3V3LA

Crystal structure of human rnf146 wwe domain in complex with iso-adpribose
Total Genus 17
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
17
sequence length
83
structure length
83
Chain Sequence
GEYAWYYEGRNGWWQYDERTSRELEDAFSKGKKNTEMLIAGFLYVADLENMVQYRRNEHGRRRKIKRDIIDIPKKGVAGLRLD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Recognition of the iso-ADP-ribose moiety in poly(ADP-ribose) by WWE domains suggests a general mechanism for poly(ADP-ribosyl)ation-dependent ubiquitination.
pubmed doi rcsb
molecule tags Ligase
source organism Homo sapiens
molecule keywords E3 ubiquitin-protein ligase RNF146
total genus 17
structure length 83
sequence length 83
chains with identical sequence B
ec nomenclature ec 2.3.2.27: RING-type E3 ubiquitin transferase.
pdb deposition date 2011-12-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02825 WWE WWE domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.720.50 Alpha Beta 2-Layer Sandwich Signal recognition particle alu RNA binding heterodimer, srp9/1 Signal recognition particle alu RNA binding heterodimer, srp9/1 3v3lA00
1UJRA 1X4RA 2RSFA 3V3LA 2DK6A 2A90A
chains in the Genus database with same CATH superfamily
2KJZA 2X5HA 3VCXA 3TU3B 5BNWA 1E8OB 4GZ6A 3TAXA 2W9JA 1914A 4N3BA 2X5GA 3PE3A 1UJRA 4UYKA 1JNRB 1X4RA 2FJAB 3ITWA 5AOXA 1QMOE 4UYJA 4AY6A 2X5TA 2K4NA 4GZ5A 4N39A 4AY5A 1U7IA 2FJDB 3BT3A 4GYYA 4N3CA 3PE4A 5C1DA 1E8OA 3V3LA 4CDRA 4XIFA 2FJEB 3GYXB 4AKXB 2FFGA 2A90A 3SK1A 4UYKB 4GZ3A 1JNZB 2RSFA 4GYWA 5AOXB 3OMSA 4N3AA 4UYJB 2DK6A 4XI9A 2FJBB
chains in the Genus database with same CATH topology
2KJZA 2X5HA 3VCXA 3TU3B 5BNWA 1E8OB 4GZ6A 3TAXA 2W9JA 1914A 4N3BA 2X5GA 3PE3A 1UJRA 4UYKA 1JNRB 1X4RA 2FJAB 3ITWA 5AOXA 1QMOE 4UYJA 4AY6A 2X5TA 2K4NA 4GZ5A 4N39A 4AY5A 1U7IA 2FJDB 3BT3A 4GYYA 4N3CA 3PE4A 5C1DA 1E8OA 3V3LA 4CDRA 4XIFA 2FJEB 3GYXB 4AKXB 2FFGA 2A90A 3SK1A 4UYKB 4GZ3A 1JNZB 2RSFA 4GYWA 5AOXB 3OMSA 4N3AA 4UYJB 2DK6A 4XI9A 2FJBB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1UJR A;  1X4R A;  2RSF A;  3V3L A;  2DK6 A;  2A90 A; 
#chains in the Genus database with same CATH topology
 2KJZ A;  2X5H A;  3VCX A;  3TU3 B;  5BNW A;  1E8O B;  4GZ6 A;  3TAX A;  2W9J A;  1914 A;  4N3B A;  2X5G A;  3PE3 A;  1UJR A;  4UYK A;  1JNR B;  1X4R A;  2FJA B;  3ITW A;  5AOX A;  1QMO E;  4UYJ A;  4AY6 A;  2X5T A;  2K4N A;  4GZ5 A;  4N39 A;  4AY5 A;  1U7I A;  2FJD B;  3BT3 A;  4GYY A;  4N3C A;  3PE4 A;  5C1D A;  1E8O A;  3V3L A;  4CDR A;  4XIF A;  2FJE B;  3GYX B;  4AKX B;  2FFG A;  2A90 A;  3SK1 A;  4UYK B;  4GZ3 A;  1JNZ B;  2RSF A;  4GYW A;  5AOX B;  3OMS A;  4N3A A;  4UYJ B;  2DK6 A;  4XI9 A;  2FJB B; 
#chains in the Genus database with same CATH homology
 2KJZ A;  2X5H A;  3VCX A;  3TU3 B;  5BNW A;  1E8O B;  4GZ6 A;  3TAX A;  2W9J A;  1914 A;  4N3B A;  2X5G A;  3PE3 A;  1UJR A;  4UYK A;  1JNR B;  1X4R A;  2FJA B;  3ITW A;  5AOX A;  1QMO E;  4UYJ A;  4AY6 A;  2X5T A;  2K4N A;  4GZ5 A;  4N39 A;  4AY5 A;  1U7I A;  2FJD B;  3BT3 A;  4GYY A;  4N3C A;  3PE4 A;  5C1D A;  1E8O A;  3V3L A;  4CDR A;  4XIF A;  2FJE B;  3GYX B;  4AKX B;  2FFG A;  2A90 A;  3SK1 A;  4UYK B;  4GZ3 A;  1JNZ B;  2RSF A;  4GYW A;  5AOX B;  3OMS A;  4N3A A;  4UYJ B;  2DK6 A;  4XI9 A;  2FJB B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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