The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
56
|
sequence length |
255
|
structure length |
248
|
Chain Sequence |
MFEARLVQGSILKKVLEALKDLINEACWDISSSGVNLQSMDSSHVSLVQLTLRSEGFDTYRCDRNLAMGVNLTSMSKILKCAGNEDIITLRAEDNADTLALVFEAPNQEKVSDYEMKLMDLDVEQLGIPEQEYSCVVKMPSGEFARICRDLSHIGDAVVISCAKDGVKFSASGELGNGNIKLSQTEAVTIEMNEPVQLTFALRYLNFFTKATPLSSTVTLSMSADVPLVVEYKIADMGHLKYYLAPKI
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
A small molecule inhibitor of monoubiquitinated proliferating cell nuclear antigen (PCNA) inhibits repair of interstrand DNA crosslink, enhances DNA double-strand break, and sensitizes cancer cells to cisplatin
doi rcsb |
| molecule tags |
Dna binding protein/inhibitor
|
| source organism |
Homo sapiens
|
| molecule keywords |
Proliferating cell nuclear antigen
|
| total genus |
56
|
| structure length |
248
|
| sequence length |
255
|
| chains with identical sequence |
B
|
| ec nomenclature | |
| pdb deposition date | 2013-08-12 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF00705 | PCNA_N | Proliferating cell nuclear antigen, N-terminal domain |
| A | PF02747 | PCNA_C | Proliferating cell nuclear antigen, C-terminal domain |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Alpha Beta | Box | Proliferating Cell Nuclear Antigen | Proliferating Cell Nuclear Antigen |
#chains in the Genus database with same CATH superfamily 1ISQ A; 3LX1 A; 2HIK B; 5JNE D; 2HII C; 2ZVW A; 1T6L A; 1CZD A; 3GPN A; 3GGR A; 3U60 F; 4L6P A; 3WGW A; 5DA7 A; 4ZTD A; 3AIZ A; 5E0T A; 3V60 B; 4YHR A; 1IZ5 A; 3GGR B; 5CFK A; 3TBL A; 5DAI A; 5E0U A; 1W60 A; 1GE8 A; 3U61 F; 2NTI C; 3G65 A; 3I2M X; 3HSL X; 1U7B A; 1PLR A; 2AWA A; 1RXZ A; 3FDS C; 3IFV A; 2ZVM A; 3F1W A; 1UL1 A; 2IZO C; 3G65 B; 1B77 A; 2IJX A; 1PLQ A; 3AIZ C; 2ZVL A; 1VYJ A; 3V62 B; 2HIK C; 1B8H A; 2OD8 A; 3FDS D; 3G65 C; 2IX2 A; 3LX2 A; 4TR6 A; 4RJF A; 5E0V A; 1U76 A; 5H0T A; 2Z0L A; 1IZ4 A; 1YYP A; 3GGR C; 1RXM A; 2AVT A; 2IX2 B; 3HI8 A; 3GPM A; 1RWZ A; 1VYM A; 2IO4 B; 3K4X A; 2IX2 C; 5IXA A; 2ZVV A; 5AUJ A; 3P91 A; 3P83 A; 3A1J A; 5A6D A; 2NTI A; 1SXJ F; 5IWD A; 2IO4 A; 3AIX A; 4D2G A; 1DML A; 2HII A; 3VKX A; 1UD9 A; 3A1J B; 5HAC A; 2NTI B; 4CS5 A; 5B7O A; 2ZVK A; 3AIX B; 2HII B; 4HK1 A; 5IY4 A; 2HIK A; 1AXC A; 2IZO B; 3A1J C; 3P87 A; 3A2F B; 4L60 A; 3V61 B; 3U5Z F; #chains in the Genus database with same CATH topology 1ISQ A; 3LX1 A; 2HIK B; 5JNE D; 2HII C; 2ZVW A; 1T6L A; 1CZD A; 3GPN A; 3GGR A; 3U60 F; 4L6P A; 3WGW A; 5DA7 A; 4ZTD A; 3AIZ A; 5E0T A; 3V60 B; 4YHR A; 1IZ5 A; 3GGR B; 5CFK A; 3TBL A; 5DAI A; 5E0U A; 1W60 A; 1GE8 A; 3U61 F; 2NTI C; 3G65 A; 3I2M X; 3HSL X; 1U7B A; 1PLR A; 2AWA A; 1RXZ A; 3FDS C; 3IFV A; 2ZVM A; 3F1W A; 1UL1 A; 2IZO C; 3G65 B; 1B77 A; 2IJX A; 1PLQ A; 3AIZ C; 2ZVL A; 1VYJ A; 3V62 B; 2HIK C; 1B8H A; 2OD8 A; 3FDS D; 3G65 C; 2IX2 A; 3LX2 A; 4TR6 A; 4RJF A; 5E0V A; 1U76 A; 5H0T A; 2Z0L A; 1IZ4 A; 1YYP A; 3GGR C; 1RXM A; 2AVT A; 2IX2 B; 3HI8 A; 3GPM A; 1RWZ A; 1VYM A; 2IO4 B; 3K4X A; 2IX2 C; 5IXA A; 2ZVV A; 5AUJ A; 3P91 A; 3P83 A; 3A1J A; 5A6D A; 2NTI A; 1SXJ F; 5IWD A; 2IO4 A; 3AIX A; 4D2G A; 1DML A; 2HII A; 3VKX A; 1UD9 A; 3A1J B; 5HAC A; 2NTI B; 4CS5 A; 5B7O A; 2ZVK A; 3AIX B; 2HII B; 4HK1 A; 5IY4 A; 2HIK A; 1AXC A; 2IZO B; 3A1J C; 3P87 A; 3A2F B; 4L60 A; 3V61 B; 3U5Z F; #chains in the Genus database with same CATH homology 1ISQ A; 3LX1 A; 2HIK B; 5JNE D; 2HII C; 2ZVW A; 1T6L A; 1CZD A; 3GPN A; 3GGR A; 3U60 F; 4L6P A; 3WGW A; 5DA7 A; 4ZTD A; 3AIZ A; 5E0T A; 3V60 B; 4YHR A; 1IZ5 A; 3GGR B; 5CFK A; 3TBL A; 5DAI A; 5E0U A; 1W60 A; 1GE8 A; 3U61 F; 2NTI C; 3G65 A; 3I2M X; 3HSL X; 1U7B A; 1PLR A; 2AWA A; 1RXZ A; 3FDS C; 3IFV A; 2ZVM A; 3F1W A; 1UL1 A; 2IZO C; 3G65 B; 1B77 A; 2IJX A; 1PLQ A; 3AIZ C; 2ZVL A; 1VYJ A; 3V62 B; 2HIK C; 1B8H A; 2OD8 A; 3FDS D; 3G65 C; 2IX2 A; 3LX2 A; 4TR6 A; 4RJF A; 5E0V A; 1U76 A; 5H0T A; 2Z0L A; 1IZ4 A; 1YYP A; 3GGR C; 1RXM A; 2AVT A; 2IX2 B; 3HI8 A; 3GPM A; 1RWZ A; 1VYM A; 2IO4 B; 3K4X A; 2IX2 C; 5IXA A; 2ZVV A; 5AUJ A; 3P91 A; 3P83 A; 3A1J A; 5A6D A; 2NTI A; 1SXJ F; 5IWD A; 2IO4 A; 3AIX A; 4D2G A; 1DML A; 2HII A; 3VKX A; 1UD9 A; 3A1J B; 5HAC A; 2NTI B; 4CS5 A; 5B7O A; 2ZVK A; 3AIX B; 2HII B; 4HK1 A; 5IY4 A; 2HIK A; 1AXC A; 2IZO B; 3A1J C; 3P87 A; 3A2F B; 4L60 A; 3V61 B; 3U5Z F;
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