3ERIA

First structural evidence of substrate specificity in mammalian peroxidases: crystal structures of substrate complexes with lactoperoxidases from two different species
Total Genus 186
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
186
sequence length
595
structure length
594
Chain Sequence
SWEVGCGAPVPLVKCDENSPYRTITGDCNNRRSPALGAANRALARWLPAEYEDGLALPFGWTQRKTRNGFRVPLAREVSNKIVGYLDEEGVLDQNRSLLFMQWGQIVDHDLDFAPETELGSNEHSKTQCEEYCIQGDNCFPIMFPKNDPKLKTQGKCMPFFRAGFVCPTPPYQSLAREQINAVTSFLDASLVYGSEPLASRLRNLSSPLGLMAVNQEAWDHGLAYLPFNNKKPSPCEFINTTARVPCFLAGDFRASEQILLATAHTLLLREHNRLARELKKLNPHWNGEKLYQEARKILGAFIQIITFRDYLPIVLGSEMQKWIPPYQGYNNSVDPRISNVFTFAFRFGHMEVPSTVSRLDENYQPWGPEAELPLHTLFFNTWRIIKDGGIDPLVRGLLAKKSKLMNQDKMVTSELRNKLFQPTHKIHGFDLAAINLQRCRDHGMPGYNSWRGFCGLSQPKTLKGLQTVLKNKILAKKLMDLYKTPDNIDIWIGGNAEPMVERGRVGPLLACLLGRQFQQIRDGDRFWWENPGVFTEKQRDSLQKVSFSRLICDNTHITKVPLHAFQANNYPHDFVDCSTVDKLDLSPWASREN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Evidence of Substrate Specificity in Mammalian Peroxidases: STRUCTURE OF THE THIOCYANATE COMPLEX WITH LACTOPEROXIDASE AND ITS INTERACTIONS AT 2.4 A RESOLUTION
pubmed doi rcsb
molecule tags Oxidoreductase
molecule keywords Lactoperoxidase
total genus 186
structure length 594
sequence length 595
ec nomenclature ec 1.11.1.7: Peroxidase.
pdb deposition date 2008-10-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03098 An_peroxidase Animal haem peroxidase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.640.10 Mainly Alpha Orthogonal Bundle Myeloperoxidase, subunit C Haem peroxidase domain superfamily, animal type 3eriA00
3KRKA 4Y55A 1CVUA 2R5LA 3UBAA 4PH9A 3PGHA 1EQHA 2OJVA 4FM5A 3ZS1C 5JVYA 4RRYA 4HHSA 4RRZA 2E9EA 5KIRA 1IGXA 3N8WB 2EHAA 3ZS0C 3GCJA 1CQEA 1DNWC 1MHLC 2IPSA 4MSFA 2NQXA 4C1MC 4DL1C 2QPKA 4M11A 3N8VA 4Z0LA 5IKVA 5GH0A 3RR3A 1D2VC 5F1AA 4KVLA 1MYPC 2Z5ZA 3NIUA 3PY4A 3NTBA 4PNXA 5F19A 4NT3A 1U67A 5IKRA 4GN6A 3N8YA 1IGZA 3F9PC 5COXA 2PT3A 1PGEA 3GC1A 4COXA 2IKCA 3N8ZA 3V6QA 5JVZA 1DIYA 6COXA 1HT8A 5FDQA 3BXIA 3R55A 5JW1A 3MDLA 1CXPC 4QYQA 3QL6A 3R4XA 3S4FA 3FAQA 3NAKA 3HS5A 4RRXA 4KSZA 2AYLA 3NYHA 2OYUP 5IKTA 4RUTA 5GLSA 4HHRA 2O86A 1EQGA 3MQEA 3TZIA 5HPWA 3OLTA 3N8XA 3NTGA 4IG5A 3R5OA 4N7AA 4OTYA 1PXXA 1CX2A 1Q4GA 1DDXA 3Q9KA 3TGYA 3ERIA 1HT5A 5FIWC 5B72A 3QF1A 3Q7DA 1PRHA 4NJBA 4OTJA 3HS6A 3QMOA 5FF1A 3GCLA 4GM7A 3LN0A 3NT1A 2EFBA 4OEKA 2PUMA 4LJJA 1PTHA 1DNUC 3HS7A 4RS0A 3OLUA 1D5LC 3ERHA 4QJQA 3FNLA 1D7WC 4O1ZA 4RRWA 3GCKA 3N8WA 3N8FA 3R5QA 3LN1A 1EBVA 4KVJA 4E1GA 5IKQA 4M10A 3OGWA 1FE2A 3RKEA 2QQTA 3I6NA 4KVKA 3SXVA 2OYEP 2QRBA 3N8YB 3QH0A 3KK6A 2GJMA 3KRQA
chains in the Genus database with same CATH superfamily
3KRKA 4Y55A 1CVUA 2R5LA 3UBAA 4PH9A 3PGHA 1EQHA 2OJVA 4FM5A 3ZS1C 5JVYA 4RRYA 4HHSA 4RRZA 2E9EA 5KIRA 1IGXA 3N8WB 2EHAA 3ZS0C 3GCJA 1CQEA 1DNWC 1MHLC 2IPSA 4MSFA 2NQXA 4C1MC 4DL1C 2QPKA 4M11A 3N8VA 4Z0LA 5IKVA 5GH0A 3RR3A 1D2VC 5F1AA 4KVLA 1MYPC 2Z5ZA 3NIUA 3PY4A 3NTBA 4PNXA 5F19A 4NT3A 1U67A 5IKRA 4GN6A 3N8YA 1IGZA 3F9PC 5COXA 2PT3A 1PGEA 3GC1A 4COXA 2IKCA 3N8ZA 3V6QA 5JVZA 1DIYA 6COXA 1HT8A 5FDQA 3BXIA 3R55A 5JW1A 3MDLA 1CXPC 4QYQA 3QL6A 3R4XA 3S4FA 3FAQA 3NAKA 3HS5A 4RRXA 4KSZA 2AYLA 3NYHA 2OYUP 5IKTA 4RUTA 5GLSA 4HHRA 2O86A 1EQGA 3MQEA 3TZIA 5HPWA 3OLTA 3N8XA 3NTGA 4IG5A 3R5OA 4N7AA 4OTYA 1PXXA 1CX2A 1Q4GA 1DDXA 3Q9KA 3TGYA 3ERIA 1HT5A 5FIWC 5B72A 3QF1A 3Q7DA 1PRHA 4NJBA 4OTJA 3HS6A 3QMOA 5FF1A 3GCLA 4GM7A 3LN0A 3NT1A 2EFBA 4OEKA 2PUMA 4LJJA 1PTHA 1DNUC 3HS7A 4RS0A 3OLUA 1D5LC 3ERHA 4QJQA 3FNLA 1D7WC 4O1ZA 4RRWA 3GCKA 3N8WA 3N8FA 3R5QA 3LN1A 1EBVA 4KVJA 4E1GA 5IKQA 4M10A 3OGWA 1FE2A 3RKEA 2QQTA 3I6NA 4KVKA 3SXVA 2OYEP 2QRBA 3N8YB 3QH0A 3KK6A 2GJMA 3KRQA
chains in the Genus database with same CATH topology
3KRKA 4Y55A 1CVUA 2R5LA 3UBAA 4PH9A 3PGHA 1EQHA 2OJVA 4FM5A 3ZS1C 5JVYA 4RRYA 4HHSA 4RRZA 2E9EA 5KIRA 1IGXA 3N8WB 2EHAA 3ZS0C 3GCJA 1CQEA 1DNWC 1MHLC 2IPSA 4MSFA 2NQXA 4C1MC 4DL1C 2QPKA 4M11A 3N8VA 4Z0LA 5IKVA 5GH0A 3RR3A 1D2VC 5F1AA 4KVLA 1MYPC 2Z5ZA 3NIUA 3PY4A 3NTBA 4PNXA 5F19A 4NT3A 1U67A 5IKRA 4GN6A 3N8YA 1IGZA 3F9PC 5COXA 2PT3A 1PGEA 3GC1A 4COXA 2IKCA 3N8ZA 3V6QA 5JVZA 1DIYA 6COXA 1HT8A 5FDQA 3BXIA 3R55A 5JW1A 3MDLA 1CXPC 4QYQA 3QL6A 3R4XA 3S4FA 3FAQA 3NAKA 3HS5A 4RRXA 4KSZA 2AYLA 3NYHA 2OYUP 5IKTA 4RUTA 5GLSA 4HHRA 2O86A 1EQGA 3MQEA 3TZIA 5HPWA 3OLTA 3N8XA 3NTGA 4IG5A 3R5OA 4N7AA 4OTYA 1PXXA 1CX2A 1Q4GA 1DDXA 3Q9KA 3TGYA 3ERIA 1HT5A 5FIWC 5B72A 3QF1A 3Q7DA 1PRHA 4NJBA 4OTJA 3HS6A 3QMOA 5FF1A 3GCLA 4GM7A 3LN0A 3NT1A 2EFBA 4OEKA 2PUMA 4LJJA 1PTHA 1DNUC 3HS7A 4RS0A 3OLUA 1D5LC 3ERHA 4QJQA 3FNLA 1D7WC 4O1ZA 4RRWA 3GCKA 3N8WA 3N8FA 3R5QA 3LN1A 1EBVA 4KVJA 4E1GA 5IKQA 4M10A 3OGWA 1FE2A 3RKEA 2QQTA 3I6NA 4KVKA 3SXVA 2OYEP 2QRBA 3N8YB 3QH0A 3KK6A 2GJMA 3KRQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3KRK A;  4Y55 A;  1CVU A;  2R5L A;  3UBA A;  4PH9 A;  3PGH A;  1EQH A;  2OJV A;  4FM5 A;  3ZS1 C;  5JVY A;  4RRY A;  4HHS A;  4RRZ A;  2E9E A;  5KIR A;  1IGX A;  3N8W B;  2EHA A;  3ZS0 C;  3GCJ A;  1CQE A;  1DNW C;  1MHL C;  2IPS A;  4MSF A;  2NQX A;  4C1M C;  4DL1 C;  2QPK A;  4M11 A;  3N8V A;  4Z0L A;  5IKV A;  5GH0 A;  3RR3 A;  1D2V C;  5F1A A;  4KVL A;  1MYP C;  2Z5Z A;  3NIU A;  3PY4 A;  3NTB A;  4PNX A;  5F19 A;  4NT3 A;  1U67 A;  5IKR A;  4GN6 A;  3N8Y A;  1IGZ A;  3F9P C;  5COX A;  2PT3 A;  1PGE A;  3GC1 A;  4COX A;  2IKC A;  3N8Z A;  3V6Q A;  5JVZ A;  1DIY A;  6COX A;  1HT8 A;  5FDQ A;  3BXI A;  3R55 A;  5JW1 A;  3MDL A;  1CXP C;  4QYQ A;  3QL6 A;  3R4X A;  3S4F A;  3FAQ A;  3NAK A;  3HS5 A;  4RRX A;  4KSZ A;  2AYL A;  3NYH A;  2OYU P;  5IKT A;  4RUT A;  5GLS A;  4HHR A;  2O86 A;  1EQG A;  3MQE A;  3TZI A;  5HPW A;  3OLT A;  3N8X A;  3NTG A;  4IG5 A;  3R5O A;  4N7A A;  4OTY A;  1PXX A;  1CX2 A;  1Q4G A;  1DDX A;  3Q9K A;  3TGY A;  3ERI A;  1HT5 A;  5FIW C;  5B72 A;  3QF1 A;  3Q7D A;  1PRH A;  4NJB A;  4OTJ A;  3HS6 A;  3QMO A;  5FF1 A;  3GCL A;  4GM7 A;  3LN0 A;  3NT1 A;  2EFB A;  4OEK A;  2PUM A;  4LJJ A;  1PTH A;  1DNU C;  3HS7 A;  4RS0 A;  3OLU A;  1D5L C;  3ERH A;  4QJQ A;  3FNL A;  1D7W C;  4O1Z A;  4RRW A;  3GCK A;  3N8W A;  3N8F A;  3R5Q A;  3LN1 A;  1EBV A;  4KVJ A;  4E1G A;  5IKQ A;  4M10 A;  3OGW A;  1FE2 A;  3RKE A;  2QQT A;  3I6N A;  4KVK A;  3SXV A;  2OYE P;  2QRB A;  3N8Y B;  3QH0 A;  3KK6 A;  2GJM A;  3KRQ A; 
#chains in the Genus database with same CATH topology
 3KRK A;  4Y55 A;  1CVU A;  2R5L A;  3UBA A;  4PH9 A;  3PGH A;  1EQH A;  2OJV A;  4FM5 A;  3ZS1 C;  5JVY A;  4RRY A;  4HHS A;  4RRZ A;  2E9E A;  5KIR A;  1IGX A;  3N8W B;  2EHA A;  3ZS0 C;  3GCJ A;  1CQE A;  1DNW C;  1MHL C;  2IPS A;  4MSF A;  2NQX A;  4C1M C;  4DL1 C;  2QPK A;  4M11 A;  3N8V A;  4Z0L A;  5IKV A;  5GH0 A;  3RR3 A;  1D2V C;  5F1A A;  4KVL A;  1MYP C;  2Z5Z A;  3NIU A;  3PY4 A;  3NTB A;  4PNX A;  5F19 A;  4NT3 A;  1U67 A;  5IKR A;  4GN6 A;  3N8Y A;  1IGZ A;  3F9P C;  5COX A;  2PT3 A;  1PGE A;  3GC1 A;  4COX A;  2IKC A;  3N8Z A;  3V6Q A;  5JVZ A;  1DIY A;  6COX A;  1HT8 A;  5FDQ A;  3BXI A;  3R55 A;  5JW1 A;  3MDL A;  1CXP C;  4QYQ A;  3QL6 A;  3R4X A;  3S4F A;  3FAQ A;  3NAK A;  3HS5 A;  4RRX A;  4KSZ A;  2AYL A;  3NYH A;  2OYU P;  5IKT A;  4RUT A;  5GLS A;  4HHR A;  2O86 A;  1EQG A;  3MQE A;  3TZI A;  5HPW A;  3OLT A;  3N8X A;  3NTG A;  4IG5 A;  3R5O A;  4N7A A;  4OTY A;  1PXX A;  1CX2 A;  1Q4G A;  1DDX A;  3Q9K A;  3TGY A;  3ERI A;  1HT5 A;  5FIW C;  5B72 A;  3QF1 A;  3Q7D A;  1PRH A;  4NJB A;  4OTJ A;  3HS6 A;  3QMO A;  5FF1 A;  3GCL A;  4GM7 A;  3LN0 A;  3NT1 A;  2EFB A;  4OEK A;  2PUM A;  4LJJ A;  1PTH A;  1DNU C;  3HS7 A;  4RS0 A;  3OLU A;  1D5L C;  3ERH A;  4QJQ A;  3FNL A;  1D7W C;  4O1Z A;  4RRW A;  3GCK A;  3N8W A;  3N8F A;  3R5Q A;  3LN1 A;  1EBV A;  4KVJ A;  4E1G A;  5IKQ A;  4M10 A;  3OGW A;  1FE2 A;  3RKE A;  2QQT A;  3I6N A;  4KVK A;  3SXV A;  2OYE P;  2QRB A;  3N8Y B;  3QH0 A;  3KK6 A;  2GJM A;  3KRQ A; 
#chains in the Genus database with same CATH homology
 3KRK A;  4Y55 A;  1CVU A;  2R5L A;  3UBA A;  4PH9 A;  3PGH A;  1EQH A;  2OJV A;  4FM5 A;  3ZS1 C;  5JVY A;  4RRY A;  4HHS A;  4RRZ A;  2E9E A;  5KIR A;  1IGX A;  3N8W B;  2EHA A;  3ZS0 C;  3GCJ A;  1CQE A;  1DNW C;  1MHL C;  2IPS A;  4MSF A;  2NQX A;  4C1M C;  4DL1 C;  2QPK A;  4M11 A;  3N8V A;  4Z0L A;  5IKV A;  5GH0 A;  3RR3 A;  1D2V C;  5F1A A;  4KVL A;  1MYP C;  2Z5Z A;  3NIU A;  3PY4 A;  3NTB A;  4PNX A;  5F19 A;  4NT3 A;  1U67 A;  5IKR A;  4GN6 A;  3N8Y A;  1IGZ A;  3F9P C;  5COX A;  2PT3 A;  1PGE A;  3GC1 A;  4COX A;  2IKC A;  3N8Z A;  3V6Q A;  5JVZ A;  1DIY A;  6COX A;  1HT8 A;  5FDQ A;  3BXI A;  3R55 A;  5JW1 A;  3MDL A;  1CXP C;  4QYQ A;  3QL6 A;  3R4X A;  3S4F A;  3FAQ A;  3NAK A;  3HS5 A;  4RRX A;  4KSZ A;  2AYL A;  3NYH A;  2OYU P;  5IKT A;  4RUT A;  5GLS A;  4HHR A;  2O86 A;  1EQG A;  3MQE A;  3TZI A;  5HPW A;  3OLT A;  3N8X A;  3NTG A;  4IG5 A;  3R5O A;  4N7A A;  4OTY A;  1PXX A;  1CX2 A;  1Q4G A;  1DDX A;  3Q9K A;  3TGY A;  3ERI A;  1HT5 A;  5FIW C;  5B72 A;  3QF1 A;  3Q7D A;  1PRH A;  4NJB A;  4OTJ A;  3HS6 A;  3QMO A;  5FF1 A;  3GCL A;  4GM7 A;  3LN0 A;  3NT1 A;  2EFB A;  4OEK A;  2PUM A;  4LJJ A;  1PTH A;  1DNU C;  3HS7 A;  4RS0 A;  3OLU A;  1D5L C;  3ERH A;  4QJQ A;  3FNL A;  1D7W C;  4O1Z A;  4RRW A;  3GCK A;  3N8W A;  3N8F A;  3R5Q A;  3LN1 A;  1EBV A;  4KVJ A;  4E1G A;  5IKQ A;  4M10 A;  3OGW A;  1FE2 A;  3RKE A;  2QQT A;  3I6N A;  4KVK A;  3SXV A;  2OYE P;  2QRB A;  3N8Y B;  3QH0 A;  3KK6 A;  2GJM A;  3KRQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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