4RJFA

Crystal structure of the human sliding clamp at 2.0 angstrom resolution
Total Genus 53
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
53
sequence length
255
structure length
255
Chain Sequence
MFEARLVQGSILKKVLEALKDLINEACWDISSSGVNLQSMDSSHVSLVQLTLRSEGFDTYRCDRNLAMGVNLTSMSKILKCAGNEDIITLRAEDNADTLALVFEAPNQEKVSDYEMKLMDLDVEQLGIPEQEYSCVVKMPSGEFARICRDLSHIGDAVVISCAKDGVKFSASGELGNGNIKLSQTSNVDKEEEAVTIEMNEPVQLTFALRYLNFFTKATPLSSTVTLSMSADVPLVVEYKIADMGHLKYYLAPKI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title p21 Exploits Residue Tyr151 as a Tether for High-Affinity PCNA Binding.
pubmed doi rcsb
molecule tags Replication
source organism Homo sapiens
molecule keywords Proliferating cell nuclear antigen
total genus 53
structure length 255
sequence length 255
chains with identical sequence C, E
ec nomenclature
pdb deposition date 2014-10-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00705 PCNA_N Proliferating cell nuclear antigen, N-terminal domain
A PF02747 PCNA_C Proliferating cell nuclear antigen, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.70.10.10 Alpha Beta Box Proliferating Cell Nuclear Antigen Proliferating Cell Nuclear Antigen 4rjfA00
2IZOB 1W60A 5DA7A 1PLQA 5H0TA 5IXAA 4YHRA 2ZVKA 3G65A 4HK1A 5A6DA 3A1JB 2ZVMA 2ZVVA 1U76A 3P91A 3LX2A 5E0TA 1SXJF 1IZ4A 2IX2A 3IFVA 4L6PA 2AWAA 2IZOC 2OD8A 3G65B 3TBLA 4CS5A 3V62B 2IO4A 1RXMA 1IZ5A 3I2MX 1UD9A 5JNED 1RWZA 3GGRA 2HIIB 3AIXA 1RXZA 5CFKA 1UL1A 2HIKA 3U5ZF 3GGRB 4D2GA 2IJXA 2AVTA 3HSLX 2HIIC 3LX1A 2NTIA 1DMLA 1U7BA 1B8HA 3VKXA 3AIZC 1VYMA 3A1JC 2Z0LA 2IX2B 1PLRA 1GE8A 1CZDA 3GPNA 4L60A 5B7OA 2IO4B 5AUJA 3G65C 1AXCA 2ZVWA 4RJFA 2ZVLA 3V61B 4ZTDA 3AIZA 3FDSD 3A1JA 3AIXB 2HIKB 1YYPA 5HACA 5DAIA 4TR6A 3FDSC 1B77A 3V60B 1VYJA 3GPMA 3U60F 3K4XA 3GGRC 1ISQA 3P83A 2NTIB 3A2FB 3P87A 5E0VA 3U61F 2HIKC 5IY4A 1T6LA 2HIIA 3HI8A 5E0UA 2IX2C 5IWDA 3WGWA 2NTIC 3F1WA
chains in the Genus database with same CATH superfamily
2IZOB 1W60A 5DA7A 1PLQA 5H0TA 5IXAA 4YHRA 2ZVKA 3G65A 4HK1A 5A6DA 3A1JB 2ZVMA 2ZVVA 1U76A 3P91A 3LX2A 5E0TA 1SXJF 1IZ4A 2IX2A 3IFVA 4L6PA 2AWAA 2IZOC 2OD8A 3G65B 3TBLA 4CS5A 3V62B 2IO4A 1RXMA 1IZ5A 3I2MX 1UD9A 5JNED 1RWZA 3GGRA 2HIIB 3AIXA 1RXZA 5CFKA 1UL1A 2HIKA 3U5ZF 3GGRB 4D2GA 2IJXA 2AVTA 3HSLX 2HIIC 3LX1A 2NTIA 1DMLA 1U7BA 1B8HA 3VKXA 3AIZC 1VYMA 3A1JC 2Z0LA 2IX2B 1PLRA 1GE8A 1CZDA 3GPNA 4L60A 5B7OA 2IO4B 5AUJA 3G65C 1AXCA 2ZVWA 4RJFA 2ZVLA 3V61B 4ZTDA 3AIZA 3FDSD 3A1JA 3AIXB 2HIKB 1YYPA 5HACA 5DAIA 4TR6A 3FDSC 1B77A 3V60B 1VYJA 3GPMA 3U60F 3K4XA 3GGRC 1ISQA 3P83A 2NTIB 3A2FB 3P87A 5E0VA 3U61F 2HIKC 5IY4A 1T6LA 2HIIA 3HI8A 5E0UA 2IX2C 5IWDA 3WGWA 2NTIC 3F1WA
chains in the Genus database with same CATH topology
2IZOB 1W60A 5DA7A 1PLQA 5H0TA 5IXAA 4YHRA 2ZVKA 3G65A 4HK1A 5A6DA 3A1JB 2ZVMA 2ZVVA 1U76A 3P91A 3LX2A 5E0TA 1SXJF 1IZ4A 2IX2A 3IFVA 4L6PA 2AWAA 2IZOC 2OD8A 3G65B 3TBLA 4CS5A 3V62B 2IO4A 1RXMA 1IZ5A 3I2MX 1UD9A 5JNED 1RWZA 3GGRA 2HIIB 3AIXA 1RXZA 5CFKA 1UL1A 2HIKA 3U5ZF 3GGRB 4D2GA 2IJXA 2AVTA 3HSLX 2HIIC 3LX1A 2NTIA 1DMLA 1U7BA 1B8HA 3VKXA 3AIZC 1VYMA 3A1JC 2Z0LA 2IX2B 1PLRA 1GE8A 1CZDA 3GPNA 4L60A 5B7OA 2IO4B 5AUJA 3G65C 1AXCA 2ZVWA 4RJFA 2ZVLA 3V61B 4ZTDA 3AIZA 3FDSD 3A1JA 3AIXB 2HIKB 1YYPA 5HACA 5DAIA 4TR6A 3FDSC 1B77A 3V60B 1VYJA 3GPMA 3U60F 3K4XA 3GGRC 1ISQA 3P83A 2NTIB 3A2FB 3P87A 5E0VA 3U61F 2HIKC 5IY4A 1T6LA 2HIIA 3HI8A 5E0UA 2IX2C 5IWDA 3WGWA 2NTIC 3F1WA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2IZO B;  1W60 A;  5DA7 A;  1PLQ A;  5H0T A;  5IXA A;  4YHR A;  2ZVK A;  3G65 A;  4HK1 A;  5A6D A;  3A1J B;  2ZVM A;  2ZVV A;  1U76 A;  3P91 A;  3LX2 A;  5E0T A;  1SXJ F;  1IZ4 A;  2IX2 A;  3IFV A;  4L6P A;  2AWA A;  2IZO C;  2OD8 A;  3G65 B;  3TBL A;  4CS5 A;  3V62 B;  2IO4 A;  1RXM A;  1IZ5 A;  3I2M X;  1UD9 A;  5JNE D;  1RWZ A;  3GGR A;  2HII B;  3AIX A;  1RXZ A;  5CFK A;  1UL1 A;  2HIK A;  3U5Z F;  3GGR B;  4D2G A;  2IJX A;  2AVT A;  3HSL X;  2HII C;  3LX1 A;  2NTI A;  1DML A;  1U7B A;  1B8H A;  3VKX A;  3AIZ C;  1VYM A;  3A1J C;  2Z0L A;  2IX2 B;  1PLR A;  1GE8 A;  1CZD A;  3GPN A;  4L60 A;  5B7O A;  2IO4 B;  5AUJ A;  3G65 C;  1AXC A;  2ZVW A;  4RJF A;  2ZVL A;  3V61 B;  4ZTD A;  3AIZ A;  3FDS D;  3A1J A;  3AIX B;  2HIK B;  1YYP A;  5HAC A;  5DAI A;  4TR6 A;  3FDS C;  1B77 A;  3V60 B;  1VYJ A;  3GPM A;  3U60 F;  3K4X A;  3GGR C;  1ISQ A;  3P83 A;  2NTI B;  3A2F B;  3P87 A;  5E0V A;  3U61 F;  2HIK C;  5IY4 A;  1T6L A;  2HII A;  3HI8 A;  5E0U A;  2IX2 C;  5IWD A;  3WGW A;  2NTI C;  3F1W A; 
#chains in the Genus database with same CATH topology
 2IZO B;  1W60 A;  5DA7 A;  1PLQ A;  5H0T A;  5IXA A;  4YHR A;  2ZVK A;  3G65 A;  4HK1 A;  5A6D A;  3A1J B;  2ZVM A;  2ZVV A;  1U76 A;  3P91 A;  3LX2 A;  5E0T A;  1SXJ F;  1IZ4 A;  2IX2 A;  3IFV A;  4L6P A;  2AWA A;  2IZO C;  2OD8 A;  3G65 B;  3TBL A;  4CS5 A;  3V62 B;  2IO4 A;  1RXM A;  1IZ5 A;  3I2M X;  1UD9 A;  5JNE D;  1RWZ A;  3GGR A;  2HII B;  3AIX A;  1RXZ A;  5CFK A;  1UL1 A;  2HIK A;  3U5Z F;  3GGR B;  4D2G A;  2IJX A;  2AVT A;  3HSL X;  2HII C;  3LX1 A;  2NTI A;  1DML A;  1U7B A;  1B8H A;  3VKX A;  3AIZ C;  1VYM A;  3A1J C;  2Z0L A;  2IX2 B;  1PLR A;  1GE8 A;  1CZD A;  3GPN A;  4L60 A;  5B7O A;  2IO4 B;  5AUJ A;  3G65 C;  1AXC A;  2ZVW A;  4RJF A;  2ZVL A;  3V61 B;  4ZTD A;  3AIZ A;  3FDS D;  3A1J A;  3AIX B;  2HIK B;  1YYP A;  5HAC A;  5DAI A;  4TR6 A;  3FDS C;  1B77 A;  3V60 B;  1VYJ A;  3GPM A;  3U60 F;  3K4X A;  3GGR C;  1ISQ A;  3P83 A;  2NTI B;  3A2F B;  3P87 A;  5E0V A;  3U61 F;  2HIK C;  5IY4 A;  1T6L A;  2HII A;  3HI8 A;  5E0U A;  2IX2 C;  5IWD A;  3WGW A;  2NTI C;  3F1W A; 
#chains in the Genus database with same CATH homology
 2IZO B;  1W60 A;  5DA7 A;  1PLQ A;  5H0T A;  5IXA A;  4YHR A;  2ZVK A;  3G65 A;  4HK1 A;  5A6D A;  3A1J B;  2ZVM A;  2ZVV A;  1U76 A;  3P91 A;  3LX2 A;  5E0T A;  1SXJ F;  1IZ4 A;  2IX2 A;  3IFV A;  4L6P A;  2AWA A;  2IZO C;  2OD8 A;  3G65 B;  3TBL A;  4CS5 A;  3V62 B;  2IO4 A;  1RXM A;  1IZ5 A;  3I2M X;  1UD9 A;  5JNE D;  1RWZ A;  3GGR A;  2HII B;  3AIX A;  1RXZ A;  5CFK A;  1UL1 A;  2HIK A;  3U5Z F;  3GGR B;  4D2G A;  2IJX A;  2AVT A;  3HSL X;  2HII C;  3LX1 A;  2NTI A;  1DML A;  1U7B A;  1B8H A;  3VKX A;  3AIZ C;  1VYM A;  3A1J C;  2Z0L A;  2IX2 B;  1PLR A;  1GE8 A;  1CZD A;  3GPN A;  4L60 A;  5B7O A;  2IO4 B;  5AUJ A;  3G65 C;  1AXC A;  2ZVW A;  4RJF A;  2ZVL A;  3V61 B;  4ZTD A;  3AIZ A;  3FDS D;  3A1J A;  3AIX B;  2HIK B;  1YYP A;  5HAC A;  5DAI A;  4TR6 A;  3FDS C;  1B77 A;  3V60 B;  1VYJ A;  3GPM A;  3U60 F;  3K4X A;  3GGR C;  1ISQ A;  3P83 A;  2NTI B;  3A2F B;  3P87 A;  5E0V A;  3U61 F;  2HIK C;  5IY4 A;  1T6L A;  2HII A;  3HI8 A;  5E0U A;  2IX2 C;  5IWD A;  3WGW A;  2NTI C;  3F1W A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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