4NGDA

Structure of human dicer platform-paz-connector helix cassette in complex with 12-mer sirna having 5'-p and uu-3' ends (1.95 angstrom resolution)
Total Genus 69
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
69
sequence length
298
structure length
280
Chain Sequence
QPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELAASGFMLSLQMLELITRLHQYIFSHILRLEKPALAYCVLPLNVVSSTLDIDFKFMEDIEKSEARIGIPSTKYTKETPFVFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLTNLNQPLLDVDHTSSRLNLLTPRHLPLSSAEKRKAKWESLQNKQILVPELCAIHPIPASLWRKAVCLPSILYRLHC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer.
pubmed doi rcsb
molecule tags Hydrolase/rna
source organism Homo sapiens
molecule keywords Endoribonuclease Dicer
total genus 69
structure length 280
sequence length 298
ec nomenclature ec 3.1.26.3: Ribonuclease III.
pdb deposition date 2013-11-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02170 PAZ PAZ domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.260.10 Mainly Beta Beta Complex paz domain paz domain 4ngdA02
2FFLA 3MJ0A 4NGBA 4NHAA 4W5QA 2XFMA 1SI2A 4NGGA 1T2SA 5JS1A 5JS2A 1T2RA 4Z4GA 4W5NA 2L5DA 5KI6A 1R4KA 4NGFA 2QVWA 4Z4CA 4W5OA 3O6EX 4NGDA 4Z4HA 4F3TA 1R6ZA 4OLAA 5T7BA 4Z4EA 4NGCA 4NH3A 2L5CA 4OLBA 3O3IX 4KRFA 1VYNA 3O7VX 3QIRA 3O7XA 4W5TA 4NH5A 4W5RA 4KREA 4Z4IA 1SI3A 4Z4FA 4NH6A
chains in the Genus database with same CATH superfamily
2FFLA 3U1UA 3MJ0A 1Z25A 4NGBA 4NHAA 4W5QA 4L1PA 2XFMA 1SI2A 2BZEA 4NGGA 1T2SA 5JS1A 3HO1A 5JS2A 1T2RA 4Z4GA 3HVRA 4W5NA 2L5DA 5KI6A 1R4KA 3HK2A 4NGFA 2QVWA 4Z4CA 4W5OA 3O6EX 4NGDA 2DB9A 4Z4HA 4F3TA 3DLHA 1R6ZA 3HM9A 3F73A 4OLAA 5T7BA 4Z4EA 4NGCA 1U04A 4NH6A 4NH3A 2L5CA 4OLBA 3O3IX 3DLBA 4KRFA 1VYNA 3O7VX 3QIRA 3O7XA 4W5TA 3HJFA 4NH5A 4W5RA 3DA5A 4KREA 4Z4IA 4L1UA 4Z4FA 1Z26A 1SI3A
chains in the Genus database with same CATH topology
2FFLA 3U1UA 3MJ0A 1Z25A 4NGBA 4NHAA 4W5QA 4L1PA 2XFMA 1SI2A 2BZEA 4NGGA 1T2SA 5JS1A 3HO1A 5JS2A 1T2RA 4Z4GA 3HVRA 4W5NA 2L5DA 5KI6A 1R4KA 3HK2A 4NGFA 2QVWA 4Z4CA 4W5OA 3O6EX 4NGDA 2DB9A 4Z4HA 4F3TA 3DLHA 1R6ZA 3HM9A 3F73A 4OLAA 5T7BA 4Z4EA 4NGCA 1U04A 4NH6A 4NH3A 2L5CA 4OLBA 3O3IX 3DLBA 4KRFA 1VYNA 3O7VX 3QIRA 3O7XA 4W5TA 3HJFA 4NH5A 4W5RA 3DA5A 4KREA 4Z4IA 4L1UA 4Z4FA 1Z26A 1SI3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2FFL A;  3MJ0 A;  4NGB A;  4NHA A;  4W5Q A;  2XFM A;  1SI2 A;  4NGG A;  1T2S A;  5JS1 A;  5JS2 A;  1T2R A;  4Z4G A;  4W5N A;  2L5D A;  5KI6 A;  1R4K A;  4NGF A;  2QVW A;  4Z4C A;  4W5O A;  3O6E X;  4NGD A;  4Z4H A;  4F3T A;  1R6Z A;  4OLA A;  5T7B A;  4Z4E A;  4NGC A;  4NH3 A;  2L5C A;  4OLB A;  3O3I X;  4KRF A;  1VYN A;  3O7V X;  3QIR A;  3O7X A;  4W5T A;  4NH5 A;  4W5R A;  4KRE A;  4Z4I A;  1SI3 A;  4Z4F A;  4NH6 A; 
#chains in the Genus database with same CATH topology
 2FFL A;  3U1U A;  3MJ0 A;  1Z25 A;  4NGB A;  4NHA A;  4W5Q A;  4L1P A;  2XFM A;  1SI2 A;  2BZE A;  4NGG A;  1T2S A;  5JS1 A;  3HO1 A;  5JS2 A;  1T2R A;  4Z4G A;  3HVR A;  4W5N A;  2L5D A;  5KI6 A;  1R4K A;  3HK2 A;  4NGF A;  2QVW A;  4Z4C A;  4W5O A;  3O6E X;  4NGD A;  2DB9 A;  4Z4H A;  4F3T A;  3DLH A;  1R6Z A;  3HM9 A;  3F73 A;  4OLA A;  5T7B A;  4Z4E A;  4NGC A;  1U04 A;  4NH6 A;  4NH3 A;  2L5C A;  4OLB A;  3O3I X;  3DLB A;  4KRF A;  1VYN A;  3O7V X;  3QIR A;  3O7X A;  4W5T A;  3HJF A;  4NH5 A;  4W5R A;  3DA5 A;  4KRE A;  4Z4I A;  4L1U A;  4Z4F A;  1Z26 A;  1SI3 A; 
#chains in the Genus database with same CATH homology
 2FFL A;  3U1U A;  3MJ0 A;  1Z25 A;  4NGB A;  4NHA A;  4W5Q A;  4L1P A;  2XFM A;  1SI2 A;  2BZE A;  4NGG A;  1T2S A;  5JS1 A;  3HO1 A;  5JS2 A;  1T2R A;  4Z4G A;  3HVR A;  4W5N A;  2L5D A;  5KI6 A;  1R4K A;  3HK2 A;  4NGF A;  2QVW A;  4Z4C A;  4W5O A;  3O6E X;  4NGD A;  2DB9 A;  4Z4H A;  4F3T A;  3DLH A;  1R6Z A;  3HM9 A;  3F73 A;  4OLA A;  5T7B A;  4Z4E A;  4NGC A;  1U04 A;  4NH6 A;  4NH3 A;  2L5C A;  4OLB A;  3O3I X;  3DLB A;  4KRF A;  1VYN A;  3O7V X;  3QIR A;  3O7X A;  4W5T A;  3HJF A;  4NH5 A;  4W5R A;  3DA5 A;  4KRE A;  4Z4I A;  4L1U A;  4Z4F A;  1Z26 A;  1SI3 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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