;  4UVW A;  4BU9 A;  3C49 A;  4J3M A;  4L09 A;  4R6E A;  4L6S A;  4BJC A;  4TK0 A;  4BU3 A;  4XHU A;  5AL3 A;  4HKI A;  2PAX A;  1UK1 A;  4HLG A;  3W51 A;  4W5S A;  4UVL A;  4PML A;  4RV6 A;  4L32 A;  4UVZ A;  4L34 A;  4BUY A;  3GEY A;  4HMH A;  4GV2 A;  4KRS A;  4TKI A;  4TK5 A;  4UND A;  3P0N A;  4BUU A;  5ADR A;  4W6E A;  4HHY A;  4PY4 A;  4UUH A;  4UX4 A;  4BUT A;  4BU8 A;  4J22 A;  4R5W A;  4KZQ A;  4UVN A;  5EBT A;  1WOK A;  3SMI A;  4UVY A;  4L0V A;  4HYF A; 
#chains in the Genus database with same CATH topology
 1KHB A;  2QEY A;  5ADT A;  4LI8 A;  4PNL A;  1YTM A;  2QF1 A;  4PAX A;  4PJT A;  4UI7 A;  4TOR A;  4ZZX A;  4L7P A;  5FH3 A;  4L7R A;  4LI6 A;  3GN7 A;  3UA9 A;  2RCW A;  4HKN A;  4TVJ A;  5FH1 A;  4YWD A;  5FH2 A;  3SE2 A;  4GNP A;  4K4E A;  4BUA A;  4X52 A;  5C5R A;  4L2G A;  3MHK A;  3SMJ A;  4BUT A;  4L7L A;  2RK7 A;  1A26 A;  4UI8 A;  5AKW A;  2QZY A;  3KR7 A;  4L70 A;  4HL5 A;  5FH0 A;  1YLH A;  4GV4 A;  4BU6 A;  4UI6 A;  2RF5 A;  4TJW A;  4F0E A;  3MOH A;  3MOE A;  5DCZ A;  5AL5 A;  4UW1 A;  4M7B A;  3DT2 A;  4GMW A;  1XKV A;  4TJY A;  4U6A A;  4HLK A;  2RKA A;  4MSK A;  4UVO A;  4DQY C;  4HLF A;  4UI5 A;  4BUS A;  5FPG A;  5A00 A;  3U9Y A;  5LXP A;  4K4F A;  4N3R A;  4BFP A;  4OX2 A;  3P0P A;  4OPX C;  4KZU A;  4PNT A;  3DTB A;  4UI4 A;  2RD6 A;  2ZCI A;  4IUE A;  4UVS A;  3CE0 A;  5C5Q A;  5FH5 A;  4GNQ A;  4F1Q A;  4UVT A;  4AVU A;  4L7O A;  4F1L A;  4WOU A;  4GV7 A;  5AL1 A;  2QF2 A;  5AEH A;  2PQF A;  4PNS A;  2FAH A;  3KR8 A;  4L2F A;  3BLJ A;  4L0B A;  5ADR A;  4YW9 A;  4ZZZ A;  5LYH A;  4OQB C;  4L10 A;  4KZL A;  4OA7 A;  1PAX A;  2OLQ A;  4BJB A;  3GJW A;  3P0Q A;  4BU7 A;  1J3B A;  4L2K A;  5AKU A;  4UVP A;  5ADS A;  4AVW A;  5I67 A;  4TKG A;  4BJ9 A;  4BU5 A;  4RCG A;  3C4H A;  1AYL A;  4TKF A;  4W5I A;  4GMU A;  4WIE A;  3UH2 A;  2FAF A;  2X5Y A;  1NHX A;  4WPT A;  4BUD A;  1UK0 A;  3GOY A;  4LI7 A;  4N4V A;  4BUX A;  4J3L A;  4J1Z A;  2PC9 A;  4MSG A;  4UXB A;  4YWB A;  2QEW A;  4BUF A;  1KHG A;  5ECE A;  4HKK A;  3DT4 A;  2PXZ X;  4UFU A;  4TOS A;  4BUV A;  4UVV A;  4L31 A;  4GNL A;  4PNR A;  4PNN A;  4UI3 A;  5FPF A;  1OEN A;  4L33 A;  4YW8 A;  4ZZY A;  4L0I A;  4HLM A;  2GMV A;  3L3L A;  5ADQ A;  4UVU A;  4MT9 A;  4BUI A;  1GS0 A;  2PAW A;  4L6Z A;  4R43 A;  3UDD A;  4GNO A;  4HHZ A;  4L0S A;  5ETY A;  4BUE A;  3L3M A;  1M51 A;  4L0T A;  4GNM A;  4GV0 A;  3MHJ A;  3U9H A;  4OQA C;  4UHG A;  4UVX A;  2PY7 X;  3UH4 A;  4J21 A;  4BS4 A;  4WPU A;  2RK8 A;  3FHB A;  4WIU A;  2OLR A;  4L7U A;  4N4T A;  4GMM A;  4TJU A;  3DT7 A;  3HKV A;  4UFY A;  4PNQ A;  4L7N A;  5AL2 A;  1EFY A;  5AL4 A;  3PAX A;  4HLH A;  4BUW A;  3MOF A;  4PJV A;  1K3C A;  5C5P A;  3KJD A;  4PNM A;  4DVI A;  3KCZ A;  4I9I A;  5LX6 A;  4UVW A;  1KHF A;  4BU9 A;  3C49 A;  4J3M A;  4L09 A;  4R6E A;  4L6S A;  4BJC A;  4TK0 A;  1YVY A;  4WPV A;  4XHU A;  1II2 A;  4BU3 A;  5AL3 A;  4HKI A;  1UK1 A;  2PAX A;  4HLG A;  3W51 A;  1AQ2 A;  4W5S A;  4UVL A;  4PML A;  4RV6 A;  4L32 A;  4UVZ A;  4L34 A;  4WL8 A;  4BUY A;  3GEY A;  4HMH A;  1OS1 A;  4GMZ A;  4GV2 A;  4KRS A;  4TKI A;  3P0N A;  4TK5 A;  4UND A;  4BUU A;  4W6E A;  4HHY A;  4PY4 A;  4UUH A;  1KHE A;  4UX4 A;  1K3D A;  2RKD A;  4BU8 A;  4J22 A;  4R5W A;  5FH4 A;  1YGG A;  4KZQ A;  4UVN A;  5EBT A;  2RKE A;  1WOK A;  3SMI A;  4UVY A;  4L0V A;  4HYF A; 
#chains in the Genus database with same CATH homology
 1KHB A;  2QEY A;  5ADT A;  4LI8 A;  4PNL A;  1YTM A;  2QF1 A;  4PAX A;  4PJT A;  4UI7 A;  4TOR A;  4ZZX A;  4L7P A;  5FH3 A;  4L7R A;  4LI6 A;  3GN7 A;  3UA9 A;  2RCW A;  4HKN A;  4TVJ A;  5FH1 A;  4YWD A;  5FH2 A;  3SE2 A;  4GNP A;  4K4E A;  4BUA A;  4X52 A;  5C5R A;  4L2G A;  3MHK A;  3SMJ A;  4BUT A;  4L7L A;  2RK7 A;  1A26 A;  4UI8 A;  5AKW A;  2QZY A;  3KR7 A;  4L70 A;  4HL5 A;  5FH0 A;  1YLH A;  4GV4 A;  4BU6 A;  4UI6 A;  2RF5 A;  4TJW A;  4F0E A;  3MOH A;  3MOE A;  5DCZ A;  5AL5 A;  4UW1 A;  4M7B A;  3DT2 A;  4GMW A;  1XKV A;  4TJY A;  4U6A A;  4HLK A;  2RKA A;  4MSK A;  4UVO A;  4DQY C;  4HLF A;  4UI5 A;  4BUS A;  5FPG A;  5A00 A;  3U9Y A;  5LXP A;  4K4F A;  4N3R A;  4BFP A;  4OX2 A;  3P0P A;  4OPX C;  4KZU A;  4PNT A;  3DTB A;  4UI4 A;  2RD6 A;  2ZCI A;  4IUE A;  4UVS A;  3CE0 A;  5C5Q A;  5FH5 A;  4GNQ A;  4F1Q A;  4UVT A;  4AVU A;  4L7O A;  4F1L A;  4WOU A;  4GV7 A;  5AL1 A;  2QF2 A;  5AEH A;  2PQF A;  4PNS A;  2FAH A;  3KR8 A;  4L2F A;  3BLJ A;  4L0B A;  5ADR A;  4YW9 A;  4ZZZ A;  5LYH A;  4OQB C;  4L10 A;  4KZL A;  4OA7 A;  1PAX A;  2OLQ A;  4BJB A;  3GJW A;  3P0Q A;  4BU7 A;  1J3B A;  4L2K A;  5AKU A;  4UVP A;  5ADS A;  4AVW A;  5I67 A;  4TKG A;  4BJ9 A;  4BU5 A;  4RCG A;  3C4H A;  1AYL A;  4TKF A;  4W5I A;  4GMU A;  4WIE A;  3UH2 A;  2FAF A;  2X5Y A;  1NHX A;  4WPT A;  4BUD A;  1UK0 A;  3GOY A;  4LI7 A;  4N4V A;  4BUX A;  4J3L A;  4J1Z A;  2PC9 A;  4MSG A;  4UXB A;  4YWB A;  2QEW A;  4BUF A;  1KHG A;  5ECE A;  4HKK A;  3DT4 A;  2PXZ X;  4UFU A;  4TOS A;  4BUV A;  4UVV A;  4L31 A;  4GNL A;  4PNR A;  4PNN A;  4UI3 A;  5FPF A;  1OEN A;  4L33 A;  4YW8 A;  4ZZY A;  4L0I A;  4HLM A;  2GMV A;  3L3L A;  5ADQ A;  4UVU A;  4MT9 A;  4BUI A;  1GS0 A;  2PAW A;  4L6Z A;  4R43 A;  3UDD A;  4GNO A;  4HHZ A;  4L0S A;  5ETY A;  4BUE A;  3L3M A;  1M51 A;  4L0T A;  4GNM A;  4GV0 A;  3MHJ A;  3U9H A;  4OQA C;  4UHG A;  4UVX A;  2PY7 X;  3UH4 A;  4J21 A;  4BS4 A;  4WPU A;  2RK8 A;  3FHB A;  4WIU A;  2OLR A;  4L7U A;  4N4T A;  4GMM A;  4TJU A;  3DT7 A;  3HKV A;  4UFY A;  4PNQ A;  4L7N A;  5AL2 A;  1EFY A;  5AL4 A;  3PAX A;  4HLH A;  4BUW A;  3MOF A;  4PJV A;  1K3C A;  5C5P A;  3KJD A;  4PNM A;  4DVI A;  3KCZ A;  4I9I A;  5LX6 A;  4UVW A;  1KHF A;  4BU9 A;  3C49 A;  4J3M A;  4L09 A;  4R6E A;  4L6S A;  4BJC A;  4TK0 A;  1YVY A;  4WPV A;  4XHU A;  1II2 A;  4BU3 A;  5AL3 A;  4HKI A;  1UK1 A;  2PAX A;  4HLG A;  3W51 A;  1AQ2 A;  4W5S A;  4UVL A;  4PML A;  4RV6 A;  4L32 A;  4UVZ A;  4L34 A;  4WL8 A;  4BUY A;  3GEY A;  4HMH A;  1OS1 A;  4GMZ A;  4GV2 A;  4KRS A;  4TKI A;  3P0N A;  4TK5 A;  4UND A;  4BUU A;  4W6E A;  4HHY A;  4PY4 A;  4UUH A;  1KHE A;  4UX4 A;  1K3D A;  2RKD A;  4BU8 A;  4J22 A;  4R5W A;  5FH4 A;  1YGG A;  4KZQ A;  4UVN A;  5EBT A;  2RKE A;  1WOK A;  3SMI A;  4UVY A;  4L0V A;  4HYF A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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