4NH3A

Structure of human dicer platform-paz-connector helix cassette in complex with 13-mer sirna having 5'-pu and uu-3' ends (2.6 angstrom resolution)
Total Genus 62
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
62
sequence length
298
structure length
268
Chain Sequence
QPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELAASGFMLSLQMLELITRLHQYIFSHILRLYCVLPLNVVTLDIDFKFMEDIEKSEARIGIPSTKYTKETPFVFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLTNLNQPLLDVDHTSSRLNLLTPLSSAEKRKAKWESLQNKQILVPELCAIHPIPASLWRKAVCLPSILYRLHC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer.
pubmed doi rcsb
molecule tags Hydrolase/rna
source organism Homo sapiens
molecule keywords Endoribonuclease Dicer
total genus 62
structure length 268
sequence length 298
ec nomenclature ec 3.1.26.3: Ribonuclease III.
pdb deposition date 2013-11-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02170 PAZ PAZ domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.260.10 Mainly Beta Beta Complex paz domain paz domain 4nh3A02
1R4KA 3O6EX 4NGFA 4OLBA 2L5DA 1SI2A 4OLAA 4W5RA 4NHAA 3O7XA 1R6ZA 1T2RA 4KREA 1T2SA 2FFLA 5JS2A 4Z4GA 1SI3A 2XFMA 4NGGA 4KRFA 4W5TA 4NGCA 3MJ0A 4NH6A 4NH3A 4W5NA 1VYNA 3O7VX 3O3IX 4Z4FA 5JS1A 4NH5A 5T7BA 4NGDA 4W5QA 2L5CA 4NGBA 2QVWA 4Z4EA 4Z4HA 4W5OA 4Z4CA 4Z4IA 5KI6A 4F3TA 3QIRA
chains in the Genus database with same CATH superfamily
1R4KA 4L1UA 3HVRA 3O6EX 4NGFA 3HM9A 4OLBA 2L5DA 1SI2A 4OLAA 4W5RA 4NHAA 2DB9A 3HK2A 3O7XA 1R6ZA 1T2RA 3F73A 4KREA 1T2SA 2BZEA 2FFLA 5JS2A 4Z4GA 1SI3A 3HO1A 2XFMA 1U04A 4NGGA 4W5TA 4KRFA 4NGCA 3MJ0A 3U1UA 4NH6A 3HJFA 4NH3A 4W5NA 1VYNA 3DLHA 3O7VX 3O3IX 1Z25A 3DLBA 4Z4FA 5JS1A 4L1PA 4NH5A 5T7BA 4NGDA 4W5QA 2L5CA 1Z26A 4NGBA 2QVWA 4Z4EA 3DA5A 4Z4HA 4W5OA 4Z4CA 4Z4IA 5KI6A 4F3TA 3QIRA
chains in the Genus database with same CATH topology
1R4KA 4L1UA 3HVRA 3O6EX 4NGFA 3HM9A 4OLBA 2L5DA 1SI2A 4OLAA 4W5RA 4NHAA 2DB9A 3HK2A 3O7XA 1R6ZA 1T2RA 3F73A 4KREA 1T2SA 2BZEA 2FFLA 5JS2A 4Z4GA 1SI3A 3HO1A 2XFMA 1U04A 4NGGA 4W5TA 4KRFA 4NGCA 3MJ0A 3U1UA 4NH6A 3HJFA 4NH3A 4W5NA 1VYNA 3DLHA 3O7VX 3O3IX 1Z25A 3DLBA 4Z4FA 5JS1A 4L1PA 4NH5A 5T7BA 4NGDA 4W5QA 2L5CA 1Z26A 4NGBA 2QVWA 4Z4EA 3DA5A 4Z4HA 4W5OA 4Z4CA 4Z4IA 5KI6A 4F3TA 3QIRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1R4K A;  3O6E X;  4NGF A;  4OLB A;  2L5D A;  1SI2 A;  4OLA A;  4W5R A;  4NHA A;  3O7X A;  1R6Z A;  1T2R A;  4KRE A;  1T2S A;  2FFL A;  5JS2 A;  4Z4G A;  1SI3 A;  2XFM A;  4NGG A;  4KRF A;  4W5T A;  4NGC A;  3MJ0 A;  4NH6 A;  4NH3 A;  4W5N A;  1VYN A;  3O7V X;  3O3I X;  4Z4F A;  5JS1 A;  4NH5 A;  5T7B A;  4NGD A;  4W5Q A;  2L5C A;  4NGB A;  2QVW A;  4Z4E A;  4Z4H A;  4W5O A;  4Z4C A;  4Z4I A;  5KI6 A;  4F3T A;  3QIR A; 
#chains in the Genus database with same CATH topology
 1R4K A;  4L1U A;  3HVR A;  3O6E X;  4NGF A;  3HM9 A;  4OLB A;  2L5D A;  1SI2 A;  4OLA A;  4W5R A;  4NHA A;  2DB9 A;  3HK2 A;  3O7X A;  1R6Z A;  1T2R A;  3F73 A;  4KRE A;  1T2S A;  2BZE A;  2FFL A;  5JS2 A;  4Z4G A;  1SI3 A;  3HO1 A;  2XFM A;  1U04 A;  4NGG A;  4W5T A;  4KRF A;  4NGC A;  3MJ0 A;  3U1U A;  4NH6 A;  3HJF A;  4NH3 A;  4W5N A;  1VYN A;  3DLH A;  3O7V X;  3O3I X;  1Z25 A;  3DLB A;  4Z4F A;  5JS1 A;  4L1P A;  4NH5 A;  5T7B A;  4NGD A;  4W5Q A;  2L5C A;  1Z26 A;  4NGB A;  2QVW A;  4Z4E A;  3DA5 A;  4Z4H A;  4W5O A;  4Z4C A;  4Z4I A;  5KI6 A;  4F3T A;  3QIR A; 
#chains in the Genus database with same CATH homology
 1R4K A;  4L1U A;  3HVR A;  3O6E X;  4NGF A;  3HM9 A;  4OLB A;  2L5D A;  1SI2 A;  4OLA A;  4W5R A;  4NHA A;  2DB9 A;  3HK2 A;  3O7X A;  1R6Z A;  1T2R A;  3F73 A;  4KRE A;  1T2S A;  2BZE A;  2FFL A;  5JS2 A;  4Z4G A;  1SI3 A;  3HO1 A;  2XFM A;  1U04 A;  4NGG A;  4W5T A;  4KRF A;  4NGC A;  3MJ0 A;  3U1U A;  4NH6 A;  3HJF A;  4NH3 A;  4W5N A;  1VYN A;  3DLH A;  3O7V X;  3O3I X;  1Z25 A;  3DLB A;  4Z4F A;  5JS1 A;  4L1P A;  4NH5 A;  5T7B A;  4NGD A;  4W5Q A;  2L5C A;  1Z26 A;  4NGB A;  2QVW A;  4Z4E A;  3DA5 A;  4Z4H A;  4W5O A;  4Z4C A;  4Z4I A;  5KI6 A;  4F3T A;  3QIR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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