4NGFA

Structure of human dicer platform-paz-connector helix cassette in complex with 17-mer sirna having 5'-p and uu-3' ends (3.1 angstrom resolution)
Total Genus 50
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
50
sequence length
298
structure length
260
Chain Sequence
QPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELKKSGFMLSLQMLELITRLHQYIFSHILRYCVLPLNVVSTLDIDFKFMEDIEKSETKETPFVFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLTNLNQPLLDVDHTSSRLNLLTPRPLSSAEKRKAKWESLQNKQILVPELCAIHPIPASLWRKAVCLPSILYRLHC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer.
pubmed doi rcsb
molecule tags Hydrolase/rna
source organism Homo sapiens
molecule keywords Endoribonuclease Dicer
total genus 50
structure length 260
sequence length 298
chains with identical sequence B, C, D
ec nomenclature ec 3.1.26.3: Ribonuclease III.
pdb deposition date 2013-11-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02170 PAZ PAZ domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.260.10 Mainly Beta Beta Complex paz domain paz domain 4ngfA02
4Z4FA 4W5RA 3O7VX 5T7BA 4NGDA 3QIRA 4W5NA 4NGBA 2XFMA 1T2SA 3O3IX 3MJ0A 2QVWA 4OLAA 4KREA 3O7XA 4W5TA 5JS1A 1R6ZA 4NGCA 4W5QA 4NH3A 4Z4CA 4Z4GA 4NH6A 4KRFA 4NGGA 1VYNA 2L5CA 1R4KA 3O6EX 4NHAA 1T2RA 4F3TA 4NH5A 4NGFA 4Z4HA 2L5DA 4W5OA 1SI3A 1SI2A 4OLBA 2FFLA 4Z4IA 4Z4EA 5KI6A 5JS2A
chains in the Genus database with same CATH superfamily
3U1UA 3HO1A 4Z4FA 4W5RA 3HM9A 5T7BA 3O7VX 2DB9A 4NGDA 3QIRA 4W5NA 4NGBA 4L1UA 2XFMA 1T2SA 3O3IX 3MJ0A 2QVWA 4OLAA 4KREA 3HK2A 3DLHA 3O7XA 1U04A 4W5TA 5JS1A 1R6ZA 4NGCA 4W5QA 4NH3A 4Z4CA 1Z26A 3HJFA 4Z4GA 4NH6A 2BZEA 4L1PA 4KRFA 4NGGA 1VYNA 3DA5A 2L5CA 1R4KA 3O6EX 4NHAA 1T2RA 3HVRA 4F3TA 4NH5A 4NGFA 4Z4HA 2L5DA 1Z25A 4W5OA 1SI3A 1SI2A 4OLBA 2FFLA 3F73A 4Z4IA 4Z4EA 5KI6A 5JS2A 3DLBA
chains in the Genus database with same CATH topology
3U1UA 3HO1A 4Z4FA 4W5RA 3HM9A 5T7BA 3O7VX 2DB9A 4NGDA 3QIRA 4W5NA 4NGBA 4L1UA 2XFMA 1T2SA 3O3IX 3MJ0A 2QVWA 4OLAA 4KREA 3HK2A 3DLHA 3O7XA 1U04A 4W5TA 5JS1A 1R6ZA 4NGCA 4W5QA 4NH3A 4Z4CA 1Z26A 3HJFA 4Z4GA 4NH6A 2BZEA 4L1PA 4KRFA 4NGGA 1VYNA 3DA5A 2L5CA 1R4KA 3O6EX 4NHAA 1T2RA 3HVRA 4F3TA 4NH5A 4NGFA 4Z4HA 2L5DA 1Z25A 4W5OA 1SI3A 1SI2A 4OLBA 2FFLA 3F73A 4Z4IA 4Z4EA 5KI6A 5JS2A 3DLBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4Z4F A;  4W5R A;  3O7V X;  5T7B A;  4NGD A;  3QIR A;  4W5N A;  4NGB A;  2XFM A;  1T2S A;  3O3I X;  3MJ0 A;  2QVW A;  4OLA A;  4KRE A;  3O7X A;  4W5T A;  5JS1 A;  1R6Z A;  4NGC A;  4W5Q A;  4NH3 A;  4Z4C A;  4Z4G A;  4NH6 A;  4KRF A;  4NGG A;  1VYN A;  2L5C A;  1R4K A;  3O6E X;  4NHA A;  1T2R A;  4F3T A;  4NH5 A;  4NGF A;  4Z4H A;  2L5D A;  4W5O A;  1SI3 A;  1SI2 A;  4OLB A;  2FFL A;  4Z4I A;  4Z4E A;  5KI6 A;  5JS2 A; 
#chains in the Genus database with same CATH topology
 3U1U A;  3HO1 A;  4Z4F A;  4W5R A;  3HM9 A;  5T7B A;  3O7V X;  2DB9 A;  4NGD A;  3QIR A;  4W5N A;  4NGB A;  4L1U A;  2XFM A;  1T2S A;  3O3I X;  3MJ0 A;  2QVW A;  4OLA A;  4KRE A;  3HK2 A;  3DLH A;  3O7X A;  1U04 A;  4W5T A;  5JS1 A;  1R6Z A;  4NGC A;  4W5Q A;  4NH3 A;  4Z4C A;  1Z26 A;  3HJF A;  4Z4G A;  4NH6 A;  2BZE A;  4L1P A;  4KRF A;  4NGG A;  1VYN A;  3DA5 A;  2L5C A;  1R4K A;  3O6E X;  4NHA A;  1T2R A;  3HVR A;  4F3T A;  4NH5 A;  4NGF A;  4Z4H A;  2L5D A;  1Z25 A;  4W5O A;  1SI3 A;  1SI2 A;  4OLB A;  2FFL A;  3F73 A;  4Z4I A;  4Z4E A;  5KI6 A;  5JS2 A;  3DLB A; 
#chains in the Genus database with same CATH homology
 3U1U A;  3HO1 A;  4Z4F A;  4W5R A;  3HM9 A;  5T7B A;  3O7V X;  2DB9 A;  4NGD A;  3QIR A;  4W5N A;  4NGB A;  4L1U A;  2XFM A;  1T2S A;  3O3I X;  3MJ0 A;  2QVW A;  4OLA A;  4KRE A;  3HK2 A;  3DLH A;  3O7X A;  1U04 A;  4W5T A;  5JS1 A;  1R6Z A;  4NGC A;  4W5Q A;  4NH3 A;  4Z4C A;  1Z26 A;  3HJF A;  4Z4G A;  4NH6 A;  2BZE A;  4L1P A;  4KRF A;  4NGG A;  1VYN A;  3DA5 A;  2L5C A;  1R4K A;  3O6E X;  4NHA A;  1T2R A;  3HVR A;  4F3T A;  4NH5 A;  4NGF A;  4Z4H A;  2L5D A;  1Z25 A;  4W5O A;  1SI3 A;  1SI2 A;  4OLB A;  2FFL A;  3F73 A;  4Z4I A;  4Z4E A;  5KI6 A;  5JS2 A;  3DLB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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