4NGBA

Structure of human dicer platform-paz-connector helix cassette in complex with 12-mer sirna having uu-3' ends (2.25 angstrom resolution)
Total Genus 70
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
70
sequence length
298
structure length
276
Chain Sequence
QPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELAASGFMLSLQMLELITRLHQYIFSHILRLEKPALAYCVLPLNVVSSTLDIDFKFMEDIEKSEARIGIPSTKYTKETPFVFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLTNLNQPLLDVDHTSSRLNLLTPLSSAEKRKAKWESLQNKQILVPELCAIHPIPASLWRKAVCLPSILYRLHC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer.
pubmed doi rcsb
molecule tags Hydrolase/rna
source organism Homo sapiens
molecule keywords Endoribonuclease Dicer
total genus 70
structure length 276
sequence length 298
ec nomenclature ec 3.1.26.3: Ribonuclease III.
pdb deposition date 2013-11-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02170 PAZ PAZ domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.260.10 Mainly Beta Beta Complex paz domain paz domain 4ngbA02
3QIRA 5KI6A 1T2RA 4Z4HA 1VYNA 4NGDA 3MJ0A 4Z4EA 4KREA 4Z4FA 4F3TA 2L5DA 4NGFA 4NGBA 4NH6A 3O6EX 4OLBA 4W5RA 1R6ZA 2FFLA 4W5OA 4NH5A 4W5QA 4OLAA 4Z4IA 4W5TA 4KRFA 5T7BA 4Z4GA 1R4KA 3O7XA 2QVWA 4Z4CA 2XFMA 3O3IX 4NGGA 3O7VX 1SI3A 4NGCA 5JS2A 1SI2A 4NH3A 5JS1A 1T2SA 4NHAA 4W5NA 2L5CA
chains in the Genus database with same CATH superfamily
3QIRA 1U04A 3DLHA 5KI6A 1T2RA 4Z4HA 3HJFA 3HO1A 1VYNA 1Z26A 4NGDA 3MJ0A 4W5NA 3U1UA 3HVRA 4Z4EA 4KREA 4Z4FA 4F3TA 2L5DA 4NGFA 4NGBA 4NH6A 3O6EX 2BZEA 4OLBA 1Z25A 4W5RA 1R6ZA 2FFLA 4W5OA 4NH5A 2DB9A 4W5QA 3HM9A 3HK2A 4OLAA 4Z4IA 4W5TA 4KRFA 5T7BA 4Z4GA 1R4KA 3O7XA 2QVWA 4Z4CA 2XFMA 3O3IX 4NGGA 4L1PA 3O7VX 1SI3A 4NGCA 5JS2A 1SI2A 4NH3A 3DLBA 3F73A 5JS1A 1T2SA 4NHAA 4L1UA 2L5CA 3DA5A
chains in the Genus database with same CATH topology
3QIRA 1U04A 3DLHA 5KI6A 1T2RA 4Z4HA 3HJFA 3HO1A 1VYNA 1Z26A 4NGDA 3MJ0A 4W5NA 3U1UA 3HVRA 4Z4EA 4KREA 4Z4FA 4F3TA 2L5DA 4NGFA 4NGBA 4NH6A 3O6EX 2BZEA 4OLBA 1Z25A 4W5RA 1R6ZA 2FFLA 4W5OA 4NH5A 2DB9A 4W5QA 3HM9A 3HK2A 4OLAA 4Z4IA 4W5TA 4KRFA 5T7BA 4Z4GA 1R4KA 3O7XA 2QVWA 4Z4CA 2XFMA 3O3IX 4NGGA 4L1PA 3O7VX 1SI3A 4NGCA 5JS2A 1SI2A 4NH3A 3DLBA 3F73A 5JS1A 1T2SA 4NHAA 4L1UA 2L5CA 3DA5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3QIR A;  5KI6 A;  1T2R A;  4Z4H A;  1VYN A;  4NGD A;  3MJ0 A;  4Z4E A;  4KRE A;  4Z4F A;  4F3T A;  2L5D A;  4NGF A;  4NGB A;  4NH6 A;  3O6E X;  4OLB A;  4W5R A;  1R6Z A;  2FFL A;  4W5O A;  4NH5 A;  4W5Q A;  4OLA A;  4Z4I A;  4W5T A;  4KRF A;  5T7B A;  4Z4G A;  1R4K A;  3O7X A;  2QVW A;  4Z4C A;  2XFM A;  3O3I X;  4NGG A;  3O7V X;  1SI3 A;  4NGC A;  5JS2 A;  1SI2 A;  4NH3 A;  5JS1 A;  1T2S A;  4NHA A;  4W5N A;  2L5C A; 
#chains in the Genus database with same CATH topology
 3QIR A;  1U04 A;  3DLH A;  5KI6 A;  1T2R A;  4Z4H A;  3HJF A;  3HO1 A;  1VYN A;  1Z26 A;  4NGD A;  3MJ0 A;  4W5N A;  3U1U A;  3HVR A;  4Z4E A;  4KRE A;  4Z4F A;  4F3T A;  2L5D A;  4NGF A;  4NGB A;  4NH6 A;  3O6E X;  2BZE A;  4OLB A;  1Z25 A;  4W5R A;  1R6Z A;  2FFL A;  4W5O A;  4NH5 A;  2DB9 A;  4W5Q A;  3HM9 A;  3HK2 A;  4OLA A;  4Z4I A;  4W5T A;  4KRF A;  5T7B A;  4Z4G A;  1R4K A;  3O7X A;  2QVW A;  4Z4C A;  2XFM A;  3O3I X;  4NGG A;  4L1P A;  3O7V X;  1SI3 A;  4NGC A;  5JS2 A;  1SI2 A;  4NH3 A;  3DLB A;  3F73 A;  5JS1 A;  1T2S A;  4NHA A;  4L1U A;  2L5C A;  3DA5 A; 
#chains in the Genus database with same CATH homology
 3QIR A;  1U04 A;  3DLH A;  5KI6 A;  1T2R A;  4Z4H A;  3HJF A;  3HO1 A;  1VYN A;  1Z26 A;  4NGD A;  3MJ0 A;  4W5N A;  3U1U A;  3HVR A;  4Z4E A;  4KRE A;  4Z4F A;  4F3T A;  2L5D A;  4NGF A;  4NGB A;  4NH6 A;  3O6E X;  2BZE A;  4OLB A;  1Z25 A;  4W5R A;  1R6Z A;  2FFL A;  4W5O A;  4NH5 A;  2DB9 A;  4W5Q A;  3HM9 A;  3HK2 A;  4OLA A;  4Z4I A;  4W5T A;  4KRF A;  5T7B A;  4Z4G A;  1R4K A;  3O7X A;  2QVW A;  4Z4C A;  2XFM A;  3O3I X;  4NGG A;  4L1P A;  3O7V X;  1SI3 A;  4NGC A;  5JS2 A;  1SI2 A;  4NH3 A;  3DLB A;  3F73 A;  5JS1 A;  1T2S A;  4NHA A;  4L1U A;  2L5C A;  3DA5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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