4WLSA

Crystal structure of the metal-free (repressor) form of e. coli cuer, a copper efflux regulator, bound to copa promoter dna
Total Genus 43
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
43
sequence length
111
structure length
111
Chain Sequence
MNISDVAKITGLTSKAIRFYEEKGLVTPPMRSENGYRTYTQQHLNELTLLRQARQVGFNLEESGELVNLFNDPQRHSADVKRRTLEKVAEIERHIEELQSMRDQLLALANA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Allosteric transcriptional regulation via changes in the overall topology of the core promoter.
pubmed doi rcsb
molecule tags Transcription regulator/dna
source organism Escherichia coli dh5[alpha]
molecule keywords HTH-type transcriptional regulator CueR
total genus 43
structure length 111
sequence length 111
chains with identical sequence B
ec nomenclature
pdb deposition date 2014-10-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00376 MerR MerR family regulatory protein
A PF09278 MerR-DNA-bind MerR, DNA binding
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1660.10 Mainly Alpha Orthogonal Bundle Multidrug-efflux Transporter Regulator; Chain: A; Domain 2 Multidrug-efflux Transporter Regulator; Chain: A; Domain 2 4wlsA00
4J2NA 4WLWA 2DG6A 3Q2YA 3GP4A 3Q5PA 3D6YA 1JBGA 2ZHHA 3D71A 1Q05A 1EXJA 1Q09A 3UCSA 3GPVA 3Q3DA 3D6ZA 5I41B 3D70A 3Q1MA 4WLSA 3Q5RA 5D8CA 3Q5SA 1Q06A 3HH0A 4R4EA 3IAOA 1R8EA 1EXIA 2JMLA 3QAOA 1R8DA 1Q0AA 1Q08A 5E01A 5D90A 4R24B 4R22B 5I44A 1Q07A 2ZHGA 2VZ4A
chains in the Genus database with same CATH superfamily
1RH6A 4J2NA 4LHFA 4WLWA 2DG6A 3Q2YA 3GP4A 3Q5PA 3D6YA 1JBGA 2ZHHA 3EZ6A 2IEFA 3D71A 1Q05A 1PM6A 1EXJA 1LX8A 3EZ9A 1Q09A 3UCSA 3GPVA 3Q3DA 3D6ZA 2OG0A 5I41B 1Y6UA 3D70A 3Q1MA 2KVVA 4WLSA 3Q5RA 5D8CA 3Q5SA 1Q06A 3HH0A 4R4EA 3IAOA 1R8EA 4DCZA 1EXIA 2JMLA 3QAOA 1R8DA 1Q0AA 1Q08A 3EZ2A 5D90A 5E01A 4R24B 3EZ7A 4R22B 5I44A 3EZFA 1Q07A 2ZHGA 2VZ4A
chains in the Genus database with same CATH topology
1RH6A 4J2NA 4LHFA 4WLWA 2DG6A 3Q2YA 3GP4A 3Q5PA 3D6YA 1JBGA 2ZHHA 3EZ6A 2IEFA 3D71A 1Q05A 1PM6A 1EXJA 1LX8A 3EZ9A 1Q09A 3UCSA 3GPVA 3Q3DA 3D6ZA 2OG0A 5I41B 1Y6UA 3D70A 3Q1MA 2KVVA 4WLSA 3Q5RA 5D8CA 3Q5SA 1Q06A 3HH0A 4R4EA 3IAOA 1R8EA 4DCZA 1EXIA 2JMLA 3QAOA 1R8DA 1Q0AA 1Q08A 3EZ2A 5D90A 5E01A 4R24B 3EZ7A 4R22B 5I44A 3EZFA 1Q07A 2ZHGA 2VZ4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4J2N A;  4WLW A;  2DG6 A;  3Q2Y A;  3GP4 A;  3Q5P A;  3D6Y A;  1JBG A;  2ZHH A;  3D71 A;  1Q05 A;  1EXJ A;  1Q09 A;  3UCS A;  3GPV A;  3Q3D A;  3D6Z A;  5I41 B;  3D70 A;  3Q1M A;  4WLS A;  3Q5R A;  5D8C A;  3Q5S A;  1Q06 A;  3HH0 A;  4R4E A;  3IAO A;  1R8E A;  1EXI A;  2JML A;  3QAO A;  1R8D A;  1Q0A A;  1Q08 A;  5E01 A;  5D90 A;  4R24 B;  4R22 B;  5I44 A;  1Q07 A;  2ZHG A;  2VZ4 A; 
#chains in the Genus database with same CATH topology
 1RH6 A;  4J2N A;  4LHF A;  4WLW A;  2DG6 A;  3Q2Y A;  3GP4 A;  3Q5P A;  3D6Y A;  1JBG A;  2ZHH A;  3EZ6 A;  2IEF A;  3D71 A;  1Q05 A;  1PM6 A;  1EXJ A;  1LX8 A;  3EZ9 A;  1Q09 A;  3UCS A;  3GPV A;  3Q3D A;  3D6Z A;  2OG0 A;  5I41 B;  1Y6U A;  3D70 A;  3Q1M A;  2KVV A;  4WLS A;  3Q5R A;  5D8C A;  3Q5S A;  1Q06 A;  3HH0 A;  4R4E A;  3IAO A;  1R8E A;  4DCZ A;  1EXI A;  2JML A;  3QAO A;  1R8D A;  1Q0A A;  1Q08 A;  3EZ2 A;  5D90 A;  5E01 A;  4R24 B;  3EZ7 A;  4R22 B;  5I44 A;  3EZF A;  1Q07 A;  2ZHG A;  2VZ4 A; 
#chains in the Genus database with same CATH homology
 1RH6 A;  4J2N A;  4LHF A;  4WLW A;  2DG6 A;  3Q2Y A;  3GP4 A;  3Q5P A;  3D6Y A;  1JBG A;  2ZHH A;  3EZ6 A;  2IEF A;  3D71 A;  1Q05 A;  1PM6 A;  1EXJ A;  1LX8 A;  3EZ9 A;  1Q09 A;  3UCS A;  3GPV A;  3Q3D A;  3D6Z A;  2OG0 A;  5I41 B;  1Y6U A;  3D70 A;  3Q1M A;  2KVV A;  4WLS A;  3Q5R A;  5D8C A;  3Q5S A;  1Q06 A;  3HH0 A;  4R4E A;  3IAO A;  1R8E A;  4DCZ A;  1EXI A;  2JML A;  3QAO A;  1R8D A;  1Q0A A;  1Q08 A;  3EZ2 A;  5D90 A;  5E01 A;  4R24 B;  3EZ7 A;  4R22 B;  5I44 A;  3EZF A;  1Q07 A;  2ZHG A;  2VZ4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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