1WAQA

Crystal structure of human growth and differentiation factor 5 (gdf-5)
Total Genus 18
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
18
sequence length
104
structure length
104
Chain Sequence
ARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A Single Residue of Gdf-5 Defines Binding Specificity to Bmp Receptor Ib.
pubmed doi rcsb
molecule tags Growth factor
source organism Homo sapiens
molecule keywords GROWTH/DIFFERENTIATION FACTOR 5
total genus 18
structure length 104
sequence length 104
ec nomenclature
pdb deposition date 2004-10-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00019 TGF_beta Transforming growth factor beta like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.90.10 Mainly Beta Ribbon Cystine Knot Cytokines, subunit B Cystine-knot cytokines 1waqA00
2B0UA 5HK5E 2QJAA 5BQEB 1QFWA 3P9WA 3E07A 2H64A 1WAQA 1NYSB 1FLTV 1XWDA 1TFGA 1BMPA 3QTKA 1KLCA 3BDYV 3S1KV 1PDGA 5BQCA 3S1BV 2KD3A 1CZ8V 1NYUB 3MJKA 4FAOA 4KZNA 4KXZA 4LXRJ 4YCIC 1TGJA 4UHZA 4EDWV 5F3HI 1MJVA 4WPBA 1BETA 1KATW 1BJ1V 2R52A 3MJGA 4QAFC 5HI4A 1M4UA 1QFWB 3FUBB 4BV4L 2GYZA 3KFDA 1REWA 2IFGE 1B8MB 1XWDB 1RV6V 2BHKA 3BUKA 2P6AA 2X1WA 4AY9A 3V2AA 1REUA 1QTYR 4XPJA 2ARVA 1BNDA 4UI1A 1B8KA 2XACA 4QHUC 3EO1C 4LXSJ 2QJBA 1WQ8A 5FV2V 4EAXA 3JVFA 4UI2B 1HCNA 4ZFFC 1WQ9A 4GLSE 1FZVA 2FJHV 2X1XE 4MQWA 1NT3A 1ZKZA 2XV7A 5BQ8D 3V6BA 1AOCA 3B4VA 1HCFA 4AY9B 4HQUA 3EVSB 1VPPV 4QCIC 4UHYA 1BTGA 1BNDB 4HQXA 4MPLA 4YCGC 2V5EB 2VXSA 4EDXV 5HK5A 1TZHV 3QB4A 5HHCA 5E4GA 1DZ7A 1FL7A 2PJYA 2R53A 2ARPA 2GYRA 1SGFB 1HCNB 1LX5A 2QCWA 1WQ9B 4EFVA 1WWWV 2VWEA 1KLAA 4HSAA 1VPFA 4UI0A 4MQWB 4GLNE 1M4UL 1MKGA 1JPYA 2C7WA 5BQ8A 5HHDA 4ZBNA 4X1JA 2TGIA 3BK3A 3SEKB 1HRPA 5HHXA 5HI3A 2GH0C 2GNNA 1FL7B 5BQBA 2ASKA 1HD4A 1ES7A 1B8MA 1TZIV 5BQEA 3IJ2A 3BMPA 1AGQA 1MKKA 2QJ9A 5AEJA 5HHVA 2H62A 2VPFA 5BPUA 5JZ7A 4MIDA 3RJRA 2QCQA 2QR0C 5BQ8B 1TGKA 1E9JA 3HH2A 1KTZA 2GOOA 4N1DA 5F3BC 2FJGV 1SG1A 5FV1V 5HI5A 1LXIA 1B98A 4EC7A 4HR9A 1HRPB 4KV5A 1S4YB
chains in the Genus database with same CATH superfamily
2B0UA 5HK5E 2QJAA 5BQEB 1QFWA 3P9WA 3E07A 2H64A 1WAQA 1NYSB 1FLTV 1XWDA 1TFGA 1BMPA 3QTKA 1KLCA 3BDYV 3S1KV 1PDGA 5BQCA 3S1BV 2KD3A 1CZ8V 1NYUB 3MJKA 4FAOA 4KZNA 4KXZA 4LXRJ 4YCIC 1TGJA 4UHZA 4EDWV 5F3HI 1MJVA 4WPBA 1BETA 1KATW 1BJ1V 2R52A 3MJGA 4QAFC 5HI4A 1M4UA 1QFWB 3FUBB 4BV4L 2GYZA 3KFDA 1REWA 2IFGE 1B8MB 1XWDB 1RV6V 2BHKA 3BUKA 2P6AA 2X1WA 4AY9A 3V2AA 1REUA 1QTYR 4XPJA 2ARVA 1BNDA 4UI1A 1B8KA 2XACA 4QHUC 3EO1C 4LXSJ 2QJBA 1WQ8A 5FV2V 4EAXA 3JVFA 4UI2B 1HCNA 4ZFFC 1WQ9A 4GLSE 1FZVA 2FJHV 2X1XE 4MQWA 1NT3A 1ZKZA 2XV7A 5BQ8D 3V6BA 1AOCA 3B4VA 1HCFA 4AY9B 4HQUA 3EVSB 1VPPV 4QCIC 4UHYA 1BTGA 1BNDB 4HQXA 4MPLA 4YCGC 2V5EB 2VXSA 4EDXV 5HK5A 1TZHV 3QB4A 5HHCA 5E4GA 1DZ7A 1FL7A 2PJYA 2R53A 2ARPA 2GYRA 1SGFB 1HCNB 1LX5A 2QCWA 1WQ9B 4EFVA 1WWWV 2VWEA 1KLAA 4HSAA 1VPFA 4UI0A 4MQWB 4GLNE 1M4UL 1MKGA 1JPYA 2C7WA 5BQ8A 5HHDA 4ZBNA 4X1JA 2TGIA 3BK3A 3SEKB 1HRPA 5HHXA 5HI3A 2GH0C 2GNNA 1FL7B 5BQBA 2ASKA 1HD4A 1ES7A 1B8MA 1TZIV 5BQEA 3IJ2A 3BMPA 1AGQA 1MKKA 2QJ9A 5AEJA 5HHVA 2H62A 2VPFA 5BPUA 5JZ7A 4MIDA 3RJRA 2QCQA 2QR0C 5BQ8B 1TGKA 1E9JA 3HH2A 1KTZA 2GOOA 4N1DA 5F3BC 2FJGV 1SG1A 5FV1V 5HI5A 1LXIA 1B98A 4EC7A 4HR9A 1HRPB 4KV5A 1S4YB
chains in the Genus database with same CATH topology
2B0UA 5HK5E 2QJAA 5BQEB 1QFWA 3P9WA 3E07A 2H64A 1WAQA 1NYSB 1FLTV 1XWDA 1TFGA 1BMPA 3QTKA 1KLCA 3BDYV 3S1KV 1PDGA 5BQCA 3S1BV 2KD3A 1CZ8V 1NYUB 3MJKA 4FAOA 4KZNA 4KXZA 4LXRJ 4YCIC 1TGJA 4UHZA 4EDWV 5F3HI 1MJVA 4WPBA 1BETA 1KATW 1BJ1V 2R52A 3MJGA 4QAFC 5HI4A 1M4UA 1QFWB 3FUBB 4BV4L 2GYZA 3KFDA 1REWA 2IFGE 1B8MB 1XWDB 1RV6V 2BHKA 3BUKA 2P6AA 2X1WA 4AY9A 3V2AA 1REUA 1QTYR 4XPJA 2ARVA 1BNDA 4UI1A 1B8KA 2XACA 4QHUC 3EO1C 4LXSJ 2QJBA 1WQ8A 5FV2V 4EAXA 3JVFA 4UI2B 1HCNA 4ZFFC 1WQ9A 4GLSE 1FZVA 2FJHV 2X1XE 4MQWA 1NT3A 1ZKZA 2XV7A 5BQ8D 3V6BA 1AOCA 3B4VA 1HCFA 4AY9B 4HQUA 3EVSB 1VPPV 4QCIC 4UHYA 1BTGA 1BNDB 4HQXA 4MPLA 4YCGC 2V5EB 2VXSA 4EDXV 5HK5A 1TZHV 3QB4A 5HHCA 5E4GA 1DZ7A 1FL7A 2PJYA 2R53A 2ARPA 2GYRA 1SGFB 1HCNB 1LX5A 2QCWA 1WQ9B 4EFVA 1WWWV 2VWEA 1KLAA 4HSAA 1VPFA 4UI0A 4MQWB 4GLNE 1M4UL 1MKGA 1JPYA 2C7WA 5BQ8A 5HHDA 4ZBNA 4X1JA 2TGIA 3BK3A 3SEKB 1HRPA 5HHXA 5HI3A 2GH0C 2GNNA 1FL7B 5BQBA 2ASKA 1HD4A 1ES7A 1B8MA 1TZIV 5BQEA 3IJ2A 3BMPA 1AGQA 1MKKA 2QJ9A 5AEJA 5HHVA 2H62A 2VPFA 5BPUA 5JZ7A 4MIDA 3RJRA 2QCQA 2QR0C 5BQ8B 1TGKA 1E9JA 3HH2A 1KTZA 2GOOA 4N1DA 5F3BC 2FJGV 1SG1A 5FV1V 5HI5A 1LXIA 1B98A 4EC7A 4HR9A 1HRPB 4KV5A 1S4YB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2B0U A;  5HK5 E;  2QJA A;  5BQE B;  1QFW A;  3P9W A;  3E07 A;  2H64 A;  1WAQ A;  1NYS B;  1FLT V;  1XWD A;  1TFG A;  1BMP A;  3QTK A;  1KLC A;  3BDY V;  3S1K V;  1PDG A;  5BQC A;  3S1B V;  2KD3 A;  1CZ8 V;  1NYU B;  3MJK A;  4FAO A;  4KZN A;  4KXZ A;  4LXR J;  4YCI C;  1TGJ A;  4UHZ A;  4EDW V;  5F3H I;  1MJV A;  4WPB A;  1BET A;  1KAT W;  1BJ1 V;  2R52 A;  3MJG A;  4QAF C;  5HI4 A;  1M4U A;  1QFW B;  3FUB B;  4BV4 L;  2GYZ A;  3KFD A;  1REW A;  2IFG E;  1B8M B;  1XWD B;  1RV6 V;  2BHK A;  3BUK A;  2P6A A;  2X1W A;  4AY9 A;  3V2A A;  1REU A;  1QTY R;  4XPJ A;  2ARV A;  1BND A;  4UI1 A;  1B8K A;  2XAC A;  4QHU C;  3EO1 C;  4LXS J;  2QJB A;  1WQ8 A;  5FV2 V;  4EAX A;  3JVF A;  4UI2 B;  1HCN A;  4ZFF C;  1WQ9 A;  4GLS E;  1FZV A;  2FJH V;  2X1X E;  4MQW A;  1NT3 A;  1ZKZ A;  2XV7 A;  5BQ8 D;  3V6B A;  1AOC A;  3B4V A;  1HCF A;  4AY9 B;  4HQU A;  3EVS B;  1VPP V;  4QCI C;  4UHY A;  1BTG A;  1BND B;  4HQX A;  4MPL A;  4YCG C;  2V5E B;  2VXS A;  4EDX V;  5HK5 A;  1TZH V;  3QB4 A;  5HHC A;  5E4G A;  1DZ7 A;  1FL7 A;  2PJY A;  2R53 A;  2ARP A;  2GYR A;  1SGF B;  1HCN B;  1LX5 A;  2QCW A;  1WQ9 B;  4EFV A;  1WWW V;  2VWE A;  1KLA A;  4HSA A;  1VPF A;  4UI0 A;  4MQW B;  4GLN E;  1M4U L;  1MKG A;  1JPY A;  2C7W A;  5BQ8 A;  5HHD A;  4ZBN A;  4X1J A;  2TGI A;  3BK3 A;  3SEK B;  1HRP A;  5HHX A;  5HI3 A;  2GH0 C;  2GNN A;  1FL7 B;  5BQB A;  2ASK A;  1HD4 A;  1ES7 A;  1B8M A;  1TZI V;  5BQE A;  3IJ2 A;  3BMP A;  1AGQ A;  1MKK A;  2QJ9 A;  5AEJ A;  5HHV A;  2H62 A;  2VPF A;  5BPU A;  5JZ7 A;  4MID A;  3RJR A;  2QCQ A;  2QR0 C;  5BQ8 B;  1TGK A;  1E9J A;  3HH2 A;  1KTZ A;  2GOO A;  4N1D A;  5F3B C;  2FJG V;  1SG1 A;  5FV1 V;  5HI5 A;  1LXI A;  1B98 A;  4EC7 A;  4HR9 A;  1HRP B;  4KV5 A;  1S4Y B; 
#chains in the Genus database with same CATH topology
 2B0U A;  5HK5 E;  2QJA A;  5BQE B;  1QFW A;  3P9W A;  3E07 A;  2H64 A;  1WAQ A;  1NYS B;  1FLT V;  1XWD A;  1TFG A;  1BMP A;  3QTK A;  1KLC A;  3BDY V;  3S1K V;  1PDG A;  5BQC A;  3S1B V;  2KD3 A;  1CZ8 V;  1NYU B;  3MJK A;  4FAO A;  4KZN A;  4KXZ A;  4LXR J;  4YCI C;  1TGJ A;  4UHZ A;  4EDW V;  5F3H I;  1MJV A;  4WPB A;  1BET A;  1KAT W;  1BJ1 V;  2R52 A;  3MJG A;  4QAF C;  5HI4 A;  1M4U A;  1QFW B;  3FUB B;  4BV4 L;  2GYZ A;  3KFD A;  1REW A;  2IFG E;  1B8M B;  1XWD B;  1RV6 V;  2BHK A;  3BUK A;  2P6A A;  2X1W A;  4AY9 A;  3V2A A;  1REU A;  1QTY R;  4XPJ A;  2ARV A;  1BND A;  4UI1 A;  1B8K A;  2XAC A;  4QHU C;  3EO1 C;  4LXS J;  2QJB A;  1WQ8 A;  5FV2 V;  4EAX A;  3JVF A;  4UI2 B;  1HCN A;  4ZFF C;  1WQ9 A;  4GLS E;  1FZV A;  2FJH V;  2X1X E;  4MQW A;  1NT3 A;  1ZKZ A;  2XV7 A;  5BQ8 D;  3V6B A;  1AOC A;  3B4V A;  1HCF A;  4AY9 B;  4HQU A;  3EVS B;  1VPP V;  4QCI C;  4UHY A;  1BTG A;  1BND B;  4HQX A;  4MPL A;  4YCG C;  2V5E B;  2VXS A;  4EDX V;  5HK5 A;  1TZH V;  3QB4 A;  5HHC A;  5E4G A;  1DZ7 A;  1FL7 A;  2PJY A;  2R53 A;  2ARP A;  2GYR A;  1SGF B;  1HCN B;  1LX5 A;  2QCW A;  1WQ9 B;  4EFV A;  1WWW V;  2VWE A;  1KLA A;  4HSA A;  1VPF A;  4UI0 A;  4MQW B;  4GLN E;  1M4U L;  1MKG A;  1JPY A;  2C7W A;  5BQ8 A;  5HHD A;  4ZBN A;  4X1J A;  2TGI A;  3BK3 A;  3SEK B;  1HRP A;  5HHX A;  5HI3 A;  2GH0 C;  2GNN A;  1FL7 B;  5BQB A;  2ASK A;  1HD4 A;  1ES7 A;  1B8M A;  1TZI V;  5BQE A;  3IJ2 A;  3BMP A;  1AGQ A;  1MKK A;  2QJ9 A;  5AEJ A;  5HHV A;  2H62 A;  2VPF A;  5BPU A;  5JZ7 A;  4MID A;  3RJR A;  2QCQ A;  2QR0 C;  5BQ8 B;  1TGK A;  1E9J A;  3HH2 A;  1KTZ A;  2GOO A;  4N1D A;  5F3B C;  2FJG V;  1SG1 A;  5FV1 V;  5HI5 A;  1LXI A;  1B98 A;  4EC7 A;  4HR9 A;  1HRP B;  4KV5 A;  1S4Y B; 
#chains in the Genus database with same CATH homology
 2B0U A;  5HK5 E;  2QJA A;  5BQE B;  1QFW A;  3P9W A;  3E07 A;  2H64 A;  1WAQ A;  1NYS B;  1FLT V;  1XWD A;  1TFG A;  1BMP A;  3QTK A;  1KLC A;  3BDY V;  3S1K V;  1PDG A;  5BQC A;  3S1B V;  2KD3 A;  1CZ8 V;  1NYU B;  3MJK A;  4FAO A;  4KZN A;  4KXZ A;  4LXR J;  4YCI C;  1TGJ A;  4UHZ A;  4EDW V;  5F3H I;  1MJV A;  4WPB A;  1BET A;  1KAT W;  1BJ1 V;  2R52 A;  3MJG A;  4QAF C;  5HI4 A;  1M4U A;  1QFW B;  3FUB B;  4BV4 L;  2GYZ A;  3KFD A;  1REW A;  2IFG E;  1B8M B;  1XWD B;  1RV6 V;  2BHK A;  3BUK A;  2P6A A;  2X1W A;  4AY9 A;  3V2A A;  1REU A;  1QTY R;  4XPJ A;  2ARV A;  1BND A;  4UI1 A;  1B8K A;  2XAC A;  4QHU C;  3EO1 C;  4LXS J;  2QJB A;  1WQ8 A;  5FV2 V;  4EAX A;  3JVF A;  4UI2 B;  1HCN A;  4ZFF C;  1WQ9 A;  4GLS E;  1FZV A;  2FJH V;  2X1X E;  4MQW A;  1NT3 A;  1ZKZ A;  2XV7 A;  5BQ8 D;  3V6B A;  1AOC A;  3B4V A;  1HCF A;  4AY9 B;  4HQU A;  3EVS B;  1VPP V;  4QCI C;  4UHY A;  1BTG A;  1BND B;  4HQX A;  4MPL A;  4YCG C;  2V5E B;  2VXS A;  4EDX V;  5HK5 A;  1TZH V;  3QB4 A;  5HHC A;  5E4G A;  1DZ7 A;  1FL7 A;  2PJY A;  2R53 A;  2ARP A;  2GYR A;  1SGF B;  1HCN B;  1LX5 A;  2QCW A;  1WQ9 B;  4EFV A;  1WWW V;  2VWE A;  1KLA A;  4HSA A;  1VPF A;  4UI0 A;  4MQW B;  4GLN E;  1M4U L;  1MKG A;  1JPY A;  2C7W A;  5BQ8 A;  5HHD A;  4ZBN A;  4X1J A;  2TGI A;  3BK3 A;  3SEK B;  1HRP A;  5HHX A;  5HI3 A;  2GH0 C;  2GNN A;  1FL7 B;  5BQB A;  2ASK A;  1HD4 A;  1ES7 A;  1B8M A;  1TZI V;  5BQE A;  3IJ2 A;  3BMP A;  1AGQ A;  1MKK A;  2QJ9 A;  5AEJ A;  5HHV A;  2H62 A;  2VPF A;  5BPU A;  5JZ7 A;  4MID A;  3RJR A;  2QCQ A;  2QR0 C;  5BQ8 B;  1TGK A;  1E9J A;  3HH2 A;  1KTZ A;  2GOO A;  4N1D A;  5F3B C;  2FJG V;  1SG1 A;  5FV1 V;  5HI5 A;  1LXI A;  1B98 A;  4EC7 A;  4HR9 A;  1HRP B;  4KV5 A;  1S4Y B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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