3ZS1C

Human myeloperoxidase inactivated by tx5
Total Genus 143
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
143
sequence length
466
structure length
465
Chain Sequence
VNCETSCVQQPPCFPLKIPPNDPRIKNQADCIPFFRSPACPGSNITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQLGLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLLREHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRKYLPTYRSYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPLLACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMSNSYPRDFVNCSTLPALNLASWREA
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title 2-Thioxanthines are Mechanism-Based Inactivators of Myeloperoxidase that Block Oxidative Stress During Inflammation.
pubmed doi rcsb
molecule tags Oxidoreductase
molecule keywords MYELOPEROXIDASE LIGHT CHAIN
total genus 143
structure length 465
sequence length 466
chains with identical sequence D
ec nomenclature ec 1.11.2.2: Myeloperoxidase.
pdb deposition date 2011-06-21
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.640.10 Mainly Alpha Orthogonal Bundle Myeloperoxidase, subunit C Haem peroxidase domain superfamily, animal type 3zs1C00
3S4FA 3GCLA 3R4XA 5IKRA 1DIYA 4GN6A 4KVLA 4RUTA 1DNUC 3N8YA 3OGWA 4RS0A 5FDQA 1MHLC 4HHSA 3I6NA 4RRXA 2PT3A 5GH0A 3R5QA 4O1ZA 4RRZA 2AYLA 3N8YB 4PH9A 3GCKA 1CX2A 1PGEA 3LN0A 2OYEP 5COXA 4MSFA 2OJVA 1HT8A 1U67A 4E1GA 3GCJA 1D2VC 1DDXA 1EQHA 4Y55A 3Q7DA 1D7WC 3QF1A 3RKEA 5F19A 3R5OA 3QMOA 1EBVA 2GJMA 3LN1A 1Q4GA 2Z5ZA 2PUMA 3V6QA 3QL6A 4C1MC 4HHRA 3UBAA 3TZIA 5IKTA 3FNLA 3N8ZA 3NYHA 3TGYA 5GLSA 4QYQA 3KK6A 3Q9KA 3HS5A 4NT3A 1PTHA 4RRYA 3N8FA 2R5LA 1PXXA 5B72A 5HPWA 5IKVA 2QQTA 4FM5A 2OYUP 4M10A 4QJQA 4N7AA 2EFBA 5FIWC 3N8XA 4M11A 3RR3A 2QPKA 4KVKA 2E9EA 4PNXA 3OLUA 3FAQA 4Z0LA 1EQGA 2IPSA 4COXA 5JVYA 3MQEA 1IGZA 1HT5A 4KVJA 4OTJA 5JVZA 4RRWA 3N8VA 1DNWC 3ERIA 3ERHA 3KRQA 1D5LC 4GM7A 1CXPC 1PRHA 3F9PC 3PY4A 3ZS1C 3HS6A 3QH0A 3NAKA 2O86A 1CQEA 3NIUA 4KSZA 4OEKA 3ZS0C 3HS7A 3N8WA 3NTBA 4OTYA 2IKCA 3OLTA 1FE2A 1IGXA 3KRKA 3NT1A 6COXA 3GC1A 3N8WB 1CVUA 2NQXA 1MYPC 4NJBA 5KIRA 2EHAA 5F1AA 3BXIA 3MDLA 3SXVA 5JW1A 3PGHA 4IG5A 5FF1A 3NTGA 5IKQA 4LJJA 4DL1C 2QRBA 3R55A
chains in the Genus database with same CATH superfamily
3S4FA 3GCLA 3R4XA 5IKRA 1DIYA 4GN6A 4KVLA 4RUTA 1DNUC 3N8YA 3OGWA 4RS0A 5FDQA 1MHLC 4HHSA 3I6NA 4RRXA 2PT3A 5GH0A 3R5QA 4O1ZA 4RRZA 2AYLA 3N8YB 4PH9A 3GCKA 1CX2A 1PGEA 3LN0A 2OYEP 5COXA 4MSFA 2OJVA 1HT8A 1U67A 4E1GA 3GCJA 1D2VC 1DDXA 1EQHA 4Y55A 3Q7DA 1D7WC 3QF1A 3RKEA 5F19A 3R5OA 3QMOA 1EBVA 2GJMA 3LN1A 1Q4GA 2Z5ZA 2PUMA 3V6QA 3QL6A 4C1MC 4HHRA 3UBAA 3TZIA 5IKTA 3FNLA 3N8ZA 3NYHA 3TGYA 5GLSA 4QYQA 3KK6A 3Q9KA 3HS5A 4NT3A 1PTHA 4RRYA 3N8FA 2R5LA 1PXXA 5B72A 5HPWA 5IKVA 2QQTA 4FM5A 2OYUP 4M10A 4QJQA 4N7AA 2EFBA 5FIWC 3N8XA 4M11A 3RR3A 2QPKA 4KVKA 2E9EA 4PNXA 3OLUA 3FAQA 4Z0LA 1EQGA 2IPSA 4COXA 5JVYA 3MQEA 1IGZA 1HT5A 4KVJA 4OTJA 5JVZA 4RRWA 3N8VA 1DNWC 3ERIA 3ERHA 3KRQA 1D5LC 4GM7A 1CXPC 1PRHA 3F9PC 3PY4A 3ZS1C 3HS6A 3QH0A 3NAKA 2O86A 1CQEA 3NIUA 4KSZA 4OEKA 3ZS0C 3HS7A 3N8WA 3NTBA 4OTYA 2IKCA 3OLTA 1FE2A 1IGXA 3KRKA 3NT1A 6COXA 3GC1A 3N8WB 1CVUA 2NQXA 1MYPC 4NJBA 5KIRA 2EHAA 5F1AA 3BXIA 3MDLA 3SXVA 5JW1A 3PGHA 4IG5A 5FF1A 3NTGA 5IKQA 4LJJA 4DL1C 2QRBA 3R55A
chains in the Genus database with same CATH topology
3S4FA 3GCLA 3R4XA 5IKRA 1DIYA 4GN6A 4KVLA 4RUTA 1DNUC 3N8YA 3OGWA 4RS0A 5FDQA 1MHLC 4HHSA 3I6NA 4RRXA 2PT3A 5GH0A 3R5QA 4O1ZA 4RRZA 2AYLA 3N8YB 4PH9A 3GCKA 1CX2A 1PGEA 3LN0A 2OYEP 5COXA 4MSFA 2OJVA 1HT8A 1U67A 4E1GA 3GCJA 1D2VC 1DDXA 1EQHA 4Y55A 3Q7DA 1D7WC 3QF1A 3RKEA 5F19A 3R5OA 3QMOA 1EBVA 2GJMA 3LN1A 1Q4GA 2Z5ZA 2PUMA 3V6QA 3QL6A 4C1MC 4HHRA 3UBAA 3TZIA 5IKTA 3FNLA 3N8ZA 3NYHA 3TGYA 5GLSA 4QYQA 3KK6A 3Q9KA 3HS5A 4NT3A 1PTHA 4RRYA 3N8FA 2R5LA 1PXXA 5B72A 5HPWA 5IKVA 2QQTA 4FM5A 2OYUP 4M10A 4QJQA 4N7AA 2EFBA 5FIWC 3N8XA 4M11A 3RR3A 2QPKA 4KVKA 2E9EA 4PNXA 3OLUA 3FAQA 4Z0LA 1EQGA 2IPSA 4COXA 5JVYA 3MQEA 1IGZA 1HT5A 4KVJA 4OTJA 5JVZA 4RRWA 3N8VA 1DNWC 3ERIA 3ERHA 3KRQA 1D5LC 4GM7A 1CXPC 1PRHA 3F9PC 3PY4A 3ZS1C 3HS6A 3QH0A 3NAKA 2O86A 1CQEA 3NIUA 4KSZA 4OEKA 3ZS0C 3HS7A 3N8WA 3NTBA 4OTYA 2IKCA 3OLTA 1FE2A 1IGXA 3KRKA 3NT1A 6COXA 3GC1A 3N8WB 1CVUA 2NQXA 1MYPC 4NJBA 5KIRA 2EHAA 5F1AA 3BXIA 3MDLA 3SXVA 5JW1A 3PGHA 4IG5A 5FF1A 3NTGA 5IKQA 4LJJA 4DL1C 2QRBA 3R55A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3S4F A;  3GCL A;  3R4X A;  5IKR A;  1DIY A;  4GN6 A;  4KVL A;  4RUT A;  1DNU C;  3N8Y A;  3OGW A;  4RS0 A;  5FDQ A;  1MHL C;  4HHS A;  3I6N A;  4RRX A;  2PT3 A;  5GH0 A;  3R5Q A;  4O1Z A;  4RRZ A;  2AYL A;  3N8Y B;  4PH9 A;  3GCK A;  1CX2 A;  1PGE A;  3LN0 A;  2OYE P;  5COX A;  4MSF A;  2OJV A;  1HT8 A;  1U67 A;  4E1G A;  3GCJ A;  1D2V C;  1DDX A;  1EQH A;  4Y55 A;  3Q7D A;  1D7W C;  3QF1 A;  3RKE A;  5F19 A;  3R5O A;  3QMO A;  1EBV A;  2GJM A;  3LN1 A;  1Q4G A;  2Z5Z A;  2PUM A;  3V6Q A;  3QL6 A;  4C1M C;  4HHR A;  3UBA A;  3TZI A;  5IKT A;  3FNL A;  3N8Z A;  3NYH A;  3TGY A;  5GLS A;  4QYQ A;  3KK6 A;  3Q9K A;  3HS5 A;  4NT3 A;  1PTH A;  4RRY A;  3N8F A;  2R5L A;  1PXX A;  5B72 A;  5HPW A;  5IKV A;  2QQT A;  4FM5 A;  2OYU P;  4M10 A;  4QJQ A;  4N7A A;  2EFB A;  5FIW C;  3N8X A;  4M11 A;  3RR3 A;  2QPK A;  4KVK A;  2E9E A;  4PNX A;  3OLU A;  3FAQ A;  4Z0L A;  1EQG A;  2IPS A;  4COX A;  5JVY A;  3MQE A;  1IGZ A;  1HT5 A;  4KVJ A;  4OTJ A;  5JVZ A;  4RRW A;  3N8V A;  1DNW C;  3ERI A;  3ERH A;  3KRQ A;  1D5L C;  4GM7 A;  1CXP C;  1PRH A;  3F9P C;  3PY4 A;  3ZS1 C;  3HS6 A;  3QH0 A;  3NAK A;  2O86 A;  1CQE A;  3NIU A;  4KSZ A;  4OEK A;  3ZS0 C;  3HS7 A;  3N8W A;  3NTB A;  4OTY A;  2IKC A;  3OLT A;  1FE2 A;  1IGX A;  3KRK A;  3NT1 A;  6COX A;  3GC1 A;  3N8W B;  1CVU A;  2NQX A;  1MYP C;  4NJB A;  5KIR A;  2EHA A;  5F1A A;  3BXI A;  3MDL A;  3SXV A;  5JW1 A;  3PGH A;  4IG5 A;  5FF1 A;  3NTG A;  5IKQ A;  4LJJ A;  4DL1 C;  2QRB A;  3R55 A; 
#chains in the Genus database with same CATH topology
 3S4F A;  3GCL A;  3R4X A;  5IKR A;  1DIY A;  4GN6 A;  4KVL A;  4RUT A;  1DNU C;  3N8Y A;  3OGW A;  4RS0 A;  5FDQ A;  1MHL C;  4HHS A;  3I6N A;  4RRX A;  2PT3 A;  5GH0 A;  3R5Q A;  4O1Z A;  4RRZ A;  2AYL A;  3N8Y B;  4PH9 A;  3GCK A;  1CX2 A;  1PGE A;  3LN0 A;  2OYE P;  5COX A;  4MSF A;  2OJV A;  1HT8 A;  1U67 A;  4E1G A;  3GCJ A;  1D2V C;  1DDX A;  1EQH A;  4Y55 A;  3Q7D A;  1D7W C;  3QF1 A;  3RKE A;  5F19 A;  3R5O A;  3QMO A;  1EBV A;  2GJM A;  3LN1 A;  1Q4G A;  2Z5Z A;  2PUM A;  3V6Q A;  3QL6 A;  4C1M C;  4HHR A;  3UBA A;  3TZI A;  5IKT A;  3FNL A;  3N8Z A;  3NYH A;  3TGY A;  5GLS A;  4QYQ A;  3KK6 A;  3Q9K A;  3HS5 A;  4NT3 A;  1PTH A;  4RRY A;  3N8F A;  2R5L A;  1PXX A;  5B72 A;  5HPW A;  5IKV A;  2QQT A;  4FM5 A;  2OYU P;  4M10 A;  4QJQ A;  4N7A A;  2EFB A;  5FIW C;  3N8X A;  4M11 A;  3RR3 A;  2QPK A;  4KVK A;  2E9E A;  4PNX A;  3OLU A;  3FAQ A;  4Z0L A;  1EQG A;  2IPS A;  4COX A;  5JVY A;  3MQE A;  1IGZ A;  1HT5 A;  4KVJ A;  4OTJ A;  5JVZ A;  4RRW A;  3N8V A;  1DNW C;  3ERI A;  3ERH A;  3KRQ A;  1D5L C;  4GM7 A;  1CXP C;  1PRH A;  3F9P C;  3PY4 A;  3ZS1 C;  3HS6 A;  3QH0 A;  3NAK A;  2O86 A;  1CQE A;  3NIU A;  4KSZ A;  4OEK A;  3ZS0 C;  3HS7 A;  3N8W A;  3NTB A;  4OTY A;  2IKC A;  3OLT A;  1FE2 A;  1IGX A;  3KRK A;  3NT1 A;  6COX A;  3GC1 A;  3N8W B;  1CVU A;  2NQX A;  1MYP C;  4NJB A;  5KIR A;  2EHA A;  5F1A A;  3BXI A;  3MDL A;  3SXV A;  5JW1 A;  3PGH A;  4IG5 A;  5FF1 A;  3NTG A;  5IKQ A;  4LJJ A;  4DL1 C;  2QRB A;  3R55 A; 
#chains in the Genus database with same CATH homology
 3S4F A;  3GCL A;  3R4X A;  5IKR A;  1DIY A;  4GN6 A;  4KVL A;  4RUT A;  1DNU C;  3N8Y A;  3OGW A;  4RS0 A;  5FDQ A;  1MHL C;  4HHS A;  3I6N A;  4RRX A;  2PT3 A;  5GH0 A;  3R5Q A;  4O1Z A;  4RRZ A;  2AYL A;  3N8Y B;  4PH9 A;  3GCK A;  1CX2 A;  1PGE A;  3LN0 A;  2OYE P;  5COX A;  4MSF A;  2OJV A;  1HT8 A;  1U67 A;  4E1G A;  3GCJ A;  1D2V C;  1DDX A;  1EQH A;  4Y55 A;  3Q7D A;  1D7W C;  3QF1 A;  3RKE A;  5F19 A;  3R5O A;  3QMO A;  1EBV A;  2GJM A;  3LN1 A;  1Q4G A;  2Z5Z A;  2PUM A;  3V6Q A;  3QL6 A;  4C1M C;  4HHR A;  3UBA A;  3TZI A;  5IKT A;  3FNL A;  3N8Z A;  3NYH A;  3TGY A;  5GLS A;  4QYQ A;  3KK6 A;  3Q9K A;  3HS5 A;  4NT3 A;  1PTH A;  4RRY A;  3N8F A;  2R5L A;  1PXX A;  5B72 A;  5HPW A;  5IKV A;  2QQT A;  4FM5 A;  2OYU P;  4M10 A;  4QJQ A;  4N7A A;  2EFB A;  5FIW C;  3N8X A;  4M11 A;  3RR3 A;  2QPK A;  4KVK A;  2E9E A;  4PNX A;  3OLU A;  3FAQ A;  4Z0L A;  1EQG A;  2IPS A;  4COX A;  5JVY A;  3MQE A;  1IGZ A;  1HT5 A;  4KVJ A;  4OTJ A;  5JVZ A;  4RRW A;  3N8V A;  1DNW C;  3ERI A;  3ERH A;  3KRQ A;  1D5L C;  4GM7 A;  1CXP C;  1PRH A;  3F9P C;  3PY4 A;  3ZS1 C;  3HS6 A;  3QH0 A;  3NAK A;  2O86 A;  1CQE A;  3NIU A;  4KSZ A;  4OEK A;  3ZS0 C;  3HS7 A;  3N8W A;  3NTB A;  4OTY A;  2IKC A;  3OLT A;  1FE2 A;  1IGX A;  3KRK A;  3NT1 A;  6COX A;  3GC1 A;  3N8W B;  1CVU A;  2NQX A;  1MYP C;  4NJB A;  5KIR A;  2EHA A;  5F1A A;  3BXI A;  3MDL A;  3SXV A;  5JW1 A;  3PGH A;  4IG5 A;  5FF1 A;  3NTG A;  5IKQ A;  4LJJ A;  4DL1 C;  2QRB A;  3R55 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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