1SI3A

Crystal structure of the paz domain of human eif2c1 in complex with a 9-mer sirna-like duplex
Total Genus 26
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
26
sequence length
126
structure length
120
Chain Sequence
MAQPVIEFMCEVLDIRNIDEQPKPLTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain.
pubmed doi rcsb
molecule tags Gene regulation/rna
source organism Homo sapiens
molecule keywords 5'-R(*CP*GP*UP*GP*AP*CP*UP*CP*U)-3'
total genus 26
structure length 120
sequence length 126
ec nomenclature
pdb deposition date 2004-02-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02170 PAZ PAZ domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.260.10 Mainly Beta Beta Complex paz domain paz domain 1si3A00
2FFLA 1SI2A 2XFMA 4NH5A 4KREA 3QIRA 4NGCA 4KRFA 4Z4CA 3O3IX 4W5NA 2L5CA 4Z4FA 3MJ0A 1R4KA 1VYNA 1T2RA 4W5QA 1R6ZA 1T2SA 4OLAA 4NGFA 4NGBA 5T7BA 3O6EX 3O7XA 4NH6A 4W5OA 5JS1A 5JS2A 4Z4GA 2QVWA 4NGDA 4NGGA 4Z4IA 4NH3A 4Z4HA 4OLBA 5KI6A 4F3TA 3O7VX 4Z4EA 4NHAA 4W5RA 4W5TA 1SI3A 2L5DA
chains in the Genus database with same CATH superfamily
3F73A 2FFLA 1SI2A 2XFMA 4NH5A 4KREA 3QIRA 4NGCA 4KRFA 3HJFA 4Z4CA 2BZEA 3O3IX 4W5NA 4L1PA 1U04A 3DA5A 2L5CA 4Z4FA 3MJ0A 1R4KA 1VYNA 1Z25A 2DB9A 1T2RA 4W5QA 1R6ZA 4L1UA 1T2SA 4OLAA 4NGFA 4NGBA 5T7BA 3O6EX 3O7XA 4NH6A 4W5OA 5JS1A 5JS2A 4Z4GA 2QVWA 4NGDA 4NGGA 3U1UA 4Z4IA 3HO1A 4NH3A 4Z4HA 3DLBA 4OLBA 3HK2A 5KI6A 4F3TA 3O7VX 3HM9A 4Z4EA 4W5RA 4W5TA 3DLHA 1SI3A 4NHAA 1Z26A 2L5DA 3HVRA
chains in the Genus database with same CATH topology
3F73A 2FFLA 1SI2A 2XFMA 4NH5A 4KREA 3QIRA 4NGCA 4KRFA 3HJFA 4Z4CA 2BZEA 3O3IX 4W5NA 4L1PA 1U04A 3DA5A 2L5CA 4Z4FA 3MJ0A 1R4KA 1VYNA 1Z25A 2DB9A 1T2RA 4W5QA 1R6ZA 4L1UA 1T2SA 4OLAA 4NGFA 4NGBA 5T7BA 3O6EX 3O7XA 4NH6A 4W5OA 5JS1A 5JS2A 4Z4GA 2QVWA 4NGDA 4NGGA 3U1UA 4Z4IA 3HO1A 4NH3A 4Z4HA 3DLBA 4OLBA 3HK2A 5KI6A 4F3TA 3O7VX 3HM9A 4Z4EA 4W5RA 4W5TA 3DLHA 1SI3A 4NHAA 1Z26A 2L5DA 3HVRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2FFL A;  1SI2 A;  2XFM A;  4NH5 A;  4KRE A;  3QIR A;  4NGC A;  4KRF A;  4Z4C A;  3O3I X;  4W5N A;  2L5C A;  4Z4F A;  3MJ0 A;  1R4K A;  1VYN A;  1T2R A;  4W5Q A;  1R6Z A;  1T2S A;  4OLA A;  4NGF A;  4NGB A;  5T7B A;  3O6E X;  3O7X A;  4NH6 A;  4W5O A;  5JS1 A;  5JS2 A;  4Z4G A;  2QVW A;  4NGD A;  4NGG A;  4Z4I A;  4NH3 A;  4Z4H A;  4OLB A;  5KI6 A;  4F3T A;  3O7V X;  4Z4E A;  4NHA A;  4W5R A;  4W5T A;  1SI3 A;  2L5D A; 
#chains in the Genus database with same CATH topology
 3F73 A;  2FFL A;  1SI2 A;  2XFM A;  4NH5 A;  4KRE A;  3QIR A;  4NGC A;  4KRF A;  3HJF A;  4Z4C A;  2BZE A;  3O3I X;  4W5N A;  4L1P A;  1U04 A;  3DA5 A;  2L5C A;  4Z4F A;  3MJ0 A;  1R4K A;  1VYN A;  1Z25 A;  2DB9 A;  1T2R A;  4W5Q A;  1R6Z A;  4L1U A;  1T2S A;  4OLA A;  4NGF A;  4NGB A;  5T7B A;  3O6E X;  3O7X A;  4NH6 A;  4W5O A;  5JS1 A;  5JS2 A;  4Z4G A;  2QVW A;  4NGD A;  4NGG A;  3U1U A;  4Z4I A;  3HO1 A;  4NH3 A;  4Z4H A;  3DLB A;  4OLB A;  3HK2 A;  5KI6 A;  4F3T A;  3O7V X;  3HM9 A;  4Z4E A;  4W5R A;  4W5T A;  3DLH A;  1SI3 A;  4NHA A;  1Z26 A;  2L5D A;  3HVR A; 
#chains in the Genus database with same CATH homology
 3F73 A;  2FFL A;  1SI2 A;  2XFM A;  4NH5 A;  4KRE A;  3QIR A;  4NGC A;  4KRF A;  3HJF A;  4Z4C A;  2BZE A;  3O3I X;  4W5N A;  4L1P A;  1U04 A;  3DA5 A;  2L5C A;  4Z4F A;  3MJ0 A;  1R4K A;  1VYN A;  1Z25 A;  2DB9 A;  1T2R A;  4W5Q A;  1R6Z A;  4L1U A;  1T2S A;  4OLA A;  4NGF A;  4NGB A;  5T7B A;  3O6E X;  3O7X A;  4NH6 A;  4W5O A;  5JS1 A;  5JS2 A;  4Z4G A;  2QVW A;  4NGD A;  4NGG A;  3U1U A;  4Z4I A;  3HO1 A;  4NH3 A;  4Z4H A;  3DLB A;  4OLB A;  3HK2 A;  5KI6 A;  4F3T A;  3O7V X;  3HM9 A;  4Z4E A;  4W5R A;  4W5T A;  3DLH A;  1SI3 A;  4NHA A;  1Z26 A;  2L5D A;  3HVR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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