4NGBA

Structure of human dicer platform-paz-connector helix cassette in complex with 12-mer sirna having uu-3' ends (2.25 angstrom resolution)
Total Genus 70
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
70
sequence length
298
structure length
276
Chain Sequence
QPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELAASGFMLSLQMLELITRLHQYIFSHILRLEKPALAYCVLPLNVVSSTLDIDFKFMEDIEKSEARIGIPSTKYTKETPFVFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLTNLNQPLLDVDHTSSRLNLLTPLSSAEKRKAKWESLQNKQILVPELCAIHPIPASLWRKAVCLPSILYRLHC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase/rna
molecule keywords Endoribonuclease Dicer
publication title A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer.
pubmed doi rcsb
source organism Homo sapiens
total genus 70
structure length 276
sequence length 298
ec nomenclature ec 3.1.26.3: Ribonuclease III.
pdb deposition date 2013-11-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02170 PAZ PAZ domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.260.10 Mainly Beta Beta Complex paz domain paz domain 4ngbA02
4NGBA 4NGGA 4OLAA 4W5OA 4NH3A 4Z4HA 4W5TA 4Z4CA 3O3IX 4Z4IA 3O6EX 3O7XA 4Z4GA 2QVWA 3MJ0A 5JS2A 2FFLA 4Z4EA 5JS1A 1VYNA 1T2SA 4KRFA 1T2RA 1R6ZA 2L5DA 4NGCA 4Z4FA 4NH5A 5KI6A 1R4KA 1SI2A 4NGDA 4W5NA 3QIRA 4W5QA 4NHAA 5T7BA 4NGFA 3O7VX 4NH6A 4KREA 4OLBA 2XFMA 4F3TA 4W5RA 2L5CA 1SI3A
chains in the Genus database with same CATH superfamily
4NGBA 4NGGA 4OLAA 1U04A 3HJFA 4W5OA 4NH3A 4Z4HA 4W5TA 4Z4CA 3O3IX 1Z25A 4Z4IA 3O6EX 3O7XA 3F73A 4Z4GA 2QVWA 3DA5A 3MJ0A 5JS2A 2FFLA 4Z4EA 3HO1A 5JS1A 4L1UA 1VYNA 1T2SA 4KRFA 1T2RA 1R6ZA 1Z26A 2L5DA 3U1UA 4NGCA 4Z4FA 3HVRA 4NH5A 5KI6A 1R4KA 1SI2A 4NGDA 4W5NA 3QIRA 4L1PA 4W5QA 3HM9A 2BZEA 4NHAA 5T7BA 3HK2A 4NGFA 3O7VX 3DLBA 3DLHA 4NH6A 4KREA 4OLBA 2XFMA 4F3TA 2DB9A 4W5RA 2L5CA 1SI3A
chains in the Genus database with same CATH topology
4NGBA 4NGGA 4OLAA 1U04A 3HJFA 4W5OA 4NH3A 4Z4HA 4W5TA 4Z4CA 3O3IX 1Z25A 4Z4IA 3O6EX 3O7XA 3F73A 4Z4GA 2QVWA 3DA5A 3MJ0A 5JS2A 2FFLA 4Z4EA 3HO1A 5JS1A 4L1UA 1VYNA 1T2SA 4KRFA 1T2RA 1R6ZA 1Z26A 2L5DA 3U1UA 4NGCA 4Z4FA 3HVRA 4NH5A 5KI6A 1R4KA 1SI2A 4NGDA 4W5NA 3QIRA 4L1PA 4W5QA 3HM9A 2BZEA 4NHAA 5T7BA 3HK2A 4NGFA 3O7VX 3DLBA 3DLHA 4NH6A 4KREA 4OLBA 2XFMA 4F3TA 2DB9A 4W5RA 2L5CA 1SI3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4NGB A;  4NGG A;  4OLA A;  4W5O A;  4NH3 A;  4Z4H A;  4W5T A;  4Z4C A;  3O3I X;  4Z4I A;  3O6E X;  3O7X A;  4Z4G A;  2QVW A;  3MJ0 A;  5JS2 A;  2FFL A;  4Z4E A;  5JS1 A;  1VYN A;  1T2S A;  4KRF A;  1T2R A;  1R6Z A;  2L5D A;  4NGC A;  4Z4F A;  4NH5 A;  5KI6 A;  1R4K A;  1SI2 A;  4NGD A;  4W5N A;  3QIR A;  4W5Q A;  4NHA A;  5T7B A;  4NGF A;  3O7V X;  4NH6 A;  4KRE A;  4OLB A;  2XFM A;  4F3T A;  4W5R A;  2L5C A;  1SI3 A; 
#chains in the Genus database with same CATH topology
 4NGB A;  4NGG A;  4OLA A;  1U04 A;  3HJF A;  4W5O A;  4NH3 A;  4Z4H A;  4W5T A;  4Z4C A;  3O3I X;  1Z25 A;  4Z4I A;  3O6E X;  3O7X A;  3F73 A;  4Z4G A;  2QVW A;  3DA5 A;  3MJ0 A;  5JS2 A;  2FFL A;  4Z4E A;  3HO1 A;  5JS1 A;  4L1U A;  1VYN A;  1T2S A;  4KRF A;  1T2R A;  1R6Z A;  1Z26 A;  2L5D A;  3U1U A;  4NGC A;  4Z4F A;  3HVR A;  4NH5 A;  5KI6 A;  1R4K A;  1SI2 A;  4NGD A;  4W5N A;  3QIR A;  4L1P A;  4W5Q A;  3HM9 A;  2BZE A;  4NHA A;  5T7B A;  3HK2 A;  4NGF A;  3O7V X;  3DLB A;  3DLH A;  4NH6 A;  4KRE A;  4OLB A;  2XFM A;  4F3T A;  2DB9 A;  4W5R A;  2L5C A;  1SI3 A; 
#chains in the Genus database with same CATH homology
 4NGB A;  4NGG A;  4OLA A;  1U04 A;  3HJF A;  4W5O A;  4NH3 A;  4Z4H A;  4W5T A;  4Z4C A;  3O3I X;  1Z25 A;  4Z4I A;  3O6E X;  3O7X A;  3F73 A;  4Z4G A;  2QVW A;  3DA5 A;  3MJ0 A;  5JS2 A;  2FFL A;  4Z4E A;  3HO1 A;  5JS1 A;  4L1U A;  1VYN A;  1T2S A;  4KRF A;  1T2R A;  1R6Z A;  1Z26 A;  2L5D A;  3U1U A;  4NGC A;  4Z4F A;  3HVR A;  4NH5 A;  5KI6 A;  1R4K A;  1SI2 A;  4NGD A;  4W5N A;  3QIR A;  4L1P A;  4W5Q A;  3HM9 A;  2BZE A;  4NHA A;  5T7B A;  3HK2 A;  4NGF A;  3O7V X;  3DLB A;  3DLH A;  4NH6 A;  4KRE A;  4OLB A;  2XFM A;  4F3T A;  2DB9 A;  4W5R A;  2L5C A;  1SI3 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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