4X8YA

Crystal structure of human pgrmc1 cytochrome b5-like domain
Total Genus 33
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
33
sequence length
112
structure length
112
Chain Sequence
SPEFDFTPAELRRFDGVQDPRILMAINGKVFDVTKGRKFYGPEGPYGVFAGRDASRGLATFCLDKEALKDEYDDLSDLTAAQQETLSDWESQFTFKYHHVGKLLKEGEEPTV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance
pubmed doi rcsb
molecule tags Membrane protein
source organism Homo sapiens
molecule keywords Membrane-associated progesterone receptor component 1
total genus 33
structure length 112
sequence length 112
chains with identical sequence B
ec nomenclature
pdb deposition date 2014-12-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00173 Cyt-b5 Cytochrome b5-like Heme/Steroid binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.10.120.10 Alpha Beta Roll Flavocytochrome B2; Chain A, domain 1 Cytochrome b5-like heme/steroid binding domain 4x8yA00
1M20A 1U9UA 3OZZB 1CYOA 1JEXA 1EUEA 4B8NA 2IBJA 1LCOA 1M2IA 3MUSA 1B5BA 1HKOA 3NERA 1LJ0A 1T0GA 3X35A 1ICCA 4HILA 4X8YA 1AXXA 1IEUA 1BFXA 1I8CA 3X34A 3X33A 2I96A 2KEOA 1ES1A 1U9MA 2OZ0A 3LF5A 1X3XA 3KS0A 1F04A 2I89A 1IB7A 1MJ4A 2AXXA 3X32A 1M2MA 2M33A 1BLVA 1EHBA 1MNYA 1I5UA 1KBIA 1M59A 1LDCA 1FCBA 1B5MA 1IETA 1J0QA 1DO9A 1F03A 1SOXA 1AQAA 4HINA 1NX7A 1AWPA 1B5AA 1CXYA 1LQXA 1I87A 1AW3A 1LR6A 1SH4A 1J03A 1LTDA
chains in the Genus database with same CATH superfamily
1M20A 1U9UA 3OZZB 1CYOA 1JEXA 1EUEA 4B8NA 2IBJA 1LCOA 1M2IA 3MUSA 1B5BA 1HKOA 3NERA 1LJ0A 1T0GA 3X35A 1ICCA 4HILA 4X8YA 1AXXA 1IEUA 1BFXA 1I8CA 3X34A 3X33A 2I96A 2KEOA 1ES1A 1U9MA 2OZ0A 3LF5A 1X3XA 3KS0A 1F04A 2I89A 1IB7A 1MJ4A 2AXXA 3X32A 1M2MA 2M33A 1BLVA 1EHBA 1MNYA 1I5UA 1KBIA 1M59A 1LDCA 1FCBA 1B5MA 1IETA 1J0QA 1DO9A 1F03A 1SOXA 1AQAA 4HINA 1NX7A 1AWPA 1B5AA 1CXYA 1LQXA 1I87A 1AW3A 1LR6A 1SH4A 1J03A 1LTDA
chains in the Genus database with same CATH topology
1M20A 1U9UA 3OZZB 1CYOA 1JEXA 1EUEA 4B8NA 2IBJA 1LCOA 1M2IA 3MUSA 1B5BA 1HKOA 3NERA 1LJ0A 1T0GA 3X35A 1ICCA 4HILA 4X8YA 1AXXA 1IEUA 1BFXA 1I8CA 3X34A 3X33A 2I96A 2KEOA 1ES1A 1U9MA 2OZ0A 3LF5A 1X3XA 3KS0A 1F04A 2I89A 1IB7A 1MJ4A 2AXXA 3X32A 1M2MA 2M33A 1BLVA 1EHBA 1MNYA 1I5UA 1KBIA 1M59A 1LDCA 1FCBA 1B5MA 1IETA 1J0QA 1DO9A 1F03A 1SOXA 1AQAA 4HINA 1NX7A 1AWPA 1B5AA 1CXYA 1LQXA 1I87A 1AW3A 1LR6A 1SH4A 1J03A 1LTDA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1M20 A;  1U9U A;  3OZZ B;  1CYO A;  1JEX A;  1EUE A;  4B8N A;  2IBJ A;  1LCO A;  1M2I A;  3MUS A;  1B5B A;  1HKO A;  3NER A;  1LJ0 A;  1T0G A;  3X35 A;  1ICC A;  4HIL A;  4X8Y A;  1AXX A;  1IEU A;  1BFX A;  1I8C A;  3X34 A;  3X33 A;  2I96 A;  2KEO A;  1ES1 A;  1U9M A;  2OZ0 A;  3LF5 A;  1X3X A;  3KS0 A;  1F04 A;  2I89 A;  1IB7 A;  1MJ4 A;  2AXX A;  3X32 A;  1M2M A;  2M33 A;  1BLV A;  1EHB A;  1MNY A;  1I5U A;  1KBI A;  1M59 A;  1LDC A;  1FCB A;  1B5M A;  1IET A;  1J0Q A;  1DO9 A;  1F03 A;  1SOX A;  1AQA A;  4HIN A;  1NX7 A;  1AWP A;  1B5A A;  1CXY A;  1LQX A;  1I87 A;  1AW3 A;  1LR6 A;  1SH4 A;  1J03 A;  1LTD A; 
#chains in the Genus database with same CATH topology
 1M20 A;  1U9U A;  3OZZ B;  1CYO A;  1JEX A;  1EUE A;  4B8N A;  2IBJ A;  1LCO A;  1M2I A;  3MUS A;  1B5B A;  1HKO A;  3NER A;  1LJ0 A;  1T0G A;  3X35 A;  1ICC A;  4HIL A;  4X8Y A;  1AXX A;  1IEU A;  1BFX A;  1I8C A;  3X34 A;  3X33 A;  2I96 A;  2KEO A;  1ES1 A;  1U9M A;  2OZ0 A;  3LF5 A;  1X3X A;  3KS0 A;  1F04 A;  2I89 A;  1IB7 A;  1MJ4 A;  2AXX A;  3X32 A;  1M2M A;  2M33 A;  1BLV A;  1EHB A;  1MNY A;  1I5U A;  1KBI A;  1M59 A;  1LDC A;  1FCB A;  1B5M A;  1IET A;  1J0Q A;  1DO9 A;  1F03 A;  1SOX A;  1AQA A;  4HIN A;  1NX7 A;  1AWP A;  1B5A A;  1CXY A;  1LQX A;  1I87 A;  1AW3 A;  1LR6 A;  1SH4 A;  1J03 A;  1LTD A; 
#chains in the Genus database with same CATH homology
 1M20 A;  1U9U A;  3OZZ B;  1CYO A;  1JEX A;  1EUE A;  4B8N A;  2IBJ A;  1LCO A;  1M2I A;  3MUS A;  1B5B A;  1HKO A;  3NER A;  1LJ0 A;  1T0G A;  3X35 A;  1ICC A;  4HIL A;  4X8Y A;  1AXX A;  1IEU A;  1BFX A;  1I8C A;  3X34 A;  3X33 A;  2I96 A;  2KEO A;  1ES1 A;  1U9M A;  2OZ0 A;  3LF5 A;  1X3X A;  3KS0 A;  1F04 A;  2I89 A;  1IB7 A;  1MJ4 A;  2AXX A;  3X32 A;  1M2M A;  2M33 A;  1BLV A;  1EHB A;  1MNY A;  1I5U A;  1KBI A;  1M59 A;  1LDC A;  1FCB A;  1B5M A;  1IET A;  1J0Q A;  1DO9 A;  1F03 A;  1SOX A;  1AQA A;  4HIN A;  1NX7 A;  1AWP A;  1B5A A;  1CXY A;  1LQX A;  1I87 A;  1AW3 A;  1LR6 A;  1SH4 A;  1J03 A;  1LTD A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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