2C7WA

Crystal structure of human vascular endothelial growth factor-b: identification of amino acids important for angiogeninc activity
Total Genus 13
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
13
sequence length
95
structure length
95
Chain Sequence
KVVSWIDVYTRATCQPREVVVPLTVELMGTVAKQLVPSCVTVQRCGGCCPDDGLECVPTGQHQVRMQILMIRYPSSQLGEMSLEEHSQCECRPKK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of Human Vascular Endothelial Growth Factor-B: Identification of Amino Acids Important for Receptor Binding
pubmed doi rcsb
molecule tags Growth factor
source organism Homo sapiens
molecule keywords VASCULAR ENDOTHELIAL GROWTH FACTOR B PRECURSOR
total genus 13
structure length 95
sequence length 95
chains with identical sequence B
ec nomenclature
pdb deposition date 2005-11-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00341 PDGF PDGF/VEGF domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.90.10 Mainly Beta Ribbon Cystine Knot Cytokines, subunit B Cystine-knot cytokines 2c7wA00
2V5EB 3BMPA 3B4VA 3SEKB 4EDXV 2VPFA 4HSAA 2H64A 4UHZA 4BV4L 1HRPB 4MPLA 1HRPA 4MIDA 5HI3A 1M4UL 1TZHV 1BETA 4XPJA 4KZNA 2XV7A 2ARVA 1AOCA 3HH2A 2GYZA 5HI4A 1WQ8A 5BQCA 1WWWV 3EVSB 2BHKA 2QJBA 1BJ1V 1VPFA 5HK5A 4AY9B 3QB4A 4HR9A 4UHYA 4AY9A 1MJVA 3BK3A 1HCNB 4UI2B 1HCNA 1XWDA 5BQBA 1KATW 4KV5A 5F3HI 1MKKA 1BMPA 4EDWV 3MJKA 3V2AA 4GLSE 1HD4A 2ASKA 4N1DA 2R53A 4YCIC 2P6AA 3IJ2A 1NT3A 2GOOA 3JVFA 2QR0C 1HCFA 3P9WA 4YCGC 4UI0A 5HHXA 1JPYA 2B0UA 1QFWB 1REUA 2QCQA 5HK5E 1QFWA 5BQEB 3E07A 2QCWA 5BQEA 1B8MB 1RV6V 1SGFB 1TGJA 3MJGA 1B8MA 4ZBNA 1S4YB 1B98A 5FV2V 1KLAA 1MKGA 1TFGA 5HHDA 3BDYV 1NYUB 2VWEA 2FJHV 2KD3A 1WQ9B 2QJ9A 4EFVA 5E4GA 5JZ7A 3S1KV 2PJYA 1REWA 1BNDB 2GNNA 5BQ8D 1BNDA 1KLCA 4KXZA 2H62A 1FL7A 1TGKA 1SG1A 2ARPA 1E9JA 1FLTV 2C7WA 1TZIV 5AEJA 4EAXA 3KFDA 1ES7A 4EC7A 1B8KA 4HQXA 4QAFC 5FV1V 1KTZA 1CZ8V 1WAQA 1LXIA 2GYRA 3EO1C 3FUBB 1BTGA 2R52A 4WPBA 3V6BA 3QTKA 4FAOA 1FL7B 2QJAA 1NYSB 4X1JA 1WQ9A 2XACA 5HHVA 1FZVA 1QTYR 1VPPV 2IFGE 1LX5A 4QCIC 5BQ8B 2TGIA 5BQ8A 1PDGA 2X1XE 1M4UA 2FJGV 4UI1A 3RJRA 1DZ7A 1ZKZA 5HHCA 4MQWA 2VXSA 5F3BC 1XWDB 5HI5A 2X1WA 4QHUC 1AGQA 3BUKA 4ZFFC 4LXRJ 4GLNE 2GH0C 4MQWB 5BPUA 4LXSJ 4HQUA 3S1BV
chains in the Genus database with same CATH superfamily
2V5EB 3BMPA 3B4VA 3SEKB 4EDXV 2VPFA 4HSAA 2H64A 4UHZA 4BV4L 1HRPB 4MPLA 1HRPA 4MIDA 5HI3A 1M4UL 1TZHV 1BETA 4XPJA 4KZNA 2XV7A 2ARVA 1AOCA 3HH2A 2GYZA 5HI4A 1WQ8A 5BQCA 1WWWV 3EVSB 2BHKA 2QJBA 1BJ1V 1VPFA 5HK5A 4AY9B 3QB4A 4HR9A 4UHYA 4AY9A 1MJVA 3BK3A 1HCNB 4UI2B 1HCNA 1XWDA 5BQBA 1KATW 4KV5A 5F3HI 1MKKA 1BMPA 4EDWV 3MJKA 3V2AA 4GLSE 1HD4A 2ASKA 4N1DA 2R53A 4YCIC 2P6AA 3IJ2A 1NT3A 2GOOA 3JVFA 2QR0C 1HCFA 3P9WA 4YCGC 4UI0A 5HHXA 1JPYA 2B0UA 1QFWB 1REUA 2QCQA 5HK5E 1QFWA 5BQEB 3E07A 2QCWA 5BQEA 1B8MB 1RV6V 1SGFB 1TGJA 3MJGA 1B8MA 4ZBNA 1S4YB 1B98A 5FV2V 1KLAA 1MKGA 1TFGA 5HHDA 3BDYV 1NYUB 2VWEA 2FJHV 2KD3A 1WQ9B 2QJ9A 4EFVA 5E4GA 5JZ7A 3S1KV 2PJYA 1REWA 1BNDB 2GNNA 5BQ8D 1BNDA 1KLCA 4KXZA 2H62A 1FL7A 1TGKA 1SG1A 2ARPA 1E9JA 1FLTV 2C7WA 1TZIV 5AEJA 4EAXA 3KFDA 1ES7A 4EC7A 1B8KA 4HQXA 4QAFC 5FV1V 1KTZA 1CZ8V 1WAQA 1LXIA 2GYRA 3EO1C 3FUBB 1BTGA 2R52A 4WPBA 3V6BA 3QTKA 4FAOA 1FL7B 2QJAA 1NYSB 4X1JA 1WQ9A 2XACA 5HHVA 1FZVA 1QTYR 1VPPV 2IFGE 1LX5A 4QCIC 5BQ8B 2TGIA 5BQ8A 1PDGA 2X1XE 1M4UA 2FJGV 4UI1A 3RJRA 1DZ7A 1ZKZA 5HHCA 4MQWA 2VXSA 5F3BC 1XWDB 5HI5A 2X1WA 4QHUC 1AGQA 3BUKA 4ZFFC 4LXRJ 4GLNE 2GH0C 4MQWB 5BPUA 4LXSJ 4HQUA 3S1BV
chains in the Genus database with same CATH topology
2V5EB 3BMPA 3B4VA 3SEKB 4EDXV 2VPFA 4HSAA 2H64A 4UHZA 4BV4L 1HRPB 4MPLA 1HRPA 4MIDA 5HI3A 1M4UL 1TZHV 1BETA 4XPJA 4KZNA 2XV7A 2ARVA 1AOCA 3HH2A 2GYZA 5HI4A 1WQ8A 5BQCA 1WWWV 3EVSB 2BHKA 2QJBA 1BJ1V 1VPFA 5HK5A 4AY9B 3QB4A 4HR9A 4UHYA 4AY9A 1MJVA 3BK3A 1HCNB 4UI2B 1HCNA 1XWDA 5BQBA 1KATW 4KV5A 5F3HI 1MKKA 1BMPA 4EDWV 3MJKA 3V2AA 4GLSE 1HD4A 2ASKA 4N1DA 2R53A 4YCIC 2P6AA 3IJ2A 1NT3A 2GOOA 3JVFA 2QR0C 1HCFA 3P9WA 4YCGC 4UI0A 5HHXA 1JPYA 2B0UA 1QFWB 1REUA 2QCQA 5HK5E 1QFWA 5BQEB 3E07A 2QCWA 5BQEA 1B8MB 1RV6V 1SGFB 1TGJA 3MJGA 1B8MA 4ZBNA 1S4YB 1B98A 5FV2V 1KLAA 1MKGA 1TFGA 5HHDA 3BDYV 1NYUB 2VWEA 2FJHV 2KD3A 1WQ9B 2QJ9A 4EFVA 5E4GA 5JZ7A 3S1KV 2PJYA 1REWA 1BNDB 2GNNA 5BQ8D 1BNDA 1KLCA 4KXZA 2H62A 1FL7A 1TGKA 1SG1A 2ARPA 1E9JA 1FLTV 2C7WA 1TZIV 5AEJA 4EAXA 3KFDA 1ES7A 4EC7A 1B8KA 4HQXA 4QAFC 5FV1V 1KTZA 1CZ8V 1WAQA 1LXIA 2GYRA 3EO1C 3FUBB 1BTGA 2R52A 4WPBA 3V6BA 3QTKA 4FAOA 1FL7B 2QJAA 1NYSB 4X1JA 1WQ9A 2XACA 5HHVA 1FZVA 1QTYR 1VPPV 2IFGE 1LX5A 4QCIC 5BQ8B 2TGIA 5BQ8A 1PDGA 2X1XE 1M4UA 2FJGV 4UI1A 3RJRA 1DZ7A 1ZKZA 5HHCA 4MQWA 2VXSA 5F3BC 1XWDB 5HI5A 2X1WA 4QHUC 1AGQA 3BUKA 4ZFFC 4LXRJ 4GLNE 2GH0C 4MQWB 5BPUA 4LXSJ 4HQUA 3S1BV
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2V5E B;  3BMP A;  3B4V A;  3SEK B;  4EDX V;  2VPF A;  4HSA A;  2H64 A;  4UHZ A;  4BV4 L;  1HRP B;  4MPL A;  1HRP A;  4MID A;  5HI3 A;  1M4U L;  1TZH V;  1BET A;  4XPJ A;  4KZN A;  2XV7 A;  2ARV A;  1AOC A;  3HH2 A;  2GYZ A;  5HI4 A;  1WQ8 A;  5BQC A;  1WWW V;  3EVS B;  2BHK A;  2QJB A;  1BJ1 V;  1VPF A;  5HK5 A;  4AY9 B;  3QB4 A;  4HR9 A;  4UHY A;  4AY9 A;  1MJV A;  3BK3 A;  1HCN B;  4UI2 B;  1HCN A;  1XWD A;  5BQB A;  1KAT W;  4KV5 A;  5F3H I;  1MKK A;  1BMP A;  4EDW V;  3MJK A;  3V2A A;  4GLS E;  1HD4 A;  2ASK A;  4N1D A;  2R53 A;  4YCI C;  2P6A A;  3IJ2 A;  1NT3 A;  2GOO A;  3JVF A;  2QR0 C;  1HCF A;  3P9W A;  4YCG C;  4UI0 A;  5HHX A;  1JPY A;  2B0U A;  1QFW B;  1REU A;  2QCQ A;  5HK5 E;  1QFW A;  5BQE B;  3E07 A;  2QCW A;  5BQE A;  1B8M B;  1RV6 V;  1SGF B;  1TGJ A;  3MJG A;  1B8M A;  4ZBN A;  1S4Y B;  1B98 A;  5FV2 V;  1KLA A;  1MKG A;  1TFG A;  5HHD A;  3BDY V;  1NYU B;  2VWE A;  2FJH V;  2KD3 A;  1WQ9 B;  2QJ9 A;  4EFV A;  5E4G A;  5JZ7 A;  3S1K V;  2PJY A;  1REW A;  1BND B;  2GNN A;  5BQ8 D;  1BND A;  1KLC A;  4KXZ A;  2H62 A;  1FL7 A;  1TGK A;  1SG1 A;  2ARP A;  1E9J A;  1FLT V;  2C7W A;  1TZI V;  5AEJ A;  4EAX A;  3KFD A;  1ES7 A;  4EC7 A;  1B8K A;  4HQX A;  4QAF C;  5FV1 V;  1KTZ A;  1CZ8 V;  1WAQ A;  1LXI A;  2GYR A;  3EO1 C;  3FUB B;  1BTG A;  2R52 A;  4WPB A;  3V6B A;  3QTK A;  4FAO A;  1FL7 B;  2QJA A;  1NYS B;  4X1J A;  1WQ9 A;  2XAC A;  5HHV A;  1FZV A;  1QTY R;  1VPP V;  2IFG E;  1LX5 A;  4QCI C;  5BQ8 B;  2TGI A;  5BQ8 A;  1PDG A;  2X1X E;  1M4U A;  2FJG V;  4UI1 A;  3RJR A;  1DZ7 A;  1ZKZ A;  5HHC A;  4MQW A;  2VXS A;  5F3B C;  1XWD B;  5HI5 A;  2X1W A;  4QHU C;  1AGQ A;  3BUK A;  4ZFF C;  4LXR J;  4GLN E;  2GH0 C;  4MQW B;  5BPU A;  4LXS J;  4HQU A;  3S1B V; 
#chains in the Genus database with same CATH topology
 2V5E B;  3BMP A;  3B4V A;  3SEK B;  4EDX V;  2VPF A;  4HSA A;  2H64 A;  4UHZ A;  4BV4 L;  1HRP B;  4MPL A;  1HRP A;  4MID A;  5HI3 A;  1M4U L;  1TZH V;  1BET A;  4XPJ A;  4KZN A;  2XV7 A;  2ARV A;  1AOC A;  3HH2 A;  2GYZ A;  5HI4 A;  1WQ8 A;  5BQC A;  1WWW V;  3EVS B;  2BHK A;  2QJB A;  1BJ1 V;  1VPF A;  5HK5 A;  4AY9 B;  3QB4 A;  4HR9 A;  4UHY A;  4AY9 A;  1MJV A;  3BK3 A;  1HCN B;  4UI2 B;  1HCN A;  1XWD A;  5BQB A;  1KAT W;  4KV5 A;  5F3H I;  1MKK A;  1BMP A;  4EDW V;  3MJK A;  3V2A A;  4GLS E;  1HD4 A;  2ASK A;  4N1D A;  2R53 A;  4YCI C;  2P6A A;  3IJ2 A;  1NT3 A;  2GOO A;  3JVF A;  2QR0 C;  1HCF A;  3P9W A;  4YCG C;  4UI0 A;  5HHX A;  1JPY A;  2B0U A;  1QFW B;  1REU A;  2QCQ A;  5HK5 E;  1QFW A;  5BQE B;  3E07 A;  2QCW A;  5BQE A;  1B8M B;  1RV6 V;  1SGF B;  1TGJ A;  3MJG A;  1B8M A;  4ZBN A;  1S4Y B;  1B98 A;  5FV2 V;  1KLA A;  1MKG A;  1TFG A;  5HHD A;  3BDY V;  1NYU B;  2VWE A;  2FJH V;  2KD3 A;  1WQ9 B;  2QJ9 A;  4EFV A;  5E4G A;  5JZ7 A;  3S1K V;  2PJY A;  1REW A;  1BND B;  2GNN A;  5BQ8 D;  1BND A;  1KLC A;  4KXZ A;  2H62 A;  1FL7 A;  1TGK A;  1SG1 A;  2ARP A;  1E9J A;  1FLT V;  2C7W A;  1TZI V;  5AEJ A;  4EAX A;  3KFD A;  1ES7 A;  4EC7 A;  1B8K A;  4HQX A;  4QAF C;  5FV1 V;  1KTZ A;  1CZ8 V;  1WAQ A;  1LXI A;  2GYR A;  3EO1 C;  3FUB B;  1BTG A;  2R52 A;  4WPB A;  3V6B A;  3QTK A;  4FAO A;  1FL7 B;  2QJA A;  1NYS B;  4X1J A;  1WQ9 A;  2XAC A;  5HHV A;  1FZV A;  1QTY R;  1VPP V;  2IFG E;  1LX5 A;  4QCI C;  5BQ8 B;  2TGI A;  5BQ8 A;  1PDG A;  2X1X E;  1M4U A;  2FJG V;  4UI1 A;  3RJR A;  1DZ7 A;  1ZKZ A;  5HHC A;  4MQW A;  2VXS A;  5F3B C;  1XWD B;  5HI5 A;  2X1W A;  4QHU C;  1AGQ A;  3BUK A;  4ZFF C;  4LXR J;  4GLN E;  2GH0 C;  4MQW B;  5BPU A;  4LXS J;  4HQU A;  3S1B V; 
#chains in the Genus database with same CATH homology
 2V5E B;  3BMP A;  3B4V A;  3SEK B;  4EDX V;  2VPF A;  4HSA A;  2H64 A;  4UHZ A;  4BV4 L;  1HRP B;  4MPL A;  1HRP A;  4MID A;  5HI3 A;  1M4U L;  1TZH V;  1BET A;  4XPJ A;  4KZN A;  2XV7 A;  2ARV A;  1AOC A;  3HH2 A;  2GYZ A;  5HI4 A;  1WQ8 A;  5BQC A;  1WWW V;  3EVS B;  2BHK A;  2QJB A;  1BJ1 V;  1VPF A;  5HK5 A;  4AY9 B;  3QB4 A;  4HR9 A;  4UHY A;  4AY9 A;  1MJV A;  3BK3 A;  1HCN B;  4UI2 B;  1HCN A;  1XWD A;  5BQB A;  1KAT W;  4KV5 A;  5F3H I;  1MKK A;  1BMP A;  4EDW V;  3MJK A;  3V2A A;  4GLS E;  1HD4 A;  2ASK A;  4N1D A;  2R53 A;  4YCI C;  2P6A A;  3IJ2 A;  1NT3 A;  2GOO A;  3JVF A;  2QR0 C;  1HCF A;  3P9W A;  4YCG C;  4UI0 A;  5HHX A;  1JPY A;  2B0U A;  1QFW B;  1REU A;  2QCQ A;  5HK5 E;  1QFW A;  5BQE B;  3E07 A;  2QCW A;  5BQE A;  1B8M B;  1RV6 V;  1SGF B;  1TGJ A;  3MJG A;  1B8M A;  4ZBN A;  1S4Y B;  1B98 A;  5FV2 V;  1KLA A;  1MKG A;  1TFG A;  5HHD A;  3BDY V;  1NYU B;  2VWE A;  2FJH V;  2KD3 A;  1WQ9 B;  2QJ9 A;  4EFV A;  5E4G A;  5JZ7 A;  3S1K V;  2PJY A;  1REW A;  1BND B;  2GNN A;  5BQ8 D;  1BND A;  1KLC A;  4KXZ A;  2H62 A;  1FL7 A;  1TGK A;  1SG1 A;  2ARP A;  1E9J A;  1FLT V;  2C7W A;  1TZI V;  5AEJ A;  4EAX A;  3KFD A;  1ES7 A;  4EC7 A;  1B8K A;  4HQX A;  4QAF C;  5FV1 V;  1KTZ A;  1CZ8 V;  1WAQ A;  1LXI A;  2GYR A;  3EO1 C;  3FUB B;  1BTG A;  2R52 A;  4WPB A;  3V6B A;  3QTK A;  4FAO A;  1FL7 B;  2QJA A;  1NYS B;  4X1J A;  1WQ9 A;  2XAC A;  5HHV A;  1FZV A;  1QTY R;  1VPP V;  2IFG E;  1LX5 A;  4QCI C;  5BQ8 B;  2TGI A;  5BQ8 A;  1PDG A;  2X1X E;  1M4U A;  2FJG V;  4UI1 A;  3RJR A;  1DZ7 A;  1ZKZ A;  5HHC A;  4MQW A;  2VXS A;  5F3B C;  1XWD B;  5HI5 A;  2X1W A;  4QHU C;  1AGQ A;  3BUK A;  4ZFF C;  4LXR J;  4GLN E;  2GH0 C;  4MQW B;  5BPU A;  4LXS J;  4HQU A;  3S1B V; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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