1SI2A

Crystal structure of the paz domain of human eif2c1 in complex with a 9-mer sirna-like duplex of deoxynucleotide overhang
Total Genus 28
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
28
sequence length
126
structure length
120
Chain Sequence
MAQPVIEFMCEVLDIRNIDEQPKPLTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain.
pubmed doi rcsb
molecule tags Gene regulation/rna/dna
source organism Homo sapiens
molecule keywords 5'-R(*CP*GP*UP*GP*AP*CP*U)-D(P*CP*T)-3'
total genus 28
structure length 120
sequence length 126
ec nomenclature
pdb deposition date 2004-02-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02170 PAZ PAZ domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.260.10 Mainly Beta Beta Complex paz domain paz domain 1si2A00
4Z4GA 5JS2A 3MJ0A 4W5NA 4NHAA 4KREA 1VYNA 4Z4HA 5KI6A 4NH3A 1SI2A 1R4KA 4Z4CA 4W5TA 3O7VX 4NGDA 4Z4FA 4NGGA 4NGBA 4NH6A 4W5OA 3O7XA 3O6EX 4NGCA 1SI3A 3QIRA 5JS1A 2L5DA 1R6ZA 4OLBA 1T2RA 4Z4IA 4NH5A 4NGFA 4KRFA 4W5QA 1T2SA 4OLAA 2FFLA 2QVWA 4W5RA 4F3TA 2L5CA 2XFMA 5T7BA 3O3IX 4Z4EA
chains in the Genus database with same CATH superfamily
4Z4GA 5JS2A 3MJ0A 4W5NA 4NHAA 4KREA 1VYNA 2DB9A 4L1UA 4Z4HA 5KI6A 3HVRA 1Z26A 3HK2A 1SI2A 4NH3A 1R4KA 4Z4CA 4W5TA 3O7VX 4NGDA 4Z4FA 1Z25A 4NGGA 4NGBA 3HJFA 4NH6A 4W5OA 3U1UA 4L1PA 3O7XA 3O6EX 3HO1A 4NGCA 1SI3A 3QIRA 3HM9A 5JS1A 2BZEA 2L5DA 1R6ZA 3DLHA 3DLBA 4OLBA 1T2RA 4Z4IA 1U04A 4NH5A 3F73A 4NGFA 4KRFA 4W5QA 1T2SA 4OLAA 2FFLA 2QVWA 4W5RA 4F3TA 2L5CA 2XFMA 5T7BA 3O3IX 3DA5A 4Z4EA
chains in the Genus database with same CATH topology
4Z4GA 5JS2A 3MJ0A 4W5NA 4NHAA 4KREA 1VYNA 2DB9A 4L1UA 4Z4HA 5KI6A 3HVRA 1Z26A 3HK2A 1SI2A 4NH3A 1R4KA 4Z4CA 4W5TA 3O7VX 4NGDA 4Z4FA 1Z25A 4NGGA 4NGBA 3HJFA 4NH6A 4W5OA 3U1UA 4L1PA 3O7XA 3O6EX 3HO1A 4NGCA 1SI3A 3QIRA 3HM9A 5JS1A 2BZEA 2L5DA 1R6ZA 3DLHA 3DLBA 4OLBA 1T2RA 4Z4IA 1U04A 4NH5A 3F73A 4NGFA 4KRFA 4W5QA 1T2SA 4OLAA 2FFLA 2QVWA 4W5RA 4F3TA 2L5CA 2XFMA 5T7BA 3O3IX 3DA5A 4Z4EA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4Z4G A;  5JS2 A;  3MJ0 A;  4W5N A;  4NHA A;  4KRE A;  1VYN A;  4Z4H A;  5KI6 A;  4NH3 A;  1SI2 A;  1R4K A;  4Z4C A;  4W5T A;  3O7V X;  4NGD A;  4Z4F A;  4NGG A;  4NGB A;  4NH6 A;  4W5O A;  3O7X A;  3O6E X;  4NGC A;  1SI3 A;  3QIR A;  5JS1 A;  2L5D A;  1R6Z A;  4OLB A;  1T2R A;  4Z4I A;  4NH5 A;  4NGF A;  4KRF A;  4W5Q A;  1T2S A;  4OLA A;  2FFL A;  2QVW A;  4W5R A;  4F3T A;  2L5C A;  2XFM A;  5T7B A;  3O3I X;  4Z4E A; 
#chains in the Genus database with same CATH topology
 4Z4G A;  5JS2 A;  3MJ0 A;  4W5N A;  4NHA A;  4KRE A;  1VYN A;  2DB9 A;  4L1U A;  4Z4H A;  5KI6 A;  3HVR A;  1Z26 A;  3HK2 A;  1SI2 A;  4NH3 A;  1R4K A;  4Z4C A;  4W5T A;  3O7V X;  4NGD A;  4Z4F A;  1Z25 A;  4NGG A;  4NGB A;  3HJF A;  4NH6 A;  4W5O A;  3U1U A;  4L1P A;  3O7X A;  3O6E X;  3HO1 A;  4NGC A;  1SI3 A;  3QIR A;  3HM9 A;  5JS1 A;  2BZE A;  2L5D A;  1R6Z A;  3DLH A;  3DLB A;  4OLB A;  1T2R A;  4Z4I A;  1U04 A;  4NH5 A;  3F73 A;  4NGF A;  4KRF A;  4W5Q A;  1T2S A;  4OLA A;  2FFL A;  2QVW A;  4W5R A;  4F3T A;  2L5C A;  2XFM A;  5T7B A;  3O3I X;  3DA5 A;  4Z4E A; 
#chains in the Genus database with same CATH homology
 4Z4G A;  5JS2 A;  3MJ0 A;  4W5N A;  4NHA A;  4KRE A;  1VYN A;  2DB9 A;  4L1U A;  4Z4H A;  5KI6 A;  3HVR A;  1Z26 A;  3HK2 A;  1SI2 A;  4NH3 A;  1R4K A;  4Z4C A;  4W5T A;  3O7V X;  4NGD A;  4Z4F A;  1Z25 A;  4NGG A;  4NGB A;  3HJF A;  4NH6 A;  4W5O A;  3U1U A;  4L1P A;  3O7X A;  3O6E X;  3HO1 A;  4NGC A;  1SI3 A;  3QIR A;  3HM9 A;  5JS1 A;  2BZE A;  2L5D A;  1R6Z A;  3DLH A;  3DLB A;  4OLB A;  1T2R A;  4Z4I A;  1U04 A;  4NH5 A;  3F73 A;  4NGF A;  4KRF A;  4W5Q A;  1T2S A;  4OLA A;  2FFL A;  2QVW A;  4W5R A;  4F3T A;  2L5C A;  2XFM A;  5T7B A;  3O3I X;  3DA5 A;  4Z4E A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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