1BETA

New protein fold revealed by a 2.3 angstrom resolution crystal structure of nerve growth factor
Total Genus 18
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
18
sequence length
107
structure length
107
Chain Sequence
GEFSVCDSVSVWVGDKTTATDIKGKEVTVLAEVNINNSVFRQYFFETKCRASNPVESGCRGIDSKHWNSYCTTTHTFVKALTTDEKQAAWRFIRIDTACVCVLSRKA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title New protein fold revealed by a 2.3-A resolution crystal structure of nerve growth factor.
pubmed doi rcsb
molecule tags Growth factor
source organism Mus musculus
molecule keywords BETA-NERVE GROWTH FACTOR
total genus 18
structure length 107
sequence length 107
ec nomenclature
pdb deposition date 1993-04-08
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.90.10 Mainly Beta Ribbon Cystine Knot Cytokines, subunit B Cystine-knot cytokines 1betA00
1AGQA 1RV6V 1TGKA 2X1XE 2QR0C 3IJ2A 1WQ9B 5HHXA 2ASKA 2H62A 1AOCA 5HK5A 2GNNA 4EC7A 4BV4L 3HH2A 1TGJA 1XWDA 4ZBNA 4EDXV 4KV5A 1LXIA 4YCGC 1BTGA 5HHCA 1FLTV 1CZ8V 4WPBA 1FL7A 3BK3A 5BQCA 4QHUC 5F3BC 4EAXA 3FUBB 4QCIC 1M4UL 1KLCA 2ARVA 3QB4A 5BQ8B 1PDGA 4LXRJ 3QTKA 2B0UA 1LX5A 1HD4A 1VPPV 5HHDA 4EFVA 2QCWA 1BMPA 3S1KV 1ZKZA 4KZNA 5HI3A 5BPUA 1XWDB 2P6AA 2VWEA 1HRPA 2VPFA 1B8MA 1WWWV 3BDYV 2C7WA 1VPFA 1HCNB 1FL7B 1KLAA 4HSAA 3P9WA 4MIDA 1HCNA 4AY9A 4N1DA 2GOOA 2GYZA 5BQBA 1E9JA 1WQ8A 1S4YB 4HQUA 1QTYR 4MQWA 2QJAA 1REWA 2FJGV 1SGFB 1HCFA 1B98A 2X1WA 1KATW 4ZFFC 2V5EB 1DZ7A 3BMPA 3B4VA 1BETA 2H64A 2KD3A 4QAFC 3S1BV 2IFGE 3RJRA 5BQ8A 3V2AA 3EVSB 1HRPB 1B8MB 1MKGA 2TGIA 2QJBA 4FAOA 3SEKB 5E4GA 5HHVA 3BUKA 5HI4A 4X1JA 4AY9B 2R52A 5BQEB 1NT3A 4UI1A 1M4UA 5FV2V 1QFWA 4GLNE 4LXSJ 5BQEA 5BQ8D 4UI2B 1NYUB 4MQWB 2GYRA 4HR9A 1MJVA 1SG1A 4MPLA 4HQXA 1ES7A 5F3HI 4GLSE 1NYSB 2ARPA 3KFDA 3E07A 4UHYA 4UHZA 2QCQA 2BHKA 1MKKA 2XV7A 1WAQA 3V6BA 1WQ9A 1TZHV 2XACA 1TFGA 3EO1C 2FJHV 5FV1V 3MJKA 2PJYA 4XPJA 2R53A 1FZVA 1BJ1V 1BNDB 1TZIV 4KXZA 2VXSA 5JZ7A 1B8KA 1BNDA 3MJGA 4EDWV 1QFWB 1REUA 2GH0C 3JVFA 4UI0A 5HK5E 5HI5A 2QJ9A 4YCIC 1KTZA 5AEJA 1JPYA
chains in the Genus database with same CATH superfamily
1AGQA 1RV6V 1TGKA 2X1XE 2QR0C 3IJ2A 1WQ9B 5HHXA 2ASKA 2H62A 1AOCA 5HK5A 2GNNA 4EC7A 4BV4L 3HH2A 1TGJA 1XWDA 4ZBNA 4EDXV 4KV5A 1LXIA 4YCGC 1BTGA 5HHCA 1FLTV 1CZ8V 4WPBA 1FL7A 3BK3A 5BQCA 4QHUC 5F3BC 4EAXA 3FUBB 4QCIC 1M4UL 1KLCA 2ARVA 3QB4A 5BQ8B 1PDGA 4LXRJ 3QTKA 2B0UA 1LX5A 1HD4A 1VPPV 5HHDA 4EFVA 2QCWA 1BMPA 3S1KV 1ZKZA 4KZNA 5HI3A 5BPUA 1XWDB 2P6AA 2VWEA 1HRPA 2VPFA 1B8MA 1WWWV 3BDYV 2C7WA 1VPFA 1HCNB 1FL7B 1KLAA 4HSAA 3P9WA 4MIDA 1HCNA 4AY9A 4N1DA 2GOOA 2GYZA 5BQBA 1E9JA 1WQ8A 1S4YB 4HQUA 1QTYR 4MQWA 2QJAA 1REWA 2FJGV 1SGFB 1HCFA 1B98A 2X1WA 1KATW 4ZFFC 2V5EB 1DZ7A 3BMPA 3B4VA 1BETA 2H64A 2KD3A 4QAFC 3S1BV 2IFGE 3RJRA 5BQ8A 3V2AA 3EVSB 1HRPB 1B8MB 1MKGA 2TGIA 2QJBA 4FAOA 3SEKB 5E4GA 5HHVA 3BUKA 5HI4A 4X1JA 4AY9B 2R52A 5BQEB 1NT3A 4UI1A 1M4UA 5FV2V 1QFWA 4GLNE 4LXSJ 5BQEA 5BQ8D 4UI2B 1NYUB 4MQWB 2GYRA 4HR9A 1MJVA 1SG1A 4MPLA 4HQXA 1ES7A 5F3HI 4GLSE 1NYSB 2ARPA 3KFDA 3E07A 4UHYA 4UHZA 2QCQA 2BHKA 1MKKA 2XV7A 1WAQA 3V6BA 1WQ9A 1TZHV 2XACA 1TFGA 3EO1C 2FJHV 5FV1V 3MJKA 2PJYA 4XPJA 2R53A 1FZVA 1BJ1V 1BNDB 1TZIV 4KXZA 2VXSA 5JZ7A 1B8KA 1BNDA 3MJGA 4EDWV 1QFWB 1REUA 2GH0C 3JVFA 4UI0A 5HK5E 5HI5A 2QJ9A 4YCIC 1KTZA 5AEJA 1JPYA
chains in the Genus database with same CATH topology
1AGQA 1RV6V 1TGKA 2X1XE 2QR0C 3IJ2A 1WQ9B 5HHXA 2ASKA 2H62A 1AOCA 5HK5A 2GNNA 4EC7A 4BV4L 3HH2A 1TGJA 1XWDA 4ZBNA 4EDXV 4KV5A 1LXIA 4YCGC 1BTGA 5HHCA 1FLTV 1CZ8V 4WPBA 1FL7A 3BK3A 5BQCA 4QHUC 5F3BC 4EAXA 3FUBB 4QCIC 1M4UL 1KLCA 2ARVA 3QB4A 5BQ8B 1PDGA 4LXRJ 3QTKA 2B0UA 1LX5A 1HD4A 1VPPV 5HHDA 4EFVA 2QCWA 1BMPA 3S1KV 1ZKZA 4KZNA 5HI3A 5BPUA 1XWDB 2P6AA 2VWEA 1HRPA 2VPFA 1B8MA 1WWWV 3BDYV 2C7WA 1VPFA 1HCNB 1FL7B 1KLAA 4HSAA 3P9WA 4MIDA 1HCNA 4AY9A 4N1DA 2GOOA 2GYZA 5BQBA 1E9JA 1WQ8A 1S4YB 4HQUA 1QTYR 4MQWA 2QJAA 1REWA 2FJGV 1SGFB 1HCFA 1B98A 2X1WA 1KATW 4ZFFC 2V5EB 1DZ7A 3BMPA 3B4VA 1BETA 2H64A 2KD3A 4QAFC 3S1BV 2IFGE 3RJRA 5BQ8A 3V2AA 3EVSB 1HRPB 1B8MB 1MKGA 2TGIA 2QJBA 4FAOA 3SEKB 5E4GA 5HHVA 3BUKA 5HI4A 4X1JA 4AY9B 2R52A 5BQEB 1NT3A 4UI1A 1M4UA 5FV2V 1QFWA 4GLNE 4LXSJ 5BQEA 5BQ8D 4UI2B 1NYUB 4MQWB 2GYRA 4HR9A 1MJVA 1SG1A 4MPLA 4HQXA 1ES7A 5F3HI 4GLSE 1NYSB 2ARPA 3KFDA 3E07A 4UHYA 4UHZA 2QCQA 2BHKA 1MKKA 2XV7A 1WAQA 3V6BA 1WQ9A 1TZHV 2XACA 1TFGA 3EO1C 2FJHV 5FV1V 3MJKA 2PJYA 4XPJA 2R53A 1FZVA 1BJ1V 1BNDB 1TZIV 4KXZA 2VXSA 5JZ7A 1B8KA 1BNDA 3MJGA 4EDWV 1QFWB 1REUA 2GH0C 3JVFA 4UI0A 5HK5E 5HI5A 2QJ9A 4YCIC 1KTZA 5AEJA 1JPYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1AGQ A;  1RV6 V;  1TGK A;  2X1X E;  2QR0 C;  3IJ2 A;  1WQ9 B;  5HHX A;  2ASK A;  2H62 A;  1AOC A;  5HK5 A;  2GNN A;  4EC7 A;  4BV4 L;  3HH2 A;  1TGJ A;  1XWD A;  4ZBN A;  4EDX V;  4KV5 A;  1LXI A;  4YCG C;  1BTG A;  5HHC A;  1FLT V;  1CZ8 V;  4WPB A;  1FL7 A;  3BK3 A;  5BQC A;  4QHU C;  5F3B C;  4EAX A;  3FUB B;  4QCI C;  1M4U L;  1KLC A;  2ARV A;  3QB4 A;  5BQ8 B;  1PDG A;  4LXR J;  3QTK A;  2B0U A;  1LX5 A;  1HD4 A;  1VPP V;  5HHD A;  4EFV A;  2QCW A;  1BMP A;  3S1K V;  1ZKZ A;  4KZN A;  5HI3 A;  5BPU A;  1XWD B;  2P6A A;  2VWE A;  1HRP A;  2VPF A;  1B8M A;  1WWW V;  3BDY V;  2C7W A;  1VPF A;  1HCN B;  1FL7 B;  1KLA A;  4HSA A;  3P9W A;  4MID A;  1HCN A;  4AY9 A;  4N1D A;  2GOO A;  2GYZ A;  5BQB A;  1E9J A;  1WQ8 A;  1S4Y B;  4HQU A;  1QTY R;  4MQW A;  2QJA A;  1REW A;  2FJG V;  1SGF B;  1HCF A;  1B98 A;  2X1W A;  1KAT W;  4ZFF C;  2V5E B;  1DZ7 A;  3BMP A;  3B4V A;  1BET A;  2H64 A;  2KD3 A;  4QAF C;  3S1B V;  2IFG E;  3RJR A;  5BQ8 A;  3V2A A;  3EVS B;  1HRP B;  1B8M B;  1MKG A;  2TGI A;  2QJB A;  4FAO A;  3SEK B;  5E4G A;  5HHV A;  3BUK A;  5HI4 A;  4X1J A;  4AY9 B;  2R52 A;  5BQE B;  1NT3 A;  4UI1 A;  1M4U A;  5FV2 V;  1QFW A;  4GLN E;  4LXS J;  5BQE A;  5BQ8 D;  4UI2 B;  1NYU B;  4MQW B;  2GYR A;  4HR9 A;  1MJV A;  1SG1 A;  4MPL A;  4HQX A;  1ES7 A;  5F3H I;  4GLS E;  1NYS B;  2ARP A;  3KFD A;  3E07 A;  4UHY A;  4UHZ A;  2QCQ A;  2BHK A;  1MKK A;  2XV7 A;  1WAQ A;  3V6B A;  1WQ9 A;  1TZH V;  2XAC A;  1TFG A;  3EO1 C;  2FJH V;  5FV1 V;  3MJK A;  2PJY A;  4XPJ A;  2R53 A;  1FZV A;  1BJ1 V;  1BND B;  1TZI V;  4KXZ A;  2VXS A;  5JZ7 A;  1B8K A;  1BND A;  3MJG A;  4EDW V;  1QFW B;  1REU A;  2GH0 C;  3JVF A;  4UI0 A;  5HK5 E;  5HI5 A;  2QJ9 A;  4YCI C;  1KTZ A;  5AEJ A;  1JPY A; 
#chains in the Genus database with same CATH topology
 1AGQ A;  1RV6 V;  1TGK A;  2X1X E;  2QR0 C;  3IJ2 A;  1WQ9 B;  5HHX A;  2ASK A;  2H62 A;  1AOC A;  5HK5 A;  2GNN A;  4EC7 A;  4BV4 L;  3HH2 A;  1TGJ A;  1XWD A;  4ZBN A;  4EDX V;  4KV5 A;  1LXI A;  4YCG C;  1BTG A;  5HHC A;  1FLT V;  1CZ8 V;  4WPB A;  1FL7 A;  3BK3 A;  5BQC A;  4QHU C;  5F3B C;  4EAX A;  3FUB B;  4QCI C;  1M4U L;  1KLC A;  2ARV A;  3QB4 A;  5BQ8 B;  1PDG A;  4LXR J;  3QTK A;  2B0U A;  1LX5 A;  1HD4 A;  1VPP V;  5HHD A;  4EFV A;  2QCW A;  1BMP A;  3S1K V;  1ZKZ A;  4KZN A;  5HI3 A;  5BPU A;  1XWD B;  2P6A A;  2VWE A;  1HRP A;  2VPF A;  1B8M A;  1WWW V;  3BDY V;  2C7W A;  1VPF A;  1HCN B;  1FL7 B;  1KLA A;  4HSA A;  3P9W A;  4MID A;  1HCN A;  4AY9 A;  4N1D A;  2GOO A;  2GYZ A;  5BQB A;  1E9J A;  1WQ8 A;  1S4Y B;  4HQU A;  1QTY R;  4MQW A;  2QJA A;  1REW A;  2FJG V;  1SGF B;  1HCF A;  1B98 A;  2X1W A;  1KAT W;  4ZFF C;  2V5E B;  1DZ7 A;  3BMP A;  3B4V A;  1BET A;  2H64 A;  2KD3 A;  4QAF C;  3S1B V;  2IFG E;  3RJR A;  5BQ8 A;  3V2A A;  3EVS B;  1HRP B;  1B8M B;  1MKG A;  2TGI A;  2QJB A;  4FAO A;  3SEK B;  5E4G A;  5HHV A;  3BUK A;  5HI4 A;  4X1J A;  4AY9 B;  2R52 A;  5BQE B;  1NT3 A;  4UI1 A;  1M4U A;  5FV2 V;  1QFW A;  4GLN E;  4LXS J;  5BQE A;  5BQ8 D;  4UI2 B;  1NYU B;  4MQW B;  2GYR A;  4HR9 A;  1MJV A;  1SG1 A;  4MPL A;  4HQX A;  1ES7 A;  5F3H I;  4GLS E;  1NYS B;  2ARP A;  3KFD A;  3E07 A;  4UHY A;  4UHZ A;  2QCQ A;  2BHK A;  1MKK A;  2XV7 A;  1WAQ A;  3V6B A;  1WQ9 A;  1TZH V;  2XAC A;  1TFG A;  3EO1 C;  2FJH V;  5FV1 V;  3MJK A;  2PJY A;  4XPJ A;  2R53 A;  1FZV A;  1BJ1 V;  1BND B;  1TZI V;  4KXZ A;  2VXS A;  5JZ7 A;  1B8K A;  1BND A;  3MJG A;  4EDW V;  1QFW B;  1REU A;  2GH0 C;  3JVF A;  4UI0 A;  5HK5 E;  5HI5 A;  2QJ9 A;  4YCI C;  1KTZ A;  5AEJ A;  1JPY A; 
#chains in the Genus database with same CATH homology
 1AGQ A;  1RV6 V;  1TGK A;  2X1X E;  2QR0 C;  3IJ2 A;  1WQ9 B;  5HHX A;  2ASK A;  2H62 A;  1AOC A;  5HK5 A;  2GNN A;  4EC7 A;  4BV4 L;  3HH2 A;  1TGJ A;  1XWD A;  4ZBN A;  4EDX V;  4KV5 A;  1LXI A;  4YCG C;  1BTG A;  5HHC A;  1FLT V;  1CZ8 V;  4WPB A;  1FL7 A;  3BK3 A;  5BQC A;  4QHU C;  5F3B C;  4EAX A;  3FUB B;  4QCI C;  1M4U L;  1KLC A;  2ARV A;  3QB4 A;  5BQ8 B;  1PDG A;  4LXR J;  3QTK A;  2B0U A;  1LX5 A;  1HD4 A;  1VPP V;  5HHD A;  4EFV A;  2QCW A;  1BMP A;  3S1K V;  1ZKZ A;  4KZN A;  5HI3 A;  5BPU A;  1XWD B;  2P6A A;  2VWE A;  1HRP A;  2VPF A;  1B8M A;  1WWW V;  3BDY V;  2C7W A;  1VPF A;  1HCN B;  1FL7 B;  1KLA A;  4HSA A;  3P9W A;  4MID A;  1HCN A;  4AY9 A;  4N1D A;  2GOO A;  2GYZ A;  5BQB A;  1E9J A;  1WQ8 A;  1S4Y B;  4HQU A;  1QTY R;  4MQW A;  2QJA A;  1REW A;  2FJG V;  1SGF B;  1HCF A;  1B98 A;  2X1W A;  1KAT W;  4ZFF C;  2V5E B;  1DZ7 A;  3BMP A;  3B4V A;  1BET A;  2H64 A;  2KD3 A;  4QAF C;  3S1B V;  2IFG E;  3RJR A;  5BQ8 A;  3V2A A;  3EVS B;  1HRP B;  1B8M B;  1MKG A;  2TGI A;  2QJB A;  4FAO A;  3SEK B;  5E4G A;  5HHV A;  3BUK A;  5HI4 A;  4X1J A;  4AY9 B;  2R52 A;  5BQE B;  1NT3 A;  4UI1 A;  1M4U A;  5FV2 V;  1QFW A;  4GLN E;  4LXS J;  5BQE A;  5BQ8 D;  4UI2 B;  1NYU B;  4MQW B;  2GYR A;  4HR9 A;  1MJV A;  1SG1 A;  4MPL A;  4HQX A;  1ES7 A;  5F3H I;  4GLS E;  1NYS B;  2ARP A;  3KFD A;  3E07 A;  4UHY A;  4UHZ A;  2QCQ A;  2BHK A;  1MKK A;  2XV7 A;  1WAQ A;  3V6B A;  1WQ9 A;  1TZH V;  2XAC A;  1TFG A;  3EO1 C;  2FJH V;  5FV1 V;  3MJK A;  2PJY A;  4XPJ A;  2R53 A;  1FZV A;  1BJ1 V;  1BND B;  1TZI V;  4KXZ A;  2VXS A;  5JZ7 A;  1B8K A;  1BND A;  3MJG A;  4EDW V;  1QFW B;  1REU A;  2GH0 C;  3JVF A;  4UI0 A;  5HK5 E;  5HI5 A;  2QJ9 A;  4YCI C;  1KTZ A;  5AEJ A;  1JPY A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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