5E0U | Genus

Total Genus 60

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	60
sequence length	255
structure length	255
Chain Sequence	MFEARLVQGSILKKVLEALKDLINEACWDISSSGVNLQSMDSSHVSLVQLTLRSEGFDTYRCDRNLAMGVNLTSMSKILKCAGNEDIITLRAEDNADTLALVFEAPNQEKVSDYEMKLMDLDVEQLGIPEQEYSCVVKMPSGEFARICRDLSHIGDAVVISCAKDGVKFSASGELGNGNIKLSQTSNVDKEEEAVTIEMNEPVQLTFALRYLNFFTKATPLSSTVTLIMSADVPLVVEYKIADMGHLKYYLAPKI

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Dna binding protein
source organism	Homo sapiens
publication title	A Disease-Causing Variant in PCNA Disrupts a Promiscuous Protein Binding Site. pubmed doi rcsb
molecule keywords	Proliferating cell nuclear antigen
total genus	60
structure length	255
sequence length	255
chains with identical sequence	B, C
ec nomenclature
pdb deposition date	2015-09-29

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00705	PCNA_N	Proliferating cell nuclear antigen, N-terminal domain
A	PF02747	PCNA_C	Proliferating cell nuclear antigen, C-terminal domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.70.10.10	Alpha Beta	Box	Proliferating Cell Nuclear Antigen	Proliferating Cell Nuclear Antigen	5e0uA00

3G65A 1UD9A 5A6DA 3GPMA 5DA7A 4CS5A 2IO4A 2ZVWA 5AUJA 4L60A 4L6PA 3P87A 3G65B 1RXMA 1YYPA 3AIZC 1PLQA 3TBLA 3I2MX 4TR6A 3GPNA 5CFKA 2IO4B 3AIXB 1CZDA 1U7BA 2HIKA 2IZOB 3V62B 3LX1A 1AXCA 3A1JA 3FDSD 2HIKB 3U60F 3FDSC 4D2GA 1B8HA 3G65C 3AIXA 5JNED 3A1JB 1RXZA 2ZVMA 4RJFA 3VKXA 3P83A 2IX2B 2IZOC 5E0UA 4YHRA 5E0VA 5HACA 5IWDA 1SXJF 2HIKC 1ISQA 2HIIB 3U5ZF 1GE8A 5IXAA 2IX2A 3WGWA 3GGRB 3A1JC 1DMLA 5B7OA 2IX2C 3V61B 1VYJA 3A2FB 2IJXA 3LX2A 2HIIA 2ZVVA 1W60A 2ZVKA 1T6LA 4ZTDA 5IY4A 5E0TA 2HIIC 1IZ5A 1PLRA 2Z0LA 3K4XA 2NTIB 3U61F 3AIZA 3HI8A 1VYMA 3P91A 2AVTA 3GGRA 1IZ4A 1RWZA 2AWAA 1U76A 3HSLX 5H0TA 3IFVA 2OD8A 2NTIA 3GGRC 1B77A 5DAIA 1UL1A 3V60B 2NTIC 4HK1A 3F1WA 2ZVLA
chains in the Genus database with same CATH superfamily

#chains in the Genus database with same CATH superfamily
 3G65 A;  1UD9 A;  5A6D A;  3GPM A;  5DA7 A;  4CS5 A;  2IO4 A;  2ZVW A;  5AUJ A;  4L60 A;  4L6P A;  3P87 A;  3G65 B;  1RXM A;  1YYP A;  3AIZ C;  1PLQ A;  3TBL A;  3I2M X;  4TR6 A;  3GPN A;  5CFK A;  2IO4 B;  3AIX B;  1CZD A;  1U7B A;  2HIK A;  2IZO B;  3V62 B;  3LX1 A;  1AXC A;  3A1J A;  3FDS D;  2HIK B;  3U60 F;  3FDS C;  4D2G A;  1B8H A;  3G65 C;  3AIX A;  5JNE D;  3A1J B;  1RXZ A;  2ZVM A;  4RJF A;  3VKX A;  3P83 A;  2IX2 B;  2IZO C;  5E0U A;  4YHR A;  5E0V A;  5HAC A;  5IWD A;  1SXJ F;  2HIK C;  1ISQ A;  2HII B;  3U5Z F;  1GE8 A;  5IXA A;  2IX2 A;  3WGW A;  3GGR B;  3A1J C;  1DML A;  5B7O A;  2IX2 C;  3V61 B;  1VYJ A;  3A2F B;  2IJX A;  3LX2 A;  2HII A;  2ZVV A;  1W60 A;  2ZVK A;  1T6L A;  4ZTD A;  5IY4 A;  5E0T A;  2HII C;  1IZ5 A;  1PLR A;  2Z0L A;  3K4X A;  2NTI B;  3U61 F;  3AIZ A;  3HI8 A;  1VYM A;  3P91 A;  2AVT A;  3GGR A;  1IZ4 A;  1RWZ A;  2AWA A;  1U76 A;  3HSL X;  5H0T A;  3IFV A;  2OD8 A;  2NTI A;  3GGR C;  1B77 A;  5DAI A;  1UL1 A;  3V60 B;  2NTI C;  4HK1 A;  3F1W A;  2ZVL A; 
#chains in the Genus database with same CATH topology
 3G65 A;  1UD9 A;  5A6D A;  3GPM A;  5DA7 A;  4CS5 A;  2IO4 A;  2ZVW A;  5AUJ A;  4L60 A;  4L6P A;  3P87 A;  3G65 B;  1RXM A;  1YYP A;  3AIZ C;  1PLQ A;  3TBL A;  3I2M X;  4TR6 A;  3GPN A;  5CFK A;  2IO4 B;  3AIX B;  1CZD A;  1U7B A;  2HIK A;  2IZO B;  3V62 B;  3LX1 A;  1AXC A;  3A1J A;  3FDS D;  2HIK B;  3U60 F;  3FDS C;  4D2G A;  1B8H A;  3G65 C;  3AIX A;  5JNE D;  3A1J B;  1RXZ A;  2ZVM A;  4RJF A;  3VKX A;  3P83 A;  2IX2 B;  2IZO C;  5E0U A;  4YHR A;  5E0V A;  5HAC A;  5IWD A;  1SXJ F;  2HIK C;  1ISQ A;  2HII B;  3U5Z F;  1GE8 A;  5IXA A;  2IX2 A;  3WGW A;  3GGR B;  3A1J C;  1DML A;  5B7O A;  2IX2 C;  3V61 B;  1VYJ A;  3A2F B;  2IJX A;  3LX2 A;  2HII A;  2ZVV A;  1W60 A;  2ZVK A;  1T6L A;  4ZTD A;  5IY4 A;  5E0T A;  2HII C;  1IZ5 A;  1PLR A;  2Z0L A;  3K4X A;  2NTI B;  3U61 F;  3AIZ A;  3HI8 A;  1VYM A;  3P91 A;  2AVT A;  3GGR A;  1IZ4 A;  1RWZ A;  2AWA A;  1U76 A;  3HSL X;  5H0T A;  3IFV A;  2OD8 A;  2NTI A;  3GGR C;  1B77 A;  5DAI A;  1UL1 A;  3V60 B;  2NTI C;  4HK1 A;  3F1W A;  2ZVL A; 
#chains in the Genus database with same CATH homology
 3G65 A;  1UD9 A;  5A6D A;  3GPM A;  5DA7 A;  4CS5 A;  2IO4 A;  2ZVW A;  5AUJ A;  4L60 A;  4L6P A;  3P87 A;  3G65 B;  1RXM A;  1YYP A;  3AIZ C;  1PLQ A;  3TBL A;  3I2M X;  4TR6 A;  3GPN A;  5CFK A;  2IO4 B;  3AIX B;  1CZD A;  1U7B A;  2HIK A;  2IZO B;  3V62 B;  3LX1 A;  1AXC A;  3A1J A;  3FDS D;  2HIK B;  3U60 F;  3FDS C;  4D2G A;  1B8H A;  3G65 C;  3AIX A;  5JNE D;  3A1J B;  1RXZ A;  2ZVM A;  4RJF A;  3VKX A;  3P83 A;  2IX2 B;  2IZO C;  5E0U A;  4YHR A;  5E0V A;  5HAC A;  5IWD A;  1SXJ F;  2HIK C;  1ISQ A;  2HII B;  3U5Z F;  1GE8 A;  5IXA A;  2IX2 A;  3WGW A;  3GGR B;  3A1J C;  1DML A;  5B7O A;  2IX2 C;  3V61 B;  1VYJ A;  3A2F B;  2IJX A;  3LX2 A;  2HII A;  2ZVV A;  1W60 A;  2ZVK A;  1T6L A;  4ZTD A;  5IY4 A;  5E0T A;  2HII C;  1IZ5 A;  1PLR A;  2Z0L A;  3K4X A;  2NTI B;  3U61 F;  3AIZ A;  3HI8 A;  1VYM A;  3P91 A;  2AVT A;  3GGR A;  1IZ4 A;  1RWZ A;  2AWA A;  1U76 A;  3HSL X;  5H0T A;  3IFV A;  2OD8 A;  2NTI A;  3GGR C;  1B77 A;  5DAI A;  1UL1 A;  3V60 B;  2NTI C;  4HK1 A;  3F1W A;  2ZVL A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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5E0UA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations