1SI2A

Crystal structure of the paz domain of human eif2c1 in complex with a 9-mer sirna-like duplex of deoxynucleotide overhang
Total Genus 28
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
28
sequence length
126
structure length
120
Chain Sequence
MAQPVIEFMCEVLDIRNIDEQPKPLTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain.
pubmed doi rcsb
molecule tags Gene regulation/rna/dna
source organism Homo sapiens
molecule keywords 5'-R(*CP*GP*UP*GP*AP*CP*U)-D(P*CP*T)-3'
total genus 28
structure length 120
sequence length 126
ec nomenclature
pdb deposition date 2004-02-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02170 PAZ PAZ domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.260.10 Mainly Beta Beta Complex paz domain paz domain 1si2A00
4Z4HA 4Z4IA 3QIRA 5KI6A 2XFMA 1VYNA 4W5RA 4NGBA 4NGGA 4NH5A 4Z4CA 4OLAA 2QVWA 4NGDA 1R6ZA 2L5CA 3MJ0A 4NGCA 3O7XA 1T2SA 1R4KA 4F3TA 1SI2A 3O6EX 2L5DA 4NGFA 2FFLA 4NH6A 4Z4EA 4NHAA 5JS1A 4W5OA 3O7VX 4NH3A 3O3IX 1SI3A 4W5NA 5T7BA 4Z4GA 1T2RA 4W5TA 4Z4FA 5JS2A 4W5QA 4KREA 4KRFA 4OLBA
chains in the Genus database with same CATH superfamily
3F73A 4Z4HA 3HM9A 4Z4IA 3QIRA 5KI6A 2XFMA 1VYNA 4L1PA 4W5RA 4NGBA 4NGGA 4NH5A 4Z4CA 4OLAA 1U04A 3U1UA 2QVWA 4NGDA 3DLBA 1R6ZA 3HVRA 2L5CA 3MJ0A 3HK2A 4NGCA 3O7XA 1T2SA 1Z26A 1R4KA 4F3TA 1SI2A 2BZEA 1Z25A 3O6EX 2L5DA 2FFLA 3DLHA 4NGFA 4L1UA 4NH6A 4Z4EA 4NHAA 2DB9A 3HJFA 5JS1A 4W5OA 3O7VX 4NH3A 3O3IX 1SI3A 4W5NA 3DA5A 5T7BA 4Z4GA 1T2RA 4W5TA 3HO1A 4Z4FA 5JS2A 4W5QA 4KREA 4KRFA 4OLBA
chains in the Genus database with same CATH topology
3F73A 4Z4HA 3HM9A 4Z4IA 3QIRA 5KI6A 2XFMA 1VYNA 4L1PA 4W5RA 4NGBA 4NGGA 4NH5A 4Z4CA 4OLAA 1U04A 3U1UA 2QVWA 4NGDA 3DLBA 1R6ZA 3HVRA 2L5CA 3MJ0A 3HK2A 4NGCA 3O7XA 1T2SA 1Z26A 1R4KA 4F3TA 1SI2A 2BZEA 1Z25A 3O6EX 2L5DA 2FFLA 3DLHA 4NGFA 4L1UA 4NH6A 4Z4EA 4NHAA 2DB9A 3HJFA 5JS1A 4W5OA 3O7VX 4NH3A 3O3IX 1SI3A 4W5NA 3DA5A 5T7BA 4Z4GA 1T2RA 4W5TA 3HO1A 4Z4FA 5JS2A 4W5QA 4KREA 4KRFA 4OLBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4Z4H A;  4Z4I A;  3QIR A;  5KI6 A;  2XFM A;  1VYN A;  4W5R A;  4NGB A;  4NGG A;  4NH5 A;  4Z4C A;  4OLA A;  2QVW A;  4NGD A;  1R6Z A;  2L5C A;  3MJ0 A;  4NGC A;  3O7X A;  1T2S A;  1R4K A;  4F3T A;  1SI2 A;  3O6E X;  2L5D A;  4NGF A;  2FFL A;  4NH6 A;  4Z4E A;  4NHA A;  5JS1 A;  4W5O A;  3O7V X;  4NH3 A;  3O3I X;  1SI3 A;  4W5N A;  5T7B A;  4Z4G A;  1T2R A;  4W5T A;  4Z4F A;  5JS2 A;  4W5Q A;  4KRE A;  4KRF A;  4OLB A; 
#chains in the Genus database with same CATH topology
 3F73 A;  4Z4H A;  3HM9 A;  4Z4I A;  3QIR A;  5KI6 A;  2XFM A;  1VYN A;  4L1P A;  4W5R A;  4NGB A;  4NGG A;  4NH5 A;  4Z4C A;  4OLA A;  1U04 A;  3U1U A;  2QVW A;  4NGD A;  3DLB A;  1R6Z A;  3HVR A;  2L5C A;  3MJ0 A;  3HK2 A;  4NGC A;  3O7X A;  1T2S A;  1Z26 A;  1R4K A;  4F3T A;  1SI2 A;  2BZE A;  1Z25 A;  3O6E X;  2L5D A;  2FFL A;  3DLH A;  4NGF A;  4L1U A;  4NH6 A;  4Z4E A;  4NHA A;  2DB9 A;  3HJF A;  5JS1 A;  4W5O A;  3O7V X;  4NH3 A;  3O3I X;  1SI3 A;  4W5N A;  3DA5 A;  5T7B A;  4Z4G A;  1T2R A;  4W5T A;  3HO1 A;  4Z4F A;  5JS2 A;  4W5Q A;  4KRE A;  4KRF A;  4OLB A; 
#chains in the Genus database with same CATH homology
 3F73 A;  4Z4H A;  3HM9 A;  4Z4I A;  3QIR A;  5KI6 A;  2XFM A;  1VYN A;  4L1P A;  4W5R A;  4NGB A;  4NGG A;  4NH5 A;  4Z4C A;  4OLA A;  1U04 A;  3U1U A;  2QVW A;  4NGD A;  3DLB A;  1R6Z A;  3HVR A;  2L5C A;  3MJ0 A;  3HK2 A;  4NGC A;  3O7X A;  1T2S A;  1Z26 A;  1R4K A;  4F3T A;  1SI2 A;  2BZE A;  1Z25 A;  3O6E X;  2L5D A;  2FFL A;  3DLH A;  4NGF A;  4L1U A;  4NH6 A;  4Z4E A;  4NHA A;  2DB9 A;  3HJF A;  5JS1 A;  4W5O A;  3O7V X;  4NH3 A;  3O3I X;  1SI3 A;  4W5N A;  3DA5 A;  5T7B A;  4Z4G A;  1T2R A;  4W5T A;  3HO1 A;  4Z4F A;  5JS2 A;  4W5Q A;  4KRE A;  4KRF A;  4OLB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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