1TFGA

An unusual feature revealed by the crystal structure at 2.2 angstroms resolution of human transforming growth factor-beta2
Total Genus 23

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
23
sequence length
112
structure length
112
Chain Sequence
ALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
EMPTYS7 (95-111)AH1 (4-8)TVIII1 (8-11)O1 (7-16)S1 (16-18)TII1 (49-52)S2 (21-23)S4 (38-40)AH2 (24-28)TIV1 (34-37)S5 (43-45)TIV2 (51-54)AH3 (57-68)O2 (15-78)S3 (33-35)S6 (78-92)3H1 (70-72)Updating...
connected with : NaN
publication title An unusual feature revealed by the crystal structure at 2.2 A resolution of human transforming growth factor-beta 2.
pubmed doi rcsb
molecule keywords TRANSFORMING GROWTH FACTOR, BETA 2
molecule tags Growth factor
source organism Homo sapiens
total genus 23
structure length 112
sequence length 112
ec nomenclature
pdb deposition date 1992-11-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00019 TGF_beta Transforming growth factor beta like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.90.10 Mainly Beta Ribbon Cystine Knot Cytokines, subunit B Cystine-knot cytokines 1tfgA00
1XWDB 2QJ9A 1ES7A 5BPUA 1REUA 4LXSJ 1HD4A 1LXIA 1SG1A 4YCIC 5E4GA 2GOOA 4QAFC 4KV5A 1WAQA 2TGIA 5HI4A 1MKKA 5HHVA 4UI0A 1BETA 1BNDA 3HH2A 4EFVA 1E9JA 1B8KA 5BQ8D 5HHXA 5BQBA 1M4UA 4X1JA 3RJRA 2C7WA 3E07A 3BMPA 2FJGV 2R53A 4KZNA 5JZ7A 1DZ7A 4MIDA 2B0UA 1RV6V 1MJVA 1KATW 4HR9A 2P6AA 2V5EB 3S1KV 4BV4L 1TGJA 3JVFA 4MQWA 3MJKA 5BQEB 4UHZA 1AGQA 5AEJA 2QJBA 3SEKB 2XACA 1VPPV 1HCFA 2X1WA 2PJYA 1FLTV 2QCWA 1AOCA 3B4VA 3BDYV 1B8MA 1LX5A 2QCQA 2ARVA 5BQ8A 1BNDB 5HK5E 1QFWA 4ZBNA 2X1XE 5HI3A 1NT3A 3P9WA 2BHKA 4HQXA 3FUBB 4AY9B 4MPLA 1PDGA 4KXZA 3S1BV 1B98A 5HI5A 5HK5A 1KLAA 4UI2B 1WQ9B 4EC7A 1NYSB 1WWWV 1HCNB 3BUKA 1FL7A 2KD3A 1BJ1V 2GYZA 3IJ2A 3BK3A 4GLSE 1HRPA 1KLCA 2VXSA 3QTKA 4UHYA 1TZIV 4EDWV 4UI1A 5F3BC 1B8MB 3V6BA 1JPYA 1SGFB 1TFGA 2H64A 2ASKA 5HHDA 2GYRA 1CZ8V 4QHUC 1S4YB 5FV1V 4FAOA 1XWDA 2VWEA 1VPFA 4WPBA 2GH0C 2R52A 5BQEA 1BMPA 4EAXA 1NYUB 3V2AA 3QB4A 2QR0C 4HSAA 4GLNE 1QTYR 2H62A 1WQ8A 4EDXV 1BTGA 1REWA 3EVSB 2XV7A 4N1DA 1ZKZA 3EO1C 1FL7B 2GNNA 4ZFFC 1KTZA 2QJAA 4MQWB 2ARPA 1FZVA 4XPJA 1TZHV 4HQUA 3KFDA 4YCGC 4AY9A 5HHCA 1HRPB 5FV2V 2IFGE 2FJHV 2VPFA 1WQ9A 5F3HI 4QCIC 1MKGA 5BQ8B 1M4UL 1TGKA 1QFWB 4LXRJ 1HCNA 5BQCA 3MJGA
chains in the Genus database with same CATH superfamily
1XWDB 2QJ9A 1ES7A 5BPUA 1REUA 4LXSJ 1HD4A 1LXIA 1SG1A 4YCIC 5E4GA 2GOOA 4QAFC 4KV5A 1WAQA 2TGIA 5HI4A 1MKKA 5HHVA 4UI0A 1BETA 1BNDA 3HH2A 4EFVA 1E9JA 1B8KA 5BQ8D 5HHXA 5BQBA 1M4UA 4X1JA 3RJRA 2C7WA 3E07A 3BMPA 2FJGV 2R53A 4KZNA 5JZ7A 1DZ7A 4MIDA 2B0UA 1RV6V 1MJVA 1KATW 4HR9A 2P6AA 2V5EB 3S1KV 4BV4L 1TGJA 3JVFA 4MQWA 3MJKA 5BQEB 4UHZA 1AGQA 5AEJA 2QJBA 3SEKB 2XACA 1VPPV 1HCFA 2X1WA 2PJYA 1FLTV 2QCWA 1AOCA 3B4VA 3BDYV 1B8MA 1LX5A 2QCQA 2ARVA 5BQ8A 1BNDB 5HK5E 1QFWA 4ZBNA 2X1XE 5HI3A 1NT3A 3P9WA 2BHKA 4HQXA 3FUBB 4AY9B 4MPLA 1PDGA 4KXZA 3S1BV 1B98A 5HI5A 5HK5A 1KLAA 4UI2B 1WQ9B 4EC7A 1NYSB 1WWWV 1HCNB 3BUKA 1FL7A 2KD3A 1BJ1V 2GYZA 3IJ2A 3BK3A 4GLSE 1HRPA 1KLCA 2VXSA 3QTKA 4UHYA 1TZIV 4EDWV 4UI1A 5F3BC 1B8MB 3V6BA 1JPYA 1SGFB 1TFGA 2H64A 2ASKA 5HHDA 2GYRA 1CZ8V 4QHUC 1S4YB 5FV1V 4FAOA 1XWDA 2VWEA 1VPFA 4WPBA 2GH0C 2R52A 5BQEA 1BMPA 4EAXA 1NYUB 3V2AA 3QB4A 2QR0C 4HSAA 4GLNE 1QTYR 2H62A 1WQ8A 4EDXV 1BTGA 1REWA 3EVSB 2XV7A 4N1DA 1ZKZA 3EO1C 1FL7B 2GNNA 4ZFFC 1KTZA 2QJAA 4MQWB 2ARPA 1FZVA 4XPJA 1TZHV 4HQUA 3KFDA 4YCGC 4AY9A 5HHCA 1HRPB 5FV2V 2IFGE 2FJHV 2VPFA 1WQ9A 5F3HI 4QCIC 1MKGA 5BQ8B 1M4UL 1TGKA 1QFWB 4LXRJ 1HCNA 5BQCA 3MJGA
chains in the Genus database with same CATH topology
1XWDB 2QJ9A 1ES7A 5BPUA 1REUA 4LXSJ 1HD4A 1LXIA 1SG1A 4YCIC 5E4GA 2GOOA 4QAFC 4KV5A 1WAQA 2TGIA 5HI4A 1MKKA 5HHVA 4UI0A 1BETA 1BNDA 3HH2A 4EFVA 1E9JA 1B8KA 5BQ8D 5HHXA 5BQBA 1M4UA 4X1JA 3RJRA 2C7WA 3E07A 3BMPA 2FJGV 2R53A 4KZNA 5JZ7A 1DZ7A 4MIDA 2B0UA 1RV6V 1MJVA 1KATW 4HR9A 2P6AA 2V5EB 3S1KV 4BV4L 1TGJA 3JVFA 4MQWA 3MJKA 5BQEB 4UHZA 1AGQA 5AEJA 2QJBA 3SEKB 2XACA 1VPPV 1HCFA 2X1WA 2PJYA 1FLTV 2QCWA 1AOCA 3B4VA 3BDYV 1B8MA 1LX5A 2QCQA 2ARVA 5BQ8A 1BNDB 5HK5E 1QFWA 4ZBNA 2X1XE 5HI3A 1NT3A 3P9WA 2BHKA 4HQXA 3FUBB 4AY9B 4MPLA 1PDGA 4KXZA 3S1BV 1B98A 5HI5A 5HK5A 1KLAA 4UI2B 1WQ9B 4EC7A 1NYSB 1WWWV 1HCNB 3BUKA 1FL7A 2KD3A 1BJ1V 2GYZA 3IJ2A 3BK3A 4GLSE 1HRPA 1KLCA 2VXSA 3QTKA 4UHYA 1TZIV 4EDWV 4UI1A 5F3BC 1B8MB 3V6BA 1JPYA 1SGFB 1TFGA 2H64A 2ASKA 5HHDA 2GYRA 1CZ8V 4QHUC 1S4YB 5FV1V 4FAOA 1XWDA 2VWEA 1VPFA 4WPBA 2GH0C 2R52A 5BQEA 1BMPA 4EAXA 1NYUB 3V2AA 3QB4A 2QR0C 4HSAA 4GLNE 1QTYR 2H62A 1WQ8A 4EDXV 1BTGA 1REWA 3EVSB 2XV7A 4N1DA 1ZKZA 3EO1C 1FL7B 2GNNA 4ZFFC 1KTZA 2QJAA 4MQWB 2ARPA 1FZVA 4XPJA 1TZHV 4HQUA 3KFDA 4YCGC 4AY9A 5HHCA 1HRPB 5FV2V 2IFGE 2FJHV 2VPFA 1WQ9A 5F3HI 4QCIC 1MKGA 5BQ8B 1M4UL 1TGKA 1QFWB 4LXRJ 1HCNA 5BQCA 3MJGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1XWD B;  2QJ9 A;  1ES7 A;  5BPU A;  1REU A;  4LXS J;  1HD4 A;  1LXI A;  1SG1 A;  4YCI C;  5E4G A;  2GOO A;  4QAF C;  4KV5 A;  1WAQ A;  2TGI A;  5HI4 A;  1MKK A;  5HHV A;  4UI0 A;  1BET A;  1BND A;  3HH2 A;  4EFV A;  1E9J A;  1B8K A;  5BQ8 D;  5HHX A;  5BQB A;  1M4U A;  4X1J A;  3RJR A;  2C7W A;  3E07 A;  3BMP A;  2FJG V;  2R53 A;  4KZN A;  5JZ7 A;  1DZ7 A;  4MID A;  2B0U A;  1RV6 V;  1MJV A;  1KAT W;  4HR9 A;  2P6A A;  2V5E B;  3S1K V;  4BV4 L;  1TGJ A;  3JVF A;  4MQW A;  3MJK A;  5BQE B;  4UHZ A;  1AGQ A;  5AEJ A;  2QJB A;  3SEK B;  2XAC A;  1VPP V;  1HCF A;  2X1W A;  2PJY A;  1FLT V;  2QCW A;  1AOC A;  3B4V A;  3BDY V;  1B8M A;  1LX5 A;  2QCQ A;  2ARV A;  5BQ8 A;  1BND B;  5HK5 E;  1QFW A;  4ZBN A;  2X1X E;  5HI3 A;  1NT3 A;  3P9W A;  2BHK A;  4HQX A;  3FUB B;  4AY9 B;  4MPL A;  1PDG A;  4KXZ A;  3S1B V;  1B98 A;  5HI5 A;  5HK5 A;  1KLA A;  4UI2 B;  1WQ9 B;  4EC7 A;  1NYS B;  1WWW V;  1HCN B;  3BUK A;  1FL7 A;  2KD3 A;  1BJ1 V;  2GYZ A;  3IJ2 A;  3BK3 A;  4GLS E;  1HRP A;  1KLC A;  2VXS A;  3QTK A;  4UHY A;  1TZI V;  4EDW V;  4UI1 A;  5F3B C;  1B8M B;  3V6B A;  1JPY A;  1SGF B;  1TFG A;  2H64 A;  2ASK A;  5HHD A;  2GYR A;  1CZ8 V;  4QHU C;  1S4Y B;  5FV1 V;  4FAO A;  1XWD A;  2VWE A;  1VPF A;  4WPB A;  2GH0 C;  2R52 A;  5BQE A;  1BMP A;  4EAX A;  1NYU B;  3V2A A;  3QB4 A;  2QR0 C;  4HSA A;  4GLN E;  1QTY R;  2H62 A;  1WQ8 A;  4EDX V;  1BTG A;  1REW A;  3EVS B;  2XV7 A;  4N1D A;  1ZKZ A;  3EO1 C;  1FL7 B;  2GNN A;  4ZFF C;  1KTZ A;  2QJA A;  4MQW B;  2ARP A;  1FZV A;  4XPJ A;  1TZH V;  4HQU A;  3KFD A;  4YCG C;  4AY9 A;  5HHC A;  1HRP B;  5FV2 V;  2IFG E;  2FJH V;  2VPF A;  1WQ9 A;  5F3H I;  4QCI C;  1MKG A;  5BQ8 B;  1M4U L;  1TGK A;  1QFW B;  4LXR J;  1HCN A;  5BQC A;  3MJG A; 
#chains in the Genus database with same CATH topology
 1XWD B;  2QJ9 A;  1ES7 A;  5BPU A;  1REU A;  4LXS J;  1HD4 A;  1LXI A;  1SG1 A;  4YCI C;  5E4G A;  2GOO A;  4QAF C;  4KV5 A;  1WAQ A;  2TGI A;  5HI4 A;  1MKK A;  5HHV A;  4UI0 A;  1BET A;  1BND A;  3HH2 A;  4EFV A;  1E9J A;  1B8K A;  5BQ8 D;  5HHX A;  5BQB A;  1M4U A;  4X1J A;  3RJR A;  2C7W A;  3E07 A;  3BMP A;  2FJG V;  2R53 A;  4KZN A;  5JZ7 A;  1DZ7 A;  4MID A;  2B0U A;  1RV6 V;  1MJV A;  1KAT W;  4HR9 A;  2P6A A;  2V5E B;  3S1K V;  4BV4 L;  1TGJ A;  3JVF A;  4MQW A;  3MJK A;  5BQE B;  4UHZ A;  1AGQ A;  5AEJ A;  2QJB A;  3SEK B;  2XAC A;  1VPP V;  1HCF A;  2X1W A;  2PJY A;  1FLT V;  2QCW A;  1AOC A;  3B4V A;  3BDY V;  1B8M A;  1LX5 A;  2QCQ A;  2ARV A;  5BQ8 A;  1BND B;  5HK5 E;  1QFW A;  4ZBN A;  2X1X E;  5HI3 A;  1NT3 A;  3P9W A;  2BHK A;  4HQX A;  3FUB B;  4AY9 B;  4MPL A;  1PDG A;  4KXZ A;  3S1B V;  1B98 A;  5HI5 A;  5HK5 A;  1KLA A;  4UI2 B;  1WQ9 B;  4EC7 A;  1NYS B;  1WWW V;  1HCN B;  3BUK A;  1FL7 A;  2KD3 A;  1BJ1 V;  2GYZ A;  3IJ2 A;  3BK3 A;  4GLS E;  1HRP A;  1KLC A;  2VXS A;  3QTK A;  4UHY A;  1TZI V;  4EDW V;  4UI1 A;  5F3B C;  1B8M B;  3V6B A;  1JPY A;  1SGF B;  1TFG A;  2H64 A;  2ASK A;  5HHD A;  2GYR A;  1CZ8 V;  4QHU C;  1S4Y B;  5FV1 V;  4FAO A;  1XWD A;  2VWE A;  1VPF A;  4WPB A;  2GH0 C;  2R52 A;  5BQE A;  1BMP A;  4EAX A;  1NYU B;  3V2A A;  3QB4 A;  2QR0 C;  4HSA A;  4GLN E;  1QTY R;  2H62 A;  1WQ8 A;  4EDX V;  1BTG A;  1REW A;  3EVS B;  2XV7 A;  4N1D A;  1ZKZ A;  3EO1 C;  1FL7 B;  2GNN A;  4ZFF C;  1KTZ A;  2QJA A;  4MQW B;  2ARP A;  1FZV A;  4XPJ A;  1TZH V;  4HQU A;  3KFD A;  4YCG C;  4AY9 A;  5HHC A;  1HRP B;  5FV2 V;  2IFG E;  2FJH V;  2VPF A;  1WQ9 A;  5F3H I;  4QCI C;  1MKG A;  5BQ8 B;  1M4U L;  1TGK A;  1QFW B;  4LXR J;  1HCN A;  5BQC A;  3MJG A; 
#chains in the Genus database with same CATH homology
 1XWD B;  2QJ9 A;  1ES7 A;  5BPU A;  1REU A;  4LXS J;  1HD4 A;  1LXI A;  1SG1 A;  4YCI C;  5E4G A;  2GOO A;  4QAF C;  4KV5 A;  1WAQ A;  2TGI A;  5HI4 A;  1MKK A;  5HHV A;  4UI0 A;  1BET A;  1BND A;  3HH2 A;  4EFV A;  1E9J A;  1B8K A;  5BQ8 D;  5HHX A;  5BQB A;  1M4U A;  4X1J A;  3RJR A;  2C7W A;  3E07 A;  3BMP A;  2FJG V;  2R53 A;  4KZN A;  5JZ7 A;  1DZ7 A;  4MID A;  2B0U A;  1RV6 V;  1MJV A;  1KAT W;  4HR9 A;  2P6A A;  2V5E B;  3S1K V;  4BV4 L;  1TGJ A;  3JVF A;  4MQW A;  3MJK A;  5BQE B;  4UHZ A;  1AGQ A;  5AEJ A;  2QJB A;  3SEK B;  2XAC A;  1VPP V;  1HCF A;  2X1W A;  2PJY A;  1FLT V;  2QCW A;  1AOC A;  3B4V A;  3BDY V;  1B8M A;  1LX5 A;  2QCQ A;  2ARV A;  5BQ8 A;  1BND B;  5HK5 E;  1QFW A;  4ZBN A;  2X1X E;  5HI3 A;  1NT3 A;  3P9W A;  2BHK A;  4HQX A;  3FUB B;  4AY9 B;  4MPL A;  1PDG A;  4KXZ A;  3S1B V;  1B98 A;  5HI5 A;  5HK5 A;  1KLA A;  4UI2 B;  1WQ9 B;  4EC7 A;  1NYS B;  1WWW V;  1HCN B;  3BUK A;  1FL7 A;  2KD3 A;  1BJ1 V;  2GYZ A;  3IJ2 A;  3BK3 A;  4GLS E;  1HRP A;  1KLC A;  2VXS A;  3QTK A;  4UHY A;  1TZI V;  4EDW V;  4UI1 A;  5F3B C;  1B8M B;  3V6B A;  1JPY A;  1SGF B;  1TFG A;  2H64 A;  2ASK A;  5HHD A;  2GYR A;  1CZ8 V;  4QHU C;  1S4Y B;  5FV1 V;  4FAO A;  1XWD A;  2VWE A;  1VPF A;  4WPB A;  2GH0 C;  2R52 A;  5BQE A;  1BMP A;  4EAX A;  1NYU B;  3V2A A;  3QB4 A;  2QR0 C;  4HSA A;  4GLN E;  1QTY R;  2H62 A;  1WQ8 A;  4EDX V;  1BTG A;  1REW A;  3EVS B;  2XV7 A;  4N1D A;  1ZKZ A;  3EO1 C;  1FL7 B;  2GNN A;  4ZFF C;  1KTZ A;  2QJA A;  4MQW B;  2ARP A;  1FZV A;  4XPJ A;  1TZH V;  4HQU A;  3KFD A;  4YCG C;  4AY9 A;  5HHC A;  1HRP B;  5FV2 V;  2IFG E;  2FJH V;  2VPF A;  1WQ9 A;  5F3H I;  4QCI C;  1MKG A;  5BQ8 B;  1M4U L;  1TGK A;  1QFW B;  4LXR J;  1HCN A;  5BQC A;  3MJG A; 
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