2GNNA

Crystal structure of the orf virus nz2 variant of vegf-e
Total Genus 14
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
14
sequence length
99
structure length
92
Chain Sequence
DSNTKGWSEVLKGSECKPRPIVVPVSETHPELTSQRFNPPCVTLMRCGGCCNDESLECVPTEEVNVTMELLGGMQRLSFVEHKKCDCRPRFT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of the Orf virus NZ2 variant of vascular endothelial growth factor-E. Implications for receptor specificity.
pubmed doi rcsb
molecule tags Hormone/growth factor
source organism Orf virus (strain nz2)
molecule keywords Vascular endothelial growth factor homolog
total genus 14
structure length 92
sequence length 99
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2006-04-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00341 PDGF PDGF/VEGF domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.90.10 Mainly Beta Ribbon Cystine Knot Cytokines, subunit B Cystine-knot cytokines 2gnnA00
2H62A 4ZBNA 1MKGA 5HHVA 2QJ9A 2R52A 3P9WA 2X1WA 2PJYA 1NYUB 5BQ8B 4QHUC 2ARPA 4BV4L 3BUKA 1M4UL 2TGIA 2VXSA 4GLNE 1HCNB 2XV7A 4N1DA 1TZIV 1KTZA 5F3BC 2P6AA 3IJ2A 1XWDB 1S4YB 4UHYA 4YCGC 5BQEA 1WQ8A 4UI2B 1BNDB 5HI3A 1HD4A 1WQ9A 1HRPB 2GH0C 5E4GA 4MQWA 1KLAA 3S1KV 1BTGA 1BETA 4AY9A 5HK5A 1B8MA 1BJ1V 5FV1V 5JZ7A 1SGFB 2V5EB 1PDGA 2GYRA 2XACA 4EDWV 4FAOA 2FJHV 2B0UA 3HH2A 3QTKA 3MJGA 2QJBA 3EVSB 4YCIC 1VPFA 4LXSJ 3BDYV 2GOOA 4EDXV 1KLCA 2BHKA 2H64A 5AEJA 3S1BV 5BQ8A 4LXRJ 4UI1A 2IFGE 1FL7A 1MKKA 2VPFA 1HCFA 2ARVA 3RJRA 1FLTV 3JVFA 4HSAA 5HHXA 3FUBB 1HCNA 1TFGA 4ZFFC 1MJVA 4UHZA 4UI0A 1ZKZA 1AOCA 1WAQA 1REWA 3V2AA 1QFWB 4EFVA 2R53A 1XWDA 5BPUA 1E9JA 3KFDA 1M4UA 2VWEA 4EAXA 1BMPA 4KXZA 4MQWB 1HRPA 1TGJA 1QTYR 3B4VA 2QCWA 4MPLA 5HHDA 1LX5A 4GLSE 5HI4A 1TZHV 2X1XE 1VPPV 2KD3A 1TGKA 1FZVA 5HK5E 4KZNA 1ES7A 3MJKA 5BQ8D 1DZ7A 1B8KA 4QCIC 4HQXA 1NT3A 1LXIA 4HR9A 4XPJA 5HHCA 1SG1A 5BQEB 4X1JA 4QAFC 1FL7B 3BK3A 2GNNA 1JPYA 1BNDA 1CZ8V 1WQ9B 2QCQA 4HQUA 4AY9B 1B98A 1REUA 4MIDA 2GYZA 2C7WA 1B8MB 3EO1C 3E07A 2QJAA 5F3HI 3BMPA 2QR0C 1AGQA 1QFWA 2FJGV 1RV6V 3QB4A 5HI5A 2ASKA 4KV5A 3V6BA 1KATW 1WWWV 1NYSB 4WPBA 5BQCA 5BQBA 3SEKB 4EC7A 5FV2V
chains in the Genus database with same CATH superfamily
2H62A 4ZBNA 1MKGA 5HHVA 2QJ9A 2R52A 3P9WA 2X1WA 2PJYA 1NYUB 5BQ8B 4QHUC 2ARPA 4BV4L 3BUKA 1M4UL 2TGIA 2VXSA 4GLNE 1HCNB 2XV7A 4N1DA 1TZIV 1KTZA 5F3BC 2P6AA 3IJ2A 1XWDB 1S4YB 4UHYA 4YCGC 5BQEA 1WQ8A 4UI2B 1BNDB 5HI3A 1HD4A 1WQ9A 1HRPB 2GH0C 5E4GA 4MQWA 1KLAA 3S1KV 1BTGA 1BETA 4AY9A 5HK5A 1B8MA 1BJ1V 5FV1V 5JZ7A 1SGFB 2V5EB 1PDGA 2GYRA 2XACA 4EDWV 4FAOA 2FJHV 2B0UA 3HH2A 3QTKA 3MJGA 2QJBA 3EVSB 4YCIC 1VPFA 4LXSJ 3BDYV 2GOOA 4EDXV 1KLCA 2BHKA 2H64A 5AEJA 3S1BV 5BQ8A 4LXRJ 4UI1A 2IFGE 1FL7A 1MKKA 2VPFA 1HCFA 2ARVA 3RJRA 1FLTV 3JVFA 4HSAA 5HHXA 3FUBB 1HCNA 1TFGA 4ZFFC 1MJVA 4UHZA 4UI0A 1ZKZA 1AOCA 1WAQA 1REWA 3V2AA 1QFWB 4EFVA 2R53A 1XWDA 5BPUA 1E9JA 3KFDA 1M4UA 2VWEA 4EAXA 1BMPA 4KXZA 4MQWB 1HRPA 1TGJA 1QTYR 3B4VA 2QCWA 4MPLA 5HHDA 1LX5A 4GLSE 5HI4A 1TZHV 2X1XE 1VPPV 2KD3A 1TGKA 1FZVA 5HK5E 4KZNA 1ES7A 3MJKA 5BQ8D 1DZ7A 1B8KA 4QCIC 4HQXA 1NT3A 1LXIA 4HR9A 4XPJA 5HHCA 1SG1A 5BQEB 4X1JA 4QAFC 1FL7B 3BK3A 2GNNA 1JPYA 1BNDA 1CZ8V 1WQ9B 2QCQA 4HQUA 4AY9B 1B98A 1REUA 4MIDA 2GYZA 2C7WA 1B8MB 3EO1C 3E07A 2QJAA 5F3HI 3BMPA 2QR0C 1AGQA 1QFWA 2FJGV 1RV6V 3QB4A 5HI5A 2ASKA 4KV5A 3V6BA 1KATW 1WWWV 1NYSB 4WPBA 5BQCA 5BQBA 3SEKB 4EC7A 5FV2V
chains in the Genus database with same CATH topology
2H62A 4ZBNA 1MKGA 5HHVA 2QJ9A 2R52A 3P9WA 2X1WA 2PJYA 1NYUB 5BQ8B 4QHUC 2ARPA 4BV4L 3BUKA 1M4UL 2TGIA 2VXSA 4GLNE 1HCNB 2XV7A 4N1DA 1TZIV 1KTZA 5F3BC 2P6AA 3IJ2A 1XWDB 1S4YB 4UHYA 4YCGC 5BQEA 1WQ8A 4UI2B 1BNDB 5HI3A 1HD4A 1WQ9A 1HRPB 2GH0C 5E4GA 4MQWA 1KLAA 3S1KV 1BTGA 1BETA 4AY9A 5HK5A 1B8MA 1BJ1V 5FV1V 5JZ7A 1SGFB 2V5EB 1PDGA 2GYRA 2XACA 4EDWV 4FAOA 2FJHV 2B0UA 3HH2A 3QTKA 3MJGA 2QJBA 3EVSB 4YCIC 1VPFA 4LXSJ 3BDYV 2GOOA 4EDXV 1KLCA 2BHKA 2H64A 5AEJA 3S1BV 5BQ8A 4LXRJ 4UI1A 2IFGE 1FL7A 1MKKA 2VPFA 1HCFA 2ARVA 3RJRA 1FLTV 3JVFA 4HSAA 5HHXA 3FUBB 1HCNA 1TFGA 4ZFFC 1MJVA 4UHZA 4UI0A 1ZKZA 1AOCA 1WAQA 1REWA 3V2AA 1QFWB 4EFVA 2R53A 1XWDA 5BPUA 1E9JA 3KFDA 1M4UA 2VWEA 4EAXA 1BMPA 4KXZA 4MQWB 1HRPA 1TGJA 1QTYR 3B4VA 2QCWA 4MPLA 5HHDA 1LX5A 4GLSE 5HI4A 1TZHV 2X1XE 1VPPV 2KD3A 1TGKA 1FZVA 5HK5E 4KZNA 1ES7A 3MJKA 5BQ8D 1DZ7A 1B8KA 4QCIC 4HQXA 1NT3A 1LXIA 4HR9A 4XPJA 5HHCA 1SG1A 5BQEB 4X1JA 4QAFC 1FL7B 3BK3A 2GNNA 1JPYA 1BNDA 1CZ8V 1WQ9B 2QCQA 4HQUA 4AY9B 1B98A 1REUA 4MIDA 2GYZA 2C7WA 1B8MB 3EO1C 3E07A 2QJAA 5F3HI 3BMPA 2QR0C 1AGQA 1QFWA 2FJGV 1RV6V 3QB4A 5HI5A 2ASKA 4KV5A 3V6BA 1KATW 1WWWV 1NYSB 4WPBA 5BQCA 5BQBA 3SEKB 4EC7A 5FV2V
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2H62 A;  4ZBN A;  1MKG A;  5HHV A;  2QJ9 A;  2R52 A;  3P9W A;  2X1W A;  2PJY A;  1NYU B;  5BQ8 B;  4QHU C;  2ARP A;  4BV4 L;  3BUK A;  1M4U L;  2TGI A;  2VXS A;  4GLN E;  1HCN B;  2XV7 A;  4N1D A;  1TZI V;  1KTZ A;  5F3B C;  2P6A A;  3IJ2 A;  1XWD B;  1S4Y B;  4UHY A;  4YCG C;  5BQE A;  1WQ8 A;  4UI2 B;  1BND B;  5HI3 A;  1HD4 A;  1WQ9 A;  1HRP B;  2GH0 C;  5E4G A;  4MQW A;  1KLA A;  3S1K V;  1BTG A;  1BET A;  4AY9 A;  5HK5 A;  1B8M A;  1BJ1 V;  5FV1 V;  5JZ7 A;  1SGF B;  2V5E B;  1PDG A;  2GYR A;  2XAC A;  4EDW V;  4FAO A;  2FJH V;  2B0U A;  3HH2 A;  3QTK A;  3MJG A;  2QJB A;  3EVS B;  4YCI C;  1VPF A;  4LXS J;  3BDY V;  2GOO A;  4EDX V;  1KLC A;  2BHK A;  2H64 A;  5AEJ A;  3S1B V;  5BQ8 A;  4LXR J;  4UI1 A;  2IFG E;  1FL7 A;  1MKK A;  2VPF A;  1HCF A;  2ARV A;  3RJR A;  1FLT V;  3JVF A;  4HSA A;  5HHX A;  3FUB B;  1HCN A;  1TFG A;  4ZFF C;  1MJV A;  4UHZ A;  4UI0 A;  1ZKZ A;  1AOC A;  1WAQ A;  1REW A;  3V2A A;  1QFW B;  4EFV A;  2R53 A;  1XWD A;  5BPU A;  1E9J A;  3KFD A;  1M4U A;  2VWE A;  4EAX A;  1BMP A;  4KXZ A;  4MQW B;  1HRP A;  1TGJ A;  1QTY R;  3B4V A;  2QCW A;  4MPL A;  5HHD A;  1LX5 A;  4GLS E;  5HI4 A;  1TZH V;  2X1X E;  1VPP V;  2KD3 A;  1TGK A;  1FZV A;  5HK5 E;  4KZN A;  1ES7 A;  3MJK A;  5BQ8 D;  1DZ7 A;  1B8K A;  4QCI C;  4HQX A;  1NT3 A;  1LXI A;  4HR9 A;  4XPJ A;  5HHC A;  1SG1 A;  5BQE B;  4X1J A;  4QAF C;  1FL7 B;  3BK3 A;  2GNN A;  1JPY A;  1BND A;  1CZ8 V;  1WQ9 B;  2QCQ A;  4HQU A;  4AY9 B;  1B98 A;  1REU A;  4MID A;  2GYZ A;  2C7W A;  1B8M B;  3EO1 C;  3E07 A;  2QJA A;  5F3H I;  3BMP A;  2QR0 C;  1AGQ A;  1QFW A;  2FJG V;  1RV6 V;  3QB4 A;  5HI5 A;  2ASK A;  4KV5 A;  3V6B A;  1KAT W;  1WWW V;  1NYS B;  4WPB A;  5BQC A;  5BQB A;  3SEK B;  4EC7 A;  5FV2 V; 
#chains in the Genus database with same CATH topology
 2H62 A;  4ZBN A;  1MKG A;  5HHV A;  2QJ9 A;  2R52 A;  3P9W A;  2X1W A;  2PJY A;  1NYU B;  5BQ8 B;  4QHU C;  2ARP A;  4BV4 L;  3BUK A;  1M4U L;  2TGI A;  2VXS A;  4GLN E;  1HCN B;  2XV7 A;  4N1D A;  1TZI V;  1KTZ A;  5F3B C;  2P6A A;  3IJ2 A;  1XWD B;  1S4Y B;  4UHY A;  4YCG C;  5BQE A;  1WQ8 A;  4UI2 B;  1BND B;  5HI3 A;  1HD4 A;  1WQ9 A;  1HRP B;  2GH0 C;  5E4G A;  4MQW A;  1KLA A;  3S1K V;  1BTG A;  1BET A;  4AY9 A;  5HK5 A;  1B8M A;  1BJ1 V;  5FV1 V;  5JZ7 A;  1SGF B;  2V5E B;  1PDG A;  2GYR A;  2XAC A;  4EDW V;  4FAO A;  2FJH V;  2B0U A;  3HH2 A;  3QTK A;  3MJG A;  2QJB A;  3EVS B;  4YCI C;  1VPF A;  4LXS J;  3BDY V;  2GOO A;  4EDX V;  1KLC A;  2BHK A;  2H64 A;  5AEJ A;  3S1B V;  5BQ8 A;  4LXR J;  4UI1 A;  2IFG E;  1FL7 A;  1MKK A;  2VPF A;  1HCF A;  2ARV A;  3RJR A;  1FLT V;  3JVF A;  4HSA A;  5HHX A;  3FUB B;  1HCN A;  1TFG A;  4ZFF C;  1MJV A;  4UHZ A;  4UI0 A;  1ZKZ A;  1AOC A;  1WAQ A;  1REW A;  3V2A A;  1QFW B;  4EFV A;  2R53 A;  1XWD A;  5BPU A;  1E9J A;  3KFD A;  1M4U A;  2VWE A;  4EAX A;  1BMP A;  4KXZ A;  4MQW B;  1HRP A;  1TGJ A;  1QTY R;  3B4V A;  2QCW A;  4MPL A;  5HHD A;  1LX5 A;  4GLS E;  5HI4 A;  1TZH V;  2X1X E;  1VPP V;  2KD3 A;  1TGK A;  1FZV A;  5HK5 E;  4KZN A;  1ES7 A;  3MJK A;  5BQ8 D;  1DZ7 A;  1B8K A;  4QCI C;  4HQX A;  1NT3 A;  1LXI A;  4HR9 A;  4XPJ A;  5HHC A;  1SG1 A;  5BQE B;  4X1J A;  4QAF C;  1FL7 B;  3BK3 A;  2GNN A;  1JPY A;  1BND A;  1CZ8 V;  1WQ9 B;  2QCQ A;  4HQU A;  4AY9 B;  1B98 A;  1REU A;  4MID A;  2GYZ A;  2C7W A;  1B8M B;  3EO1 C;  3E07 A;  2QJA A;  5F3H I;  3BMP A;  2QR0 C;  1AGQ A;  1QFW A;  2FJG V;  1RV6 V;  3QB4 A;  5HI5 A;  2ASK A;  4KV5 A;  3V6B A;  1KAT W;  1WWW V;  1NYS B;  4WPB A;  5BQC A;  5BQB A;  3SEK B;  4EC7 A;  5FV2 V; 
#chains in the Genus database with same CATH homology
 2H62 A;  4ZBN A;  1MKG A;  5HHV A;  2QJ9 A;  2R52 A;  3P9W A;  2X1W A;  2PJY A;  1NYU B;  5BQ8 B;  4QHU C;  2ARP A;  4BV4 L;  3BUK A;  1M4U L;  2TGI A;  2VXS A;  4GLN E;  1HCN B;  2XV7 A;  4N1D A;  1TZI V;  1KTZ A;  5F3B C;  2P6A A;  3IJ2 A;  1XWD B;  1S4Y B;  4UHY A;  4YCG C;  5BQE A;  1WQ8 A;  4UI2 B;  1BND B;  5HI3 A;  1HD4 A;  1WQ9 A;  1HRP B;  2GH0 C;  5E4G A;  4MQW A;  1KLA A;  3S1K V;  1BTG A;  1BET A;  4AY9 A;  5HK5 A;  1B8M A;  1BJ1 V;  5FV1 V;  5JZ7 A;  1SGF B;  2V5E B;  1PDG A;  2GYR A;  2XAC A;  4EDW V;  4FAO A;  2FJH V;  2B0U A;  3HH2 A;  3QTK A;  3MJG A;  2QJB A;  3EVS B;  4YCI C;  1VPF A;  4LXS J;  3BDY V;  2GOO A;  4EDX V;  1KLC A;  2BHK A;  2H64 A;  5AEJ A;  3S1B V;  5BQ8 A;  4LXR J;  4UI1 A;  2IFG E;  1FL7 A;  1MKK A;  2VPF A;  1HCF A;  2ARV A;  3RJR A;  1FLT V;  3JVF A;  4HSA A;  5HHX A;  3FUB B;  1HCN A;  1TFG A;  4ZFF C;  1MJV A;  4UHZ A;  4UI0 A;  1ZKZ A;  1AOC A;  1WAQ A;  1REW A;  3V2A A;  1QFW B;  4EFV A;  2R53 A;  1XWD A;  5BPU A;  1E9J A;  3KFD A;  1M4U A;  2VWE A;  4EAX A;  1BMP A;  4KXZ A;  4MQW B;  1HRP A;  1TGJ A;  1QTY R;  3B4V A;  2QCW A;  4MPL A;  5HHD A;  1LX5 A;  4GLS E;  5HI4 A;  1TZH V;  2X1X E;  1VPP V;  2KD3 A;  1TGK A;  1FZV A;  5HK5 E;  4KZN A;  1ES7 A;  3MJK A;  5BQ8 D;  1DZ7 A;  1B8K A;  4QCI C;  4HQX A;  1NT3 A;  1LXI A;  4HR9 A;  4XPJ A;  5HHC A;  1SG1 A;  5BQE B;  4X1J A;  4QAF C;  1FL7 B;  3BK3 A;  2GNN A;  1JPY A;  1BND A;  1CZ8 V;  1WQ9 B;  2QCQ A;  4HQU A;  4AY9 B;  1B98 A;  1REU A;  4MID A;  2GYZ A;  2C7W A;  1B8M B;  3EO1 C;  3E07 A;  2QJA A;  5F3H I;  3BMP A;  2QR0 C;  1AGQ A;  1QFW A;  2FJG V;  1RV6 V;  3QB4 A;  5HI5 A;  2ASK A;  4KV5 A;  3V6B A;  1KAT W;  1WWW V;  1NYS B;  4WPB A;  5BQC A;  5BQB A;  3SEK B;  4EC7 A;  5FV2 V; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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