3I6NA

Mode of binding of the tuberculosis prodrug isoniazid to peroxidases: crystal structure of bovine lactoperoxidase with isoniazid at 2.7 resolution
Total Genus 182
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
182
sequence length
595
structure length
594
Chain Sequence
SWEVGCGAPVPLVKCDENSPYRTITGDCNNRRSPALGAANRALARWLPAEYEDGLALPFGWTQRKTRNGFRVPLAREVSNKIVGYLDEEGVLDQNRSLLFMQWGQIVDHDLDFAPETELGSNEHSKTQCEEYCIQGDNCFPIMFPKNDPKLKTQGKCMPFFRAGFVCPTPPYQSLAREQINAVTSFLDASLVYGSEPLASRLRNLSSPLGLMAVNQEAWDHGLAYLPFNNKKPSPCEFINTTARVPCFLAGDFRASEQILLATAHTLLLREHNRLARELKKLNPHWNGEKLYQEARKILGAFIQIITFRDYLPIVLGSEMQKWIPPYQGYNNSVDPRISNVFTFAFRFGHMEVPSTVSRLDENYQPWGPEAELPLHTLFFNTWRIIKDGGIDPLVRGLLAKKSKLMNQDKMVTSELRNKLFQPTHKIHGFDLAAINLQRCRDHGMPGYNSWRGFCGLSQPKTLKGLQTVLKNKILAKKLMDLYKTPDNIDIWIGGNAEPMVERGRVGPLLACLLGRQFQQIRDGDRFWWENPGVFTEKQRDSLQKVSFSRLICDNTHITKVPLHAFQANNYPHDFVDCSTVDKLDLSPWASREN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Mode of binding of the tuberculosis prodrug isoniazid to heme peroxidases: binding studies and crystal structure of bovine lactoperoxidase with isoniazid at 2.7 A resolution.
pubmed doi rcsb
molecule keywords Lactoperoxidase
molecule tags Oxidoreductase
total genus 182
structure length 594
sequence length 595
ec nomenclature ec 1.11.1.7: Peroxidase.
pdb deposition date 2009-07-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03098 An_peroxidase Animal haem peroxidase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.640.10 Mainly Alpha Orthogonal Bundle Myeloperoxidase, subunit C Haem peroxidase domain superfamily, animal type 3i6nA00
3TGYA 1U67A 4OTYA 4LJJA 4N7AA 3N8FA 3NIUA 2Z5ZA 3FAQA 4HHSA 5FDQA 3GCLA 2QRBA 4RRZA 3I6NA 1IGXA 1D5LC 3R55A 5IKTA 3MQEA 1CQEA 1PTHA 3N8YA 1CX2A 4M11A 3RKEA 4C1MC 1EQGA 1FE2A 3NYHA 2O86A 2AYLA 4Y55A 5KIRA 2EHAA 2PUMA 4KVLA 3PGHA 1DDXA 1CVUA 3NTGA 4KSZA 5IKVA 4RRYA 5JVYA 4RRXA 3RR3A 4NJBA 3ZS0C 3V6QA 3N8YB 2GJMA 4IG5A 5F1AA 3MDLA 4FM5A 2OYEP 1EBVA 5JW1A 4GM7A 3ZS1C 1MYPC 4RUTA 3FNLA 2OJVA 3OLTA 5GLSA 4OEKA 2IKCA 2R5LA 3NT1A 3S4FA 3R4XA 1HT5A 3GCJA 1Q4GA 3BXIA 3QF1A 4NT3A 1D7WC 3R5OA 3UBAA 3KK6A 2QQTA 2EFBA 1PGEA 4Z0LA 5FIWC 5HPWA 4M10A 3LN1A 4PH9A 4KVKA 3R5QA 4E1GA 3F9PC 1IGZA 3QH0A 1DNUC 3N8WB 3N8VA 3HS7A 4O1ZA 3TZIA 1CXPC 2PT3A 4OTJA 6COXA 4DL1C 1PRHA 2QPKA 3KRQA 2NQXA 3KRKA 3NTBA 5JVZA 1DNWC 3HS5A 3NAKA 3OLUA 5F19A 3N8WA 4RRWA 2E9EA 4KVJA 3OGWA 4QJQA 3PY4A 1HT8A 3N8XA 5IKQA 4GN6A 5COXA 2IPSA 4QYQA 5IKRA 3LN0A 4COXA 1MHLC 3Q7DA 3QL6A 3SXVA 3ERIA 3GCKA 5B72A 4PNXA 1PXXA 2OYUP 3ERHA 3GC1A 4HHRA 1DIYA 3HS6A 4MSFA 3N8ZA 3Q9KA 4RS0A 5GH0A 1EQHA 3QMOA 1D2VC 5FF1A
chains in the Genus database with same CATH superfamily
3TGYA 1U67A 4OTYA 4LJJA 4N7AA 3N8FA 3NIUA 2Z5ZA 3FAQA 4HHSA 5FDQA 3GCLA 2QRBA 4RRZA 3I6NA 1IGXA 1D5LC 3R55A 5IKTA 3MQEA 1CQEA 1PTHA 3N8YA 1CX2A 4M11A 3RKEA 4C1MC 1EQGA 1FE2A 3NYHA 2O86A 2AYLA 4Y55A 5KIRA 2EHAA 2PUMA 4KVLA 3PGHA 1DDXA 1CVUA 3NTGA 4KSZA 5IKVA 4RRYA 5JVYA 4RRXA 3RR3A 4NJBA 3ZS0C 3V6QA 3N8YB 2GJMA 4IG5A 5F1AA 3MDLA 4FM5A 2OYEP 1EBVA 5JW1A 4GM7A 3ZS1C 1MYPC 4RUTA 3FNLA 2OJVA 3OLTA 5GLSA 4OEKA 2IKCA 2R5LA 3NT1A 3S4FA 3R4XA 1HT5A 3GCJA 1Q4GA 3BXIA 3QF1A 4NT3A 1D7WC 3R5OA 3UBAA 3KK6A 2QQTA 2EFBA 1PGEA 4Z0LA 5FIWC 5HPWA 4M10A 3LN1A 4PH9A 4KVKA 3R5QA 4E1GA 3F9PC 1IGZA 3QH0A 1DNUC 3N8WB 3N8VA 3HS7A 4O1ZA 3TZIA 1CXPC 2PT3A 4OTJA 6COXA 4DL1C 1PRHA 2QPKA 3KRQA 2NQXA 3KRKA 3NTBA 5JVZA 1DNWC 3HS5A 3NAKA 3OLUA 5F19A 3N8WA 4RRWA 2E9EA 4KVJA 3OGWA 4QJQA 3PY4A 1HT8A 3N8XA 5IKQA 4GN6A 5COXA 2IPSA 4QYQA 5IKRA 3LN0A 4COXA 1MHLC 3Q7DA 3QL6A 3SXVA 3ERIA 3GCKA 5B72A 4PNXA 1PXXA 2OYUP 3ERHA 3GC1A 4HHRA 1DIYA 3HS6A 4MSFA 3N8ZA 3Q9KA 4RS0A 5GH0A 1EQHA 3QMOA 1D2VC 5FF1A
chains in the Genus database with same CATH topology
3TGYA 1U67A 4OTYA 4LJJA 4N7AA 3N8FA 3NIUA 2Z5ZA 3FAQA 4HHSA 5FDQA 3GCLA 2QRBA 4RRZA 3I6NA 1IGXA 1D5LC 3R55A 5IKTA 3MQEA 1CQEA 1PTHA 3N8YA 1CX2A 4M11A 3RKEA 4C1MC 1EQGA 1FE2A 3NYHA 2O86A 2AYLA 4Y55A 5KIRA 2EHAA 2PUMA 4KVLA 3PGHA 1DDXA 1CVUA 3NTGA 4KSZA 5IKVA 4RRYA 5JVYA 4RRXA 3RR3A 4NJBA 3ZS0C 3V6QA 3N8YB 2GJMA 4IG5A 5F1AA 3MDLA 4FM5A 2OYEP 1EBVA 5JW1A 4GM7A 3ZS1C 1MYPC 4RUTA 3FNLA 2OJVA 3OLTA 5GLSA 4OEKA 2IKCA 2R5LA 3NT1A 3S4FA 3R4XA 1HT5A 3GCJA 1Q4GA 3BXIA 3QF1A 4NT3A 1D7WC 3R5OA 3UBAA 3KK6A 2QQTA 2EFBA 1PGEA 4Z0LA 5FIWC 5HPWA 4M10A 3LN1A 4PH9A 4KVKA 3R5QA 4E1GA 3F9PC 1IGZA 3QH0A 1DNUC 3N8WB 3N8VA 3HS7A 4O1ZA 3TZIA 1CXPC 2PT3A 4OTJA 6COXA 4DL1C 1PRHA 2QPKA 3KRQA 2NQXA 3KRKA 3NTBA 5JVZA 1DNWC 3HS5A 3NAKA 3OLUA 5F19A 3N8WA 4RRWA 2E9EA 4KVJA 3OGWA 4QJQA 3PY4A 1HT8A 3N8XA 5IKQA 4GN6A 5COXA 2IPSA 4QYQA 5IKRA 3LN0A 4COXA 1MHLC 3Q7DA 3QL6A 3SXVA 3ERIA 3GCKA 5B72A 4PNXA 1PXXA 2OYUP 3ERHA 3GC1A 4HHRA 1DIYA 3HS6A 4MSFA 3N8ZA 3Q9KA 4RS0A 5GH0A 1EQHA 3QMOA 1D2VC 5FF1A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3TGY A;  1U67 A;  4OTY A;  4LJJ A;  4N7A A;  3N8F A;  3NIU A;  2Z5Z A;  3FAQ A;  4HHS A;  5FDQ A;  3GCL A;  2QRB A;  4RRZ A;  3I6N A;  1IGX A;  1D5L C;  3R55 A;  5IKT A;  3MQE A;  1CQE A;  1PTH A;  3N8Y A;  1CX2 A;  4M11 A;  3RKE A;  4C1M C;  1EQG A;  1FE2 A;  3NYH A;  2O86 A;  2AYL A;  4Y55 A;  5KIR A;  2EHA A;  2PUM A;  4KVL A;  3PGH A;  1DDX A;  1CVU A;  3NTG A;  4KSZ A;  5IKV A;  4RRY A;  5JVY A;  4RRX A;  3RR3 A;  4NJB A;  3ZS0 C;  3V6Q A;  3N8Y B;  2GJM A;  4IG5 A;  5F1A A;  3MDL A;  4FM5 A;  2OYE P;  1EBV A;  5JW1 A;  4GM7 A;  3ZS1 C;  1MYP C;  4RUT A;  3FNL A;  2OJV A;  3OLT A;  5GLS A;  4OEK A;  2IKC A;  2R5L A;  3NT1 A;  3S4F A;  3R4X A;  1HT5 A;  3GCJ A;  1Q4G A;  3BXI A;  3QF1 A;  4NT3 A;  1D7W C;  3R5O A;  3UBA A;  3KK6 A;  2QQT A;  2EFB A;  1PGE A;  4Z0L A;  5FIW C;  5HPW A;  4M10 A;  3LN1 A;  4PH9 A;  4KVK A;  3R5Q A;  4E1G A;  3F9P C;  1IGZ A;  3QH0 A;  1DNU C;  3N8W B;  3N8V A;  3HS7 A;  4O1Z A;  3TZI A;  1CXP C;  2PT3 A;  4OTJ A;  6COX A;  4DL1 C;  1PRH A;  2QPK A;  3KRQ A;  2NQX A;  3KRK A;  3NTB A;  5JVZ A;  1DNW C;  3HS5 A;  3NAK A;  3OLU A;  5F19 A;  3N8W A;  4RRW A;  2E9E A;  4KVJ A;  3OGW A;  4QJQ A;  3PY4 A;  1HT8 A;  3N8X A;  5IKQ A;  4GN6 A;  5COX A;  2IPS A;  4QYQ A;  5IKR A;  3LN0 A;  4COX A;  1MHL C;  3Q7D A;  3QL6 A;  3SXV A;  3ERI A;  3GCK A;  5B72 A;  4PNX A;  1PXX A;  2OYU P;  3ERH A;  3GC1 A;  4HHR A;  1DIY A;  3HS6 A;  4MSF A;  3N8Z A;  3Q9K A;  4RS0 A;  5GH0 A;  1EQH A;  3QMO A;  1D2V C;  5FF1 A; 
#chains in the Genus database with same CATH topology
 3TGY A;  1U67 A;  4OTY A;  4LJJ A;  4N7A A;  3N8F A;  3NIU A;  2Z5Z A;  3FAQ A;  4HHS A;  5FDQ A;  3GCL A;  2QRB A;  4RRZ A;  3I6N A;  1IGX A;  1D5L C;  3R55 A;  5IKT A;  3MQE A;  1CQE A;  1PTH A;  3N8Y A;  1CX2 A;  4M11 A;  3RKE A;  4C1M C;  1EQG A;  1FE2 A;  3NYH A;  2O86 A;  2AYL A;  4Y55 A;  5KIR A;  2EHA A;  2PUM A;  4KVL A;  3PGH A;  1DDX A;  1CVU A;  3NTG A;  4KSZ A;  5IKV A;  4RRY A;  5JVY A;  4RRX A;  3RR3 A;  4NJB A;  3ZS0 C;  3V6Q A;  3N8Y B;  2GJM A;  4IG5 A;  5F1A A;  3MDL A;  4FM5 A;  2OYE P;  1EBV A;  5JW1 A;  4GM7 A;  3ZS1 C;  1MYP C;  4RUT A;  3FNL A;  2OJV A;  3OLT A;  5GLS A;  4OEK A;  2IKC A;  2R5L A;  3NT1 A;  3S4F A;  3R4X A;  1HT5 A;  3GCJ A;  1Q4G A;  3BXI A;  3QF1 A;  4NT3 A;  1D7W C;  3R5O A;  3UBA A;  3KK6 A;  2QQT A;  2EFB A;  1PGE A;  4Z0L A;  5FIW C;  5HPW A;  4M10 A;  3LN1 A;  4PH9 A;  4KVK A;  3R5Q A;  4E1G A;  3F9P C;  1IGZ A;  3QH0 A;  1DNU C;  3N8W B;  3N8V A;  3HS7 A;  4O1Z A;  3TZI A;  1CXP C;  2PT3 A;  4OTJ A;  6COX A;  4DL1 C;  1PRH A;  2QPK A;  3KRQ A;  2NQX A;  3KRK A;  3NTB A;  5JVZ A;  1DNW C;  3HS5 A;  3NAK A;  3OLU A;  5F19 A;  3N8W A;  4RRW A;  2E9E A;  4KVJ A;  3OGW A;  4QJQ A;  3PY4 A;  1HT8 A;  3N8X A;  5IKQ A;  4GN6 A;  5COX A;  2IPS A;  4QYQ A;  5IKR A;  3LN0 A;  4COX A;  1MHL C;  3Q7D A;  3QL6 A;  3SXV A;  3ERI A;  3GCK A;  5B72 A;  4PNX A;  1PXX A;  2OYU P;  3ERH A;  3GC1 A;  4HHR A;  1DIY A;  3HS6 A;  4MSF A;  3N8Z A;  3Q9K A;  4RS0 A;  5GH0 A;  1EQH A;  3QMO A;  1D2V C;  5FF1 A; 
#chains in the Genus database with same CATH homology
 3TGY A;  1U67 A;  4OTY A;  4LJJ A;  4N7A A;  3N8F A;  3NIU A;  2Z5Z A;  3FAQ A;  4HHS A;  5FDQ A;  3GCL A;  2QRB A;  4RRZ A;  3I6N A;  1IGX A;  1D5L C;  3R55 A;  5IKT A;  3MQE A;  1CQE A;  1PTH A;  3N8Y A;  1CX2 A;  4M11 A;  3RKE A;  4C1M C;  1EQG A;  1FE2 A;  3NYH A;  2O86 A;  2AYL A;  4Y55 A;  5KIR A;  2EHA A;  2PUM A;  4KVL A;  3PGH A;  1DDX A;  1CVU A;  3NTG A;  4KSZ A;  5IKV A;  4RRY A;  5JVY A;  4RRX A;  3RR3 A;  4NJB A;  3ZS0 C;  3V6Q A;  3N8Y B;  2GJM A;  4IG5 A;  5F1A A;  3MDL A;  4FM5 A;  2OYE P;  1EBV A;  5JW1 A;  4GM7 A;  3ZS1 C;  1MYP C;  4RUT A;  3FNL A;  2OJV A;  3OLT A;  5GLS A;  4OEK A;  2IKC A;  2R5L A;  3NT1 A;  3S4F A;  3R4X A;  1HT5 A;  3GCJ A;  1Q4G A;  3BXI A;  3QF1 A;  4NT3 A;  1D7W C;  3R5O A;  3UBA A;  3KK6 A;  2QQT A;  2EFB A;  1PGE A;  4Z0L A;  5FIW C;  5HPW A;  4M10 A;  3LN1 A;  4PH9 A;  4KVK A;  3R5Q A;  4E1G A;  3F9P C;  1IGZ A;  3QH0 A;  1DNU C;  3N8W B;  3N8V A;  3HS7 A;  4O1Z A;  3TZI A;  1CXP C;  2PT3 A;  4OTJ A;  6COX A;  4DL1 C;  1PRH A;  2QPK A;  3KRQ A;  2NQX A;  3KRK A;  3NTB A;  5JVZ A;  1DNW C;  3HS5 A;  3NAK A;  3OLU A;  5F19 A;  3N8W A;  4RRW A;  2E9E A;  4KVJ A;  3OGW A;  4QJQ A;  3PY4 A;  1HT8 A;  3N8X A;  5IKQ A;  4GN6 A;  5COX A;  2IPS A;  4QYQ A;  5IKR A;  3LN0 A;  4COX A;  1MHL C;  3Q7D A;  3QL6 A;  3SXV A;  3ERI A;  3GCK A;  5B72 A;  4PNX A;  1PXX A;  2OYU P;  3ERH A;  3GC1 A;  4HHR A;  1DIY A;  3HS6 A;  4MSF A;  3N8Z A;  3Q9K A;  4RS0 A;  5GH0 A;  1EQH A;  3QMO A;  1D2V C;  5FF1 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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