4NGCA

Structure of human dicer platform-paz-connector helix cassette in complex with 12-mer sirna having ua-3' ends (2.1 angstrom resolution)
Total Genus 71
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
71
sequence length
299
structure length
276
Chain Sequence
DQPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELAASGFMLSLQMLELITRLHQYIFSHILRLEKPALYCVLPLNVVSSTLDIDFKFMEDIEKSEARIGIPSTKYTKETPFVFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLTNLNQPLLDVDHTSSRLNLLTPLSSAEKRKAKWESLQNKQILVPELCAIHPIPASLWRKAVCLPSILYRLHC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer.
pubmed doi rcsb
molecule tags Hydrolase/rna
source organism Homo sapiens
molecule keywords Endoribonuclease Dicer
total genus 71
structure length 276
sequence length 299
ec nomenclature ec 3.1.26.3: Ribonuclease III.
pdb deposition date 2013-11-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02170 PAZ PAZ domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.260.10 Mainly Beta Beta Complex paz domain paz domain 4ngcA02
4W5OA 4OLBA 1SI2A 4Z4IA 4W5RA 3MJ0A 4NH6A 4OLAA 4KREA 4F3TA 4NGCA 3QIRA 4Z4EA 4NH5A 5T7BA 4Z4FA 1T2RA 4NGDA 4NH3A 4KRFA 4NGGA 3O7XA 3O6EX 5KI6A 3O7VX 1T2SA 5JS1A 2L5CA 2XFMA 2QVWA 4Z4CA 4W5NA 1R4KA 1R6ZA 1SI3A 4W5TA 1VYNA 2FFLA 4NHAA 3O3IX 4NGFA 4W5QA 4Z4HA 5JS2A 4NGBA 2L5DA 4Z4GA
chains in the Genus database with same CATH superfamily
4W5OA 4OLBA 3HJFA 3HK2A 3HVRA 1SI2A 4Z4IA 4W5RA 2DB9A 1U04A 3MJ0A 4NH6A 4OLAA 4KREA 4F3TA 4NGCA 3QIRA 3F73A 4Z4EA 4NH5A 5T7BA 4Z4FA 1T2RA 4NGDA 3U1UA 1Z26A 4NH3A 4KRFA 4NGGA 3O7XA 3O6EX 5KI6A 3O7VX 1T2SA 5JS1A 3HO1A 2L5CA 3HM9A 2XFMA 3DLBA 2QVWA 4Z4CA 1Z25A 4W5NA 1R4KA 3DA5A 2BZEA 1R6ZA 4L1PA 1SI3A 4W5TA 1VYNA 2FFLA 4NHAA 3O3IX 4NGFA 4W5QA 4L1UA 5JS2A 4Z4HA 3DLHA 2L5DA 4NGBA 4Z4GA
chains in the Genus database with same CATH topology
4W5OA 4OLBA 3HJFA 3HK2A 3HVRA 1SI2A 4Z4IA 4W5RA 2DB9A 1U04A 3MJ0A 4NH6A 4OLAA 4KREA 4F3TA 4NGCA 3QIRA 3F73A 4Z4EA 4NH5A 5T7BA 4Z4FA 1T2RA 4NGDA 3U1UA 1Z26A 4NH3A 4KRFA 4NGGA 3O7XA 3O6EX 5KI6A 3O7VX 1T2SA 5JS1A 3HO1A 2L5CA 3HM9A 2XFMA 3DLBA 2QVWA 4Z4CA 1Z25A 4W5NA 1R4KA 3DA5A 2BZEA 1R6ZA 4L1PA 1SI3A 4W5TA 1VYNA 2FFLA 4NHAA 3O3IX 4NGFA 4W5QA 4L1UA 5JS2A 4Z4HA 3DLHA 2L5DA 4NGBA 4Z4GA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4W5O A;  4OLB A;  1SI2 A;  4Z4I A;  4W5R A;  3MJ0 A;  4NH6 A;  4OLA A;  4KRE A;  4F3T A;  4NGC A;  3QIR A;  4Z4E A;  4NH5 A;  5T7B A;  4Z4F A;  1T2R A;  4NGD A;  4NH3 A;  4KRF A;  4NGG A;  3O7X A;  3O6E X;  5KI6 A;  3O7V X;  1T2S A;  5JS1 A;  2L5C A;  2XFM A;  2QVW A;  4Z4C A;  4W5N A;  1R4K A;  1R6Z A;  1SI3 A;  4W5T A;  1VYN A;  2FFL A;  4NHA A;  3O3I X;  4NGF A;  4W5Q A;  4Z4H A;  5JS2 A;  4NGB A;  2L5D A;  4Z4G A; 
#chains in the Genus database with same CATH topology
 4W5O A;  4OLB A;  3HJF A;  3HK2 A;  3HVR A;  1SI2 A;  4Z4I A;  4W5R A;  2DB9 A;  1U04 A;  3MJ0 A;  4NH6 A;  4OLA A;  4KRE A;  4F3T A;  4NGC A;  3QIR A;  3F73 A;  4Z4E A;  4NH5 A;  5T7B A;  4Z4F A;  1T2R A;  4NGD A;  3U1U A;  1Z26 A;  4NH3 A;  4KRF A;  4NGG A;  3O7X A;  3O6E X;  5KI6 A;  3O7V X;  1T2S A;  5JS1 A;  3HO1 A;  2L5C A;  3HM9 A;  2XFM A;  3DLB A;  2QVW A;  4Z4C A;  1Z25 A;  4W5N A;  1R4K A;  3DA5 A;  2BZE A;  1R6Z A;  4L1P A;  1SI3 A;  4W5T A;  1VYN A;  2FFL A;  4NHA A;  3O3I X;  4NGF A;  4W5Q A;  4L1U A;  5JS2 A;  4Z4H A;  3DLH A;  2L5D A;  4NGB A;  4Z4G A; 
#chains in the Genus database with same CATH homology
 4W5O A;  4OLB A;  3HJF A;  3HK2 A;  3HVR A;  1SI2 A;  4Z4I A;  4W5R A;  2DB9 A;  1U04 A;  3MJ0 A;  4NH6 A;  4OLA A;  4KRE A;  4F3T A;  4NGC A;  3QIR A;  3F73 A;  4Z4E A;  4NH5 A;  5T7B A;  4Z4F A;  1T2R A;  4NGD A;  3U1U A;  1Z26 A;  4NH3 A;  4KRF A;  4NGG A;  3O7X A;  3O6E X;  5KI6 A;  3O7V X;  1T2S A;  5JS1 A;  3HO1 A;  2L5C A;  3HM9 A;  2XFM A;  3DLB A;  2QVW A;  4Z4C A;  1Z25 A;  4W5N A;  1R4K A;  3DA5 A;  2BZE A;  1R6Z A;  4L1P A;  1SI3 A;  4W5T A;  1VYN A;  2FFL A;  4NHA A;  3O3I X;  4NGF A;  4W5Q A;  4L1U A;  5JS2 A;  4Z4H A;  3DLH A;  2L5D A;  4NGB A;  4Z4G A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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