4WLWA

Crystal structure of the ag(i) (activator) form of e. coli cuer, a copper efflux regulator, bound to copa promoter dna
Total Genus 46
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
46
sequence length
130
structure length
130
Chain Sequence
MNISDVAKITGLTSKAIRFYEEKGLVTPPMRSENGYRTYTQQHLNELTLLRQARQVGFNLEESGELVNLFNDPQRHSADVKRRTLEKVAEIERHIEELQSMRDQLLALANACPGDDSADCPIIENLSGCC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title TRANSCRIPTION. Allosteric transcriptional regulation via changes in the overall topology of the core promoter.
pubmed doi rcsb
molecule keywords HTH-type transcriptional regulator CueR
molecule tags Transcription/dna
source organism Escherichia coli
total genus 46
structure length 130
sequence length 130
ec nomenclature
pdb deposition date 2014-10-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00376 MerR MerR family regulatory protein
A PF09278 MerR-DNA-bind MerR, DNA binding
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1660.10 Mainly Alpha Orthogonal Bundle Multidrug-efflux Transporter Regulator; Chain: A; Domain 2 Multidrug-efflux Transporter Regulator; Chain: A; Domain 2 4wlwA00
5E01A 2DG6A 1Q08A 4WLWA 3D70A 3D71A 1EXJA 3Q3DA 1Q07A 3GP4A 1R8DA 1Q09A 2VZ4A 2JMLA 5I44A 1JBGA 3HH0A 5I41B 2ZHGA 3Q5RA 3Q2YA 5D90A 4R22B 3Q5SA 1Q05A 3Q5PA 3UCSA 3GPVA 4J2NA 4WLSA 1R8EA 1Q06A 2ZHHA 3QAOA 5D8CA 3D6ZA 3Q1MA 3D6YA 1EXIA 4R24B 1Q0AA 3IAOA 4R4EA
chains in the Genus database with same CATH superfamily
5E01A 2DG6A 1Q08A 4WLWA 3D70A 3D71A 1EXJA 3EZFA 3Q3DA 1Q07A 3GP4A 1R8DA 1RH6A 1Q09A 3EZ2A 2VZ4A 2JMLA 2KVVA 5I44A 2IEFA 2OG0A 4LHFA 1JBGA 1PM6A 3HH0A 5I41B 2ZHGA 3Q5RA 1Y6UA 4DCZA 1LX8A 3Q2YA 5D90A 4R22B 3Q5SA 1Q05A 3Q5PA 3EZ7A 3UCSA 3GPVA 4J2NA 4WLSA 1R8EA 1Q06A 2ZHHA 3QAOA 3EZ6A 5D8CA 3D6ZA 3Q1MA 3D6YA 1EXIA 4R24B 3EZ9A 1Q0AA 3IAOA 4R4EA
chains in the Genus database with same CATH topology
5E01A 2DG6A 1Q08A 4WLWA 3D70A 3D71A 1EXJA 3EZFA 3Q3DA 1Q07A 3GP4A 1R8DA 1RH6A 1Q09A 3EZ2A 2VZ4A 2JMLA 2KVVA 5I44A 2IEFA 2OG0A 4LHFA 1JBGA 1PM6A 3HH0A 5I41B 2ZHGA 3Q5RA 1Y6UA 4DCZA 1LX8A 3Q2YA 5D90A 4R22B 3Q5SA 1Q05A 3Q5PA 3EZ7A 3UCSA 3GPVA 4J2NA 4WLSA 1R8EA 1Q06A 2ZHHA 3QAOA 3EZ6A 5D8CA 3D6ZA 3Q1MA 3D6YA 1EXIA 4R24B 3EZ9A 1Q0AA 3IAOA 4R4EA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5E01 A;  2DG6 A;  1Q08 A;  4WLW A;  3D70 A;  3D71 A;  1EXJ A;  3Q3D A;  1Q07 A;  3GP4 A;  1R8D A;  1Q09 A;  2VZ4 A;  2JML A;  5I44 A;  1JBG A;  3HH0 A;  5I41 B;  2ZHG A;  3Q5R A;  3Q2Y A;  5D90 A;  4R22 B;  3Q5S A;  1Q05 A;  3Q5P A;  3UCS A;  3GPV A;  4J2N A;  4WLS A;  1R8E A;  1Q06 A;  2ZHH A;  3QAO A;  5D8C A;  3D6Z A;  3Q1M A;  3D6Y A;  1EXI A;  4R24 B;  1Q0A A;  3IAO A;  4R4E A; 
#chains in the Genus database with same CATH topology
 5E01 A;  2DG6 A;  1Q08 A;  4WLW A;  3D70 A;  3D71 A;  1EXJ A;  3EZF A;  3Q3D A;  1Q07 A;  3GP4 A;  1R8D A;  1RH6 A;  1Q09 A;  3EZ2 A;  2VZ4 A;  2JML A;  2KVV A;  5I44 A;  2IEF A;  2OG0 A;  4LHF A;  1JBG A;  1PM6 A;  3HH0 A;  5I41 B;  2ZHG A;  3Q5R A;  1Y6U A;  4DCZ A;  1LX8 A;  3Q2Y A;  5D90 A;  4R22 B;  3Q5S A;  1Q05 A;  3Q5P A;  3EZ7 A;  3UCS A;  3GPV A;  4J2N A;  4WLS A;  1R8E A;  1Q06 A;  2ZHH A;  3QAO A;  3EZ6 A;  5D8C A;  3D6Z A;  3Q1M A;  3D6Y A;  1EXI A;  4R24 B;  3EZ9 A;  1Q0A A;  3IAO A;  4R4E A; 
#chains in the Genus database with same CATH homology
 5E01 A;  2DG6 A;  1Q08 A;  4WLW A;  3D70 A;  3D71 A;  1EXJ A;  3EZF A;  3Q3D A;  1Q07 A;  3GP4 A;  1R8D A;  1RH6 A;  1Q09 A;  3EZ2 A;  2VZ4 A;  2JML A;  2KVV A;  5I44 A;  2IEF A;  2OG0 A;  4LHF A;  1JBG A;  1PM6 A;  3HH0 A;  5I41 B;  2ZHG A;  3Q5R A;  1Y6U A;  4DCZ A;  1LX8 A;  3Q2Y A;  5D90 A;  4R22 B;  3Q5S A;  1Q05 A;  3Q5P A;  3EZ7 A;  3UCS A;  3GPV A;  4J2N A;  4WLS A;  1R8E A;  1Q06 A;  2ZHH A;  3QAO A;  3EZ6 A;  5D8C A;  3D6Z A;  3Q1M A;  3D6Y A;  1EXI A;  4R24 B;  3EZ9 A;  1Q0A A;  3IAO A;  4R4E A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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