4NGBA

Structure of human dicer platform-paz-connector helix cassette in complex with 12-mer sirna having uu-3' ends (2.25 angstrom resolution)
Total Genus 70
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
70
sequence length
298
structure length
276
Chain Sequence
QPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELAASGFMLSLQMLELITRLHQYIFSHILRLEKPALAYCVLPLNVVSSTLDIDFKFMEDIEKSEARIGIPSTKYTKETPFVFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLTNLNQPLLDVDHTSSRLNLLTPLSSAEKRKAKWESLQNKQILVPELCAIHPIPASLWRKAVCLPSILYRLHC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase/rna
source organism Homo sapiens
publication title A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer.
pubmed doi rcsb
molecule keywords Endoribonuclease Dicer
total genus 70
structure length 276
sequence length 298
ec nomenclature ec 3.1.26.3: Ribonuclease III.
pdb deposition date 2013-11-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02170 PAZ PAZ domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.260.10 Mainly Beta Beta Complex paz domain paz domain 4ngbA02
1T2SA 4Z4CA 4NH3A 4Z4FA 2L5DA 2FFLA 4NH5A 5JS2A 4W5OA 1R4KA 1SI2A 4OLAA 3O7XA 5KI6A 4W5RA 4F3TA 2XFMA 3O3IX 4W5QA 3O7VX 4NGCA 2L5CA 3O6EX 4NGDA 4W5NA 3MJ0A 1T2RA 4NH6A 4Z4GA 4NGFA 4Z4EA 4OLBA 4KRFA 5JS1A 4NHAA 1R6ZA 4KREA 3QIRA 5T7BA 4NGGA 1SI3A 4NGBA 1VYNA 2QVWA 4W5TA 4Z4HA 4Z4IA
chains in the Genus database with same CATH superfamily
1T2SA 3HJFA 4Z4CA 4NH3A 4Z4FA 2DB9A 2FFLA 2L5DA 1Z25A 4NH5A 5JS2A 4W5OA 3HVRA 1R4KA 1SI2A 3DLHA 4OLAA 3O7XA 5KI6A 4W5RA 3HK2A 4F3TA 1Z26A 2BZEA 2XFMA 3F73A 3O3IX 4L1UA 4W5QA 3HO1A 3O7VX 4NGCA 2L5CA 3O6EX 3DLBA 4NGDA 4W5NA 3MJ0A 1T2RA 4NH6A 3U1UA 4Z4GA 4NGFA 4Z4EA 4L1PA 4OLBA 4KRFA 1U04A 4NHAA 1R6ZA 3DA5A 5JS1A 4KREA 3QIRA 5T7BA 4NGGA 3HM9A 1SI3A 4NGBA 1VYNA 2QVWA 4W5TA 4Z4HA 4Z4IA
chains in the Genus database with same CATH topology
1T2SA 3HJFA 4Z4CA 4NH3A 4Z4FA 2DB9A 2FFLA 2L5DA 1Z25A 4NH5A 5JS2A 4W5OA 3HVRA 1R4KA 1SI2A 3DLHA 4OLAA 3O7XA 5KI6A 4W5RA 3HK2A 4F3TA 1Z26A 2BZEA 2XFMA 3F73A 3O3IX 4L1UA 4W5QA 3HO1A 3O7VX 4NGCA 2L5CA 3O6EX 3DLBA 4NGDA 4W5NA 3MJ0A 1T2RA 4NH6A 3U1UA 4Z4GA 4NGFA 4Z4EA 4L1PA 4OLBA 4KRFA 1U04A 4NHAA 1R6ZA 3DA5A 5JS1A 4KREA 3QIRA 5T7BA 4NGGA 3HM9A 1SI3A 4NGBA 1VYNA 2QVWA 4W5TA 4Z4HA 4Z4IA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1T2S A;  4Z4C A;  4NH3 A;  4Z4F A;  2L5D A;  2FFL A;  4NH5 A;  5JS2 A;  4W5O A;  1R4K A;  1SI2 A;  4OLA A;  3O7X A;  5KI6 A;  4W5R A;  4F3T A;  2XFM A;  3O3I X;  4W5Q A;  3O7V X;  4NGC A;  2L5C A;  3O6E X;  4NGD A;  4W5N A;  3MJ0 A;  1T2R A;  4NH6 A;  4Z4G A;  4NGF A;  4Z4E A;  4OLB A;  4KRF A;  5JS1 A;  4NHA A;  1R6Z A;  4KRE A;  3QIR A;  5T7B A;  4NGG A;  1SI3 A;  4NGB A;  1VYN A;  2QVW A;  4W5T A;  4Z4H A;  4Z4I A; 
#chains in the Genus database with same CATH topology
 1T2S A;  3HJF A;  4Z4C A;  4NH3 A;  4Z4F A;  2DB9 A;  2FFL A;  2L5D A;  1Z25 A;  4NH5 A;  5JS2 A;  4W5O A;  3HVR A;  1R4K A;  1SI2 A;  3DLH A;  4OLA A;  3O7X A;  5KI6 A;  4W5R A;  3HK2 A;  4F3T A;  1Z26 A;  2BZE A;  2XFM A;  3F73 A;  3O3I X;  4L1U A;  4W5Q A;  3HO1 A;  3O7V X;  4NGC A;  2L5C A;  3O6E X;  3DLB A;  4NGD A;  4W5N A;  3MJ0 A;  1T2R A;  4NH6 A;  3U1U A;  4Z4G A;  4NGF A;  4Z4E A;  4L1P A;  4OLB A;  4KRF A;  1U04 A;  4NHA A;  1R6Z A;  3DA5 A;  5JS1 A;  4KRE A;  3QIR A;  5T7B A;  4NGG A;  3HM9 A;  1SI3 A;  4NGB A;  1VYN A;  2QVW A;  4W5T A;  4Z4H A;  4Z4I A; 
#chains in the Genus database with same CATH homology
 1T2S A;  3HJF A;  4Z4C A;  4NH3 A;  4Z4F A;  2DB9 A;  2FFL A;  2L5D A;  1Z25 A;  4NH5 A;  5JS2 A;  4W5O A;  3HVR A;  1R4K A;  1SI2 A;  3DLH A;  4OLA A;  3O7X A;  5KI6 A;  4W5R A;  3HK2 A;  4F3T A;  1Z26 A;  2BZE A;  2XFM A;  3F73 A;  3O3I X;  4L1U A;  4W5Q A;  3HO1 A;  3O7V X;  4NGC A;  2L5C A;  3O6E X;  3DLB A;  4NGD A;  4W5N A;  3MJ0 A;  1T2R A;  4NH6 A;  3U1U A;  4Z4G A;  4NGF A;  4Z4E A;  4L1P A;  4OLB A;  4KRF A;  1U04 A;  4NHA A;  1R6Z A;  3DA5 A;  5JS1 A;  4KRE A;  3QIR A;  5T7B A;  4NGG A;  3HM9 A;  1SI3 A;  4NGB A;  1VYN A;  2QVW A;  4W5T A;  4Z4H A;  4Z4I A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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