2KVDA

Mesencephalic astrocyte-derived neurotrophic factor (manf)
Total Genus 43
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
43
sequence length
160
structure length
160
Chain Sequence
GSLRPGDCEVCISYLGRFYQDLKDRDVTFSPATIENELIKFCREARGKENRLCYYIGATDDAATKIINEVSKPLAHHIPVEKICEKLKKKDSQICELKYDKQIDLSTVDLKKLRVKELKKILDDWGETCKGCAEKSDYIRKINELMPKYAPKAASARTDL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) Has a Unique Mechanism to Rescue Apoptotic Neurons
pubmed doi rcsb
molecule tags Hormone
source organism Homo sapiens
molecule keywords Mesencephalic astrocyte-derived neurotrophic factor
total genus 43
structure length 160
sequence length 160
ec nomenclature
pdb deposition date 2010-03-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF10208 Armet Degradation arginine-rich protein for mis-folding
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.225.10 Mainly Alpha Orthogonal Bundle NK-Lysin Saposin-like 2kvdA01
1.10.720.30 Mainly Alpha Orthogonal Bundle Transcription Termination Factor Rho, Rna-binding Domain; Chain A, Domain 1 SAP domain 2kvdA02
2KW9A 1JEQA 3S63A 1N69A 1NKLA 4UZWA 3BQQA 2JSAA 2DOBA 3RFIA 2R0RA 2GTGA 2KVDA 2RQYA 1SN6A 3S64A 2RB3A 1H1JS 2Z9AA 1QDMA 2KVUA 2LPNA 2RNNA 2JS9A 2WQGA 2KVEA 1L9LA 1M12A 2QYPA 2W51A 4BITA 1JJRA 4DDJA 2RNOA 1ZBHA 2W50A 1OF9A 4UEXA 4V2OA 2JVWA 2R1QA 1V66A 3BQPA
chains in the Genus database with same CATH superfamily
2A8VA 5CIUA 3RFIA 2KVDA 2RQYA 3LLRA 3S64A 2QNFA 1QDMA 2LC3A 2JS9A 2KVEA 1M12A 2W51A 2DK4A 3EUJB 2W50A 1OF9A 4V2OA 2JQ3A 1A8VA 2R1QA 1V66A 3BQPA 3QKJA 1JEQA 3EUKE 3FLGA 1EN7A 2GTGA 2HJQA 3L0OA 2RB3A 2KVUA 1H9FA 2MPHA 1GJJA 2RNNA 3CJLA 2G80A 1JJRA 4BITA 1GL9B 2KW9A 3S63A 2QNCA 3BQQA 1E7LA 2JSAA 1Y02A 2LD7A 1GKUB 1JEIA 1H1JS 1E7DA 2LPNA 2WQGA 1A63A 4DDJA 2ODCI 1YNSA 2JVWA 1N69A 1A62A 1NKLA 4UZWA 2DOBA 2R0RA 1KHCA 1SN6A 2Z9AA 1H9EA 1L9LA 2ODGC 2QYPA 2KFVA 1ZS9A 2RNOA 1ZBHA 4UEXA
chains in the Genus database with same CATH topology
2KW9A 1JEQA 3S63A 1N69A 1NKLA 4UZWA 3BQQA 2JSAA 2DOBA 3RFIA 2R0RA 2GTGA 2KVDA 2RQYA 1SN6A 3S64A 2RB3A 1H1JS 2Z9AA 1QDMA 2KVUA 2LPNA 2RNNA 2JS9A 2WQGA 2KVEA 1L9LA 1M12A 2QYPA 2W51A 4BITA 1JJRA 4DDJA 2RNOA 1ZBHA 2W50A 1OF9A 4UEXA 4V2OA 2JVWA 2R1QA 1V66A 3BQPA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2KW9 A;  1JEQ A;  3S63 A;  1N69 A;  1NKL A;  4UZW A;  3BQQ A;  2JSA A;  2DOB A;  3RFI A;  2R0R A;  2GTG A;  2KVD A;  2RQY A;  1SN6 A;  3S64 A;  2RB3 A;  1H1J S;  2Z9A A;  1QDM A;  2KVU A;  2LPN A;  2RNN A;  2JS9 A;  2WQG A;  2KVE A;  1L9L A;  1M12 A;  2QYP A;  2W51 A;  4BIT A;  1JJR A;  4DDJ A;  2RNO A;  1ZBH A;  2W50 A;  1OF9 A;  4UEX A;  4V2O A;  2JVW A;  2R1Q A;  1V66 A;  3BQP A; 
#chains in the Genus database with same CATH topology
 2A8V A;  5CIU A;  3RFI A;  2KVD A;  2RQY A;  3LLR A;  3S64 A;  2QNF A;  1QDM A;  2LC3 A;  2JS9 A;  2KVE A;  1M12 A;  2W51 A;  2DK4 A;  3EUJ B;  2W50 A;  1OF9 A;  4V2O A;  2JQ3 A;  1A8V A;  2R1Q A;  1V66 A;  3BQP A;  3QKJ A;  1JEQ A;  3EUK E;  3FLG A;  1EN7 A;  2GTG A;  2HJQ A;  3L0O A;  2RB3 A;  2KVU A;  1H9F A;  2MPH A;  1GJJ A;  2RNN A;  3CJL A;  2G80 A;  1JJR A;  4BIT A;  1GL9 B;  2KW9 A;  3S63 A;  2QNC A;  3BQQ A;  1E7L A;  2JSA A;  1Y02 A;  2LD7 A;  1GKU B;  1JEI A;  1H1J S;  1E7D A;  2LPN A;  2WQG A;  1A63 A;  4DDJ A;  2ODC I;  1YNS A;  2JVW A;  1N69 A;  1A62 A;  1NKL A;  4UZW A;  2DOB A;  2R0R A;  1KHC A;  1SN6 A;  2Z9A A;  1H9E A;  1L9L A;  2ODG C;  2QYP A;  2KFV A;  1ZS9 A;  2RNO A;  1ZBH A;  4UEX A; 
#chains in the Genus database with same CATH homology
 2KW9 A;  1JEQ A;  3S63 A;  1N69 A;  1NKL A;  4UZW A;  3BQQ A;  2JSA A;  2DOB A;  3RFI A;  2R0R A;  2GTG A;  2KVD A;  2RQY A;  1SN6 A;  3S64 A;  2RB3 A;  1H1J S;  2Z9A A;  1QDM A;  2KVU A;  2LPN A;  2RNN A;  2JS9 A;  2WQG A;  2KVE A;  1L9L A;  1M12 A;  2QYP A;  2W51 A;  4BIT A;  1JJR A;  4DDJ A;  2RNO A;  1ZBH A;  2W50 A;  1OF9 A;  4UEX A;  4V2O A;  2JVW A;  2R1Q A;  1V66 A;  3BQP A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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