2EB1 | Genus

Total Genus 59

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	59
sequence length	191
structure length	171
Chain Sequence	NHLISGFENFEKKINYRFKNKAYLLQAFTHASYHYNTITDCYQRLEFLGDAILDYLITKHLYEDPRQHSPGVLTDLRSALVNNTIFASLAVKYDYHKYFKAVSPELFHVIDDFVQFQLEKEDIEVPKAMGDIFESLAGAIYMDSGMSLETVWQVYYPMMRPLIEKFSANVP

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Hydrolase
source organism	Homo sapiens
publication title	Homodimeric Structure and Double-stranded RNA Cleavage Activity of the C-terminal RNase III Domain of Human Dicer pubmed doi rcsb
molecule keywords	Endoribonuclease Dicer
total genus	59
structure length	171
sequence length	191
chains with identical sequence	B, C
ec nomenclature	ec 3.1.26.3: Ribonuclease III.
pdb deposition date	2007-02-05

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00636	Ribonuclease_3	Ribonuclease III domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.10.1520.10	Mainly Alpha	Orthogonal Bundle	Ribonuclease iii, N-terminal Endonuclease Domain; Chain A	Ribonuclease III domain	2eb1A00

1YZ9A 4OOGC 4M2ZA 3O2RA 1RC7A 1U61A 3C4TA 2NUGA 2NUEA 4M30A 2EZ6A 2A11A 3N3WA 2NUFA 1YYOA 1O0WA 1I4SA 4OUNA 2QVWA 3O2RB 1JFZA 1YYWA 2GSLA 3C4BA 1YYKA 2EB1A 3RV1A 1RC5A 2FFLA 3RV0A
chains in the Genus database with same CATH superfamily

1YZ9A 4OOGC 4M2ZA 3O2RA 1RC7A 1U61A 3C4TA 2NUGA 2NUEA 4M30A 2EZ6A 2A11A 1ZTDA 3N3WA 2NUFA 1YYOA 1O0WA 1I4SA 4OUNA 2QVWA 3O2RB 1JFZA 1YYWA 2GSLA 3C4BA 1YYKA 2EB1A 3RV1A 1RC5A 2FFLA 3RV0A
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 1YZ9 A;  4OOG C;  4M2Z A;  3O2R A;  1RC7 A;  1U61 A;  3C4T A;  2NUG A;  2NUE A;  4M30 A;  2EZ6 A;  2A11 A;  3N3W A;  2NUF A;  1YYO A;  1O0W A;  1I4S A;  4OUN A;  2QVW A;  3O2R B;  1JFZ A;  1YYW A;  2GSL A;  3C4B A;  1YYK A;  2EB1 A;  3RV1 A;  1RC5 A;  2FFL A;  3RV0 A; 
#chains in the Genus database with same CATH topology
 1YZ9 A;  4OOG C;  4M2Z A;  3O2R A;  1RC7 A;  1U61 A;  3C4T A;  2NUG A;  2NUE A;  4M30 A;  2EZ6 A;  2A11 A;  1ZTD A;  3N3W A;  2NUF A;  1YYO A;  1O0W A;  1I4S A;  4OUN A;  2QVW A;  3O2R B;  1JFZ A;  1YYW A;  2GSL A;  3C4B A;  1YYK A;  2EB1 A;  3RV1 A;  1RC5 A;  2FFL A;  3RV0 A; 
#chains in the Genus database with same CATH homology
 1YZ9 A;  4OOG C;  4M2Z A;  3O2R A;  1RC7 A;  1U61 A;  3C4T A;  2NUG A;  2NUE A;  4M30 A;  2EZ6 A;  2A11 A;  3N3W A;  2NUF A;  1YYO A;  1O0W A;  1I4S A;  4OUN A;  2QVW A;  3O2R B;  1JFZ A;  1YYW A;  2GSL A;  3C4B A;  1YYK A;  2EB1 A;  3RV1 A;  1RC5 A;  2FFL A;  3RV0 A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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2EB1A

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations