4NGFA

Structure of human dicer platform-paz-connector helix cassette in complex with 17-mer sirna having 5'-p and uu-3' ends (3.1 angstrom resolution)
Total Genus 50
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
50
sequence length
298
structure length
260
Chain Sequence
QPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELKKSGFMLSLQMLELITRLHQYIFSHILRYCVLPLNVVSTLDIDFKFMEDIEKSETKETPFVFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLTNLNQPLLDVDHTSSRLNLLTPRPLSSAEKRKAKWESLQNKQILVPELCAIHPIPASLWRKAVCLPSILYRLHC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer.
pubmed doi rcsb
molecule tags Hydrolase/rna
source organism Homo sapiens
molecule keywords Endoribonuclease Dicer
total genus 50
structure length 260
sequence length 298
chains with identical sequence B, C, D
ec nomenclature ec 3.1.26.3: Ribonuclease III.
pdb deposition date 2013-11-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02170 PAZ PAZ domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.260.10 Mainly Beta Beta Complex paz domain paz domain 4ngfA02
5JS2A 4Z4FA 1T2SA 3QIRA 1VYNA 4OLBA 4Z4GA 4NGGA 4NGBA 1T2RA 5T7BA 3O6EX 2L5CA 5KI6A 2QVWA 3MJ0A 1SI2A 4NGCA 1R6ZA 2L5DA 4W5OA 2XFMA 4Z4IA 4NGFA 4NHAA 4W5QA 4NH5A 4W5NA 4W5RA 4W5TA 3O3IX 4KREA 4NGDA 4Z4CA 5JS1A 3O7VX 4NH6A 1R4KA 3O7XA 4KRFA 4Z4HA 4OLAA 4Z4EA 2FFLA 4F3TA 4NH3A 1SI3A
chains in the Genus database with same CATH superfamily
5JS2A 4L1PA 1T2SA 3QIRA 4Z4FA 1VYNA 3DLHA 3F73A 4OLBA 4L1UA 4Z4GA 1U04A 4NGGA 4NGBA 1T2RA 5T7BA 3O6EX 3HO1A 2L5CA 3DA5A 5KI6A 2QVWA 3MJ0A 3DLBA 1SI2A 4NGCA 2BZEA 2DB9A 1R6ZA 1Z25A 2L5DA 3U1UA 4W5OA 2XFMA 4Z4IA 4NGFA 4NHAA 1Z26A 4W5QA 4NH5A 4W5NA 4W5RA 3HVRA 4W5TA 3O3IX 3HK2A 4NGDA 4KREA 4Z4CA 5JS1A 3O7VX 4NH6A 1R4KA 3HM9A 3O7XA 3HJFA 4KRFA 4Z4HA 4OLAA 4Z4EA 2FFLA 4F3TA 4NH3A 1SI3A
chains in the Genus database with same CATH topology
5JS2A 4L1PA 1T2SA 3QIRA 4Z4FA 1VYNA 3DLHA 3F73A 4OLBA 4L1UA 4Z4GA 1U04A 4NGGA 4NGBA 1T2RA 5T7BA 3O6EX 3HO1A 2L5CA 3DA5A 5KI6A 2QVWA 3MJ0A 3DLBA 1SI2A 4NGCA 2BZEA 2DB9A 1R6ZA 1Z25A 2L5DA 3U1UA 4W5OA 2XFMA 4Z4IA 4NGFA 4NHAA 1Z26A 4W5QA 4NH5A 4W5NA 4W5RA 3HVRA 4W5TA 3O3IX 3HK2A 4NGDA 4KREA 4Z4CA 5JS1A 3O7VX 4NH6A 1R4KA 3HM9A 3O7XA 3HJFA 4KRFA 4Z4HA 4OLAA 4Z4EA 2FFLA 4F3TA 4NH3A 1SI3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5JS2 A;  4Z4F A;  1T2S A;  3QIR A;  1VYN A;  4OLB A;  4Z4G A;  4NGG A;  4NGB A;  1T2R A;  5T7B A;  3O6E X;  2L5C A;  5KI6 A;  2QVW A;  3MJ0 A;  1SI2 A;  4NGC A;  1R6Z A;  2L5D A;  4W5O A;  2XFM A;  4Z4I A;  4NGF A;  4NHA A;  4W5Q A;  4NH5 A;  4W5N A;  4W5R A;  4W5T A;  3O3I X;  4KRE A;  4NGD A;  4Z4C A;  5JS1 A;  3O7V X;  4NH6 A;  1R4K A;  3O7X A;  4KRF A;  4Z4H A;  4OLA A;  4Z4E A;  2FFL A;  4F3T A;  4NH3 A;  1SI3 A; 
#chains in the Genus database with same CATH topology
 5JS2 A;  4L1P A;  1T2S A;  3QIR A;  4Z4F A;  1VYN A;  3DLH A;  3F73 A;  4OLB A;  4L1U A;  4Z4G A;  1U04 A;  4NGG A;  4NGB A;  1T2R A;  5T7B A;  3O6E X;  3HO1 A;  2L5C A;  3DA5 A;  5KI6 A;  2QVW A;  3MJ0 A;  3DLB A;  1SI2 A;  4NGC A;  2BZE A;  2DB9 A;  1R6Z A;  1Z25 A;  2L5D A;  3U1U A;  4W5O A;  2XFM A;  4Z4I A;  4NGF A;  4NHA A;  1Z26 A;  4W5Q A;  4NH5 A;  4W5N A;  4W5R A;  3HVR A;  4W5T A;  3O3I X;  3HK2 A;  4NGD A;  4KRE A;  4Z4C A;  5JS1 A;  3O7V X;  4NH6 A;  1R4K A;  3HM9 A;  3O7X A;  3HJF A;  4KRF A;  4Z4H A;  4OLA A;  4Z4E A;  2FFL A;  4F3T A;  4NH3 A;  1SI3 A; 
#chains in the Genus database with same CATH homology
 5JS2 A;  4L1P A;  1T2S A;  3QIR A;  4Z4F A;  1VYN A;  3DLH A;  3F73 A;  4OLB A;  4L1U A;  4Z4G A;  1U04 A;  4NGG A;  4NGB A;  1T2R A;  5T7B A;  3O6E X;  3HO1 A;  2L5C A;  3DA5 A;  5KI6 A;  2QVW A;  3MJ0 A;  3DLB A;  1SI2 A;  4NGC A;  2BZE A;  2DB9 A;  1R6Z A;  1Z25 A;  2L5D A;  3U1U A;  4W5O A;  2XFM A;  4Z4I A;  4NGF A;  4NHA A;  1Z26 A;  4W5Q A;  4NH5 A;  4W5N A;  4W5R A;  3HVR A;  4W5T A;  3O3I X;  3HK2 A;  4NGD A;  4KRE A;  4Z4C A;  5JS1 A;  3O7V X;  4NH6 A;  1R4K A;  3HM9 A;  3O7X A;  3HJF A;  4KRF A;  4Z4H A;  4OLA A;  4Z4E A;  2FFL A;  4F3T A;  4NH3 A;  1SI3 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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