4WLWA

Crystal structure of the ag(i) (activator) form of e. coli cuer, a copper efflux regulator, bound to copa promoter dna
Total Genus 46
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
46
sequence length
130
structure length
130
Chain Sequence
MNISDVAKITGLTSKAIRFYEEKGLVTPPMRSENGYRTYTQQHLNELTLLRQARQVGFNLEESGELVNLFNDPQRHSADVKRRTLEKVAEIERHIEELQSMRDQLLALANACPGDDSADCPIIENLSGCC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title TRANSCRIPTION. Allosteric transcriptional regulation via changes in the overall topology of the core promoter.
pubmed doi rcsb
molecule tags Transcription/dna
source organism Escherichia coli
molecule keywords HTH-type transcriptional regulator CueR
total genus 46
structure length 130
sequence length 130
ec nomenclature
pdb deposition date 2014-10-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00376 MerR MerR family regulatory protein
A PF09278 MerR-DNA-bind MerR, DNA binding
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1660.10 Mainly Alpha Orthogonal Bundle Multidrug-efflux Transporter Regulator; Chain: A; Domain 2 Multidrug-efflux Transporter Regulator; Chain: A; Domain 2 4wlwA00
1EXIA 3QAOA 3Q1MA 1Q08A 3Q5RA 3Q2YA 1Q09A 5I41B 4J2NA 4R22B 3IAOA 2DG6A 5D8CA 4R24B 3Q5PA 1EXJA 3D6ZA 1R8DA 1Q06A 1Q05A 1JBGA 5E01A 2VZ4A 3Q3DA 3D6YA 1Q0AA 4WLSA 4WLWA 3D70A 4R4EA 5I44A 2ZHHA 2JMLA 3GP4A 3HH0A 3Q5SA 3D71A 1Q07A 5D90A 2ZHGA 3GPVA 3UCSA 1R8EA
chains in the Genus database with same CATH superfamily
1EXIA 3QAOA 3Q1MA 1Q08A 3Q5RA 3Q2YA 1Y6UA 1Q09A 5I41B 4J2NA 4R22B 3EZ7A 2KVVA 2OG0A 3IAOA 1PM6A 2DG6A 5D8CA 1RH6A 4R24B 3Q5PA 1EXJA 3D6ZA 1R8DA 2IEFA 1Q06A 1Q05A 1JBGA 5E01A 2VZ4A 3Q3DA 3EZ2A 3D6YA 1Q0AA 4WLSA 4WLWA 3D70A 4R4EA 5I44A 2ZHHA 4LHFA 1LX8A 2JMLA 4DCZA 3GP4A 3HH0A 3EZ6A 3Q5SA 3EZFA 3D71A 1Q07A 3EZ9A 5D90A 2ZHGA 3GPVA 3UCSA 1R8EA
chains in the Genus database with same CATH topology
1EXIA 3QAOA 3Q1MA 1Q08A 3Q5RA 3Q2YA 1Y6UA 1Q09A 5I41B 4J2NA 4R22B 3EZ7A 2KVVA 2OG0A 3IAOA 1PM6A 2DG6A 5D8CA 1RH6A 4R24B 3Q5PA 1EXJA 3D6ZA 1R8DA 2IEFA 1Q06A 1Q05A 1JBGA 5E01A 2VZ4A 3Q3DA 3EZ2A 3D6YA 1Q0AA 4WLSA 4WLWA 3D70A 4R4EA 5I44A 2ZHHA 4LHFA 1LX8A 2JMLA 4DCZA 3GP4A 3HH0A 3EZ6A 3Q5SA 3EZFA 3D71A 1Q07A 3EZ9A 5D90A 2ZHGA 3GPVA 3UCSA 1R8EA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1EXI A;  3QAO A;  3Q1M A;  1Q08 A;  3Q5R A;  3Q2Y A;  1Q09 A;  5I41 B;  4J2N A;  4R22 B;  3IAO A;  2DG6 A;  5D8C A;  4R24 B;  3Q5P A;  1EXJ A;  3D6Z A;  1R8D A;  1Q06 A;  1Q05 A;  1JBG A;  5E01 A;  2VZ4 A;  3Q3D A;  3D6Y A;  1Q0A A;  4WLS A;  4WLW A;  3D70 A;  4R4E A;  5I44 A;  2ZHH A;  2JML A;  3GP4 A;  3HH0 A;  3Q5S A;  3D71 A;  1Q07 A;  5D90 A;  2ZHG A;  3GPV A;  3UCS A;  1R8E A; 
#chains in the Genus database with same CATH topology
 1EXI A;  3QAO A;  3Q1M A;  1Q08 A;  3Q5R A;  3Q2Y A;  1Y6U A;  1Q09 A;  5I41 B;  4J2N A;  4R22 B;  3EZ7 A;  2KVV A;  2OG0 A;  3IAO A;  1PM6 A;  2DG6 A;  5D8C A;  1RH6 A;  4R24 B;  3Q5P A;  1EXJ A;  3D6Z A;  1R8D A;  2IEF A;  1Q06 A;  1Q05 A;  1JBG A;  5E01 A;  2VZ4 A;  3Q3D A;  3EZ2 A;  3D6Y A;  1Q0A A;  4WLS A;  4WLW A;  3D70 A;  4R4E A;  5I44 A;  2ZHH A;  4LHF A;  1LX8 A;  2JML A;  4DCZ A;  3GP4 A;  3HH0 A;  3EZ6 A;  3Q5S A;  3EZF A;  3D71 A;  1Q07 A;  3EZ9 A;  5D90 A;  2ZHG A;  3GPV A;  3UCS A;  1R8E A; 
#chains in the Genus database with same CATH homology
 1EXI A;  3QAO A;  3Q1M A;  1Q08 A;  3Q5R A;  3Q2Y A;  1Y6U A;  1Q09 A;  5I41 B;  4J2N A;  4R22 B;  3EZ7 A;  2KVV A;  2OG0 A;  3IAO A;  1PM6 A;  2DG6 A;  5D8C A;  1RH6 A;  4R24 B;  3Q5P A;  1EXJ A;  3D6Z A;  1R8D A;  2IEF A;  1Q06 A;  1Q05 A;  1JBG A;  5E01 A;  2VZ4 A;  3Q3D A;  3EZ2 A;  3D6Y A;  1Q0A A;  4WLS A;  4WLW A;  3D70 A;  4R4E A;  5I44 A;  2ZHH A;  4LHF A;  1LX8 A;  2JML A;  4DCZ A;  3GP4 A;  3HH0 A;  3EZ6 A;  3Q5S A;  3EZF A;  3D71 A;  1Q07 A;  3EZ9 A;  5D90 A;  2ZHG A;  3GPV A;  3UCS A;  1R8E A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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