4NGGA

Structure of human dicer platform-paz-connector helix cassette in complex with 13-mer sirna having 5'-a and uu-3' ends (2.6 angstrom resolution)
Total Genus 65
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
65
sequence length
298
structure length
267
Chain Sequence
QPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELAASGFMLSLQMLELITRLHQYIFSHILRLEYCVLPLNVVNDSTLDIDFKFMEDIEKSEARIGIPSTKYTKETPFVFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLTNLNQPLLDVDHTSSRLNLLTPRRKAKWESLQNKQILVPELCAIHPIPASLWRKAVCLPSILYRLHC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer.
pubmed doi rcsb
molecule tags Hydrolase/rna
source organism Homo sapiens
molecule keywords Endoribonuclease Dicer
total genus 65
structure length 267
sequence length 298
ec nomenclature ec 3.1.26.3: Ribonuclease III.
pdb deposition date 2013-11-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02170 PAZ PAZ domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.260.10 Mainly Beta Beta Complex paz domain paz domain 4nggA02
2L5DA 4OLBA 3O7XA 4NH3A 5JS2A 1T2SA 3O7VX 4NGFA 4NHAA 4Z4HA 2FFLA 1SI2A 1SI3A 4W5RA 1R6ZA 4W5OA 2XFMA 4Z4IA 4Z4FA 4NGGA 4KREA 4Z4GA 4W5TA 3MJ0A 4NGDA 4OLAA 4Z4CA 2L5CA 5JS1A 1T2RA 4NGBA 5KI6A 4W5QA 4W5NA 4NH6A 4NH5A 4Z4EA 3O3IX 5T7BA 2QVWA 1VYNA 3O6EX 4F3TA 3QIRA 4KRFA 1R4KA 4NGCA
chains in the Genus database with same CATH superfamily
2L5DA 4OLBA 3O7XA 4NH3A 3HM9A 5JS2A 1T2SA 3O7VX 4NGFA 4NHAA 4Z4HA 2FFLA 1Z25A 1SI2A 4W5RA 1SI3A 1R6ZA 4W5OA 2XFMA 4Z4IA 4Z4FA 4NGGA 4KREA 3HK2A 1Z26A 4Z4GA 4W5TA 3HJFA 3MJ0A 3HVRA 2DB9A 4NGDA 4OLAA 2L5CA 2BZEA 4Z4CA 3HO1A 5JS1A 3U1UA 1T2RA 4NGBA 5KI6A 4W5QA 4W5NA 4NH6A 3F73A 4NH5A 4L1PA 4Z4EA 3DLHA 4L1UA 3DLBA 3O3IX 5T7BA 2QVWA 1VYNA 3O6EX 4F3TA 3DA5A 3QIRA 1U04A 4KRFA 1R4KA 4NGCA
chains in the Genus database with same CATH topology
2L5DA 4OLBA 3O7XA 4NH3A 3HM9A 5JS2A 1T2SA 3O7VX 4NGFA 4NHAA 4Z4HA 2FFLA 1Z25A 1SI2A 4W5RA 1SI3A 1R6ZA 4W5OA 2XFMA 4Z4IA 4Z4FA 4NGGA 4KREA 3HK2A 1Z26A 4Z4GA 4W5TA 3HJFA 3MJ0A 3HVRA 2DB9A 4NGDA 4OLAA 2L5CA 2BZEA 4Z4CA 3HO1A 5JS1A 3U1UA 1T2RA 4NGBA 5KI6A 4W5QA 4W5NA 4NH6A 3F73A 4NH5A 4L1PA 4Z4EA 3DLHA 4L1UA 3DLBA 3O3IX 5T7BA 2QVWA 1VYNA 3O6EX 4F3TA 3DA5A 3QIRA 1U04A 4KRFA 1R4KA 4NGCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2L5D A;  4OLB A;  3O7X A;  4NH3 A;  5JS2 A;  1T2S A;  3O7V X;  4NGF A;  4NHA A;  4Z4H A;  2FFL A;  1SI2 A;  1SI3 A;  4W5R A;  1R6Z A;  4W5O A;  2XFM A;  4Z4I A;  4Z4F A;  4NGG A;  4KRE A;  4Z4G A;  4W5T A;  3MJ0 A;  4NGD A;  4OLA A;  4Z4C A;  2L5C A;  5JS1 A;  1T2R A;  4NGB A;  5KI6 A;  4W5Q A;  4W5N A;  4NH6 A;  4NH5 A;  4Z4E A;  3O3I X;  5T7B A;  2QVW A;  1VYN A;  3O6E X;  4F3T A;  3QIR A;  4KRF A;  1R4K A;  4NGC A; 
#chains in the Genus database with same CATH topology
 2L5D A;  4OLB A;  3O7X A;  4NH3 A;  3HM9 A;  5JS2 A;  1T2S A;  3O7V X;  4NGF A;  4NHA A;  4Z4H A;  2FFL A;  1Z25 A;  1SI2 A;  4W5R A;  1SI3 A;  1R6Z A;  4W5O A;  2XFM A;  4Z4I A;  4Z4F A;  4NGG A;  4KRE A;  3HK2 A;  1Z26 A;  4Z4G A;  4W5T A;  3HJF A;  3MJ0 A;  3HVR A;  2DB9 A;  4NGD A;  4OLA A;  2L5C A;  2BZE A;  4Z4C A;  3HO1 A;  5JS1 A;  3U1U A;  1T2R A;  4NGB A;  5KI6 A;  4W5Q A;  4W5N A;  4NH6 A;  3F73 A;  4NH5 A;  4L1P A;  4Z4E A;  3DLH A;  4L1U A;  3DLB A;  3O3I X;  5T7B A;  2QVW A;  1VYN A;  3O6E X;  4F3T A;  3DA5 A;  3QIR A;  1U04 A;  4KRF A;  1R4K A;  4NGC A; 
#chains in the Genus database with same CATH homology
 2L5D A;  4OLB A;  3O7X A;  4NH3 A;  3HM9 A;  5JS2 A;  1T2S A;  3O7V X;  4NGF A;  4NHA A;  4Z4H A;  2FFL A;  1Z25 A;  1SI2 A;  4W5R A;  1SI3 A;  1R6Z A;  4W5O A;  2XFM A;  4Z4I A;  4Z4F A;  4NGG A;  4KRE A;  3HK2 A;  1Z26 A;  4Z4G A;  4W5T A;  3HJF A;  3MJ0 A;  3HVR A;  2DB9 A;  4NGD A;  4OLA A;  2L5C A;  2BZE A;  4Z4C A;  3HO1 A;  5JS1 A;  3U1U A;  1T2R A;  4NGB A;  5KI6 A;  4W5Q A;  4W5N A;  4NH6 A;  3F73 A;  4NH5 A;  4L1P A;  4Z4E A;  3DLH A;  4L1U A;  3DLB A;  3O3I X;  5T7B A;  2QVW A;  1VYN A;  3O6E X;  4F3T A;  3DA5 A;  3QIR A;  1U04 A;  4KRF A;  1R4K A;  4NGC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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