4NGGA

Structure of human dicer platform-paz-connector helix cassette in complex with 13-mer sirna having 5'-a and uu-3' ends (2.6 angstrom resolution)
Total Genus 65
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
65
sequence length
298
structure length
267
Chain Sequence
QPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELAASGFMLSLQMLELITRLHQYIFSHILRLEYCVLPLNVVNDSTLDIDFKFMEDIEKSEARIGIPSTKYTKETPFVFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLTNLNQPLLDVDHTSSRLNLLTPRRKAKWESLQNKQILVPELCAIHPIPASLWRKAVCLPSILYRLHC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer.
pubmed doi rcsb
molecule tags Hydrolase/rna
source organism Homo sapiens
molecule keywords Endoribonuclease Dicer
total genus 65
structure length 267
sequence length 298
ec nomenclature ec 3.1.26.3: Ribonuclease III.
pdb deposition date 2013-11-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02170 PAZ PAZ domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.260.10 Mainly Beta Beta Complex paz domain paz domain 4nggA02
3O7XA 4W5OA 2QVWA 4NGFA 1SI2A 1R4KA 4KREA 4NGBA 1SI3A 4Z4HA 4Z4CA 3QIRA 5T7BA 5JS2A 4OLAA 2L5DA 4Z4EA 4NHAA 1VYNA 4NH3A 4NGCA 2L5CA 3O6EX 3O7VX 4W5RA 4W5TA 4NH6A 4NGDA 3MJ0A 4W5NA 5JS1A 4Z4IA 4W5QA 4F3TA 4KRFA 4NGGA 5KI6A 3O3IX 4NH5A 4OLBA 1R6ZA 2FFLA 1T2RA 1T2SA 2XFMA 4Z4GA 4Z4FA
chains in the Genus database with same CATH superfamily
3O7XA 2QVWA 4NGFA 1SI2A 1R4KA 3DA5A 3F73A 4KREA 4L1PA 4NGBA 1SI3A 3HJFA 4Z4HA 3U1UA 3QIRA 4Z4CA 4L1UA 5JS2A 5T7BA 4OLAA 1Z25A 3HVRA 2L5DA 4Z4EA 4NHAA 1VYNA 4NH3A 4NGCA 2L5CA 3O6EX 3HM9A 4W5RA 4W5TA 3O7VX 4NH6A 3MJ0A 4NGDA 1U04A 2XFMA 4W5QA 4Z4IA 4W5NA 5JS1A 3HO1A 4F3TA 2DB9A 1Z26A 3DLHA 4KRFA 3HK2A 5KI6A 3O3IX 4NGGA 4NH5A 4OLBA 1R6ZA 2FFLA 1T2RA 1T2SA 3DLBA 4W5OA 2BZEA 4Z4GA 4Z4FA
chains in the Genus database with same CATH topology
3O7XA 2QVWA 4NGFA 1SI2A 1R4KA 3DA5A 3F73A 4KREA 4L1PA 4NGBA 1SI3A 3HJFA 4Z4HA 3U1UA 3QIRA 4Z4CA 4L1UA 5JS2A 5T7BA 4OLAA 1Z25A 3HVRA 2L5DA 4Z4EA 4NHAA 1VYNA 4NH3A 4NGCA 2L5CA 3O6EX 3HM9A 4W5RA 4W5TA 3O7VX 4NH6A 3MJ0A 4NGDA 1U04A 2XFMA 4W5QA 4Z4IA 4W5NA 5JS1A 3HO1A 4F3TA 2DB9A 1Z26A 3DLHA 4KRFA 3HK2A 5KI6A 3O3IX 4NGGA 4NH5A 4OLBA 1R6ZA 2FFLA 1T2RA 1T2SA 3DLBA 4W5OA 2BZEA 4Z4GA 4Z4FA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3O7X A;  4W5O A;  2QVW A;  4NGF A;  1SI2 A;  1R4K A;  4KRE A;  4NGB A;  1SI3 A;  4Z4H A;  4Z4C A;  3QIR A;  5T7B A;  5JS2 A;  4OLA A;  2L5D A;  4Z4E A;  4NHA A;  1VYN A;  4NH3 A;  4NGC A;  2L5C A;  3O6E X;  3O7V X;  4W5R A;  4W5T A;  4NH6 A;  4NGD A;  3MJ0 A;  4W5N A;  5JS1 A;  4Z4I A;  4W5Q A;  4F3T A;  4KRF A;  4NGG A;  5KI6 A;  3O3I X;  4NH5 A;  4OLB A;  1R6Z A;  2FFL A;  1T2R A;  1T2S A;  2XFM A;  4Z4G A;  4Z4F A; 
#chains in the Genus database with same CATH topology
 3O7X A;  2QVW A;  4NGF A;  1SI2 A;  1R4K A;  3DA5 A;  3F73 A;  4KRE A;  4L1P A;  4NGB A;  1SI3 A;  3HJF A;  4Z4H A;  3U1U A;  3QIR A;  4Z4C A;  4L1U A;  5JS2 A;  5T7B A;  4OLA A;  1Z25 A;  3HVR A;  2L5D A;  4Z4E A;  4NHA A;  1VYN A;  4NH3 A;  4NGC A;  2L5C A;  3O6E X;  3HM9 A;  4W5R A;  4W5T A;  3O7V X;  4NH6 A;  3MJ0 A;  4NGD A;  1U04 A;  2XFM A;  4W5Q A;  4Z4I A;  4W5N A;  5JS1 A;  3HO1 A;  4F3T A;  2DB9 A;  1Z26 A;  3DLH A;  4KRF A;  3HK2 A;  5KI6 A;  3O3I X;  4NGG A;  4NH5 A;  4OLB A;  1R6Z A;  2FFL A;  1T2R A;  1T2S A;  3DLB A;  4W5O A;  2BZE A;  4Z4G A;  4Z4F A; 
#chains in the Genus database with same CATH homology
 3O7X A;  2QVW A;  4NGF A;  1SI2 A;  1R4K A;  3DA5 A;  3F73 A;  4KRE A;  4L1P A;  4NGB A;  1SI3 A;  3HJF A;  4Z4H A;  3U1U A;  3QIR A;  4Z4C A;  4L1U A;  5JS2 A;  5T7B A;  4OLA A;  1Z25 A;  3HVR A;  2L5D A;  4Z4E A;  4NHA A;  1VYN A;  4NH3 A;  4NGC A;  2L5C A;  3O6E X;  3HM9 A;  4W5R A;  4W5T A;  3O7V X;  4NH6 A;  3MJ0 A;  4NGD A;  1U04 A;  2XFM A;  4W5Q A;  4Z4I A;  4W5N A;  5JS1 A;  3HO1 A;  4F3T A;  2DB9 A;  1Z26 A;  3DLH A;  4KRF A;  3HK2 A;  5KI6 A;  3O3I X;  4NGG A;  4NH5 A;  4OLB A;  1R6Z A;  2FFL A;  1T2R A;  1T2S A;  3DLB A;  4W5O A;  2BZE A;  4Z4G A;  4Z4F A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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