2KVDA

Mesencephalic astrocyte-derived neurotrophic factor (manf)
Total Genus 43
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
43
sequence length
160
structure length
160
Chain Sequence
GSLRPGDCEVCISYLGRFYQDLKDRDVTFSPATIENELIKFCREARGKENRLCYYIGATDDAATKIINEVSKPLAHHIPVEKICEKLKKKDSQICELKYDKQIDLSTVDLKKLRVKELKKILDDWGETCKGCAEKSDYIRKINELMPKYAPKAASARTDL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) Has a Unique Mechanism to Rescue Apoptotic Neurons
pubmed doi rcsb
molecule tags Hormone
source organism Homo sapiens
molecule keywords Mesencephalic astrocyte-derived neurotrophic factor
total genus 43
structure length 160
sequence length 160
ec nomenclature
pdb deposition date 2010-03-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF10208 Armet Degradation arginine-rich protein for mis-folding
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.225.10 Mainly Alpha Orthogonal Bundle NK-Lysin Saposin-like 2kvdA01
1.10.720.30 Mainly Alpha Orthogonal Bundle Transcription Termination Factor Rho, Rna-binding Domain; Chain A, Domain 1 SAP domain 2kvdA02
2QYPA 2W50A 2KVUA 1QDMA 2KVDA 4UEXA 2LPNA 2KVEA 2WQGA 2GTGA 1M12A 1N69A 3BQQA 2JVWA 2Z9AA 4DDJA 4BITA 1OF9A 2JSAA 2W51A 3RFIA 1L9LA 2DOBA 2RNOA 1V66A 2R1QA 2JS9A 2RNNA 4V2OA 4UZWA 1H1JS 2RB3A 2R0RA 1JJRA 1JEQA 2RQYA 1SN6A 1ZBHA 3BQPA 3S64A 2KW9A 1NKLA 3S63A
chains in the Genus database with same CATH superfamily
2W50A 1GJJA 2LPNA 2HJQA 2JVWA 2Z9AA 4DDJA 1A63A 2JQ3A 2W51A 1L9LA 2DOBA 4V2OA 2RB3A 1JEQA 3EUKE 2RQYA 1SN6A 3S64A 2KW9A 3L0OA 2G80A 2KVUA 4UEXA 1Y02A 2GTGA 1N69A 3BQQA 3FLGA 2DK4A 1V66A 2R1QA 2JS9A 1ZS9A 3BQPA 3EUJB 2QNCA 1NKLA 3S63A 3QKJA 2KVEA 2WQGA 1M12A 4BITA 1OF9A 1GL9B 2RNNA 4UZWA 1JJRA 1E7DA 1ZBHA 1EN7A 1H9EA 1KHCA 3CJLA 1H9FA 1GKUB 1YNSA 2QYPA 2ODGC 3LLRA 1QDMA 2KVDA 2MPHA 1A8VA 2LC3A 2KFVA 2ODCI 1E7LA 2JSAA 3RFIA 5CIUA 1JEIA 2RNOA 2QNFA 2LD7A 2A8VA 1A62A 1H1JS 2R0RA
chains in the Genus database with same CATH topology
2QYPA 2W50A 2KVUA 1QDMA 2KVDA 4UEXA 2LPNA 2KVEA 2WQGA 2GTGA 1M12A 1N69A 3BQQA 2JVWA 2Z9AA 4DDJA 4BITA 1OF9A 2JSAA 2W51A 3RFIA 1L9LA 2DOBA 2RNOA 1V66A 2R1QA 2JS9A 2RNNA 4V2OA 4UZWA 1H1JS 2RB3A 2R0RA 1JJRA 1JEQA 2RQYA 1SN6A 1ZBHA 3BQPA 3S64A 2KW9A 1NKLA 3S63A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2QYP A;  2W50 A;  2KVU A;  1QDM A;  2KVD A;  4UEX A;  2LPN A;  2KVE A;  2WQG A;  2GTG A;  1M12 A;  1N69 A;  3BQQ A;  2JVW A;  2Z9A A;  4DDJ A;  4BIT A;  1OF9 A;  2JSA A;  2W51 A;  3RFI A;  1L9L A;  2DOB A;  2RNO A;  1V66 A;  2R1Q A;  2JS9 A;  2RNN A;  4V2O A;  4UZW A;  1H1J S;  2RB3 A;  2R0R A;  1JJR A;  1JEQ A;  2RQY A;  1SN6 A;  1ZBH A;  3BQP A;  3S64 A;  2KW9 A;  1NKL A;  3S63 A; 
#chains in the Genus database with same CATH topology
 2W50 A;  1GJJ A;  2LPN A;  2HJQ A;  2JVW A;  2Z9A A;  4DDJ A;  1A63 A;  2JQ3 A;  2W51 A;  1L9L A;  2DOB A;  4V2O A;  2RB3 A;  1JEQ A;  3EUK E;  2RQY A;  1SN6 A;  3S64 A;  2KW9 A;  3L0O A;  2G80 A;  2KVU A;  4UEX A;  1Y02 A;  2GTG A;  1N69 A;  3BQQ A;  3FLG A;  2DK4 A;  1V66 A;  2R1Q A;  2JS9 A;  1ZS9 A;  3BQP A;  3EUJ B;  2QNC A;  1NKL A;  3S63 A;  3QKJ A;  2KVE A;  2WQG A;  1M12 A;  4BIT A;  1OF9 A;  1GL9 B;  2RNN A;  4UZW A;  1JJR A;  1E7D A;  1ZBH A;  1EN7 A;  1H9E A;  1KHC A;  3CJL A;  1H9F A;  1GKU B;  1YNS A;  2QYP A;  2ODG C;  3LLR A;  1QDM A;  2KVD A;  2MPH A;  1A8V A;  2LC3 A;  2KFV A;  2ODC I;  1E7L A;  2JSA A;  3RFI A;  5CIU A;  1JEI A;  2RNO A;  2QNF A;  2LD7 A;  2A8V A;  1A62 A;  1H1J S;  2R0R A; 
#chains in the Genus database with same CATH homology
 2QYP A;  2W50 A;  2KVU A;  1QDM A;  2KVD A;  4UEX A;  2LPN A;  2KVE A;  2WQG A;  2GTG A;  1M12 A;  1N69 A;  3BQQ A;  2JVW A;  2Z9A A;  4DDJ A;  4BIT A;  1OF9 A;  2JSA A;  2W51 A;  3RFI A;  1L9L A;  2DOB A;  2RNO A;  1V66 A;  2R1Q A;  2JS9 A;  2RNN A;  4V2O A;  4UZW A;  1H1J S;  2RB3 A;  2R0R A;  1JJR A;  1JEQ A;  2RQY A;  1SN6 A;  1ZBH A;  3BQP A;  3S64 A;  2KW9 A;  1NKL A;  3S63 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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