3I6NA

Mode of binding of the tuberculosis prodrug isoniazid to peroxidases: crystal structure of bovine lactoperoxidase with isoniazid at 2.7 resolution
Total Genus 182
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
182
sequence length
595
structure length
594
Chain Sequence
SWEVGCGAPVPLVKCDENSPYRTITGDCNNRRSPALGAANRALARWLPAEYEDGLALPFGWTQRKTRNGFRVPLAREVSNKIVGYLDEEGVLDQNRSLLFMQWGQIVDHDLDFAPETELGSNEHSKTQCEEYCIQGDNCFPIMFPKNDPKLKTQGKCMPFFRAGFVCPTPPYQSLAREQINAVTSFLDASLVYGSEPLASRLRNLSSPLGLMAVNQEAWDHGLAYLPFNNKKPSPCEFINTTARVPCFLAGDFRASEQILLATAHTLLLREHNRLARELKKLNPHWNGEKLYQEARKILGAFIQIITFRDYLPIVLGSEMQKWIPPYQGYNNSVDPRISNVFTFAFRFGHMEVPSTVSRLDENYQPWGPEAELPLHTLFFNTWRIIKDGGIDPLVRGLLAKKSKLMNQDKMVTSELRNKLFQPTHKIHGFDLAAINLQRCRDHGMPGYNSWRGFCGLSQPKTLKGLQTVLKNKILAKKLMDLYKTPDNIDIWIGGNAEPMVERGRVGPLLACLLGRQFQQIRDGDRFWWENPGVFTEKQRDSLQKVSFSRLICDNTHITKVPLHAFQANNYPHDFVDCSTVDKLDLSPWASREN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Mode of binding of the tuberculosis prodrug isoniazid to heme peroxidases: binding studies and crystal structure of bovine lactoperoxidase with isoniazid at 2.7 A resolution.
pubmed doi rcsb
molecule keywords Lactoperoxidase
molecule tags Oxidoreductase
total genus 182
structure length 594
sequence length 595
ec nomenclature ec 1.11.1.7: Peroxidase.
pdb deposition date 2009-07-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03098 An_peroxidase Animal haem peroxidase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.640.10 Mainly Alpha Orthogonal Bundle Myeloperoxidase, subunit C Haem peroxidase domain superfamily, animal type 3i6nA00
3QH0A 4KSZA 3UBAA 3QL6A 4RRXA 4KVJA 3R5OA 3NAKA 5IKQA 4DL1C 4NJBA 1D5LC 1CVUA 2IKCA 3HS5A 1FE2A 1D7WC 3OLUA 3OLTA 5GH0A 3RR3A 3R55A 4RUTA 3TGYA 4IG5A 3GCJA 2OJVA 5B72A 3N8XA 4Y55A 2AYLA 3NIUA 3TZIA 2EHAA 2NQXA 3BXIA 3MDLA 4HHSA 4LJJA 2E9EA 5JW1A 4NT3A 1DDXA 5HPWA 5F1AA 1PGEA 5COXA 2GJMA 3NYHA 5IKRA 4RRZA 1D2VC 2QPKA 3LN1A 3N8WA 3GC1A 4RS0A 4OEKA 3N8ZA 3R4XA 5IKTA 1Q4GA 2PT3A 5KIRA 4COXA 1DNUC 3PY4A 2QRBA 3Q7DA 5F19A 1DIYA 4QJQA 1EBVA 3KRQA 3V6QA 3R5QA 1CQEA 3NT1A 3SXVA 4GN6A 3S4FA 4PNXA 3Q9KA 3ZS1C 5FF1A 2R5LA 2OYUP 5FDQA 5GLSA 3ERHA 4QYQA 1PRHA 4OTJA 3RKEA 3N8YA 3NTBA 3ERIA 3N8FA 2O86A 3I6NA 1MYPC 1EQHA 5IKVA 4M11A 4RRYA 4HHRA 4N7AA 6COXA 3N8VA 4GM7A 1HT8A 3FNLA 1IGXA 5JVYA 2QQTA 4M10A 4O1ZA 3ZS0C 1EQGA 3QF1A 1IGZA 1PXXA 4MSFA 3MQEA 4KVLA 2IPSA 3N8WB 1U67A 3F9PC 3HS7A 3HS6A 5JVZA 4E1GA 2PUMA 2OYEP 3FAQA 2Z5ZA 4OTYA 3PGHA 3OGWA 3QMOA 3GCLA 3KRKA 3NTGA 4C1MC 1PTHA 4KVKA 1HT5A 1CXPC 4FM5A 5FIWC 1DNWC 4PH9A 2EFBA 4Z0LA 3N8YB 4RRWA 1MHLC 3GCKA 3KK6A 3LN0A 1CX2A
chains in the Genus database with same CATH superfamily
3QH0A 4KSZA 3UBAA 3QL6A 4RRXA 4KVJA 3R5OA 3NAKA 5IKQA 4DL1C 4NJBA 1D5LC 1CVUA 2IKCA 3HS5A 1FE2A 1D7WC 3OLUA 3OLTA 5GH0A 3RR3A 3R55A 4RUTA 3TGYA 4IG5A 3GCJA 2OJVA 5B72A 3N8XA 4Y55A 2AYLA 3NIUA 3TZIA 2EHAA 2NQXA 3BXIA 3MDLA 4HHSA 4LJJA 2E9EA 5JW1A 4NT3A 1DDXA 5HPWA 5F1AA 1PGEA 5COXA 2GJMA 3NYHA 5IKRA 4RRZA 1D2VC 2QPKA 3LN1A 3N8WA 3GC1A 4RS0A 4OEKA 3N8ZA 3R4XA 5IKTA 1Q4GA 2PT3A 5KIRA 4COXA 1DNUC 3PY4A 2QRBA 3Q7DA 5F19A 1DIYA 4QJQA 1EBVA 3KRQA 3V6QA 3R5QA 1CQEA 3NT1A 3SXVA 4GN6A 3S4FA 4PNXA 3Q9KA 3ZS1C 5FF1A 2R5LA 2OYUP 5FDQA 5GLSA 3ERHA 4QYQA 1PRHA 4OTJA 3RKEA 3N8YA 3NTBA 3ERIA 3N8FA 2O86A 3I6NA 1MYPC 1EQHA 5IKVA 4M11A 4RRYA 4HHRA 4N7AA 6COXA 3N8VA 4GM7A 1HT8A 3FNLA 1IGXA 5JVYA 2QQTA 4M10A 4O1ZA 3ZS0C 1EQGA 3QF1A 1IGZA 1PXXA 4MSFA 3MQEA 4KVLA 2IPSA 3N8WB 1U67A 3F9PC 3HS7A 3HS6A 5JVZA 4E1GA 2PUMA 2OYEP 3FAQA 2Z5ZA 4OTYA 3PGHA 3OGWA 3QMOA 3GCLA 3KRKA 3NTGA 4C1MC 1PTHA 4KVKA 1HT5A 1CXPC 4FM5A 5FIWC 1DNWC 4PH9A 2EFBA 4Z0LA 3N8YB 4RRWA 1MHLC 3GCKA 3KK6A 3LN0A 1CX2A
chains in the Genus database with same CATH topology
3QH0A 4KSZA 3UBAA 3QL6A 4RRXA 4KVJA 3R5OA 3NAKA 5IKQA 4DL1C 4NJBA 1D5LC 1CVUA 2IKCA 3HS5A 1FE2A 1D7WC 3OLUA 3OLTA 5GH0A 3RR3A 3R55A 4RUTA 3TGYA 4IG5A 3GCJA 2OJVA 5B72A 3N8XA 4Y55A 2AYLA 3NIUA 3TZIA 2EHAA 2NQXA 3BXIA 3MDLA 4HHSA 4LJJA 2E9EA 5JW1A 4NT3A 1DDXA 5HPWA 5F1AA 1PGEA 5COXA 2GJMA 3NYHA 5IKRA 4RRZA 1D2VC 2QPKA 3LN1A 3N8WA 3GC1A 4RS0A 4OEKA 3N8ZA 3R4XA 5IKTA 1Q4GA 2PT3A 5KIRA 4COXA 1DNUC 3PY4A 2QRBA 3Q7DA 5F19A 1DIYA 4QJQA 1EBVA 3KRQA 3V6QA 3R5QA 1CQEA 3NT1A 3SXVA 4GN6A 3S4FA 4PNXA 3Q9KA 3ZS1C 5FF1A 2R5LA 2OYUP 5FDQA 5GLSA 3ERHA 4QYQA 1PRHA 4OTJA 3RKEA 3N8YA 3NTBA 3ERIA 3N8FA 2O86A 3I6NA 1MYPC 1EQHA 5IKVA 4M11A 4RRYA 4HHRA 4N7AA 6COXA 3N8VA 4GM7A 1HT8A 3FNLA 1IGXA 5JVYA 2QQTA 4M10A 4O1ZA 3ZS0C 1EQGA 3QF1A 1IGZA 1PXXA 4MSFA 3MQEA 4KVLA 2IPSA 3N8WB 1U67A 3F9PC 3HS7A 3HS6A 5JVZA 4E1GA 2PUMA 2OYEP 3FAQA 2Z5ZA 4OTYA 3PGHA 3OGWA 3QMOA 3GCLA 3KRKA 3NTGA 4C1MC 1PTHA 4KVKA 1HT5A 1CXPC 4FM5A 5FIWC 1DNWC 4PH9A 2EFBA 4Z0LA 3N8YB 4RRWA 1MHLC 3GCKA 3KK6A 3LN0A 1CX2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3QH0 A;  4KSZ A;  3UBA A;  3QL6 A;  4RRX A;  4KVJ A;  3R5O A;  3NAK A;  5IKQ A;  4DL1 C;  4NJB A;  1D5L C;  1CVU A;  2IKC A;  3HS5 A;  1FE2 A;  1D7W C;  3OLU A;  3OLT A;  5GH0 A;  3RR3 A;  3R55 A;  4RUT A;  3TGY A;  4IG5 A;  3GCJ A;  2OJV A;  5B72 A;  3N8X A;  4Y55 A;  2AYL A;  3NIU A;  3TZI A;  2EHA A;  2NQX A;  3BXI A;  3MDL A;  4HHS A;  4LJJ A;  2E9E A;  5JW1 A;  4NT3 A;  1DDX A;  5HPW A;  5F1A A;  1PGE A;  5COX A;  2GJM A;  3NYH A;  5IKR A;  4RRZ A;  1D2V C;  2QPK A;  3LN1 A;  3N8W A;  3GC1 A;  4RS0 A;  4OEK A;  3N8Z A;  3R4X A;  5IKT A;  1Q4G A;  2PT3 A;  5KIR A;  4COX A;  1DNU C;  3PY4 A;  2QRB A;  3Q7D A;  5F19 A;  1DIY A;  4QJQ A;  1EBV A;  3KRQ A;  3V6Q A;  3R5Q A;  1CQE A;  3NT1 A;  3SXV A;  4GN6 A;  3S4F A;  4PNX A;  3Q9K A;  3ZS1 C;  5FF1 A;  2R5L A;  2OYU P;  5FDQ A;  5GLS A;  3ERH A;  4QYQ A;  1PRH A;  4OTJ A;  3RKE A;  3N8Y A;  3NTB A;  3ERI A;  3N8F A;  2O86 A;  3I6N A;  1MYP C;  1EQH A;  5IKV A;  4M11 A;  4RRY A;  4HHR A;  4N7A A;  6COX A;  3N8V A;  4GM7 A;  1HT8 A;  3FNL A;  1IGX A;  5JVY A;  2QQT A;  4M10 A;  4O1Z A;  3ZS0 C;  1EQG A;  3QF1 A;  1IGZ A;  1PXX A;  4MSF A;  3MQE A;  4KVL A;  2IPS A;  3N8W B;  1U67 A;  3F9P C;  3HS7 A;  3HS6 A;  5JVZ A;  4E1G A;  2PUM A;  2OYE P;  3FAQ A;  2Z5Z A;  4OTY A;  3PGH A;  3OGW A;  3QMO A;  3GCL A;  3KRK A;  3NTG A;  4C1M C;  1PTH A;  4KVK A;  1HT5 A;  1CXP C;  4FM5 A;  5FIW C;  1DNW C;  4PH9 A;  2EFB A;  4Z0L A;  3N8Y B;  4RRW A;  1MHL C;  3GCK A;  3KK6 A;  3LN0 A;  1CX2 A; 
#chains in the Genus database with same CATH topology
 3QH0 A;  4KSZ A;  3UBA A;  3QL6 A;  4RRX A;  4KVJ A;  3R5O A;  3NAK A;  5IKQ A;  4DL1 C;  4NJB A;  1D5L C;  1CVU A;  2IKC A;  3HS5 A;  1FE2 A;  1D7W C;  3OLU A;  3OLT A;  5GH0 A;  3RR3 A;  3R55 A;  4RUT A;  3TGY A;  4IG5 A;  3GCJ A;  2OJV A;  5B72 A;  3N8X A;  4Y55 A;  2AYL A;  3NIU A;  3TZI A;  2EHA A;  2NQX A;  3BXI A;  3MDL A;  4HHS A;  4LJJ A;  2E9E A;  5JW1 A;  4NT3 A;  1DDX A;  5HPW A;  5F1A A;  1PGE A;  5COX A;  2GJM A;  3NYH A;  5IKR A;  4RRZ A;  1D2V C;  2QPK A;  3LN1 A;  3N8W A;  3GC1 A;  4RS0 A;  4OEK A;  3N8Z A;  3R4X A;  5IKT A;  1Q4G A;  2PT3 A;  5KIR A;  4COX A;  1DNU C;  3PY4 A;  2QRB A;  3Q7D A;  5F19 A;  1DIY A;  4QJQ A;  1EBV A;  3KRQ A;  3V6Q A;  3R5Q A;  1CQE A;  3NT1 A;  3SXV A;  4GN6 A;  3S4F A;  4PNX A;  3Q9K A;  3ZS1 C;  5FF1 A;  2R5L A;  2OYU P;  5FDQ A;  5GLS A;  3ERH A;  4QYQ A;  1PRH A;  4OTJ A;  3RKE A;  3N8Y A;  3NTB A;  3ERI A;  3N8F A;  2O86 A;  3I6N A;  1MYP C;  1EQH A;  5IKV A;  4M11 A;  4RRY A;  4HHR A;  4N7A A;  6COX A;  3N8V A;  4GM7 A;  1HT8 A;  3FNL A;  1IGX A;  5JVY A;  2QQT A;  4M10 A;  4O1Z A;  3ZS0 C;  1EQG A;  3QF1 A;  1IGZ A;  1PXX A;  4MSF A;  3MQE A;  4KVL A;  2IPS A;  3N8W B;  1U67 A;  3F9P C;  3HS7 A;  3HS6 A;  5JVZ A;  4E1G A;  2PUM A;  2OYE P;  3FAQ A;  2Z5Z A;  4OTY A;  3PGH A;  3OGW A;  3QMO A;  3GCL A;  3KRK A;  3NTG A;  4C1M C;  1PTH A;  4KVK A;  1HT5 A;  1CXP C;  4FM5 A;  5FIW C;  1DNW C;  4PH9 A;  2EFB A;  4Z0L A;  3N8Y B;  4RRW A;  1MHL C;  3GCK A;  3KK6 A;  3LN0 A;  1CX2 A; 
#chains in the Genus database with same CATH homology
 3QH0 A;  4KSZ A;  3UBA A;  3QL6 A;  4RRX A;  4KVJ A;  3R5O A;  3NAK A;  5IKQ A;  4DL1 C;  4NJB A;  1D5L C;  1CVU A;  2IKC A;  3HS5 A;  1FE2 A;  1D7W C;  3OLU A;  3OLT A;  5GH0 A;  3RR3 A;  3R55 A;  4RUT A;  3TGY A;  4IG5 A;  3GCJ A;  2OJV A;  5B72 A;  3N8X A;  4Y55 A;  2AYL A;  3NIU A;  3TZI A;  2EHA A;  2NQX A;  3BXI A;  3MDL A;  4HHS A;  4LJJ A;  2E9E A;  5JW1 A;  4NT3 A;  1DDX A;  5HPW A;  5F1A A;  1PGE A;  5COX A;  2GJM A;  3NYH A;  5IKR A;  4RRZ A;  1D2V C;  2QPK A;  3LN1 A;  3N8W A;  3GC1 A;  4RS0 A;  4OEK A;  3N8Z A;  3R4X A;  5IKT A;  1Q4G A;  2PT3 A;  5KIR A;  4COX A;  1DNU C;  3PY4 A;  2QRB A;  3Q7D A;  5F19 A;  1DIY A;  4QJQ A;  1EBV A;  3KRQ A;  3V6Q A;  3R5Q A;  1CQE A;  3NT1 A;  3SXV A;  4GN6 A;  3S4F A;  4PNX A;  3Q9K A;  3ZS1 C;  5FF1 A;  2R5L A;  2OYU P;  5FDQ A;  5GLS A;  3ERH A;  4QYQ A;  1PRH A;  4OTJ A;  3RKE A;  3N8Y A;  3NTB A;  3ERI A;  3N8F A;  2O86 A;  3I6N A;  1MYP C;  1EQH A;  5IKV A;  4M11 A;  4RRY A;  4HHR A;  4N7A A;  6COX A;  3N8V A;  4GM7 A;  1HT8 A;  3FNL A;  1IGX A;  5JVY A;  2QQT A;  4M10 A;  4O1Z A;  3ZS0 C;  1EQG A;  3QF1 A;  1IGZ A;  1PXX A;  4MSF A;  3MQE A;  4KVL A;  2IPS A;  3N8W B;  1U67 A;  3F9P C;  3HS7 A;  3HS6 A;  5JVZ A;  4E1G A;  2PUM A;  2OYE P;  3FAQ A;  2Z5Z A;  4OTY A;  3PGH A;  3OGW A;  3QMO A;  3GCL A;  3KRK A;  3NTG A;  4C1M C;  1PTH A;  4KVK A;  1HT5 A;  1CXP C;  4FM5 A;  5FIW C;  1DNW C;  4PH9 A;  2EFB A;  4Z0L A;  3N8Y B;  4RRW A;  1MHL C;  3GCK A;  3KK6 A;  3LN0 A;  1CX2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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