4NHAA

Structure of human dicer platform-paz-connector helix cassette in complex with 16-mer sirna having 5'-p and uu-3' ends (3.4 angstrom resolution)
Total Genus 43
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
43
sequence length
294
structure length
234
Chain Sequence
LYVIGMVLTTPLPDELRKLYPPEDTTRCFGILTAKPIPQIPVYTRSGEVTISIELKKSGFMLSLQMLELITRLHQYIFSHILRLSAYCVLPLNVTLDIDFKFMEDIEKSTKYTKETPFVFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLTNLNQPLLDVDHTSSRLNLLTPKQILVPELCAIHPIPASLWRKAVCLPSILYRLHC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer.
pubmed doi rcsb
molecule tags Hydrolase/rna
source organism Homo sapiens
molecule keywords Endoribonuclease Dicer
total genus 43
structure length 234
sequence length 294
ec nomenclature ec 3.1.26.3: Ribonuclease III.
pdb deposition date 2013-11-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02170 PAZ PAZ domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.260.10 Mainly Beta Beta Complex paz domain paz domain 4nhaA02
1R4KA 4NGBA 4Z4EA 4NH5A 1R6ZA 4NGDA 4OLAA 4W5QA 5JS1A 1VYNA 4KRFA 4W5OA 4Z4GA 4NGGA 4W5RA 4NH3A 3MJ0A 4NHAA 5KI6A 3O7XA 1T2RA 4KREA 2FFLA 4NGFA 3QIRA 5JS2A 4F3TA 2L5DA 4W5NA 2QVWA 1SI2A 4Z4FA 4W5TA 4NGCA 4Z4IA 3O3IX 4OLBA 1SI3A 4Z4HA 5T7BA 2XFMA 4NH6A 3O7VX 2L5CA 1T2SA 4Z4CA 3O6EX
chains in the Genus database with same CATH superfamily
1R4KA 4NGBA 4Z4EA 4NH5A 1R6ZA 4NGDA 4OLAA 4W5QA 5JS1A 3DLHA 1VYNA 4KRFA 4W5OA 4Z4GA 4NGGA 4W5RA 3F73A 1Z25A 4NH3A 3MJ0A 4NHAA 5KI6A 3O7XA 3HVRA 1T2RA 4KREA 2FFLA 3HK2A 2BZEA 4NGFA 3QIRA 4L1UA 1Z26A 3HO1A 4Z4CA 4F3TA 2L5DA 4W5NA 3U1UA 2QVWA 1SI2A 4Z4FA 4W5TA 3HJFA 4NGCA 4Z4IA 3O3IX 3DLBA 4OLBA 4L1PA 3DA5A 1SI3A 1U04A 4Z4HA 2DB9A 5T7BA 2XFMA 3HM9A 3O7VX 2L5CA 4NH6A 1T2SA 5JS2A 3O6EX
chains in the Genus database with same CATH topology
1R4KA 4NGBA 4Z4EA 4NH5A 1R6ZA 4NGDA 4OLAA 4W5QA 5JS1A 3DLHA 1VYNA 4KRFA 4W5OA 4Z4GA 4NGGA 4W5RA 3F73A 1Z25A 4NH3A 3MJ0A 4NHAA 5KI6A 3O7XA 3HVRA 1T2RA 4KREA 2FFLA 3HK2A 2BZEA 4NGFA 3QIRA 4L1UA 1Z26A 3HO1A 4Z4CA 4F3TA 2L5DA 4W5NA 3U1UA 2QVWA 1SI2A 4Z4FA 4W5TA 3HJFA 4NGCA 4Z4IA 3O3IX 3DLBA 4OLBA 4L1PA 3DA5A 1SI3A 1U04A 4Z4HA 2DB9A 5T7BA 2XFMA 3HM9A 3O7VX 2L5CA 4NH6A 1T2SA 5JS2A 3O6EX
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1R4K A;  4NGB A;  4Z4E A;  4NH5 A;  1R6Z A;  4NGD A;  4OLA A;  4W5Q A;  5JS1 A;  1VYN A;  4KRF A;  4W5O A;  4Z4G A;  4NGG A;  4W5R A;  4NH3 A;  3MJ0 A;  4NHA A;  5KI6 A;  3O7X A;  1T2R A;  4KRE A;  2FFL A;  4NGF A;  3QIR A;  5JS2 A;  4F3T A;  2L5D A;  4W5N A;  2QVW A;  1SI2 A;  4Z4F A;  4W5T A;  4NGC A;  4Z4I A;  3O3I X;  4OLB A;  1SI3 A;  4Z4H A;  5T7B A;  2XFM A;  4NH6 A;  3O7V X;  2L5C A;  1T2S A;  4Z4C A;  3O6E X; 
#chains in the Genus database with same CATH topology
 1R4K A;  4NGB A;  4Z4E A;  4NH5 A;  1R6Z A;  4NGD A;  4OLA A;  4W5Q A;  5JS1 A;  3DLH A;  1VYN A;  4KRF A;  4W5O A;  4Z4G A;  4NGG A;  4W5R A;  3F73 A;  1Z25 A;  4NH3 A;  3MJ0 A;  4NHA A;  5KI6 A;  3O7X A;  3HVR A;  1T2R A;  4KRE A;  2FFL A;  3HK2 A;  2BZE A;  4NGF A;  3QIR A;  4L1U A;  1Z26 A;  3HO1 A;  4Z4C A;  4F3T A;  2L5D A;  4W5N A;  3U1U A;  2QVW A;  1SI2 A;  4Z4F A;  4W5T A;  3HJF A;  4NGC A;  4Z4I A;  3O3I X;  3DLB A;  4OLB A;  4L1P A;  3DA5 A;  1SI3 A;  1U04 A;  4Z4H A;  2DB9 A;  5T7B A;  2XFM A;  3HM9 A;  3O7V X;  2L5C A;  4NH6 A;  1T2S A;  5JS2 A;  3O6E X; 
#chains in the Genus database with same CATH homology
 1R4K A;  4NGB A;  4Z4E A;  4NH5 A;  1R6Z A;  4NGD A;  4OLA A;  4W5Q A;  5JS1 A;  3DLH A;  1VYN A;  4KRF A;  4W5O A;  4Z4G A;  4NGG A;  4W5R A;  3F73 A;  1Z25 A;  4NH3 A;  3MJ0 A;  4NHA A;  5KI6 A;  3O7X A;  3HVR A;  1T2R A;  4KRE A;  2FFL A;  3HK2 A;  2BZE A;  4NGF A;  3QIR A;  4L1U A;  1Z26 A;  3HO1 A;  4Z4C A;  4F3T A;  2L5D A;  4W5N A;  3U1U A;  2QVW A;  1SI2 A;  4Z4F A;  4W5T A;  3HJF A;  4NGC A;  4Z4I A;  3O3I X;  3DLB A;  4OLB A;  4L1P A;  3DA5 A;  1SI3 A;  1U04 A;  4Z4H A;  2DB9 A;  5T7B A;  2XFM A;  3HM9 A;  3O7V X;  2L5C A;  4NH6 A;  1T2S A;  5JS2 A;  3O6E X; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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