2GOOA

Ternary complex of bmp-2 bound to bmpr-ia-ecd and actrii-ecd
Total Genus 15
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
15
sequence length
103
structure length
103
Chain Sequence
SSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of the ternary signaling complex of a TGF-beta superfamily member.
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords Bone morphogenetic protein 2
total genus 15
structure length 103
sequence length 103
chains with identical sequence D
ec nomenclature
pdb deposition date 2006-04-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00019 TGF_beta Transforming growth factor beta like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.90.10 Mainly Beta Ribbon Cystine Knot Cytokines, subunit B Cystine-knot cytokines 2gooA00
5HI4A 2XACA 1SG1A 1KATW 4KZNA 4EDXV 1MKKA 4AY9A 1NYSB 1KTZA 1TGKA 1LX5A 2FJHV 4UI1A 5AEJA 1AGQA 1HRPB 4HR9A 4HSAA 1SGFB 2XV7A 4YCGC 3QB4A 1B8KA 1HCNB 1XWDB 2QCWA 1KLAA 4UHYA 3BDYV 3BK3A 5HHCA 4EFVA 1HCFA 5BPUA 1BMPA 1HRPA 4EDWV 1NT3A 3SEKB 5HI3A 3EO1C 2GNNA 1HCNA 1XWDA 1JPYA 1PDGA 4KXZA 3MJGA 3JVFA 1BTGA 2ARPA 4KV5A 5F3HI 4ZFFC 3QTKA 1B8MB 5HK5E 4EC7A 1BNDA 1QTYR 1WAQA 2P6AA 2VPFA 3EVSB 1WQ9B 4GLNE 1E9JA 2QR0C 3P9WA 1FZVA 1B8MA 2B0UA 4ZBNA 2IFGE 4QCIC 1QFWB 2FJGV 2R53A 1WQ9A 2TGIA 4LXSJ 2QJBA 5BQCA 1FLTV 1TZIV 1WWWV 2QCQA 4MIDA 2C7WA 3S1KV 4HQUA 1REWA 1AOCA 1TZHV 1REUA 4QHUC 2H62A 5E4GA 5HHDA 2VWEA 4MPLA 3BMPA 2PJYA 1KLCA 5HHXA 2BHKA 2H64A 5HI5A 1ES7A 1M4UL 5BQEB 2GH0C 3V6BA 4UHZA 2GOOA 5BQBA 3MJKA 5BQ8B 2X1WA 3S1BV 4QAFC 2GYRA 1MJVA 2QJ9A 2KD3A 4GLSE 4XPJA 1WQ8A 1NYUB 4WPBA 4AY9B 2X1XE 3B4VA 1S4YB 5HK5A 5FV1V 1TFGA 4LXRJ 4YCIC 1LXIA 1HD4A 2V5EB 5F3BC 3V2AA 1QFWA 1MKGA 4MQWB 5HHVA 1DZ7A 4N1DA 5JZ7A 4HQXA 1BJ1V 1ZKZA 3E07A 3HH2A 1CZ8V 2R52A 1B98A 4MQWA 4EAXA 2ASKA 4FAOA 4UI0A 1BETA 2GYZA 3FUBB 4X1JA 1FL7B 1RV6V 2QJAA 1TGJA 1VPFA 5BQEA 3KFDA 2ARVA 3RJRA 1BNDB 5BQ8A 2VXSA 4BV4L 5BQ8D 5FV2V 3IJ2A 1M4UA 1VPPV 4UI2B 1FL7A 3BUKA
chains in the Genus database with same CATH superfamily
5HI4A 2XACA 1SG1A 1KATW 4KZNA 4EDXV 1MKKA 4AY9A 1NYSB 1KTZA 1TGKA 1LX5A 2FJHV 4UI1A 5AEJA 1AGQA 1HRPB 4HR9A 4HSAA 1SGFB 2XV7A 4YCGC 3QB4A 1B8KA 1HCNB 1XWDB 2QCWA 1KLAA 4UHYA 3BDYV 3BK3A 5HHCA 4EFVA 1HCFA 5BPUA 1BMPA 1HRPA 4EDWV 1NT3A 3SEKB 5HI3A 3EO1C 2GNNA 1HCNA 1XWDA 1JPYA 1PDGA 4KXZA 3MJGA 3JVFA 1BTGA 2ARPA 4KV5A 5F3HI 4ZFFC 3QTKA 1B8MB 5HK5E 4EC7A 1BNDA 1QTYR 1WAQA 2P6AA 2VPFA 3EVSB 1WQ9B 4GLNE 1E9JA 2QR0C 3P9WA 1FZVA 1B8MA 2B0UA 4ZBNA 2IFGE 4QCIC 1QFWB 2FJGV 2R53A 1WQ9A 2TGIA 4LXSJ 2QJBA 5BQCA 1FLTV 1TZIV 1WWWV 2QCQA 4MIDA 2C7WA 3S1KV 4HQUA 1REWA 1AOCA 1TZHV 1REUA 4QHUC 2H62A 5E4GA 5HHDA 2VWEA 4MPLA 3BMPA 2PJYA 1KLCA 5HHXA 2BHKA 2H64A 5HI5A 1ES7A 1M4UL 5BQEB 2GH0C 3V6BA 4UHZA 2GOOA 5BQBA 3MJKA 5BQ8B 2X1WA 3S1BV 4QAFC 2GYRA 1MJVA 2QJ9A 2KD3A 4GLSE 4XPJA 1WQ8A 1NYUB 4WPBA 4AY9B 2X1XE 3B4VA 1S4YB 5HK5A 5FV1V 1TFGA 4LXRJ 4YCIC 1LXIA 1HD4A 2V5EB 5F3BC 3V2AA 1QFWA 1MKGA 4MQWB 5HHVA 1DZ7A 4N1DA 5JZ7A 4HQXA 1BJ1V 1ZKZA 3E07A 3HH2A 1CZ8V 2R52A 1B98A 4MQWA 4EAXA 2ASKA 4FAOA 4UI0A 1BETA 2GYZA 3FUBB 4X1JA 1FL7B 1RV6V 2QJAA 1TGJA 1VPFA 5BQEA 3KFDA 2ARVA 3RJRA 1BNDB 5BQ8A 2VXSA 4BV4L 5BQ8D 5FV2V 3IJ2A 1M4UA 1VPPV 4UI2B 1FL7A 3BUKA
chains in the Genus database with same CATH topology
5HI4A 2XACA 1SG1A 1KATW 4KZNA 4EDXV 1MKKA 4AY9A 1NYSB 1KTZA 1TGKA 1LX5A 2FJHV 4UI1A 5AEJA 1AGQA 1HRPB 4HR9A 4HSAA 1SGFB 2XV7A 4YCGC 3QB4A 1B8KA 1HCNB 1XWDB 2QCWA 1KLAA 4UHYA 3BDYV 3BK3A 5HHCA 4EFVA 1HCFA 5BPUA 1BMPA 1HRPA 4EDWV 1NT3A 3SEKB 5HI3A 3EO1C 2GNNA 1HCNA 1XWDA 1JPYA 1PDGA 4KXZA 3MJGA 3JVFA 1BTGA 2ARPA 4KV5A 5F3HI 4ZFFC 3QTKA 1B8MB 5HK5E 4EC7A 1BNDA 1QTYR 1WAQA 2P6AA 2VPFA 3EVSB 1WQ9B 4GLNE 1E9JA 2QR0C 3P9WA 1FZVA 1B8MA 2B0UA 4ZBNA 2IFGE 4QCIC 1QFWB 2FJGV 2R53A 1WQ9A 2TGIA 4LXSJ 2QJBA 5BQCA 1FLTV 1TZIV 1WWWV 2QCQA 4MIDA 2C7WA 3S1KV 4HQUA 1REWA 1AOCA 1TZHV 1REUA 4QHUC 2H62A 5E4GA 5HHDA 2VWEA 4MPLA 3BMPA 2PJYA 1KLCA 5HHXA 2BHKA 2H64A 5HI5A 1ES7A 1M4UL 5BQEB 2GH0C 3V6BA 4UHZA 2GOOA 5BQBA 3MJKA 5BQ8B 2X1WA 3S1BV 4QAFC 2GYRA 1MJVA 2QJ9A 2KD3A 4GLSE 4XPJA 1WQ8A 1NYUB 4WPBA 4AY9B 2X1XE 3B4VA 1S4YB 5HK5A 5FV1V 1TFGA 4LXRJ 4YCIC 1LXIA 1HD4A 2V5EB 5F3BC 3V2AA 1QFWA 1MKGA 4MQWB 5HHVA 1DZ7A 4N1DA 5JZ7A 4HQXA 1BJ1V 1ZKZA 3E07A 3HH2A 1CZ8V 2R52A 1B98A 4MQWA 4EAXA 2ASKA 4FAOA 4UI0A 1BETA 2GYZA 3FUBB 4X1JA 1FL7B 1RV6V 2QJAA 1TGJA 1VPFA 5BQEA 3KFDA 2ARVA 3RJRA 1BNDB 5BQ8A 2VXSA 4BV4L 5BQ8D 5FV2V 3IJ2A 1M4UA 1VPPV 4UI2B 1FL7A 3BUKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5HI4 A;  2XAC A;  1SG1 A;  1KAT W;  4KZN A;  4EDX V;  1MKK A;  4AY9 A;  1NYS B;  1KTZ A;  1TGK A;  1LX5 A;  2FJH V;  4UI1 A;  5AEJ A;  1AGQ A;  1HRP B;  4HR9 A;  4HSA A;  1SGF B;  2XV7 A;  4YCG C;  3QB4 A;  1B8K A;  1HCN B;  1XWD B;  2QCW A;  1KLA A;  4UHY A;  3BDY V;  3BK3 A;  5HHC A;  4EFV A;  1HCF A;  5BPU A;  1BMP A;  1HRP A;  4EDW V;  1NT3 A;  3SEK B;  5HI3 A;  3EO1 C;  2GNN A;  1HCN A;  1XWD A;  1JPY A;  1PDG A;  4KXZ A;  3MJG A;  3JVF A;  1BTG A;  2ARP A;  4KV5 A;  5F3H I;  4ZFF C;  3QTK A;  1B8M B;  5HK5 E;  4EC7 A;  1BND A;  1QTY R;  1WAQ A;  2P6A A;  2VPF A;  3EVS B;  1WQ9 B;  4GLN E;  1E9J A;  2QR0 C;  3P9W A;  1FZV A;  1B8M A;  2B0U A;  4ZBN A;  2IFG E;  4QCI C;  1QFW B;  2FJG V;  2R53 A;  1WQ9 A;  2TGI A;  4LXS J;  2QJB A;  5BQC A;  1FLT V;  1TZI V;  1WWW V;  2QCQ A;  4MID A;  2C7W A;  3S1K V;  4HQU A;  1REW A;  1AOC A;  1TZH V;  1REU A;  4QHU C;  2H62 A;  5E4G A;  5HHD A;  2VWE A;  4MPL A;  3BMP A;  2PJY A;  1KLC A;  5HHX A;  2BHK A;  2H64 A;  5HI5 A;  1ES7 A;  1M4U L;  5BQE B;  2GH0 C;  3V6B A;  4UHZ A;  2GOO A;  5BQB A;  3MJK A;  5BQ8 B;  2X1W A;  3S1B V;  4QAF C;  2GYR A;  1MJV A;  2QJ9 A;  2KD3 A;  4GLS E;  4XPJ A;  1WQ8 A;  1NYU B;  4WPB A;  4AY9 B;  2X1X E;  3B4V A;  1S4Y B;  5HK5 A;  5FV1 V;  1TFG A;  4LXR J;  4YCI C;  1LXI A;  1HD4 A;  2V5E B;  5F3B C;  3V2A A;  1QFW A;  1MKG A;  4MQW B;  5HHV A;  1DZ7 A;  4N1D A;  5JZ7 A;  4HQX A;  1BJ1 V;  1ZKZ A;  3E07 A;  3HH2 A;  1CZ8 V;  2R52 A;  1B98 A;  4MQW A;  4EAX A;  2ASK A;  4FAO A;  4UI0 A;  1BET A;  2GYZ A;  3FUB B;  4X1J A;  1FL7 B;  1RV6 V;  2QJA A;  1TGJ A;  1VPF A;  5BQE A;  3KFD A;  2ARV A;  3RJR A;  1BND B;  5BQ8 A;  2VXS A;  4BV4 L;  5BQ8 D;  5FV2 V;  3IJ2 A;  1M4U A;  1VPP V;  4UI2 B;  1FL7 A;  3BUK A; 
#chains in the Genus database with same CATH topology
 5HI4 A;  2XAC A;  1SG1 A;  1KAT W;  4KZN A;  4EDX V;  1MKK A;  4AY9 A;  1NYS B;  1KTZ A;  1TGK A;  1LX5 A;  2FJH V;  4UI1 A;  5AEJ A;  1AGQ A;  1HRP B;  4HR9 A;  4HSA A;  1SGF B;  2XV7 A;  4YCG C;  3QB4 A;  1B8K A;  1HCN B;  1XWD B;  2QCW A;  1KLA A;  4UHY A;  3BDY V;  3BK3 A;  5HHC A;  4EFV A;  1HCF A;  5BPU A;  1BMP A;  1HRP A;  4EDW V;  1NT3 A;  3SEK B;  5HI3 A;  3EO1 C;  2GNN A;  1HCN A;  1XWD A;  1JPY A;  1PDG A;  4KXZ A;  3MJG A;  3JVF A;  1BTG A;  2ARP A;  4KV5 A;  5F3H I;  4ZFF C;  3QTK A;  1B8M B;  5HK5 E;  4EC7 A;  1BND A;  1QTY R;  1WAQ A;  2P6A A;  2VPF A;  3EVS B;  1WQ9 B;  4GLN E;  1E9J A;  2QR0 C;  3P9W A;  1FZV A;  1B8M A;  2B0U A;  4ZBN A;  2IFG E;  4QCI C;  1QFW B;  2FJG V;  2R53 A;  1WQ9 A;  2TGI A;  4LXS J;  2QJB A;  5BQC A;  1FLT V;  1TZI V;  1WWW V;  2QCQ A;  4MID A;  2C7W A;  3S1K V;  4HQU A;  1REW A;  1AOC A;  1TZH V;  1REU A;  4QHU C;  2H62 A;  5E4G A;  5HHD A;  2VWE A;  4MPL A;  3BMP A;  2PJY A;  1KLC A;  5HHX A;  2BHK A;  2H64 A;  5HI5 A;  1ES7 A;  1M4U L;  5BQE B;  2GH0 C;  3V6B A;  4UHZ A;  2GOO A;  5BQB A;  3MJK A;  5BQ8 B;  2X1W A;  3S1B V;  4QAF C;  2GYR A;  1MJV A;  2QJ9 A;  2KD3 A;  4GLS E;  4XPJ A;  1WQ8 A;  1NYU B;  4WPB A;  4AY9 B;  2X1X E;  3B4V A;  1S4Y B;  5HK5 A;  5FV1 V;  1TFG A;  4LXR J;  4YCI C;  1LXI A;  1HD4 A;  2V5E B;  5F3B C;  3V2A A;  1QFW A;  1MKG A;  4MQW B;  5HHV A;  1DZ7 A;  4N1D A;  5JZ7 A;  4HQX A;  1BJ1 V;  1ZKZ A;  3E07 A;  3HH2 A;  1CZ8 V;  2R52 A;  1B98 A;  4MQW A;  4EAX A;  2ASK A;  4FAO A;  4UI0 A;  1BET A;  2GYZ A;  3FUB B;  4X1J A;  1FL7 B;  1RV6 V;  2QJA A;  1TGJ A;  1VPF A;  5BQE A;  3KFD A;  2ARV A;  3RJR A;  1BND B;  5BQ8 A;  2VXS A;  4BV4 L;  5BQ8 D;  5FV2 V;  3IJ2 A;  1M4U A;  1VPP V;  4UI2 B;  1FL7 A;  3BUK A; 
#chains in the Genus database with same CATH homology
 5HI4 A;  2XAC A;  1SG1 A;  1KAT W;  4KZN A;  4EDX V;  1MKK A;  4AY9 A;  1NYS B;  1KTZ A;  1TGK A;  1LX5 A;  2FJH V;  4UI1 A;  5AEJ A;  1AGQ A;  1HRP B;  4HR9 A;  4HSA A;  1SGF B;  2XV7 A;  4YCG C;  3QB4 A;  1B8K A;  1HCN B;  1XWD B;  2QCW A;  1KLA A;  4UHY A;  3BDY V;  3BK3 A;  5HHC A;  4EFV A;  1HCF A;  5BPU A;  1BMP A;  1HRP A;  4EDW V;  1NT3 A;  3SEK B;  5HI3 A;  3EO1 C;  2GNN A;  1HCN A;  1XWD A;  1JPY A;  1PDG A;  4KXZ A;  3MJG A;  3JVF A;  1BTG A;  2ARP A;  4KV5 A;  5F3H I;  4ZFF C;  3QTK A;  1B8M B;  5HK5 E;  4EC7 A;  1BND A;  1QTY R;  1WAQ A;  2P6A A;  2VPF A;  3EVS B;  1WQ9 B;  4GLN E;  1E9J A;  2QR0 C;  3P9W A;  1FZV A;  1B8M A;  2B0U A;  4ZBN A;  2IFG E;  4QCI C;  1QFW B;  2FJG V;  2R53 A;  1WQ9 A;  2TGI A;  4LXS J;  2QJB A;  5BQC A;  1FLT V;  1TZI V;  1WWW V;  2QCQ A;  4MID A;  2C7W A;  3S1K V;  4HQU A;  1REW A;  1AOC A;  1TZH V;  1REU A;  4QHU C;  2H62 A;  5E4G A;  5HHD A;  2VWE A;  4MPL A;  3BMP A;  2PJY A;  1KLC A;  5HHX A;  2BHK A;  2H64 A;  5HI5 A;  1ES7 A;  1M4U L;  5BQE B;  2GH0 C;  3V6B A;  4UHZ A;  2GOO A;  5BQB A;  3MJK A;  5BQ8 B;  2X1W A;  3S1B V;  4QAF C;  2GYR A;  1MJV A;  2QJ9 A;  2KD3 A;  4GLS E;  4XPJ A;  1WQ8 A;  1NYU B;  4WPB A;  4AY9 B;  2X1X E;  3B4V A;  1S4Y B;  5HK5 A;  5FV1 V;  1TFG A;  4LXR J;  4YCI C;  1LXI A;  1HD4 A;  2V5E B;  5F3B C;  3V2A A;  1QFW A;  1MKG A;  4MQW B;  5HHV A;  1DZ7 A;  4N1D A;  5JZ7 A;  4HQX A;  1BJ1 V;  1ZKZ A;  3E07 A;  3HH2 A;  1CZ8 V;  2R52 A;  1B98 A;  4MQW A;  4EAX A;  2ASK A;  4FAO A;  4UI0 A;  1BET A;  2GYZ A;  3FUB B;  4X1J A;  1FL7 B;  1RV6 V;  2QJA A;  1TGJ A;  1VPF A;  5BQE A;  3KFD A;  2ARV A;  3RJR A;  1BND B;  5BQ8 A;  2VXS A;  4BV4 L;  5BQ8 D;  5FV2 V;  3IJ2 A;  1M4U A;  1VPP V;  4UI2 B;  1FL7 A;  3BUK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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