4IG5A

Crystal structure of methimazole inhibited dimeric goat lactoperoxidase at 1.97a resolution
Total Genus 193
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
193
sequence length
595
structure length
595
Chain Sequence
SWEVGCGAPVPLVTCDEQSPYRTITGDCNNRRSPALGAANRALARWLPAEYEDGLAVPFGWTQRKTRNGFRVPLAREVSNKIVGYLDEEGVLDQNRSLLFMQWGQIVDHDLDFAPETELGSSEHSKVQCEEYCVQGDECFPIMFPKNDPKLKTQGKCMPFFRAGFVCPTPPYQSLARDQINAVTSFLDASLVYGSEPSLASRLRNLSSPLGLMAVNQEAWDHGLAYPPFNNVKPSPCEFINTTAHVPCFQAGDSRASEQILLATVHTLLLREHNRLARELKRLNPHWDGEMLYQEARKILGAFIQIITFRDYLPIVLGSEMQKWIPPYQGYNNSVDPRISNVFTFAFRFGHMEVPSTVSRLDENYQPWGPEAELPLHTLFFNTWRIIKDGGIDPLVRGLLAKNSKLMNQNKMVTSELRNKLFQPTHKVHGFDLAAINLQRCRDHGMPGYNSWRGFCGLSQPKTLKGLQAVLKNKVLAKKLLDLYKTPDNIDIWIGGNAEPMVERGRVGPLLACLLGRQFQQIRDGDRFWWENPGVFTEKQRDSLQKVSFSRLICDNTHITKVPLHAFQANNYPHDFVDCSAVDKLDLSPWASREN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Oxidoreductase/oxidoreductase inhibitor
publication title Mode of binding of the antithyroid drug propylthiouracil to mammalian haem peroxidases
pubmed doi rcsb
molecule keywords Lactoperoxidase
total genus 193
structure length 595
sequence length 595
chains with identical sequence B
ec nomenclature ec 1.11.1.7: Peroxidase.
pdb deposition date 2012-12-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03098 An_peroxidase Animal haem peroxidase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.640.10 Mainly Alpha Orthogonal Bundle Myeloperoxidase, subunit C Haem peroxidase domain superfamily, animal type 4ig5A00
1PGEA 4IG5A 1EQHA 5F1AA 2PT3A 3N8ZA 1CQEA 4HHRA 1PTHA 3GC1A 4KVKA 4MSFA 3N8FA 3HS5A 3N8YB 1EQGA 5COXA 4PNXA 5KIRA 3GCLA 4Y55A 2QPKA 4RRWA 5IKRA 1PXXA 4GN6A 4OTJA 4Z0LA 3F9PC 3Q7DA 3OGWA 1EBVA 5IKTA 2QRBA 4GM7A 4C1MC 2OYUP 4RS0A 1CX2A 1IGZA 3N8WA 5IKVA 3N8VA 3TGYA 3HS6A 4DL1C 1D5LC 1IGXA 3ERIA 1FE2A 1MHLC 3HS7A 1Q4GA 4RUTA 3NTBA 3NTGA 4NT3A 4OTYA 3Q9KA 5FF1A 3R5OA 4KVLA 1PRHA 3I6NA 2PUMA 3LN1A 2QQTA 3NT1A 3KRKA 2GJMA 5JVZA 4COXA 5FIWC 3BXIA 4NJBA 4PH9A 3KK6A 3R5QA 3RKEA 1DNUC 3LN0A 3S4FA 4QJQA 3N8XA 3NYHA 5B72A 1CXPC 3MDLA 3TZIA 5JVYA 2OJVA 3GCJA 4E1GA 2OYEP 3KRQA 4M10A 2IKCA 6COXA 1U67A 3FNLA 3PGHA 3N8WB 3QL6A 4QYQA 3NIUA 3SXVA 1CVUA 3OLUA 1D2VC 3N8YA 1D7WC 4HHSA 2AYLA 2Z5ZA 5JW1A 4FM5A 4RRXA 5F19A 3QMOA 4RRZA 2NQXA 4O1ZA 3NAKA 3PY4A 4N7AA 1DIYA 3ZS0C 4KSZA 2E9EA 3UBAA 3OLTA 1MYPC 1DNWC 4OEKA 2EFBA 2R5LA 3MQEA 3R4XA 3QH0A 3ZS1C 2IPSA 3V6QA 5HPWA 3FAQA 3ERHA 1HT5A 5FDQA 2O86A 3R55A 5GLSA 4RRYA 1DDXA 2EHAA 4LJJA 4KVJA 4M11A 5IKQA 1HT8A 3QF1A 5GH0A 3RR3A 3GCKA
chains in the Genus database with same CATH superfamily
1PGEA 4IG5A 1EQHA 5F1AA 2PT3A 3N8ZA 1CQEA 4HHRA 1PTHA 3GC1A 4KVKA 4MSFA 3N8FA 3HS5A 3N8YB 1EQGA 5COXA 4PNXA 5KIRA 3GCLA 4Y55A 2QPKA 4RRWA 5IKRA 1PXXA 4GN6A 4OTJA 4Z0LA 3F9PC 3Q7DA 3OGWA 1EBVA 5IKTA 2QRBA 4GM7A 4C1MC 2OYUP 4RS0A 1CX2A 1IGZA 3N8WA 5IKVA 3N8VA 3TGYA 3HS6A 4DL1C 1D5LC 1IGXA 3ERIA 1FE2A 1MHLC 3HS7A 1Q4GA 4RUTA 3NTBA 3NTGA 4NT3A 4OTYA 3Q9KA 5FF1A 3R5OA 4KVLA 1PRHA 3I6NA 2PUMA 3LN1A 2QQTA 3NT1A 3KRKA 2GJMA 5JVZA 4COXA 5FIWC 3BXIA 4NJBA 4PH9A 3KK6A 3R5QA 3RKEA 1DNUC 3LN0A 3S4FA 4QJQA 3N8XA 3NYHA 5B72A 1CXPC 3MDLA 3TZIA 5JVYA 2OJVA 3GCJA 4E1GA 2OYEP 3KRQA 4M10A 2IKCA 6COXA 1U67A 3FNLA 3PGHA 3N8WB 3QL6A 4QYQA 3NIUA 3SXVA 1CVUA 3OLUA 1D2VC 3N8YA 1D7WC 4HHSA 2AYLA 2Z5ZA 5JW1A 4FM5A 4RRXA 5F19A 3QMOA 4RRZA 2NQXA 4O1ZA 3NAKA 3PY4A 4N7AA 1DIYA 3ZS0C 4KSZA 2E9EA 3UBAA 3OLTA 1MYPC 1DNWC 4OEKA 2EFBA 2R5LA 3MQEA 3R4XA 3QH0A 3ZS1C 2IPSA 3V6QA 5HPWA 3FAQA 3ERHA 1HT5A 5FDQA 2O86A 3R55A 5GLSA 4RRYA 1DDXA 2EHAA 4LJJA 4KVJA 4M11A 5IKQA 1HT8A 3QF1A 5GH0A 3RR3A 3GCKA
chains in the Genus database with same CATH topology
1PGEA 4IG5A 1EQHA 5F1AA 2PT3A 3N8ZA 1CQEA 4HHRA 1PTHA 3GC1A 4KVKA 4MSFA 3N8FA 3HS5A 3N8YB 1EQGA 5COXA 4PNXA 5KIRA 3GCLA 4Y55A 2QPKA 4RRWA 5IKRA 1PXXA 4GN6A 4OTJA 4Z0LA 3F9PC 3Q7DA 3OGWA 1EBVA 5IKTA 2QRBA 4GM7A 4C1MC 2OYUP 4RS0A 1CX2A 1IGZA 3N8WA 5IKVA 3N8VA 3TGYA 3HS6A 4DL1C 1D5LC 1IGXA 3ERIA 1FE2A 1MHLC 3HS7A 1Q4GA 4RUTA 3NTBA 3NTGA 4NT3A 4OTYA 3Q9KA 5FF1A 3R5OA 4KVLA 1PRHA 3I6NA 2PUMA 3LN1A 2QQTA 3NT1A 3KRKA 2GJMA 5JVZA 4COXA 5FIWC 3BXIA 4NJBA 4PH9A 3KK6A 3R5QA 3RKEA 1DNUC 3LN0A 3S4FA 4QJQA 3N8XA 3NYHA 5B72A 1CXPC 3MDLA 3TZIA 5JVYA 2OJVA 3GCJA 4E1GA 2OYEP 3KRQA 4M10A 2IKCA 6COXA 1U67A 3FNLA 3PGHA 3N8WB 3QL6A 4QYQA 3NIUA 3SXVA 1CVUA 3OLUA 1D2VC 3N8YA 1D7WC 4HHSA 2AYLA 2Z5ZA 5JW1A 4FM5A 4RRXA 5F19A 3QMOA 4RRZA 2NQXA 4O1ZA 3NAKA 3PY4A 4N7AA 1DIYA 3ZS0C 4KSZA 2E9EA 3UBAA 3OLTA 1MYPC 1DNWC 4OEKA 2EFBA 2R5LA 3MQEA 3R4XA 3QH0A 3ZS1C 2IPSA 3V6QA 5HPWA 3FAQA 3ERHA 1HT5A 5FDQA 2O86A 3R55A 5GLSA 4RRYA 1DDXA 2EHAA 4LJJA 4KVJA 4M11A 5IKQA 1HT8A 3QF1A 5GH0A 3RR3A 3GCKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1PGE A;  4IG5 A;  1EQH A;  5F1A A;  2PT3 A;  3N8Z A;  1CQE A;  4HHR A;  1PTH A;  3GC1 A;  4KVK A;  4MSF A;  3N8F A;  3HS5 A;  3N8Y B;  1EQG A;  5COX A;  4PNX A;  5KIR A;  3GCL A;  4Y55 A;  2QPK A;  4RRW A;  5IKR A;  1PXX A;  4GN6 A;  4OTJ A;  4Z0L A;  3F9P C;  3Q7D A;  3OGW A;  1EBV A;  5IKT A;  2QRB A;  4GM7 A;  4C1M C;  2OYU P;  4RS0 A;  1CX2 A;  1IGZ A;  3N8W A;  5IKV A;  3N8V A;  3TGY A;  3HS6 A;  4DL1 C;  1D5L C;  1IGX A;  3ERI A;  1FE2 A;  1MHL C;  3HS7 A;  1Q4G A;  4RUT A;  3NTB A;  3NTG A;  4NT3 A;  4OTY A;  3Q9K A;  5FF1 A;  3R5O A;  4KVL A;  1PRH A;  3I6N A;  2PUM A;  3LN1 A;  2QQT A;  3NT1 A;  3KRK A;  2GJM A;  5JVZ A;  4COX A;  5FIW C;  3BXI A;  4NJB A;  4PH9 A;  3KK6 A;  3R5Q A;  3RKE A;  1DNU C;  3LN0 A;  3S4F A;  4QJQ A;  3N8X A;  3NYH A;  5B72 A;  1CXP C;  3MDL A;  3TZI A;  5JVY A;  2OJV A;  3GCJ A;  4E1G A;  2OYE P;  3KRQ A;  4M10 A;  2IKC A;  6COX A;  1U67 A;  3FNL A;  3PGH A;  3N8W B;  3QL6 A;  4QYQ A;  3NIU A;  3SXV A;  1CVU A;  3OLU A;  1D2V C;  3N8Y A;  1D7W C;  4HHS A;  2AYL A;  2Z5Z A;  5JW1 A;  4FM5 A;  4RRX A;  5F19 A;  3QMO A;  4RRZ A;  2NQX A;  4O1Z A;  3NAK A;  3PY4 A;  4N7A A;  1DIY A;  3ZS0 C;  4KSZ A;  2E9E A;  3UBA A;  3OLT A;  1MYP C;  1DNW C;  4OEK A;  2EFB A;  2R5L A;  3MQE A;  3R4X A;  3QH0 A;  3ZS1 C;  2IPS A;  3V6Q A;  5HPW A;  3FAQ A;  3ERH A;  1HT5 A;  5FDQ A;  2O86 A;  3R55 A;  5GLS A;  4RRY A;  1DDX A;  2EHA A;  4LJJ A;  4KVJ A;  4M11 A;  5IKQ A;  1HT8 A;  3QF1 A;  5GH0 A;  3RR3 A;  3GCK A; 
#chains in the Genus database with same CATH topology
 1PGE A;  4IG5 A;  1EQH A;  5F1A A;  2PT3 A;  3N8Z A;  1CQE A;  4HHR A;  1PTH A;  3GC1 A;  4KVK A;  4MSF A;  3N8F A;  3HS5 A;  3N8Y B;  1EQG A;  5COX A;  4PNX A;  5KIR A;  3GCL A;  4Y55 A;  2QPK A;  4RRW A;  5IKR A;  1PXX A;  4GN6 A;  4OTJ A;  4Z0L A;  3F9P C;  3Q7D A;  3OGW A;  1EBV A;  5IKT A;  2QRB A;  4GM7 A;  4C1M C;  2OYU P;  4RS0 A;  1CX2 A;  1IGZ A;  3N8W A;  5IKV A;  3N8V A;  3TGY A;  3HS6 A;  4DL1 C;  1D5L C;  1IGX A;  3ERI A;  1FE2 A;  1MHL C;  3HS7 A;  1Q4G A;  4RUT A;  3NTB A;  3NTG A;  4NT3 A;  4OTY A;  3Q9K A;  5FF1 A;  3R5O A;  4KVL A;  1PRH A;  3I6N A;  2PUM A;  3LN1 A;  2QQT A;  3NT1 A;  3KRK A;  2GJM A;  5JVZ A;  4COX A;  5FIW C;  3BXI A;  4NJB A;  4PH9 A;  3KK6 A;  3R5Q A;  3RKE A;  1DNU C;  3LN0 A;  3S4F A;  4QJQ A;  3N8X A;  3NYH A;  5B72 A;  1CXP C;  3MDL A;  3TZI A;  5JVY A;  2OJV A;  3GCJ A;  4E1G A;  2OYE P;  3KRQ A;  4M10 A;  2IKC A;  6COX A;  1U67 A;  3FNL A;  3PGH A;  3N8W B;  3QL6 A;  4QYQ A;  3NIU A;  3SXV A;  1CVU A;  3OLU A;  1D2V C;  3N8Y A;  1D7W C;  4HHS A;  2AYL A;  2Z5Z A;  5JW1 A;  4FM5 A;  4RRX A;  5F19 A;  3QMO A;  4RRZ A;  2NQX A;  4O1Z A;  3NAK A;  3PY4 A;  4N7A A;  1DIY A;  3ZS0 C;  4KSZ A;  2E9E A;  3UBA A;  3OLT A;  1MYP C;  1DNW C;  4OEK A;  2EFB A;  2R5L A;  3MQE A;  3R4X A;  3QH0 A;  3ZS1 C;  2IPS A;  3V6Q A;  5HPW A;  3FAQ A;  3ERH A;  1HT5 A;  5FDQ A;  2O86 A;  3R55 A;  5GLS A;  4RRY A;  1DDX A;  2EHA A;  4LJJ A;  4KVJ A;  4M11 A;  5IKQ A;  1HT8 A;  3QF1 A;  5GH0 A;  3RR3 A;  3GCK A; 
#chains in the Genus database with same CATH homology
 1PGE A;  4IG5 A;  1EQH A;  5F1A A;  2PT3 A;  3N8Z A;  1CQE A;  4HHR A;  1PTH A;  3GC1 A;  4KVK A;  4MSF A;  3N8F A;  3HS5 A;  3N8Y B;  1EQG A;  5COX A;  4PNX A;  5KIR A;  3GCL A;  4Y55 A;  2QPK A;  4RRW A;  5IKR A;  1PXX A;  4GN6 A;  4OTJ A;  4Z0L A;  3F9P C;  3Q7D A;  3OGW A;  1EBV A;  5IKT A;  2QRB A;  4GM7 A;  4C1M C;  2OYU P;  4RS0 A;  1CX2 A;  1IGZ A;  3N8W A;  5IKV A;  3N8V A;  3TGY A;  3HS6 A;  4DL1 C;  1D5L C;  1IGX A;  3ERI A;  1FE2 A;  1MHL C;  3HS7 A;  1Q4G A;  4RUT A;  3NTB A;  3NTG A;  4NT3 A;  4OTY A;  3Q9K A;  5FF1 A;  3R5O A;  4KVL A;  1PRH A;  3I6N A;  2PUM A;  3LN1 A;  2QQT A;  3NT1 A;  3KRK A;  2GJM A;  5JVZ A;  4COX A;  5FIW C;  3BXI A;  4NJB A;  4PH9 A;  3KK6 A;  3R5Q A;  3RKE A;  1DNU C;  3LN0 A;  3S4F A;  4QJQ A;  3N8X A;  3NYH A;  5B72 A;  1CXP C;  3MDL A;  3TZI A;  5JVY A;  2OJV A;  3GCJ A;  4E1G A;  2OYE P;  3KRQ A;  4M10 A;  2IKC A;  6COX A;  1U67 A;  3FNL A;  3PGH A;  3N8W B;  3QL6 A;  4QYQ A;  3NIU A;  3SXV A;  1CVU A;  3OLU A;  1D2V C;  3N8Y A;  1D7W C;  4HHS A;  2AYL A;  2Z5Z A;  5JW1 A;  4FM5 A;  4RRX A;  5F19 A;  3QMO A;  4RRZ A;  2NQX A;  4O1Z A;  3NAK A;  3PY4 A;  4N7A A;  1DIY A;  3ZS0 C;  4KSZ A;  2E9E A;  3UBA A;  3OLT A;  1MYP C;  1DNW C;  4OEK A;  2EFB A;  2R5L A;  3MQE A;  3R4X A;  3QH0 A;  3ZS1 C;  2IPS A;  3V6Q A;  5HPW A;  3FAQ A;  3ERH A;  1HT5 A;  5FDQ A;  2O86 A;  3R55 A;  5GLS A;  4RRY A;  1DDX A;  2EHA A;  4LJJ A;  4KVJ A;  4M11 A;  5IKQ A;  1HT8 A;  3QF1 A;  5GH0 A;  3RR3 A;  3GCK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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