1VYJA

Structural and biochemical studies of human pcna complexes provide the basis for association with cdk/cyclin and rationale for inhibitor design
Total Genus 64
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
64
sequence length
257
structure length
257
Chain Sequence
MFEARLVQGSILKKVLEALKDLINEACWDISSSGVNLQSMDSSHVSLVQLTLRSEGFDTYRCDRNLAMGVNLTSMSKILKCAGNEDIITLRAEDNADTLALVFEAPNQEKVSDYEMKLMDLDVEQLGIPEQEYSCVVKMPSGEFARICRDLSHIGDAVVISCAKDGVKFSASGELGNGNIKLSQTSNVDKEEEAVTIEMNEPVQLTFALRYLNFFTKATPLSSTVTLSMSADVPLVVEYKIADMGHLKYYLAPKIED
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural and Biochemical Studies of Human Proliferating Cell Nuclear Antigen Complexes Provide a Rationale for Cyclin Association and Inhibitor Design
pubmed doi rcsb
molecule tags Dna binding protein
source organism Homo sapiens
molecule keywords PROLIFERATING CELL NUCLEAR ANTIGEN
total genus 64
structure length 257
sequence length 257
chains with identical sequence C, E, G, I, K
ec nomenclature
pdb deposition date 2004-04-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00705 PCNA_N Proliferating cell nuclear antigen, N-terminal domain
A PF02747 PCNA_C Proliferating cell nuclear antigen, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.70.10.10 Alpha Beta Box Proliferating Cell Nuclear Antigen Proliferating Cell Nuclear Antigen 1vyjA00
3VKXA 3TBLA 3GGRC 4D2GA 5E0VA 2IJXA 3LX2A 5IXAA 1RWZA 4CS5A 3A2FB 2HIKA 5DA7A 3P87A 5AUJA 2IX2A 3V62B 2NTIC 3GPNA 2IO4A 1UL1A 3U61F 2ZVKA 2HIIB 5CFKA 3WGWA 3FDSC 3F1WA 5B7OA 3GGRB 1B8HA 1T6LA 1PLQA 3LX1A 3G65A 1VYMA 2HIKC 4L60A 2AWAA 3HSLX 2IX2C 3A1JA 1AXCA 3GPMA 5E0TA 1U76A 4L6PA 3AIXB 2NTIB 1ISQA 1IZ5A 1IZ4A 3AIZA 2AVTA 3IFVA 2ZVMA 3FDSD 3G65C 4HK1A 1RXMA 3I2MX 1B77A 2HIKB 2IZOC 4TR6A 2ZVVA 3HI8A 3V60B 1W60A 1PLRA 3U5ZF 3A1JC 5DAIA 4ZTDA 1VYJA 2IX2B 1CZDA 2HIIA 5IY4A 4RJFA 2IO4B 3AIZC 1U7BA 3GGRA 5IWDA 3P91A 3V61B 5JNED 5E0UA 2ZVLA 1SXJF 1DMLA 2ZVWA 5H0TA 5HACA 4YHRA 3G65B 2Z0LA 3K4XA 3AIXA 2NTIA 1GE8A 2IZOB 1YYPA 2OD8A 1UD9A 5A6DA 1RXZA 3A1JB 3P83A 2HIIC 3U60F
chains in the Genus database with same CATH superfamily
3VKXA 3TBLA 3GGRC 4D2GA 5E0VA 2IJXA 3LX2A 5IXAA 1RWZA 4CS5A 3A2FB 2HIKA 5DA7A 3P87A 5AUJA 2IX2A 3V62B 2NTIC 3GPNA 2IO4A 1UL1A 3U61F 2ZVKA 2HIIB 5CFKA 3WGWA 3FDSC 3F1WA 5B7OA 3GGRB 1B8HA 1T6LA 1PLQA 3LX1A 3G65A 1VYMA 2HIKC 4L60A 2AWAA 3HSLX 2IX2C 3A1JA 1AXCA 3GPMA 5E0TA 1U76A 4L6PA 3AIXB 2NTIB 1ISQA 1IZ5A 1IZ4A 3AIZA 2AVTA 3IFVA 2ZVMA 3FDSD 3G65C 4HK1A 1RXMA 3I2MX 1B77A 2HIKB 2IZOC 4TR6A 2ZVVA 3HI8A 3V60B 1W60A 1PLRA 3U5ZF 3A1JC 5DAIA 4ZTDA 1VYJA 2IX2B 1CZDA 2HIIA 5IY4A 4RJFA 2IO4B 3AIZC 1U7BA 3GGRA 5IWDA 3P91A 3V61B 5JNED 5E0UA 2ZVLA 1SXJF 1DMLA 2ZVWA 5H0TA 5HACA 4YHRA 3G65B 2Z0LA 3K4XA 3AIXA 2NTIA 1GE8A 2IZOB 1YYPA 2OD8A 1UD9A 5A6DA 1RXZA 3A1JB 3P83A 2HIIC 3U60F
chains in the Genus database with same CATH topology
3VKXA 3TBLA 3GGRC 4D2GA 5E0VA 2IJXA 3LX2A 5IXAA 1RWZA 4CS5A 3A2FB 2HIKA 5DA7A 3P87A 5AUJA 2IX2A 3V62B 2NTIC 3GPNA 2IO4A 1UL1A 3U61F 2ZVKA 2HIIB 5CFKA 3WGWA 3FDSC 3F1WA 5B7OA 3GGRB 1B8HA 1T6LA 1PLQA 3LX1A 3G65A 1VYMA 2HIKC 4L60A 2AWAA 3HSLX 2IX2C 3A1JA 1AXCA 3GPMA 5E0TA 1U76A 4L6PA 3AIXB 2NTIB 1ISQA 1IZ5A 1IZ4A 3AIZA 2AVTA 3IFVA 2ZVMA 3FDSD 3G65C 4HK1A 1RXMA 3I2MX 1B77A 2HIKB 2IZOC 4TR6A 2ZVVA 3HI8A 3V60B 1W60A 1PLRA 3U5ZF 3A1JC 5DAIA 4ZTDA 1VYJA 2IX2B 1CZDA 2HIIA 5IY4A 4RJFA 2IO4B 3AIZC 1U7BA 3GGRA 5IWDA 3P91A 3V61B 5JNED 5E0UA 2ZVLA 1SXJF 1DMLA 2ZVWA 5H0TA 5HACA 4YHRA 3G65B 2Z0LA 3K4XA 3AIXA 2NTIA 1GE8A 2IZOB 1YYPA 2OD8A 1UD9A 5A6DA 1RXZA 3A1JB 3P83A 2HIIC 3U60F
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3VKX A;  3TBL A;  3GGR C;  4D2G A;  5E0V A;  2IJX A;  3LX2 A;  5IXA A;  1RWZ A;  4CS5 A;  3A2F B;  2HIK A;  5DA7 A;  3P87 A;  5AUJ A;  2IX2 A;  3V62 B;  2NTI C;  3GPN A;  2IO4 A;  1UL1 A;  3U61 F;  2ZVK A;  2HII B;  5CFK A;  3WGW A;  3FDS C;  3F1W A;  5B7O A;  3GGR B;  1B8H A;  1T6L A;  1PLQ A;  3LX1 A;  3G65 A;  1VYM A;  2HIK C;  4L60 A;  2AWA A;  3HSL X;  2IX2 C;  3A1J A;  1AXC A;  3GPM A;  5E0T A;  1U76 A;  4L6P A;  3AIX B;  2NTI B;  1ISQ A;  1IZ5 A;  1IZ4 A;  3AIZ A;  2AVT A;  3IFV A;  2ZVM A;  3FDS D;  3G65 C;  4HK1 A;  1RXM A;  3I2M X;  1B77 A;  2HIK B;  2IZO C;  4TR6 A;  2ZVV A;  3HI8 A;  3V60 B;  1W60 A;  1PLR A;  3U5Z F;  3A1J C;  5DAI A;  4ZTD A;  1VYJ A;  2IX2 B;  1CZD A;  2HII A;  5IY4 A;  4RJF A;  2IO4 B;  3AIZ C;  1U7B A;  3GGR A;  5IWD A;  3P91 A;  3V61 B;  5JNE D;  5E0U A;  2ZVL A;  1SXJ F;  1DML A;  2ZVW A;  5H0T A;  5HAC A;  4YHR A;  3G65 B;  2Z0L A;  3K4X A;  3AIX A;  2NTI A;  1GE8 A;  2IZO B;  1YYP A;  2OD8 A;  1UD9 A;  5A6D A;  1RXZ A;  3A1J B;  3P83 A;  2HII C;  3U60 F; 
#chains in the Genus database with same CATH topology
 3VKX A;  3TBL A;  3GGR C;  4D2G A;  5E0V A;  2IJX A;  3LX2 A;  5IXA A;  1RWZ A;  4CS5 A;  3A2F B;  2HIK A;  5DA7 A;  3P87 A;  5AUJ A;  2IX2 A;  3V62 B;  2NTI C;  3GPN A;  2IO4 A;  1UL1 A;  3U61 F;  2ZVK A;  2HII B;  5CFK A;  3WGW A;  3FDS C;  3F1W A;  5B7O A;  3GGR B;  1B8H A;  1T6L A;  1PLQ A;  3LX1 A;  3G65 A;  1VYM A;  2HIK C;  4L60 A;  2AWA A;  3HSL X;  2IX2 C;  3A1J A;  1AXC A;  3GPM A;  5E0T A;  1U76 A;  4L6P A;  3AIX B;  2NTI B;  1ISQ A;  1IZ5 A;  1IZ4 A;  3AIZ A;  2AVT A;  3IFV A;  2ZVM A;  3FDS D;  3G65 C;  4HK1 A;  1RXM A;  3I2M X;  1B77 A;  2HIK B;  2IZO C;  4TR6 A;  2ZVV A;  3HI8 A;  3V60 B;  1W60 A;  1PLR A;  3U5Z F;  3A1J C;  5DAI A;  4ZTD A;  1VYJ A;  2IX2 B;  1CZD A;  2HII A;  5IY4 A;  4RJF A;  2IO4 B;  3AIZ C;  1U7B A;  3GGR A;  5IWD A;  3P91 A;  3V61 B;  5JNE D;  5E0U A;  2ZVL A;  1SXJ F;  1DML A;  2ZVW A;  5H0T A;  5HAC A;  4YHR A;  3G65 B;  2Z0L A;  3K4X A;  3AIX A;  2NTI A;  1GE8 A;  2IZO B;  1YYP A;  2OD8 A;  1UD9 A;  5A6D A;  1RXZ A;  3A1J B;  3P83 A;  2HII C;  3U60 F; 
#chains in the Genus database with same CATH homology
 3VKX A;  3TBL A;  3GGR C;  4D2G A;  5E0V A;  2IJX A;  3LX2 A;  5IXA A;  1RWZ A;  4CS5 A;  3A2F B;  2HIK A;  5DA7 A;  3P87 A;  5AUJ A;  2IX2 A;  3V62 B;  2NTI C;  3GPN A;  2IO4 A;  1UL1 A;  3U61 F;  2ZVK A;  2HII B;  5CFK A;  3WGW A;  3FDS C;  3F1W A;  5B7O A;  3GGR B;  1B8H A;  1T6L A;  1PLQ A;  3LX1 A;  3G65 A;  1VYM A;  2HIK C;  4L60 A;  2AWA A;  3HSL X;  2IX2 C;  3A1J A;  1AXC A;  3GPM A;  5E0T A;  1U76 A;  4L6P A;  3AIX B;  2NTI B;  1ISQ A;  1IZ5 A;  1IZ4 A;  3AIZ A;  2AVT A;  3IFV A;  2ZVM A;  3FDS D;  3G65 C;  4HK1 A;  1RXM A;  3I2M X;  1B77 A;  2HIK B;  2IZO C;  4TR6 A;  2ZVV A;  3HI8 A;  3V60 B;  1W60 A;  1PLR A;  3U5Z F;  3A1J C;  5DAI A;  4ZTD A;  1VYJ A;  2IX2 B;  1CZD A;  2HII A;  5IY4 A;  4RJF A;  2IO4 B;  3AIZ C;  1U7B A;  3GGR A;  5IWD A;  3P91 A;  3V61 B;  5JNE D;  5E0U A;  2ZVL A;  1SXJ F;  1DML A;  2ZVW A;  5H0T A;  5HAC A;  4YHR A;  3G65 B;  2Z0L A;  3K4X A;  3AIX A;  2NTI A;  1GE8 A;  2IZO B;  1YYP A;  2OD8 A;  1UD9 A;  5A6D A;  1RXZ A;  3A1J B;  3P83 A;  2HII C;  3U60 F; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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