4NGFA

Structure of human dicer platform-paz-connector helix cassette in complex with 17-mer sirna having 5'-p and uu-3' ends (3.1 angstrom resolution)
Total Genus 50
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
50
sequence length
298
structure length
260
Chain Sequence
QPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELKKSGFMLSLQMLELITRLHQYIFSHILRYCVLPLNVVSTLDIDFKFMEDIEKSETKETPFVFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLTNLNQPLLDVDHTSSRLNLLTPRPLSSAEKRKAKWESLQNKQILVPELCAIHPIPASLWRKAVCLPSILYRLHC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer.
pubmed doi rcsb
molecule tags Hydrolase/rna
source organism Homo sapiens
molecule keywords Endoribonuclease Dicer
total genus 50
structure length 260
sequence length 298
chains with identical sequence B, C, D
ec nomenclature ec 3.1.26.3: Ribonuclease III.
pdb deposition date 2013-11-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02170 PAZ PAZ domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.260.10 Mainly Beta Beta Complex paz domain paz domain 4ngfA02
4Z4GA 5JS2A 4Z4FA 1SI3A 4W5OA 4OLBA 4Z4HA 5T7BA 3QIRA 4F3TA 2L5CA 3O7VX 2FFLA 1VYNA 2XFMA 4OLAA 4NGDA 4NGGA 4Z4EA 4NHAA 4W5TA 2L5DA 5KI6A 4NH5A 4NGCA 4KREA 4NH6A 3O6EX 3O3IX 4NGBA 3O7XA 4Z4IA 1R6ZA 5JS1A 4KRFA 1R4KA 4NH3A 1SI2A 1T2RA 4W5RA 3MJ0A 4Z4CA 4W5QA 4W5NA 1T2SA 4NGFA 2QVWA
chains in the Genus database with same CATH superfamily
1U04A 4Z4GA 5JS2A 3HO1A 4Z4FA 1SI3A 4W5OA 4OLBA 4Z4HA 5T7BA 1Z26A 3QIRA 3DA5A 3DLBA 4F3TA 2L5CA 3O7VX 2FFLA 3DLHA 1VYNA 2XFMA 3HJFA 4OLAA 3HK2A 4NGDA 4NGGA 4Z4EA 4NHAA 4W5TA 2L5DA 5KI6A 4NH5A 4NGCA 3HVRA 4KREA 4NH6A 2BZEA 1Z25A 3O6EX 3O3IX 4NGBA 3O7XA 3HM9A 1R6ZA 4Z4IA 2DB9A 5JS1A 4KRFA 1R4KA 4NH3A 1SI2A 4L1PA 1T2RA 4W5RA 3U1UA 3MJ0A 4Z4CA 4W5QA 4W5NA 1T2SA 4NGFA 2QVWA 3F73A 4L1UA
chains in the Genus database with same CATH topology
1U04A 4Z4GA 5JS2A 3HO1A 4Z4FA 1SI3A 4W5OA 4OLBA 4Z4HA 5T7BA 1Z26A 3QIRA 3DA5A 3DLBA 4F3TA 2L5CA 3O7VX 2FFLA 3DLHA 1VYNA 2XFMA 3HJFA 4OLAA 3HK2A 4NGDA 4NGGA 4Z4EA 4NHAA 4W5TA 2L5DA 5KI6A 4NH5A 4NGCA 3HVRA 4KREA 4NH6A 2BZEA 1Z25A 3O6EX 3O3IX 4NGBA 3O7XA 3HM9A 1R6ZA 4Z4IA 2DB9A 5JS1A 4KRFA 1R4KA 4NH3A 1SI2A 4L1PA 1T2RA 4W5RA 3U1UA 3MJ0A 4Z4CA 4W5QA 4W5NA 1T2SA 4NGFA 2QVWA 3F73A 4L1UA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4Z4G A;  5JS2 A;  4Z4F A;  1SI3 A;  4W5O A;  4OLB A;  4Z4H A;  5T7B A;  3QIR A;  4F3T A;  2L5C A;  3O7V X;  2FFL A;  1VYN A;  2XFM A;  4OLA A;  4NGD A;  4NGG A;  4Z4E A;  4NHA A;  4W5T A;  2L5D A;  5KI6 A;  4NH5 A;  4NGC A;  4KRE A;  4NH6 A;  3O6E X;  3O3I X;  4NGB A;  3O7X A;  4Z4I A;  1R6Z A;  5JS1 A;  4KRF A;  1R4K A;  4NH3 A;  1SI2 A;  1T2R A;  4W5R A;  3MJ0 A;  4Z4C A;  4W5Q A;  4W5N A;  1T2S A;  4NGF A;  2QVW A; 
#chains in the Genus database with same CATH topology
 1U04 A;  4Z4G A;  5JS2 A;  3HO1 A;  4Z4F A;  1SI3 A;  4W5O A;  4OLB A;  4Z4H A;  5T7B A;  1Z26 A;  3QIR A;  3DA5 A;  3DLB A;  4F3T A;  2L5C A;  3O7V X;  2FFL A;  3DLH A;  1VYN A;  2XFM A;  3HJF A;  4OLA A;  3HK2 A;  4NGD A;  4NGG A;  4Z4E A;  4NHA A;  4W5T A;  2L5D A;  5KI6 A;  4NH5 A;  4NGC A;  3HVR A;  4KRE A;  4NH6 A;  2BZE A;  1Z25 A;  3O6E X;  3O3I X;  4NGB A;  3O7X A;  3HM9 A;  1R6Z A;  4Z4I A;  2DB9 A;  5JS1 A;  4KRF A;  1R4K A;  4NH3 A;  1SI2 A;  4L1P A;  1T2R A;  4W5R A;  3U1U A;  3MJ0 A;  4Z4C A;  4W5Q A;  4W5N A;  1T2S A;  4NGF A;  2QVW A;  3F73 A;  4L1U A; 
#chains in the Genus database with same CATH homology
 1U04 A;  4Z4G A;  5JS2 A;  3HO1 A;  4Z4F A;  1SI3 A;  4W5O A;  4OLB A;  4Z4H A;  5T7B A;  1Z26 A;  3QIR A;  3DA5 A;  3DLB A;  4F3T A;  2L5C A;  3O7V X;  2FFL A;  3DLH A;  1VYN A;  2XFM A;  3HJF A;  4OLA A;  3HK2 A;  4NGD A;  4NGG A;  4Z4E A;  4NHA A;  4W5T A;  2L5D A;  5KI6 A;  4NH5 A;  4NGC A;  3HVR A;  4KRE A;  4NH6 A;  2BZE A;  1Z25 A;  3O6E X;  3O3I X;  4NGB A;  3O7X A;  3HM9 A;  1R6Z A;  4Z4I A;  2DB9 A;  5JS1 A;  4KRF A;  1R4K A;  4NH3 A;  1SI2 A;  4L1P A;  1T2R A;  4W5R A;  3U1U A;  3MJ0 A;  4Z4C A;  4W5Q A;  4W5N A;  1T2S A;  4NGF A;  2QVW A;  3F73 A;  4L1U A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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