2B0U | Genus

Total Genus 21

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	21
sequence length	116
structure length	116
Chain Sequence	GLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

publication title	The Structure of the Follistatin:Activin Complex Reveals Antagonism of Both Type I and Type II Receptor Binding. pubmed doi rcsb
molecule keywords	Inhibin beta A chain
molecule tags	Signaling protein
source organism	Homo sapiens
total genus	21
structure length	116
sequence length	116
chains with identical sequence	B
ec nomenclature
pdb deposition date	2005-09-14

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00019	TGF_beta	Transforming growth factor beta like domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
2.10.90.10	Mainly Beta	Ribbon	Cystine Knot Cytokines, subunit B	Cystine-knot cytokines	2b0uA00

4MPLA 1BJ1V 5BQEA 1HCNB 2GNNA 4EFVA 1TGKA 1VPPV 2VXSA 5HK5A 1HRPB 4XPJA 1QFWB 2VWEA 5HHDA 1REWA 2C7WA 4MQWA 5BQ8A 4UHYA 1WQ8A 2GOOA 2QCQA 1WWWV 1TZIV 4KZNA 1NYSB 5HHCA 3MJKA 5BQBA 1BNDA 1S4YB 2V5EB 4HQUA 4HSAA 5HI3A 1MKGA 4EDXV 5HHVA 1CZ8V 1M4UL 1QTYR 5HHXA 1NT3A 1BTGA 4ZBNA 4ZFFC 4EDWV 4AY9B 1MKKA 2R53A 1LX5A 2ASKA 2QJ9A 1JPYA 5HK5E 2VPFA 2IFGE 2H62A 3EO1C 3EVSB 5BQEB 2FJHV 1KLCA 4X1JA 2ARVA 3E07A 4YCIC 4QHUC 2FJGV 1HD4A 4UI1A 1PDGA 1NYUB 2GYRA 2GYZA 5BQ8B 3SEKB 3QTKA 1E9JA 2H64A 1FL7A 1BMPA 4GLNE 1WQ9A 2BHKA 1RV6V 1BETA 2QJAA 2XACA 4KV5A 4WPBA 3IJ2A 2QCWA 4EAXA 1MJVA 5F3HI 2QJBA 1B8MA 1ES7A 1ZKZA 2ARPA 1AOCA 1M4UA 2TGIA 2X1WA 1TZHV 2KD3A 4GLSE 1QFWA 3S1BV 4BV4L 1VPFA 4HR9A 1AGQA 4LXSJ 4HQXA 3HH2A 3QB4A 2GH0C 4MQWB 5FV2V 1B98A 3P9WA 5HI4A 4FAOA 2X1XE 5FV1V 5HI5A 1WAQA 1KLAA 2B0UA 1BNDB 4YCGC 1KATW 3BUKA 5JZ7A 5BQCA 4UHZA 3BDYV 3KFDA 3FUBB 1SGFB 1TFGA 1XWDA 1B8KA 1LXIA 3BMPA 4QAFC 1HCNA 5AEJA 2XV7A 5E4GA 5BQ8D 1HRPA 1REUA 1TGJA 1SG1A 3RJRA 4QCIC 2QR0C 1HCFA 2P6AA 4MIDA 1KTZA 5F3BC 4EC7A 1FL7B 3B4VA 1FZVA 2PJYA 5BPUA 1DZ7A 1WQ9B 3S1KV 4N1DA 3BK3A 3V6BA 4LXRJ 3JVFA 3MJGA 4KXZA 3V2AA 4AY9A 1FLTV 4UI0A 1B8MB 4UI2B 1XWDB 2R52A
chains in the Genus database with same CATH superfamily

#chains in the Genus database with same CATH superfamily
 4MPL A;  1BJ1 V;  5BQE A;  1HCN B;  2GNN A;  4EFV A;  1TGK A;  1VPP V;  2VXS A;  5HK5 A;  1HRP B;  4XPJ A;  1QFW B;  2VWE A;  5HHD A;  1REW A;  2C7W A;  4MQW A;  5BQ8 A;  4UHY A;  1WQ8 A;  2GOO A;  2QCQ A;  1WWW V;  1TZI V;  4KZN A;  1NYS B;  5HHC A;  3MJK A;  5BQB A;  1BND A;  1S4Y B;  2V5E B;  4HQU A;  4HSA A;  5HI3 A;  1MKG A;  4EDX V;  5HHV A;  1CZ8 V;  1M4U L;  1QTY R;  5HHX A;  1NT3 A;  1BTG A;  4ZBN A;  4ZFF C;  4EDW V;  4AY9 B;  1MKK A;  2R53 A;  1LX5 A;  2ASK A;  2QJ9 A;  1JPY A;  5HK5 E;  2VPF A;  2IFG E;  2H62 A;  3EO1 C;  3EVS B;  5BQE B;  2FJH V;  1KLC A;  4X1J A;  2ARV A;  3E07 A;  4YCI C;  4QHU C;  2FJG V;  1HD4 A;  4UI1 A;  1PDG A;  1NYU B;  2GYR A;  2GYZ A;  5BQ8 B;  3SEK B;  3QTK A;  1E9J A;  2H64 A;  1FL7 A;  1BMP A;  4GLN E;  1WQ9 A;  2BHK A;  1RV6 V;  1BET A;  2QJA A;  2XAC A;  4KV5 A;  4WPB A;  3IJ2 A;  2QCW A;  4EAX A;  1MJV A;  5F3H I;  2QJB A;  1B8M A;  1ES7 A;  1ZKZ A;  2ARP A;  1AOC A;  1M4U A;  2TGI A;  2X1W A;  1TZH V;  2KD3 A;  4GLS E;  1QFW A;  3S1B V;  4BV4 L;  1VPF A;  4HR9 A;  1AGQ A;  4LXS J;  4HQX A;  3HH2 A;  3QB4 A;  2GH0 C;  4MQW B;  5FV2 V;  1B98 A;  3P9W A;  5HI4 A;  4FAO A;  2X1X E;  5FV1 V;  5HI5 A;  1WAQ A;  1KLA A;  2B0U A;  1BND B;  4YCG C;  1KAT W;  3BUK A;  5JZ7 A;  5BQC A;  4UHZ A;  3BDY V;  3KFD A;  3FUB B;  1SGF B;  1TFG A;  1XWD A;  1B8K A;  1LXI A;  3BMP A;  4QAF C;  1HCN A;  5AEJ A;  2XV7 A;  5E4G A;  5BQ8 D;  1HRP A;  1REU A;  1TGJ A;  1SG1 A;  3RJR A;  4QCI C;  2QR0 C;  1HCF A;  2P6A A;  4MID A;  1KTZ A;  5F3B C;  4EC7 A;  1FL7 B;  3B4V A;  1FZV A;  2PJY A;  5BPU A;  1DZ7 A;  1WQ9 B;  3S1K V;  4N1D A;  3BK3 A;  3V6B A;  4LXR J;  3JVF A;  3MJG A;  4KXZ A;  3V2A A;  4AY9 A;  1FLT V;  4UI0 A;  1B8M B;  4UI2 B;  1XWD B;  2R52 A; 
#chains in the Genus database with same CATH topology
 4MPL A;  1BJ1 V;  5BQE A;  1HCN B;  2GNN A;  4EFV A;  1TGK A;  1VPP V;  2VXS A;  5HK5 A;  1HRP B;  4XPJ A;  1QFW B;  2VWE A;  5HHD A;  1REW A;  2C7W A;  4MQW A;  5BQ8 A;  4UHY A;  1WQ8 A;  2GOO A;  2QCQ A;  1WWW V;  1TZI V;  4KZN A;  1NYS B;  5HHC A;  3MJK A;  5BQB A;  1BND A;  1S4Y B;  2V5E B;  4HQU A;  4HSA A;  5HI3 A;  1MKG A;  4EDX V;  5HHV A;  1CZ8 V;  1M4U L;  1QTY R;  5HHX A;  1NT3 A;  1BTG A;  4ZBN A;  4ZFF C;  4EDW V;  4AY9 B;  1MKK A;  2R53 A;  1LX5 A;  2ASK A;  2QJ9 A;  1JPY A;  5HK5 E;  2VPF A;  2IFG E;  2H62 A;  3EO1 C;  3EVS B;  5BQE B;  2FJH V;  1KLC A;  4X1J A;  2ARV A;  3E07 A;  4YCI C;  4QHU C;  2FJG V;  1HD4 A;  4UI1 A;  1PDG A;  1NYU B;  2GYR A;  2GYZ A;  5BQ8 B;  3SEK B;  3QTK A;  1E9J A;  2H64 A;  1FL7 A;  1BMP A;  4GLN E;  1WQ9 A;  2BHK A;  1RV6 V;  1BET A;  2QJA A;  2XAC A;  4KV5 A;  4WPB A;  3IJ2 A;  2QCW A;  4EAX A;  1MJV A;  5F3H I;  2QJB A;  1B8M A;  1ES7 A;  1ZKZ A;  2ARP A;  1AOC A;  1M4U A;  2TGI A;  2X1W A;  1TZH V;  2KD3 A;  4GLS E;  1QFW A;  3S1B V;  4BV4 L;  1VPF A;  4HR9 A;  1AGQ A;  4LXS J;  4HQX A;  3HH2 A;  3QB4 A;  2GH0 C;  4MQW B;  5FV2 V;  1B98 A;  3P9W A;  5HI4 A;  4FAO A;  2X1X E;  5FV1 V;  5HI5 A;  1WAQ A;  1KLA A;  2B0U A;  1BND B;  4YCG C;  1KAT W;  3BUK A;  5JZ7 A;  5BQC A;  4UHZ A;  3BDY V;  3KFD A;  3FUB B;  1SGF B;  1TFG A;  1XWD A;  1B8K A;  1LXI A;  3BMP A;  4QAF C;  1HCN A;  5AEJ A;  2XV7 A;  5E4G A;  5BQ8 D;  1HRP A;  1REU A;  1TGJ A;  1SG1 A;  3RJR A;  4QCI C;  2QR0 C;  1HCF A;  2P6A A;  4MID A;  1KTZ A;  5F3B C;  4EC7 A;  1FL7 B;  3B4V A;  1FZV A;  2PJY A;  5BPU A;  1DZ7 A;  1WQ9 B;  3S1K V;  4N1D A;  3BK3 A;  3V6B A;  4LXR J;  3JVF A;  3MJG A;  4KXZ A;  3V2A A;  4AY9 A;  1FLT V;  4UI0 A;  1B8M B;  4UI2 B;  1XWD B;  2R52 A; 
#chains in the Genus database with same CATH homology
 4MPL A;  1BJ1 V;  5BQE A;  1HCN B;  2GNN A;  4EFV A;  1TGK A;  1VPP V;  2VXS A;  5HK5 A;  1HRP B;  4XPJ A;  1QFW B;  2VWE A;  5HHD A;  1REW A;  2C7W A;  4MQW A;  5BQ8 A;  4UHY A;  1WQ8 A;  2GOO A;  2QCQ A;  1WWW V;  1TZI V;  4KZN A;  1NYS B;  5HHC A;  3MJK A;  5BQB A;  1BND A;  1S4Y B;  2V5E B;  4HQU A;  4HSA A;  5HI3 A;  1MKG A;  4EDX V;  5HHV A;  1CZ8 V;  1M4U L;  1QTY R;  5HHX A;  1NT3 A;  1BTG A;  4ZBN A;  4ZFF C;  4EDW V;  4AY9 B;  1MKK A;  2R53 A;  1LX5 A;  2ASK A;  2QJ9 A;  1JPY A;  5HK5 E;  2VPF A;  2IFG E;  2H62 A;  3EO1 C;  3EVS B;  5BQE B;  2FJH V;  1KLC A;  4X1J A;  2ARV A;  3E07 A;  4YCI C;  4QHU C;  2FJG V;  1HD4 A;  4UI1 A;  1PDG A;  1NYU B;  2GYR A;  2GYZ A;  5BQ8 B;  3SEK B;  3QTK A;  1E9J A;  2H64 A;  1FL7 A;  1BMP A;  4GLN E;  1WQ9 A;  2BHK A;  1RV6 V;  1BET A;  2QJA A;  2XAC A;  4KV5 A;  4WPB A;  3IJ2 A;  2QCW A;  4EAX A;  1MJV A;  5F3H I;  2QJB A;  1B8M A;  1ES7 A;  1ZKZ A;  2ARP A;  1AOC A;  1M4U A;  2TGI A;  2X1W A;  1TZH V;  2KD3 A;  4GLS E;  1QFW A;  3S1B V;  4BV4 L;  1VPF A;  4HR9 A;  1AGQ A;  4LXS J;  4HQX A;  3HH2 A;  3QB4 A;  2GH0 C;  4MQW B;  5FV2 V;  1B98 A;  3P9W A;  5HI4 A;  4FAO A;  2X1X E;  5FV1 V;  5HI5 A;  1WAQ A;  1KLA A;  2B0U A;  1BND B;  4YCG C;  1KAT W;  3BUK A;  5JZ7 A;  5BQC A;  4UHZ A;  3BDY V;  3KFD A;  3FUB B;  1SGF B;  1TFG A;  1XWD A;  1B8K A;  1LXI A;  3BMP A;  4QAF C;  1HCN A;  5AEJ A;  2XV7 A;  5E4G A;  5BQ8 D;  1HRP A;  1REU A;  1TGJ A;  1SG1 A;  3RJR A;  4QCI C;  2QR0 C;  1HCF A;  2P6A A;  4MID A;  1KTZ A;  5F3B C;  4EC7 A;  1FL7 B;  3B4V A;  1FZV A;  2PJY A;  5BPU A;  1DZ7 A;  1WQ9 B;  3S1K V;  4N1D A;  3BK3 A;  3V6B A;  4LXR J;  3JVF A;  3MJG A;  4KXZ A;  3V2A A;  4AY9 A;  1FLT V;  4UI0 A;  1B8M B;  4UI2 B;  1XWD B;  2R52 A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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2B0UA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations