4NGCA

Structure of human dicer platform-paz-connector helix cassette in complex with 12-mer sirna having ua-3' ends (2.1 angstrom resolution)
Total Genus 71
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
71
sequence length
299
structure length
276
Chain Sequence
DQPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELAASGFMLSLQMLELITRLHQYIFSHILRLEKPALYCVLPLNVVSSTLDIDFKFMEDIEKSEARIGIPSTKYTKETPFVFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLTNLNQPLLDVDHTSSRLNLLTPLSSAEKRKAKWESLQNKQILVPELCAIHPIPASLWRKAVCLPSILYRLHC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer.
pubmed doi rcsb
molecule tags Hydrolase/rna
source organism Homo sapiens
molecule keywords Endoribonuclease Dicer
total genus 71
structure length 276
sequence length 299
ec nomenclature ec 3.1.26.3: Ribonuclease III.
pdb deposition date 2013-11-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02170 PAZ PAZ domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.260.10 Mainly Beta Beta Complex paz domain paz domain 4ngcA02
3QIRA 5JS1A 1SI3A 2L5DA 4Z4FA 2QVWA 4NGGA 4OLAA 3O3IX 4NGFA 4NHAA 4Z4CA 4NH5A 4NGCA 4W5TA 4Z4HA 2FFLA 4W5OA 2XFMA 3O6EX 1VYNA 3MJ0A 4W5QA 4Z4GA 4NH3A 5T7BA 3O7XA 4OLBA 1R4KA 4NH6A 1T2RA 4W5RA 3O7VX 5KI6A 4NGDA 4NGBA 4Z4EA 4Z4IA 2L5CA 1R6ZA 1T2SA 1SI2A 4KREA 4W5NA 4F3TA 5JS2A 4KRFA
chains in the Genus database with same CATH superfamily
3QIRA 5JS1A 1SI3A 4KRFA 3HK2A 2L5DA 4Z4FA 2QVWA 1Z25A 3F73A 4NGGA 3O3IX 4NGFA 4OLAA 4NHAA 4Z4CA 4NH5A 4NGCA 4W5NA 4W5TA 4Z4HA 2FFLA 4W5OA 4L1UA 2XFMA 3DLBA 3HM9A 3O6EX 2BZEA 2DB9A 1VYNA 4W5QA 4Z4GA 3MJ0A 5T7BA 4NH3A 3O7XA 4OLBA 1R4KA 4NH6A 1Z26A 3DLHA 1T2RA 3DA5A 4W5RA 3O7VX 5KI6A 4NGDA 4NGBA 4Z4EA 3HO1A 4Z4IA 2L5CA 3HVRA 1R6ZA 4L1PA 1T2SA 1SI2A 3HJFA 4F3TA 4KREA 3U1UA 5JS2A 1U04A
chains in the Genus database with same CATH topology
3QIRA 5JS1A 1SI3A 4KRFA 3HK2A 2L5DA 4Z4FA 2QVWA 1Z25A 3F73A 4NGGA 3O3IX 4NGFA 4OLAA 4NHAA 4Z4CA 4NH5A 4NGCA 4W5NA 4W5TA 4Z4HA 2FFLA 4W5OA 4L1UA 2XFMA 3DLBA 3HM9A 3O6EX 2BZEA 2DB9A 1VYNA 4W5QA 4Z4GA 3MJ0A 5T7BA 4NH3A 3O7XA 4OLBA 1R4KA 4NH6A 1Z26A 3DLHA 1T2RA 3DA5A 4W5RA 3O7VX 5KI6A 4NGDA 4NGBA 4Z4EA 3HO1A 4Z4IA 2L5CA 3HVRA 1R6ZA 4L1PA 1T2SA 1SI2A 3HJFA 4F3TA 4KREA 3U1UA 5JS2A 1U04A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3QIR A;  5JS1 A;  1SI3 A;  2L5D A;  4Z4F A;  2QVW A;  4NGG A;  4OLA A;  3O3I X;  4NGF A;  4NHA A;  4Z4C A;  4NH5 A;  4NGC A;  4W5T A;  4Z4H A;  2FFL A;  4W5O A;  2XFM A;  3O6E X;  1VYN A;  3MJ0 A;  4W5Q A;  4Z4G A;  4NH3 A;  5T7B A;  3O7X A;  4OLB A;  1R4K A;  4NH6 A;  1T2R A;  4W5R A;  3O7V X;  5KI6 A;  4NGD A;  4NGB A;  4Z4E A;  4Z4I A;  2L5C A;  1R6Z A;  1T2S A;  1SI2 A;  4KRE A;  4W5N A;  4F3T A;  5JS2 A;  4KRF A; 
#chains in the Genus database with same CATH topology
 3QIR A;  5JS1 A;  1SI3 A;  4KRF A;  3HK2 A;  2L5D A;  4Z4F A;  2QVW A;  1Z25 A;  3F73 A;  4NGG A;  3O3I X;  4NGF A;  4OLA A;  4NHA A;  4Z4C A;  4NH5 A;  4NGC A;  4W5N A;  4W5T A;  4Z4H A;  2FFL A;  4W5O A;  4L1U A;  2XFM A;  3DLB A;  3HM9 A;  3O6E X;  2BZE A;  2DB9 A;  1VYN A;  4W5Q A;  4Z4G A;  3MJ0 A;  5T7B A;  4NH3 A;  3O7X A;  4OLB A;  1R4K A;  4NH6 A;  1Z26 A;  3DLH A;  1T2R A;  3DA5 A;  4W5R A;  3O7V X;  5KI6 A;  4NGD A;  4NGB A;  4Z4E A;  3HO1 A;  4Z4I A;  2L5C A;  3HVR A;  1R6Z A;  4L1P A;  1T2S A;  1SI2 A;  3HJF A;  4F3T A;  4KRE A;  3U1U A;  5JS2 A;  1U04 A; 
#chains in the Genus database with same CATH homology
 3QIR A;  5JS1 A;  1SI3 A;  4KRF A;  3HK2 A;  2L5D A;  4Z4F A;  2QVW A;  1Z25 A;  3F73 A;  4NGG A;  3O3I X;  4NGF A;  4OLA A;  4NHA A;  4Z4C A;  4NH5 A;  4NGC A;  4W5N A;  4W5T A;  4Z4H A;  2FFL A;  4W5O A;  4L1U A;  2XFM A;  3DLB A;  3HM9 A;  3O6E X;  2BZE A;  2DB9 A;  1VYN A;  4W5Q A;  4Z4G A;  3MJ0 A;  5T7B A;  4NH3 A;  3O7X A;  4OLB A;  1R4K A;  4NH6 A;  1Z26 A;  3DLH A;  1T2R A;  3DA5 A;  4W5R A;  3O7V X;  5KI6 A;  4NGD A;  4NGB A;  4Z4E A;  3HO1 A;  4Z4I A;  2L5C A;  3HVR A;  1R6Z A;  4L1P A;  1T2S A;  1SI2 A;  3HJF A;  4F3T A;  4KRE A;  3U1U A;  5JS2 A;  1U04 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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