1XWDB

Crystal structure of human follicle stimulating hormone complexed with its receptor
Total Genus 7
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
7
sequence length
105
structure length
105
Chain Sequence
CELTNITIAIEKEECRFCISINTTWCAGYCYTRDLVYKDPARPKIQKTCTFKELVYETVRVPGCAHHADSLYTYPVATQCHCGKCDSDSTDCTVRGLGPSYCSFG
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Structure of human follicle-stimulating hormone in complex with its receptor.
pubmed doi rcsb
molecule tags Hormone/growth factor
source organism Homo sapiens
molecule keywords Glycoprotein hormones alpha chain
total genus 7
structure length 105
sequence length 105
chains with identical sequence E
ec nomenclature
pdb deposition date 2004-10-30
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.90.10 Mainly Beta Ribbon Cystine Knot Cytokines, subunit B Cystine-knot cytokines 1xwdB00
3E07A 1HRPB 4KXZA 1VPPV 1E9JA 4FAOA 2GYRA 4QCIC 2BHKA 4MIDA 5AEJA 1BNDA 1VPFA 2FJHV 1ES7A 3B4VA 1TGKA 4YCIC 1AOCA 1KATW 2TGIA 4XPJA 4EC7A 5BPUA 1HCNB 3MJKA 5F3HI 2H62A 1MKGA 3S1KV 5FV1V 1MKKA 1NT3A 1TGJA 2R52A 4KZNA 4UHYA 4ZFFC 1AGQA 3IJ2A 3JVFA 3BDYV 5BQBA 1XWDA 1FL7B 5BQ8A 2GNNA 2VPFA 1BETA 2P6AA 3EO1C 1DZ7A 3BMPA 4HSAA 3BK3A 1FL7A 2QCWA 5BQCA 5JZ7A 1FLTV 1TZHV 2V5EB 2GOOA 3EVSB 1SGFB 5HK5E 5BQEB 4X1JA 4AY9B 1M4UA 2B0UA 1HRPA 3BUKA 2C7WA 2ARVA 2VWEA 1LXIA 2QJBA 2FJGV 1MJVA 2H64A 1TFGA 1REUA 1B8MB 4GLNE 3P9WA 2R53A 4EDXV 1BJ1V 2X1WA 1S4YB 4BV4L 4EFVA 4MQWB 1KTZA 4UI2B 1HCNA 1WQ9B 5HI3A 5E4GA 3HH2A 3QTKA 2QJ9A 5HHVA 4QHUC 1BMPA 1QTYR 4MQWA 3FUBB 1NYUB 4UHZA 4UI0A 1WWWV 1CZ8V 3QB4A 4HQUA 4GLSE 4EDWV 3SEKB 1QFWB 1KLCA 4YCGC 5BQ8D 5HK5A 5HHCA 2KD3A 4WPBA 3RJRA 1KLAA 5HI5A 1WQ8A 5BQEA 4AY9A 3KFDA 1QFWA 2QR0C 2VXSA 1NYSB 3V6BA 2ASKA 1B8MA 1B98A 2IFGE 1WAQA 1BNDB 5F3BC 1M4UL 4MPLA 2X1XE 4UI1A 4LXSJ 4QAFC 1RV6V 4KV5A 1ZKZA 1WQ9A 2GH0C 4LXRJ 4EAXA 1TZIV 1XWDB 5BQ8B 4HR9A 2ARPA 4HQXA 5FV2V 1SG1A 5HI4A 4ZBNA 2XACA 2XV7A 1HD4A 1LX5A 1BTGA 3V2AA 1PDGA 2QCQA 1JPYA 5HHDA 1FZVA 1B8KA 5HHXA 2QJAA 2PJYA 1REWA 3MJGA 4N1DA 2GYZA 3S1BV 1HCFA
chains in the Genus database with same CATH superfamily
3E07A 1HRPB 4KXZA 1VPPV 1E9JA 4FAOA 2GYRA 4QCIC 2BHKA 4MIDA 5AEJA 1BNDA 1VPFA 2FJHV 1ES7A 3B4VA 1TGKA 4YCIC 1AOCA 1KATW 2TGIA 4XPJA 4EC7A 5BPUA 1HCNB 3MJKA 5F3HI 2H62A 1MKGA 3S1KV 5FV1V 1MKKA 1NT3A 1TGJA 2R52A 4KZNA 4UHYA 4ZFFC 1AGQA 3IJ2A 3JVFA 3BDYV 5BQBA 1XWDA 1FL7B 5BQ8A 2GNNA 2VPFA 1BETA 2P6AA 3EO1C 1DZ7A 3BMPA 4HSAA 3BK3A 1FL7A 2QCWA 5BQCA 5JZ7A 1FLTV 1TZHV 2V5EB 2GOOA 3EVSB 1SGFB 5HK5E 5BQEB 4X1JA 4AY9B 1M4UA 2B0UA 1HRPA 3BUKA 2C7WA 2ARVA 2VWEA 1LXIA 2QJBA 2FJGV 1MJVA 2H64A 1TFGA 1REUA 1B8MB 4GLNE 3P9WA 2R53A 4EDXV 1BJ1V 2X1WA 1S4YB 4BV4L 4EFVA 4MQWB 1KTZA 4UI2B 1HCNA 1WQ9B 5HI3A 5E4GA 3HH2A 3QTKA 2QJ9A 5HHVA 4QHUC 1BMPA 1QTYR 4MQWA 3FUBB 1NYUB 4UHZA 4UI0A 1WWWV 1CZ8V 3QB4A 4HQUA 4GLSE 4EDWV 3SEKB 1QFWB 1KLCA 4YCGC 5BQ8D 5HK5A 5HHCA 2KD3A 4WPBA 3RJRA 1KLAA 5HI5A 1WQ8A 5BQEA 4AY9A 3KFDA 1QFWA 2QR0C 2VXSA 1NYSB 3V6BA 2ASKA 1B8MA 1B98A 2IFGE 1WAQA 1BNDB 5F3BC 1M4UL 4MPLA 2X1XE 4UI1A 4LXSJ 4QAFC 1RV6V 4KV5A 1ZKZA 1WQ9A 2GH0C 4LXRJ 4EAXA 1TZIV 1XWDB 5BQ8B 4HR9A 2ARPA 4HQXA 5FV2V 1SG1A 5HI4A 4ZBNA 2XACA 2XV7A 1HD4A 1LX5A 1BTGA 3V2AA 1PDGA 2QCQA 1JPYA 5HHDA 1FZVA 1B8KA 5HHXA 2QJAA 2PJYA 1REWA 3MJGA 4N1DA 2GYZA 3S1BV 1HCFA
chains in the Genus database with same CATH topology
3E07A 1HRPB 4KXZA 1VPPV 1E9JA 4FAOA 2GYRA 4QCIC 2BHKA 4MIDA 5AEJA 1BNDA 1VPFA 2FJHV 1ES7A 3B4VA 1TGKA 4YCIC 1AOCA 1KATW 2TGIA 4XPJA 4EC7A 5BPUA 1HCNB 3MJKA 5F3HI 2H62A 1MKGA 3S1KV 5FV1V 1MKKA 1NT3A 1TGJA 2R52A 4KZNA 4UHYA 4ZFFC 1AGQA 3IJ2A 3JVFA 3BDYV 5BQBA 1XWDA 1FL7B 5BQ8A 2GNNA 2VPFA 1BETA 2P6AA 3EO1C 1DZ7A 3BMPA 4HSAA 3BK3A 1FL7A 2QCWA 5BQCA 5JZ7A 1FLTV 1TZHV 2V5EB 2GOOA 3EVSB 1SGFB 5HK5E 5BQEB 4X1JA 4AY9B 1M4UA 2B0UA 1HRPA 3BUKA 2C7WA 2ARVA 2VWEA 1LXIA 2QJBA 2FJGV 1MJVA 2H64A 1TFGA 1REUA 1B8MB 4GLNE 3P9WA 2R53A 4EDXV 1BJ1V 2X1WA 1S4YB 4BV4L 4EFVA 4MQWB 1KTZA 4UI2B 1HCNA 1WQ9B 5HI3A 5E4GA 3HH2A 3QTKA 2QJ9A 5HHVA 4QHUC 1BMPA 1QTYR 4MQWA 3FUBB 1NYUB 4UHZA 4UI0A 1WWWV 1CZ8V 3QB4A 4HQUA 4GLSE 4EDWV 3SEKB 1QFWB 1KLCA 4YCGC 5BQ8D 5HK5A 5HHCA 2KD3A 4WPBA 3RJRA 1KLAA 5HI5A 1WQ8A 5BQEA 4AY9A 3KFDA 1QFWA 2QR0C 2VXSA 1NYSB 3V6BA 2ASKA 1B8MA 1B98A 2IFGE 1WAQA 1BNDB 5F3BC 1M4UL 4MPLA 2X1XE 4UI1A 4LXSJ 4QAFC 1RV6V 4KV5A 1ZKZA 1WQ9A 2GH0C 4LXRJ 4EAXA 1TZIV 1XWDB 5BQ8B 4HR9A 2ARPA 4HQXA 5FV2V 1SG1A 5HI4A 4ZBNA 2XACA 2XV7A 1HD4A 1LX5A 1BTGA 3V2AA 1PDGA 2QCQA 1JPYA 5HHDA 1FZVA 1B8KA 5HHXA 2QJAA 2PJYA 1REWA 3MJGA 4N1DA 2GYZA 3S1BV 1HCFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3E07 A;  1HRP B;  4KXZ A;  1VPP V;  1E9J A;  4FAO A;  2GYR A;  4QCI C;  2BHK A;  4MID A;  5AEJ A;  1BND A;  1VPF A;  2FJH V;  1ES7 A;  3B4V A;  1TGK A;  4YCI C;  1AOC A;  1KAT W;  2TGI A;  4XPJ A;  4EC7 A;  5BPU A;  1HCN B;  3MJK A;  5F3H I;  2H62 A;  1MKG A;  3S1K V;  5FV1 V;  1MKK A;  1NT3 A;  1TGJ A;  2R52 A;  4KZN A;  4UHY A;  4ZFF C;  1AGQ A;  3IJ2 A;  3JVF A;  3BDY V;  5BQB A;  1XWD A;  1FL7 B;  5BQ8 A;  2GNN A;  2VPF A;  1BET A;  2P6A A;  3EO1 C;  1DZ7 A;  3BMP A;  4HSA A;  3BK3 A;  1FL7 A;  2QCW A;  5BQC A;  5JZ7 A;  1FLT V;  1TZH V;  2V5E B;  2GOO A;  3EVS B;  1SGF B;  5HK5 E;  5BQE B;  4X1J A;  4AY9 B;  1M4U A;  2B0U A;  1HRP A;  3BUK A;  2C7W A;  2ARV A;  2VWE A;  1LXI A;  2QJB A;  2FJG V;  1MJV A;  2H64 A;  1TFG A;  1REU A;  1B8M B;  4GLN E;  3P9W A;  2R53 A;  4EDX V;  1BJ1 V;  2X1W A;  1S4Y B;  4BV4 L;  4EFV A;  4MQW B;  1KTZ A;  4UI2 B;  1HCN A;  1WQ9 B;  5HI3 A;  5E4G A;  3HH2 A;  3QTK A;  2QJ9 A;  5HHV A;  4QHU C;  1BMP A;  1QTY R;  4MQW A;  3FUB B;  1NYU B;  4UHZ A;  4UI0 A;  1WWW V;  1CZ8 V;  3QB4 A;  4HQU A;  4GLS E;  4EDW V;  3SEK B;  1QFW B;  1KLC A;  4YCG C;  5BQ8 D;  5HK5 A;  5HHC A;  2KD3 A;  4WPB A;  3RJR A;  1KLA A;  5HI5 A;  1WQ8 A;  5BQE A;  4AY9 A;  3KFD A;  1QFW A;  2QR0 C;  2VXS A;  1NYS B;  3V6B A;  2ASK A;  1B8M A;  1B98 A;  2IFG E;  1WAQ A;  1BND B;  5F3B C;  1M4U L;  4MPL A;  2X1X E;  4UI1 A;  4LXS J;  4QAF C;  1RV6 V;  4KV5 A;  1ZKZ A;  1WQ9 A;  2GH0 C;  4LXR J;  4EAX A;  1TZI V;  1XWD B;  5BQ8 B;  4HR9 A;  2ARP A;  4HQX A;  5FV2 V;  1SG1 A;  5HI4 A;  4ZBN A;  2XAC A;  2XV7 A;  1HD4 A;  1LX5 A;  1BTG A;  3V2A A;  1PDG A;  2QCQ A;  1JPY A;  5HHD A;  1FZV A;  1B8K A;  5HHX A;  2QJA A;  2PJY A;  1REW A;  3MJG A;  4N1D A;  2GYZ A;  3S1B V;  1HCF A; 
#chains in the Genus database with same CATH topology
 3E07 A;  1HRP B;  4KXZ A;  1VPP V;  1E9J A;  4FAO A;  2GYR A;  4QCI C;  2BHK A;  4MID A;  5AEJ A;  1BND A;  1VPF A;  2FJH V;  1ES7 A;  3B4V A;  1TGK A;  4YCI C;  1AOC A;  1KAT W;  2TGI A;  4XPJ A;  4EC7 A;  5BPU A;  1HCN B;  3MJK A;  5F3H I;  2H62 A;  1MKG A;  3S1K V;  5FV1 V;  1MKK A;  1NT3 A;  1TGJ A;  2R52 A;  4KZN A;  4UHY A;  4ZFF C;  1AGQ A;  3IJ2 A;  3JVF A;  3BDY V;  5BQB A;  1XWD A;  1FL7 B;  5BQ8 A;  2GNN A;  2VPF A;  1BET A;  2P6A A;  3EO1 C;  1DZ7 A;  3BMP A;  4HSA A;  3BK3 A;  1FL7 A;  2QCW A;  5BQC A;  5JZ7 A;  1FLT V;  1TZH V;  2V5E B;  2GOO A;  3EVS B;  1SGF B;  5HK5 E;  5BQE B;  4X1J A;  4AY9 B;  1M4U A;  2B0U A;  1HRP A;  3BUK A;  2C7W A;  2ARV A;  2VWE A;  1LXI A;  2QJB A;  2FJG V;  1MJV A;  2H64 A;  1TFG A;  1REU A;  1B8M B;  4GLN E;  3P9W A;  2R53 A;  4EDX V;  1BJ1 V;  2X1W A;  1S4Y B;  4BV4 L;  4EFV A;  4MQW B;  1KTZ A;  4UI2 B;  1HCN A;  1WQ9 B;  5HI3 A;  5E4G A;  3HH2 A;  3QTK A;  2QJ9 A;  5HHV A;  4QHU C;  1BMP A;  1QTY R;  4MQW A;  3FUB B;  1NYU B;  4UHZ A;  4UI0 A;  1WWW V;  1CZ8 V;  3QB4 A;  4HQU A;  4GLS E;  4EDW V;  3SEK B;  1QFW B;  1KLC A;  4YCG C;  5BQ8 D;  5HK5 A;  5HHC A;  2KD3 A;  4WPB A;  3RJR A;  1KLA A;  5HI5 A;  1WQ8 A;  5BQE A;  4AY9 A;  3KFD A;  1QFW A;  2QR0 C;  2VXS A;  1NYS B;  3V6B A;  2ASK A;  1B8M A;  1B98 A;  2IFG E;  1WAQ A;  1BND B;  5F3B C;  1M4U L;  4MPL A;  2X1X E;  4UI1 A;  4LXS J;  4QAF C;  1RV6 V;  4KV5 A;  1ZKZ A;  1WQ9 A;  2GH0 C;  4LXR J;  4EAX A;  1TZI V;  1XWD B;  5BQ8 B;  4HR9 A;  2ARP A;  4HQX A;  5FV2 V;  1SG1 A;  5HI4 A;  4ZBN A;  2XAC A;  2XV7 A;  1HD4 A;  1LX5 A;  1BTG A;  3V2A A;  1PDG A;  2QCQ A;  1JPY A;  5HHD A;  1FZV A;  1B8K A;  5HHX A;  2QJA A;  2PJY A;  1REW A;  3MJG A;  4N1D A;  2GYZ A;  3S1B V;  1HCF A; 
#chains in the Genus database with same CATH homology
 3E07 A;  1HRP B;  4KXZ A;  1VPP V;  1E9J A;  4FAO A;  2GYR A;  4QCI C;  2BHK A;  4MID A;  5AEJ A;  1BND A;  1VPF A;  2FJH V;  1ES7 A;  3B4V A;  1TGK A;  4YCI C;  1AOC A;  1KAT W;  2TGI A;  4XPJ A;  4EC7 A;  5BPU A;  1HCN B;  3MJK A;  5F3H I;  2H62 A;  1MKG A;  3S1K V;  5FV1 V;  1MKK A;  1NT3 A;  1TGJ A;  2R52 A;  4KZN A;  4UHY A;  4ZFF C;  1AGQ A;  3IJ2 A;  3JVF A;  3BDY V;  5BQB A;  1XWD A;  1FL7 B;  5BQ8 A;  2GNN A;  2VPF A;  1BET A;  2P6A A;  3EO1 C;  1DZ7 A;  3BMP A;  4HSA A;  3BK3 A;  1FL7 A;  2QCW A;  5BQC A;  5JZ7 A;  1FLT V;  1TZH V;  2V5E B;  2GOO A;  3EVS B;  1SGF B;  5HK5 E;  5BQE B;  4X1J A;  4AY9 B;  1M4U A;  2B0U A;  1HRP A;  3BUK A;  2C7W A;  2ARV A;  2VWE A;  1LXI A;  2QJB A;  2FJG V;  1MJV A;  2H64 A;  1TFG A;  1REU A;  1B8M B;  4GLN E;  3P9W A;  2R53 A;  4EDX V;  1BJ1 V;  2X1W A;  1S4Y B;  4BV4 L;  4EFV A;  4MQW B;  1KTZ A;  4UI2 B;  1HCN A;  1WQ9 B;  5HI3 A;  5E4G A;  3HH2 A;  3QTK A;  2QJ9 A;  5HHV A;  4QHU C;  1BMP A;  1QTY R;  4MQW A;  3FUB B;  1NYU B;  4UHZ A;  4UI0 A;  1WWW V;  1CZ8 V;  3QB4 A;  4HQU A;  4GLS E;  4EDW V;  3SEK B;  1QFW B;  1KLC A;  4YCG C;  5BQ8 D;  5HK5 A;  5HHC A;  2KD3 A;  4WPB A;  3RJR A;  1KLA A;  5HI5 A;  1WQ8 A;  5BQE A;  4AY9 A;  3KFD A;  1QFW A;  2QR0 C;  2VXS A;  1NYS B;  3V6B A;  2ASK A;  1B8M A;  1B98 A;  2IFG E;  1WAQ A;  1BND B;  5F3B C;  1M4U L;  4MPL A;  2X1X E;  4UI1 A;  4LXS J;  4QAF C;  1RV6 V;  4KV5 A;  1ZKZ A;  1WQ9 A;  2GH0 C;  4LXR J;  4EAX A;  1TZI V;  1XWD B;  5BQ8 B;  4HR9 A;  2ARP A;  4HQX A;  5FV2 V;  1SG1 A;  5HI4 A;  4ZBN A;  2XAC A;  2XV7 A;  1HD4 A;  1LX5 A;  1BTG A;  3V2A A;  1PDG A;  2QCQ A;  1JPY A;  5HHD A;  1FZV A;  1B8K A;  5HHX A;  2QJA A;  2PJY A;  1REW A;  3MJG A;  4N1D A;  2GYZ A;  3S1B V;  1HCF A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...